Article
Neurosciences
Weijia Peng, Ying Ouyang, Shuyi Wang, Jiawei Hou, Zeyu Zhu, Yang Yang, Ruiyu Zhou, Rongbiao Pi
Summary: L-F001 has a protective effect against RSL3-induced ferroptosis in HT22 cells by reducing cell death rate, attenuating mitochondrial shrinkage, and inhibiting the generation of ROS and lipid peroxidation. Additionally, L-F001 restores lipid peroxidation balance, decreases intracellular Fe2+ level, restores FTH1 level, and suppresses JNK activation.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Cell Biology
Xiangnan Zheng, Yuqiong Liang, Cen Zhang
Summary: Ferroptosis is a type of regulated cell death that is dependent on iron and involves the accumulation of intracellular lipid peroxides. It exhibits distinct features from other forms of regulated cell death in terms of morphology, biochemistry, and immunology. Ferroptosis is regulated by iron metabolism, lipid metabolism, antioxidant defense systems, and various signaling pathways. Hypoxia, which occurs in both physiological and pathological conditions, has been found to regulate ferroptosis in certain cell types and conditions through the activation of hypoxia-inducible factor (HIF) signaling and other mechanisms. This review provides an overview of the basic mechanisms and regulations of ferroptosis and hypoxia, as well as the regulation of ferroptosis by hypoxia in different physiological and pathological conditions, which may have implications for the treatment of various diseases.
Article
Multidisciplinary Sciences
Jiao Luo, Xiujun Tan, Ling Ye, Chenglin Wang
Summary: The study reveals that the JNK signaling pathway plays a positive role in the formation of dental papilla cell polarity, as indicated by the up-regulation of polarity-related genes and rescue effects of RhoA Q63L mutant. JNK activation is linked to polarization, migration, and differentiation of dental papilla cells, highlighting its importance in tooth development.
Review
Immunology
Xu-Dong Zhang, Zhong-Yuan Liu, Mao-Sen Wang, Yu-Xiang Guo, Xiang-Kun Wang, Kai Luo, Shuai Huang, Ren-Feng Li
Summary: Regulation of cell mortality for disease treatment has been a focus of research, with the iron-dependent regulated cell death called Ferroptosis being extensively studied. Studies have shown that regulation of ferroptosis brings new treatment strategies for various diseases. Genes involved in iron and lipid metabolism can regulate ferroptosis by controlling iron overload and lipid peroxidation. Glutathione (GSH), the body's primary non-enzymatic antioxidant, also plays a crucial role in combating lipid peroxidation by assisting glutathione peroxidase 4 (GPX4). This review summarizes recent research on the mechanism of ferroptosis and comprehensively analyzes the regulation of ferroptosis through iron and lipid metabolism, as well as the metabolism of GPX4 and GSH.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Sean K. Ryan, Matija Zelic, Yingnan Han, Erin Teeple, Luoman Chen, Mahdiar Sadeghi, Srinivas Shankara, Lilu Guo, Cong Li, Fabrizio Pontarelli, Elizabeth H. Jensen, Ashley L. Comer, Dinesh Kumar, Mindy Zhang, Joseph Gans, Bailin Zhang, Jonathan D. Proto, Jacqueline Saleh, James C. Dodge, Virginia Savova, Deepak Rajpal, Dimitry Ofengeim, Timothy R. Hammond
Summary: Iron dysregulation is associated with multiple neurodegenerative diseases, including Parkinson's disease. In this study, it is found that iron-loaded microglia are responsive to iron and susceptible to ferroptosis, a form of cell death that is dependent on iron. Iron overload also induces a shift in the microglial transcriptional state that is similar to the transcriptomic signature found in postmortem brain microglia of Parkinson's disease. The removal of microglia delays iron-induced neurotoxicity, suggesting the contribution of microglial response to neurodegeneration.
NATURE NEUROSCIENCE
(2023)
Review
Oncology
Yonghao Sun, Zuoxing Xue, Tao Huang, Xiangyu Che, Guangzhen Wu
Summary: Ferroptosis is a type of regulated cell death mediated by lipid peroxidation and iron dependence, which is closely associated with various diseases, including cancer. Changes in lipid metabolism, such as lipid peroxidation and ferroptosis, play critical roles in cancer therapy. This review provides an overview of the characteristics of ferroptosis and analyzes the connections between several metabolic mechanisms and ferroptosis. The effects of lipid peroxides, signaling pathways, and molecules involved in lipid metabolism on ferroptosis are extensively discussed. Furthermore, the review highlights ferroptosis-based treatments and provides examples of their combination with other therapies.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Xiaogang Zheng, Xiaodong Jin, Fei Ye, Xiongxiong Liu, Boyi Yu, Zheng Li, Ting Zhao, Weiqiang Chen, Xinguo Liu, Cuixia Di, Qiang Li
Summary: Ferroptosis is a regulated cell death mode triggered by iron-dependent toxic membrane lipid peroxidation. It has attracted extensive attention due to its association with various diseases. The potential applications of ferroptosis in radiotherapy and immunotherapy have been elucidated, providing new strategies for clinical tumor treatment.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jing Tan, Wei Gao, Wanchao Yang, Xianzhang Zeng, Linlin Wang, Xiaoguang Cui
Summary: JNK1 exacerbates ischemia-reperfusion injury in lung transplantation, while JNK2 alleviates it. JNK1 silencing attenuates lung graft dysfunction by inhibiting inflammation and apoptosis.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Masashi Okada, Yurika Nakagawa-Saito, Yuta Mitobe, Asuka Sugai, Keita Togashi, Shuhei Suzuki, Chifumi Kitanaka
Summary: Glioma stem cells (GSCs) play a critical role in the malignancy of glioblastoma multiforme (GBM) by resisting therapy and promoting tumor initiation. This study reveals that phospholipase C (PLC) epsilon is highly expressed in GSCs and maintains their stemness and survival capacity through the activation of JNK pathway. PLC epsilon may serve as a promising therapeutic target for GSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jiangtao Cui, Yikun Wang, Xiaoting Tian, Yayou Miao, Lifang Ma, Congcong Zhang, Xin Xu, Jiayi Wang, Wentao Fang, Xiao Zhang
Summary: LPCAT3 is regulated by YAP, ZEB, and EP300. The combination of ACSL4, LPCAT3, and YAP determines the ferroptosis sensitivity of LUAD.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Ting Hong, Guang Lei, Xue Chen, He Li, Xiaoye Zhang, Nayiyuan Wu, Yu Zhao, Yilei Zhang, Jing Wang
Summary: The study reveals that ferroptosis contributes to the efficacy of PARP inhibitor olaparib by downregulating SLC7A11 expression. Interference with ferroptosis leads to resistance to olaparib, while boosting ferroptosis enhances sensitivity to PARP inhibitors in BRCA-proficient ovarian cancer cells.
Article
Oncology
Yaofeng Xu, Yuguo Gu, Wanbo Ji, Qirong Dong
Summary: The study explored the activation of ERK and JNK signaling pathway and osteogenesis-related factors in knee osteoarthritis patients. The levels of P-JNK, P-ERK, and OMD were significantly altered in the subchondral bone of knee arthritis participants, as well as in the model group of mice. Treatment with anisomycin showed varying effects on osteoblasts, influencing OMD and OCN levels.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Keiko Tanimura, Tadaaki Yamada, Mano Horinaka, Yuki Katayama, Sarina Fukui, Kenji Morimoto, Takayuki Nakano, Shinsaku Tokuda, Yoshie Morimoto, Masahiro Iwasaku, Yoshiko Kaneko, Junji Uchino, Kazue Yoneda, Seiji Yano, Toshiyuki Sakai, Koichi Takayama
Summary: Through activation of the JNK/c-Jun signaling, novel adaptive resistance has been identified as a key factor leading to failure of ALK-TKIs treatment, suggesting that combination therapy targeting JNK and ALK-TKIs may significantly delay regrowth of lung cancer cells and potentially improve patient outcomes.
Review
Biochemistry & Molecular Biology
Feifei Pu, Fengxia Chen, Zhicai Zhang, Deyao Shi, Binlong Zhong, Xiao Lv, Andrew Blake Tucker, Jiaming Fan, Alexander J. Li, Kevin Qin, Daniel Hu, Connie Chen, Hao Wang, Fang He, Na Ni, Linjuan Huang, Qing Liu, William Wagstaff, Hue H. Luu, Rex C. Haydon, Le Shen, Tong-Chuan He, Jianxiang Liu, Zengwu Shao
Summary: The treatment of cancer involves surgical excision, radiotherapy, and chemotherapy. Chemotherapy drugs interfere with tumor growth and induce cancer cell death. Ferroptosis, a newly discovered iron-dependent type of cell death, is negatively correlated with cancer development and primarily caused by an abnormal increase in iron-dependent reactive oxygen species and the imbalance of redox homeostasis.
Review
Biochemistry & Molecular Biology
Hyunwook Cho, Jung-Mi Hah
Summary: JNK3 plays a crucial role in neurodegenerative diseases, and this study summarizes the research on JNK3 inhibitors, focusing on structural and docking insights.
Article
Chemistry, Organic
Yalan Wu, Wenyi Huang, Danfeng Peng, Xin-An Huang, Jiangyong Gu, Shengjun Wu, Tao Deng, Fang Liu
Summary: A mild synthetic method has been presented for preparing dihydroquinolines which have shown great potential for fluorescence detection of biorelevant hydroxyl radicals (center dot OH). One of the synthetic dihydroquinolines has been demonstrated to enable sensitive and selective detection of center dot OH and intracellular organelle-targeted fluorescence imaging. Dihydroquinoline also exhibits promising potential for constructing advanced fluorescence probes for center dot OH with tunable photophysical properties.
Article
Pharmacology & Pharmacy
Chun-Ping Liu, Jian-Xing Liu, Jiangyong Gu, Fang Liu, Jin-Hua Li, Bin-Yang, Yuan-Zheng, Jie-Li, Shou-hai Wu, Qing-he Wu, Xian-Zhang, Long-Mei Li, Hai-Long Yang, Lei Wang, Xiong Li
Summary: Three bioactive components in Sarcandra glabra, Caffeoylquinic acids, coumarins, and dicaffeoyl derivatives, have shown significant anti-inflammatory effects by targeting the MAPK-NF-kappa B pathway. This plant has the potential to be used in the treatment of acute lung injury by suppressing inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Editorial Material
Chemistry, Multidisciplinary
Ruoyu Zhang, Fang Liu, Ye Tian, Wei Cao, Ruibing Wang
FRONTIERS IN CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Jie Bai, Zitong Ding, Wencan Ke, Dongmei Xu, Museng Wang, Wenkang Huang, Yixin Zhang, Fang Liu, Xusheng Guo
Summary: This study investigated the effects of different inoculants on the fermentation quality, bacterial community dynamics, and metabolic pathways in alfalfa silage using SMRT sequencing technology. The results showed that the adaptation and competition of inoculated bacteria could significantly impact the bacterial community structure and metabolic pathways during ensiling, affecting the fermentation process and quality of the silage products.
MICROBIAL BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Siyu Zhang, Yifan Wang, Yujie Sun, Guangjian Zhao, Juan Wang, Lu Liu, Fang Liu, Peng Wang, Jinbo Yang, Ximing Xu
Summary: This study identified Hinokiflavone as a potential MDM2 inhibitor that suppresses mdm2 mRNA synthesis, leading to increased p53 protein expression and activation of the p53 pathway, ultimately reducing the survival rate of colon cells through cell cycle arrest and apoptosis induction.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Engineering, Environmental
Fang Liu, Jie Bai, Wenkang Huang, Fuhou Li, Wencan Ke, Yixin Zhang, Dongmei Xie, Bo Zhang, Xusheng Guo
Summary: The novel strain Lactobacillus pentosus 3-27 (LP3-27) can effectively degrade beta-cypermethrin in contaminated silage, leading to improved fermentation quality and simplified bacterial interaction networks. LP3-27 dominance in the bacterial community is correlated with beta-cypermethrin degradation, with higher degradation rates observed in silage with 35% DM. This suggests that LP3-27 has the potential to be used as a bioremediation agent in contaminated silage production.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Medicinal
Siyu Zhang, Yifan Wang, Lu Liu, Guangjian Zhao, Yujie Sun, Juan Wang, Fang Liu, Peng Wang, Ximing Xu
Summary: In this study, virtual screening based on pharmacophore model was used to discover a novel USP7 inhibitor, TS-4, which exhibited inhibitory activity against USP7 and antiproliferative activity on human colon cancer cells. Molecular dynamics simulation revealed the mechanism of interaction between TS-4 and USP7.
MOLECULAR INFORMATICS
(2022)
Article
Food Science & Technology
Siyu Zhang, Yifan Wang, Yujie Sun, Guangjian Zhao, Juan Wang, Lu Liu, Fang Liu, Peng Wang, Ximing Xu
Summary: Naringenin and its derivatives have potential therapeutic and anti-metastatic effects in cancer therapy by regulating MDM2 and activating the p53 pathway.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Meng Song, Zijun Chen, Ruian Qiu, Tingwei Zhi, Wenmin Xie, Yingya Zhou, Nachuan Luo, Fuqian Chen, Fang Liu, Chuangpeng Shen, Sheng Lin, Fengxue Zhang, Yong Gao, Changhui Liu
Summary: Excessive accumulation of bile acids (BA) in hepatocytes triggers inflammatory response and recruitment of macrophages, accelerating cholestatic liver injury. This study reveals the importance of crosstalk between hepatocytes and macrophages in the pathogenesis of cholestasis and suggests that blocking this crosstalk by inhibiting NLRP3 inflammasome activation may be a novel therapeutic strategy for cholestasis.
Editorial Material
Chemistry, Multidisciplinary
Jingshan S. Du, Tongkai Chen, Fang Liu, Shengpeng Wang, Jinming Zhang, Ruoyu Zhang
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Analytical
Fuqian Chen, Xiaotong Xia, Dong Ye, Ting Li, Xinxin Huang, Chun Cai, Chenchen Zhu, Chaozhan Lin, Tao Deng, Fang Liu
Summary: Researchers have developed new phthalhydrazide CL probes (GL-1/2/3/4) through derivatization of luminol. Among them, GL-1 shows enhanced CL performance with bright green emission and has great potential in various analytical applications like bloodstain imaging, enzyme-based immunoassay, and glucose/glucose oxidase reaction analysis.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Jiayan Zhu, Ting Li, Shihui Zhang, Xiaomei Zou, Yingchun Zhou, Weiguo Lu, Zhihui Liu, Tao Deng, Fang Liu
Summary: Horseradish peroxidase (HRP) combined with its fluorescence substrates, such as Amplex red, is widely used in biochemical analysis. However, Amplex red has limitations due to nonspecific responsiveness. In this study, three new dihydrofluorescein derivatives were identified as improved HRP substrates. The most promising derivative, DCFH-1, exhibited excellent sensitivity and selectivity for HRP detection, outperforming Amplex red. DCFH-1 was further used in a fluorescence ELISA for the quantification of inflammatory cytokine biomarkers, yielding successful results.
Article
Chemistry, Organic
Xiaotong Xia, Shuru Liu, Wenming Liu, Qiuying Xu, Ximing Xu, Fang Liu, Tao Deng
Summary: A phthalimide probe with a hydroxylamine group was synthesized for fluorescence sensing of copper ions, and it successfully triggered a copper-mediated hydroxyl rearrangement reaction, providing a new approach for the preparation of novel ESIPT dyes under physiological conditions.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Organic
Tao Deng, Jing Zhao, Danfeng Peng, Xinqian He, Xin-an Huang, Chaozhan Lin, Chenchen Zhu, Lei Wang, Fang Liu
Summary: In this study, a fluorescent probe TTPy was prepared and shown to bind with human serum albumin, enabling fluorescent labeling under visible light irradiation. Competitive binding assay revealed its interaction with a group of non-steroidal anti-inflammatory drugs at their binding site.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Review
Chemistry, Analytical
Fuqian Chen, Wenming Liu, Huan Li, Tao Deng, Bengang Xing, Fang Liu
Summary: This article summarizes the recent achievements in the design of rhodamine dyes for STED super-resolution bio-imaging, classifying them according to different biological targets. The focus is on the basic principles of structure design and the relationship between chemical modification and the function of STED imaging.
ANALYSIS & SENSING
(2022)
