The Mechanisms of Action of Curcumin in Alzheimer’s Disease

Analysis of different innovative formulations of curcumin for improved relative oral bioavailability in human subjects

(2017) Martin Purpura et al.   EUROPEAN JOURNAL OF NUTRITION

Role of Glutamate and NMDA Receptors in Alzheimer’s Disease

(2017) Rui Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

The Essential Medicinal Chemistry of Curcumin

(2017) Kathryn M. Nelson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

(2016) Ajaikumar B Kunnumakkara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Reversal of Beta-Amyloid-Induced Neurotoxicity in PC12 Cells by Curcumin, the Important Role of ROS-Mediated Signaling and ERK Pathway

(2016) Cun-dong Fan et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Imbalanced cholesterol metabolism in Alzheimer's disease

(2016) Zhao Xue-shan et al.   CLINICA CHIMICA ACTA

Downstream modulation of extrinsic apoptotic pathway in streptozotocin-induced Alzheimer's dementia in rats: Erythropoietin versus curcumin

(2016) Doaa M. Samy et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

PI3k/Akt signalling pathway plays a crucial role in the anti-inflammatory effects of curcumin in LPS-activated microglia

(2016) Antonia Cianciulli et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Curcumin ameliorates insulin signalling pathway in brain of Alzheimer’s disease transgenic mice

(2016) Hui-li Feng et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Protective effects of a natural product, curcumin, against amyloid β induced mitochondrial and synaptic toxicities in Alzheimer's disease

(2016) P Hemachandra Reddy et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors

(2016) Rita Maria Concetta Di Martino et al.   JOURNAL OF MEDICINAL CHEMISTRY

Curcumin as potential therapeutic natural product: a nanobiotechnological perspective

(2016) Soumitra Shome et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Curcumin improves episodic memory in cadmium induced memory impairment through inhibition of acetylcholinesterase and adenosine deaminase activities in a rat model

(2016) Ayodele Jacob Akinyemi et al.   METABOLIC BRAIN DISEASE

Curcumin Ameliorates Memory Decline via Inhibiting BACE1 Expression and β-Amyloid Pathology in 5×FAD Transgenic Mice

(2016) Kunmu Zheng et al.   MOLECULAR NEUROBIOLOGY

Copper Ion Binding Site in β-Amyloid Peptide

(2016) Diana Yugay et al.   NANO LETTERS

Curcumin improves tau-induced neuronal dysfunction of nematodes

(2016) Tomohiro Miyasaka et al.   NEUROBIOLOGY OF AGING

Novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer's disease

(2016) Madhuri Venigalla et al.   NEUROCHEMISTRY INTERNATIONAL

Curcumin Protects against Monosodium Glutamate Neurotoxicity and Decreasing NMDA2B and mGluR5 Expression in Rat Hippocampus

(2016) Rania M. Khalil et al.   NEUROSIGNALS

Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer’s Disease

(2016) Joana S. Cristóvão et al.   Oxidative Medicine and Cellular Longevity

Curcumin rescues high fat diet-induced obesity and insulin sensitivity in mice through regulating SREBP pathway

(2016) Lili Ding et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Curcumin Attenuates Beta-Amyloid-Induced Neuroinflammation via Activation of Peroxisome Proliferator-Activated Receptor-Gamma Function in a Rat Model of Alzheimer's Disease

(2016) Zun-Jing Liu et al.   Frontiers in Pharmacology

Copper-induced structural conversion templates prion protein oligomerization and neurotoxicity

(2016) C.-F. Yen et al.   Science Advances

Curcumin Attenuates Amyloid-β Aggregate Toxicity and Modulates Amyloid-β Aggregation Pathway

(2015) Arjun Thapa et al.   ACS Chemical Neuroscience

Nucleus basalis of Meynert revisited: anatomy, history and differential involvement in Alzheimer’s and Parkinson’s disease

(2015) Alan King Lun Liu et al.   ACTA NEUROPATHOLOGICA

Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer’s disease

(2015) K. G. Goozee et al.   BRITISH JOURNAL OF NUTRITION

Curcumin attenuates memory deficits and the impairment of cholinergic and purinergic signaling in rats chronically exposed to cadmium

(2015) Pauline da Costa et al.   ENVIRONMENTAL TOXICOLOGY

Natural Compounds Modulating Mitochondrial Functions

(2015) Lara Gibellini et al.   Evidence-based Complementary and Alternative Medicine

Protection of curcumin against amyloid-β-induced cell damage and death involves the prevention from NMDA receptor-mediated intracellular Ca2+elevation

(2015) Han-Chang Huang et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Curcumin inhibits apoptosis by regulating intracellular calcium release, reactive oxygen species and mitochondrial depolarization levels in SH-SY5Y neuronal cells

(2015) Abdülhadi Cihangir Uğuz et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Early Statin Use and the Progression of Alzheimer Disease

(2015) Feng-Cheng Lin et al.   MEDICINE

Synthetic Curcumin Analogs as Inhibitors of β -Amyloid Peptide Aggregation: Potential Therapeutic and Diagnostic Agents for Alzheimer's Disease

(2015) Syed Abbas Bukhari et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Curcumin inhibits Aβ-induced microglial inflammatory responses in vitro: Involvement of ERK1/2 and p38 signaling pathways

(2015) Xiaolei Shi et al.   NEUROSCIENCE LETTERS

A review on Alzheimer's disease pathophysiology and its management: an update

(2015) Anil Kumar et al.   Pharmacological Reports

Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brains

(2015) Douglas G. Walker et al.   Alzheimers Research & Therapy

Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population

(2014) Katherine HM Cox et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Curcumin enhances cell-surface LDLR level and promotes LDL uptake through downregulation of PCSK9 gene expression in HepG2 cells

(2014) Mi-Hsueh Tai et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Dietary factors affecting polyphenol bioavailability

(2014) Torsten Bohn   NUTRITION REVIEWS

Curcumin mediates presenilin-1 activity to reduce β-amyloid production in a model of Alzheimer’s disease

(2014) Zhang Xiong et al.   Pharmacological Reports

Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis

(2013) Krishnendu Sinha et al.   ARCHIVES OF TOXICOLOGY

Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer's disease

(2013) Julius Popp et al.   BIOCHEMICAL PHARMACOLOGY

Complexation between Cu(II) and curcumin in the presence of two different segments of amyloid β

(2013) Angela L. Picciano et al.   BIOPHYSICAL CHEMISTRY

Neuroprotective Properties of Curcumin in Alzheimer’s Disease – Merits and Limitations

(2013) Dawn Chin et al.   CURRENT MEDICINAL CHEMISTRY

Natural Products as Promising Drug Candidates for the Treatment of Alzheimer’s Disease: Molecular Mechanism Aspect

(2013) Niloufar Ansari et al.   Current Neuropharmacology

Acetylcholinesterase Inhibitors: Pharmacology and Toxicology

(2013) Mirjana B. Colovic et al.   Current Neuropharmacology

Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease

(2013) Zhiyou Cai et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Curcumin attenuates amyloid-β-induced tau hyperphosphorylation in human neuroblastoma SH-SY5Y cells involving PTEN/Akt/GSK-3β signaling pathway

(2013) Han-Chang Huang et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Membrane-Mediated Neuroprotection by Curcumin from Amyloid-β-Peptide-Induced Toxicity

(2013) Arjun Thapa et al.   LANGMUIR

Protective effect of curcumin against chronic alcohol-induced cognitive deficits and neuroinflammation in the adult rat brain

(2013) V. Tiwari et al.   NEUROSCIENCE

Curcumin-induced upregulation of the anti-tau cochaperone BAG2 in primary rat cortical neurons

(2013) Sachin P. Patil et al.   NEUROSCIENCE LETTERS

Effect of Curcumin on the metal ion induced fibrillization of Amyloid-β peptide

(2013) Rona Banerjee   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Copper dysfunction in Alzheimer's disease: From meta-analysis of biochemical studies to new insight into genetics

(2012) Rosanna Squitti   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Curcumin inhibits cholesterol uptake in Caco-2 cells by down-regulation of NPC1L1 expression

(2012) Dan Feng et al.   Lipids in Health and Disease

Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study

(2012) John M Ringman et al.   Alzheimers Research & Therapy

Microglia Function in Alzheimer’s Disease

(2012) Egle Solito et al.   Frontiers in Pharmacology

Oxidative Stress and Antioxidant Defense

(2012) Esra Birben et al.   World Allergy Organization Journal

Discovery of curcumin, a component of golden spice, and its miraculous biological activities

(2011) Subash C Gupta et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Dual effects of curcumin on neuronal oxidative stress in the presence of Cu(II)

(2011) Han-Chang Huang et al.   FOOD AND CHEMICAL TOXICOLOGY

Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease

(2011) Robin B. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Linking lipids to Alzheimer's disease: cholesterol and beyond

(2011) Gilbert Di Paolo et al.   NATURE REVIEWS NEUROSCIENCE

Revisiting the cholinergic hypothesis in the development of Alzheimer's disease

(2011) Laura A. Craig et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet

(2010) Minji Kim et al.   Nutrition Research and Practice

Six-Month Randomized, Placebo-Controlled, Double-Blind, Pilot Clinical Trial of Curcumin in Patients With Alzheimer Disease

(2009) Larry Baum et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

The Cochaperone BAG2 Sweeps Paired Helical Filament- Insoluble Tau from the Microtubule

(2009) D. C. Carrettiero et al.   JOURNAL OF NEUROSCIENCE

Role of NMDA receptor–dependent activation of SREBP1 in excitotoxic and ischemic neuronal injuries

(2009) Changiz Taghibiglou et al.   NATURE MEDICINE

Curcumin inhibits cellular cholesterol accumulation by regulating SREBP-1/caveolin-1 signaling pathway in vascular smooth muscle cells

(2008) Hao-yu YUAN et al.   ACTA PHARMACOLOGICA SINICA

Curcumin ameliorates impaired insulin/IGF signalling and memory deficit in a streptozotocin-treated rat model

(2008) Ahmet Turan Isik et al.   AGE

Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease

(2008) Jack T. Rogers et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Activity-Regulated Cytoskeleton-Associated Protein in Rodent Brain is Down-Regulated by High Fat Dietin vivoand by 27-Hydroxycholesterolin vitro

(2008) Laura Mateos et al.   BRAIN PATHOLOGY

Antioxidant and radical scavenging properties of curcumin

(2008) Tuba Ak et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: Blockage by curcumin

(2008) Raozhou Lin et al.   NEUROSCIENCE LETTERS