Targeting NMDA Receptors at the Neurovascular Unit: Past and Future Treatments for Central Nervous System Diseases

Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association

(2022) Connie W. Tsao et al.   CIRCULATION

Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis

(2022) Kjetil Bjornevik et al.   SCIENCE

Analysis of global prevalence of mental and substance use disorders within countries: focus on sociodemographic characteristics and income levels

(2022) João Mauricio Castaldelli-Maia et al.   INTERNATIONAL REVIEW OF PSYCHIATRY

Calmodulin binding proteins and neuroinflammation in multiple neurodegenerative diseases

(2022) Danton H. O’Day et al.   BMC NEUROSCIENCE

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

(2022) Vassily Trubetskoy et al.   NATURE

NMDA mediates disruption of blood-brain barrier permeability via Rho/ROCK signaling pathway

(2022) Yachun Yu et al.   NEUROCHEMISTRY INTERNATIONAL

Association of Iatrogenic Infarcts With Clinical and Cognitive Outcomes in the Evaluating Neuroprotection in Aneurysm Coiling Therapy Trial

(2022) Aravind Ganesh et al.   NEUROLOGY

2022 Guideline for the Management of Patients With Spontaneous Intracerebral Hemorrhage: A Guideline From the American Heart Association/American Stroke Association

(2022) Steven M. Greenberg et al.   STROKE

Cerebral Glutamate Regulation and Receptor Changes in Perioperative Neuroinflammation and Cognitive Dysfunction

(2022) Yan Zhang et al.   Biomolecules

Activation of non-classical NMDA receptors by glycine impairs barrier function of brain endothelial cells

(2022) Lisa Epping et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Postsynaptic signaling at glutamatergic synapses as therapeutic targets

(2022) Yang Ge et al.   CURRENT OPINION IN NEUROBIOLOGY

Memantine in neurological disorders – schizophrenia and depression

(2021) Kamila Czarnecka et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The receptor hypothesis and the pathogenesis of depression: genetic bases and biological correlates

(2021) Hui-Qin Wang et al.   PHARMACOLOGICAL RESEARCH

Edaravone Dexborneol Versus Edaravone Alone for the Treatment of Acute Ischemic Stroke

(2021) Jie Xu et al.   STROKE

Novel Glutamatergic Modulators for the Treatment of Mood Disorders: Current Status

(2021) Ioline D. Henter et al.   CNS DRUGS

NMDA receptor function in inhibitory neurons

(2021) Sam A. Booker et al.   NEUROPHARMACOLOGY

Plasmin-resistant PSD-95 inhibitors resolve effect-modifying drug-drug interactions between alteplase and nerinetide in acute stroke

(2021) Diana Mayor-Nunez et al.   Science Translational Medicine

Gender and Socioeconomic Disparities in Global Burden of Epilepsy: An Analysis of Time Trends From 1990 to 2017

(2021) Yin Hu et al.   Frontiers in Neurology

Blood–brain barrier leakage and hemorrhagic transformation: The Reperfusion Injury in Ischemic StroKe (RISK) study

(2021) Francesco Arba et al.   EUROPEAN JOURNAL OF NEUROLOGY

The effects of memantine on the serum concentrations of matrix metalloproteinases and neurologic function of patients with ischemic stroke

(2021) Nahid Beladi Moghadam et al.   JOURNAL OF CLINICAL NEUROSCIENCE

A GluN2B-selective inhibitor of NMDA receptor function with enhanced potency at acidic pH and oral bioavailability for clinical use

(2021) Scott J Myers et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Positive allosteric modulation of NMDA receptors: mechanisms, physiological impact and therapeutic potential

(2021) Chloé Geoffroy et al.   JOURNAL OF PHYSIOLOGY-LONDON

Transcranial Magnetic Stimulation Exerts “Rejuvenation” Effects on Corticostriatal Synapses after Partial Dopamine Depletion

(2021) Giuseppina Natale et al.   MOVEMENT DISORDERS

Roles of the tissue-type plasminogen activator in immune response

(2021) Célia Seillier et al.   CELLULAR IMMUNOLOGY

Amantadine treatment and delayed onset of levodopa‐induced dyskinesia in patients with early Parkinson's disease

(2021) Chi‐Chuan Wang et al.   EUROPEAN JOURNAL OF NEUROLOGY

PSD-95: An Effective Target for Stroke Therapy Using Neuroprotective Peptides

(2021) Lola Ugalde-Triviño et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of NMDA Receptors Downregulates Astrocytic AQP4 to Suppress Seizures

(2020) Shuisheng Lei et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Microglial NMDA receptors drive pro‐inflammatory responses via PARP‐1/TRMP2 signaling

(2020) Prajwal Raghunatha et al.   GLIA

Nonionotropic Action of Endothelial NMDA Receptors on Blood–Brain Barrier Permeability via Rho/ROCK-Mediated Phosphorylation of Myosin

(2020) Anupriya Mehra et al.   JOURNAL OF NEUROSCIENCE

Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial

(2020) Michael D Hill et al.   LANCET

NYX‐458 improves cognitive performance in a primate Parkinson's disease model

(2020) A.L Barth et al.   MOVEMENT DISORDERS

Spatiotemporal Regulation of Signaling: Focus on T Cell Activation and the Immunological Synapse

(2020) Esther Garcia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synergy between plasminogen activator inhibitor-1, α-synuclein, and neuroinflammation in Parkinson’s disease

(2020) Carolyn J. Reuland et al.   MEDICAL HYPOTHESES

Autoimmune encephalitis mediated by B-cell response against N-methyl-d-aspartate receptor

(2020) Isabelle Wagnon et al.   BRAIN

Allosteric modulation of NMDA receptors prevents the antibody effects of patients with anti-NMDAR encephalitis

(2020) Francesco Mannara et al.   BRAIN

Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities

(2020) Sarah J. Tabrizi et al.   Nature Reviews Neurology

Elevated plasma levels of D-serine in some patients with amyotrophic lateral sclerosis

(2020) Aven Lee et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Molecular Mechanisms of Glutamate Toxicity in Parkinson’s Disease

(2020) Ji Wang et al.   Frontiers in Neuroscience

Blood–Brain Barrier Leakage Is Increased in Parkinson’s Disease

(2020) Sarah Al-Bachari et al.   Frontiers in Physiology

NMDA Receptors in Astrocytes: In Search for Roles in Neurotransmission and Astrocytic Homeostasis

(2019) Katarzyna Skowrońska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of NMDA Receptors in Alzheimer’s Disease

(2019) Jinping Liu et al.   Frontiers in Neuroscience

Dissociating nNOS (Neuronal NO Synthase)-CAPON (Carboxy-Terminal Postsynaptic Density-95/Discs Large/Zona Occludens-1 Ligand of nNOS) Interaction Promotes Functional Recovery After Stroke via Enhanced Structural Neuroplasticity

(2019) Huan-Yu Ni et al.   STROKE

Tissue‐type plasminogen activator neutralizes LPS but not protease‐activated receptor‐mediated inflammatory responses to plasmin

(2019) Cristina Zalfa et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Disrupted neuronal trafficking in amyotrophic lateral sclerosis

(2019) Katja Burk et al.   ACTA NEUROPATHOLOGICA

Alpha-synuclein targets GluN2A NMDA receptor subunit causing striatal synaptic dysfunction and visuospatial memory alteration

(2019) Valentina Durante et al.   BRAIN

Endothelial NMDA receptors mediate activity-dependent brain hemodynamic responses in mice

(2019) Adam D. Hogan-Cann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Blood-Brain Barrier Breakdown During Acute Phase of the Pilocarpine Model of Epilepsy Is Dynamic and Time-Dependent

(2019) Natália Ferreira Mendes et al.   Frontiers in Neurology

Excess glutamate secreted from astrocytes drives upregulation of P-glycoprotein in endothelial cells in amyotrophic lateral sclerosis

(2019) Loqman A. Mohamed et al.   EXPERIMENTAL NEUROLOGY

An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models

(2019) Josep Dalmau et al.   LANCET NEUROLOGY

Autoimmune receptor encephalitis in mice induced by active immunization with conformationally stabilized holoreceptors

(2019) Brian E. Jones et al.   Science Translational Medicine

Tau binding protein CAPON induces tau aggregation and neurodegeneration

(2019) Shoko Hashimoto et al.   Nature Communications

Autism Associated With Anti-NMDAR Encephalitis: Glutamate-Related Therapy

(2019) Ruu-Fen Tzang et al.   Frontiers in Psychiatry

Role of tissue plasminogen activator and plasminogen activator inhibitor as potential biomarkers in psychosis

(2019) Sarah Elmi et al.   Asian Journal of Psychiatry

Recent CPP-based applications in medicine

(2019) Kaido Kurrikoff et al.   Expert Opinion on Drug Delivery

Roles of Glutamate Receptors in Parkinson’s Disease

(2019) Zhu Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NYX ‐2925 induces metabotropic NMDAR signaling that enhances synaptic NMDAR and AMPAR

(2019) M. Scott Bowers et al.   JOURNAL OF NEUROCHEMISTRY

N-Methyl-D-aspartate receptor antagonist d-methadone produces rapid, mTORC1-dependent antidepressant effects

(2019) Manoela V. Fogaça et al.   NEUROPSYCHOPHARMACOLOGY

The role of NMDA receptor in neurobiology and treatment of major depressive disorder: Evidence from translational research

(2019) Meysam Amidfar et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

NMDA receptor modulation of glutamate release in activated neutrophils

(2019) Ana Gutierrez del Arroyo et al.   EBioMedicine

Circulating tPA contributes to neurovascular coupling by a mechanism involving the endothelial NMDA receptors

(2019) Antoine Anfray et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ketamine in seizure management and future pharmacogenomic considerations

(2019) Giovanna Soldatelli Borsato et al.   PHARMACOGENOMICS JOURNAL

The origin of NMDA receptor hypofunction in schizophrenia

(2019) Kazu Nakazawa et al.   PHARMACOLOGY & THERAPEUTICS

Traumatic Brain Injuries: Pathophysiology and Potential Therapeutic Targets

(2019) Si Yun Ng et al.   Frontiers in Cellular Neuroscience

Dendritic NMDA receptors in parvalbumin neurons enable strong and stable neuronal assemblies

(2019) Jonathan H Cornford et al.   eLife

The Effect of a Single Dose of Intravenous Ketamine on Suicidal Ideation: A Systematic Review and Individual Participant Data Meta-Analysis

(2018) Samuel T. Wilkinson et al.   AMERICAN JOURNAL OF PSYCHIATRY

Tissue-Type Plasminogen Activator Controlled Corticogenesis Through a Mechanism Dependent of NMDA Receptors Expressed on Radial Glial Cells

(2018) Nolwenn Pasquet et al.   CEREBRAL CORTEX

Positive Allosteric Modulation as a Potential Therapeutic Strategy in Anti-NMDA Receptor Encephalitis

(2018) Natasha Warikoo et al.   JOURNAL OF NEUROSCIENCE

Estimating the global incidence of traumatic brain injury

(2018) Michael C. Dewan et al.   JOURNAL OF NEUROSURGERY

NYX-2925 is a novel NMDA receptor modulator that induces rapid and long-lasting analgesia in rat models of neuropathic pain

(2018) Nayereh Ghoreishi-Haack et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Excitotoxicity in the pathogenesis of neurological and psychiatric disorders: Therapeutic implications

(2018) Jordi Olloquequi et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Genetic deletion of NMDA receptors suppresses GABAergic synaptic transmission in two distinct types of central neurons

(2018) Xinglong Gu et al.   NEUROSCIENCE LETTERS

Safety and Optimal Neuroprotection of neu2000 in acute Ischemic stroke with reCanalization: study protocol for a randomized, double-blinded, placebo-controlled, phase-II trial

(2018) Ji Man Hong et al.   Trials

Role of plasminogen activator inhibitor‑1 in the diagnosis and prognosis of patients with Parkinson's disease

(2018) Hong Pan et al.   Experimental and Therapeutic Medicine

NMDA Receptor Autoantibodies in Autoimmune Encephalitis Cause a Subunit-Specific Nanoscale Redistribution of NMDA Receptors

(2018) Laurent Ladépêche et al.   Cell Reports

Release of IL-6 After Stroke Contributes to Impaired Cerebral Autoregulation and Hippocampal Neuronal Necrosis Through NMDA Receptor Activation and Upregulation of ET-1 and JNK

(2018) William M. Armstead et al.   Translational Stroke Research

NMDA antagonists for treating the non-motor symptoms in Parkinson’s disease

(2018) Brigitte Vanle et al.   Translational Psychiatry

Tissue plasminogen activator promotes white matter integrity and functional recovery in a murine model of traumatic brain injury

(2018) Yuguo Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blood-Brain Barrier: From Physiology to Disease and Back

(2018) Melanie D. Sweeney et al.   PHYSIOLOGICAL REVIEWS

Role of Glutamate and NMDA Receptors in Alzheimer’s Disease

(2017) Rui Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Astrocytes drive cortical vasodilatory signaling by activating endothelial NMDA receptors

(2017) Lingling Lu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Unconventional NMDA Receptor Signaling

(2017) Kim Dore et al.   JOURNAL OF NEUROSCIENCE

Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research

(2017) Andrew I R Maas et al.   LANCET NEUROLOGY

Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial

(2017) Koji Abe et al.   LANCET NEUROLOGY

Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors

(2017) A. C. Penn et al.   NATURE

Tissue-type plasminogen activator is a homeostatic regulator of synaptic function in the central nervous system

(2017) Manuel Yepes et al.   Neural Regeneration Research

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

(2017) Costantino Iadecola   NEURON

Neuroprotective efficacy of poly-arginine R18 and NA-1 (TAT-NR2B9c) peptides following transient middle cerebral artery occlusion in the rat

(2017) Diego Milani et al.   NEUROSCIENCE RESEARCH

NMDA Receptors Regulate the Development of Neuronal Intrinsic Excitability through Cell-Autonomous Mechanisms

(2017) Guoqiang Hou et al.   Frontiers in Cellular Neuroscience

Input-dependent regulation of excitability controls dendritic maturation in somatosensory thalamocortical neurons

(2017) Laura Frangeul et al.   Nature Communications

Dynamic disorganization of synaptic NMDA receptors triggered by autoantibodies from psychotic patients

(2017) Julie Jézéquel et al.   Nature Communications

Role of tissue-type plasminogen activator and plasminogen activator inhibitor-1 in psychological stress and depression

(2017) Shih-Jen Tsai   Oncotarget

Mechanical stress activates NMDA receptors in the absence of agonists

(2017) Mohammad Mehdi Maneshi et al.   Scientific Reports

Elevated levels of tissue plasminogen activator and E-selectin in male children with autism spectrum disorder

(2016) Şeref Şimşek et al.   Autism Research

Intravenous Esketamine in Adult Treatment-Resistant Depression: A Double-Blind, Double-Randomization, Placebo-Controlled Study

(2016) Jaskaran B. Singh et al.   BIOLOGICAL PSYCHIATRY

Alpha-Synuclein Produces Early Behavioral Alterations via Striatal Cholinergic Synaptic Dysfunction by Interacting With GluN2D N -Methyl-D-Aspartate Receptor Subunit

(2016) Alessandro Tozzi et al.   BIOLOGICAL PSYCHIATRY

Neuroendothelial NMDA receptors as therapeutic targets in experimental autoimmune encephalomyelitis

(2016) Richard Macrez et al.   BRAIN

The Development of Rapastinel (Formerly GLYX-13); A Rapid Acting and Long Lasting Antidepressant

(2016) Joseph Moskal et al.   Current Neuropharmacology

Ketamine: 50 Years of Modulating the Mind

(2016) Linda Li et al.   Frontiers in Human Neuroscience

Variation in worldwide incidence of amyotrophic lateral sclerosis: a meta-analysis

(2016) Benoît Marin et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Schizophrenia

(2016) Michael J Owen et al.   LANCET

Mechanisms of glutamate toxicity in multiple sclerosis: biomarker and therapeutic opportunities

(2016) Richard Macrez et al.   LANCET NEUROLOGY

Multiple sclerosis should be treated using a step-down strategy rather than a step-up strategy–YES

(2016) Gavin Giovannoni   Multiple Sclerosis Journal

Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles

(2016) Anusha Mishra et al.   NATURE NEUROSCIENCE

Gene discovery in amyotrophic lateral sclerosis: implications for clinical management

(2016) Ammar Al-Chalabi et al.   Nature Reviews Neurology

Emerging roles of GluN3-containing NMDA receptors in the CNS

(2016) Isabel Pérez-Otaño et al.   NATURE REVIEWS NEUROSCIENCE

Neocortical neurogenesis and the etiology of autism spectrum disorder

(2016) Alan Packer   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Roles of NMDARs in maintenance of the mouse cerebrovascular endothelial cell-constructed tight junction barrier

(2016) Jui-Tai Chen et al.   TOXICOLOGY

Physiological Roles of Non-Neuronal NMDA Receptors

(2016) Adam D. Hogan-Cann et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Tissue-type plasminogen activator controls neuronal death by raising surface dynamics of extrasynaptic NMDA receptors

(2016) Flavie Lesept et al.   Cell Death & Disease

Multiple sclerosis should be treated using a step-down strategy rather than a step-up strategy–YES

(2016) Gavin Giovannoni   Multiple Sclerosis Journal

PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits

(2016) Matthew J. Broadhead et al.   Scientific Reports

ATP from synaptic terminals and astrocytes regulates NMDA receptors and synaptic plasticity through PSD-95 multi-protein complex

(2016) U. Lalo et al.   Scientific Reports

Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5–Nrf2 pathway

(2015) D Jimenez-Blasco et al.   CELL DEATH AND DIFFERENTIATION

Poly-Arginine and Arginine-Rich Peptides are Neuroprotective in Stroke Models

(2015) Bruno P Meloni et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Zinc transporter-1: a novel NMDA receptor-binding protein at the postsynaptic density

(2015) Manuela Mellone et al.   JOURNAL OF NEUROCHEMISTRY

Experimental approaches for elucidating co-agonist regulation of NMDA receptor in motor neurons: Therapeutic implications for amyotrophic lateral sclerosis (ALS)

(2015) Praveen Paul et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Cholesterol modulates open probability and desensitization of NMDA receptors

(2015) Miloslav Korinek et al.   JOURNAL OF PHYSIOLOGY-LONDON

Randomized Proof of Concept Trial of GLYX-13, an N-Methyl-D-Aspartate Receptor Glycine Site Partial Agonist, in Major Depressive Disorder Nonresponsive to a Previous Antidepressant Agent

(2015) SHELDON PRESKORN et al.   Journal of Psychiatric Practice

Anticorps anti-NR1 dans l’encéphalite anti-récepteur N-méthyl-D-aspartate et la schizophrénie

(2015) Emmanuel Le Guen et al.   M S-MEDECINE SCIENCES

Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era

(2015) Ximena Paez-Colasante et al.   Nature Reviews Neurology

Context-Dependent GluN2B-Selective Inhibitors of NMDA Receptor Function Are Neuroprotective with Minimal Side Effects

(2015) Hongjie Yuan et al.   NEURON

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders

(2015) Sacha B. Nelson et al.   NEURON

A Metabotropic-Like Flux-Independent NMDA Receptor Regulates Ca2+ Exit from Endoplasmic Reticulum and Mitochondrial Membrane Potential in Cultured Astrocytes

(2015) Pavel Montes de Oca Balderas et al.   PLoS One

Ketamine for the treatment of refractory status epilepticus

(2015) Yao Fang et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Impacts of tissue-type plasminogen activator (tPA) on neuronal survival

(2015) Arnaud Chevilley et al.   Frontiers in Cellular Neuroscience

Tissue-type plasminogen activator is a neuroprotectant in the central nervous system

(2015) Manuel Yepes   Frontiers in Cellular Neuroscience

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease

(2015) Sergio T. Ferreira et al.   Frontiers in Cellular Neuroscience

Conformations of tissue plasminogen activator (tPA) orchestrate neuronal survival by a crosstalk between EGFR and NMDAR

(2015) T Bertrand et al.   Cell Death & Disease

Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule

(2015) Vojtech Vyklicky et al.   Scientific Reports

Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions

(2015) Anders Bach et al.   Scientific Reports

Human N-methyl D-aspartate receptor antibodies alter memory and behaviour in mice

(2014) Jesús Planagumà et al.   BRAIN

Neuronal Hyperactivity Recruits Microglial Processes via Neuronal NMDA Receptors and Microglial P2Y12 Receptors after Status Epilepticus

(2014) U. B. Eyo et al.   JOURNAL OF NEUROSCIENCE

Interaction of nNOS with PSD-95 Negatively Controls Regenerative Repair after Stroke

(2014) C.-X. Luo et al.   JOURNAL OF NEUROSCIENCE

Safety and efficacy of uric acid in patients with acute stroke (URICO-ICTUS): a randomised, double-blind phase 2b/3 trial

(2014) Ángel Chamorro et al.   LANCET NEUROLOGY

Engineering a memory with LTD and LTP

(2014) Sadegh Nabavi et al.   NATURE

CAPON-nNOS coupling can serve as a target for developing new anxiolytics

(2014) Li-Juan Zhu et al.   NATURE MEDICINE

Extrasynaptic NMDA Receptor Involvement in Central Nervous System Disorders

(2014) Matthew P. Parsons et al.   NEURON

Tramiprosate protects neurons against ischemic stroke by disrupting the interaction between PSD95 and nNOS

(2014) Shuangchan Wu et al.   NEUROPHARMACOLOGY

Patches of Disorganization in the Neocortex of Children with Autism

(2014) Rich Stoner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Geographic Access to Acute Stroke Care in the United States

(2014) Opeolu Adeoye et al.   STROKE

Immune Responses in Parkinson’s Disease: Interplay between Central and Peripheral Immune Systems

(2014) Xiaomin Su et al.   Biomed Research International

The nNOS-p38MAPK Pathway Is Mediated by NOS1AP during Neuronal Death

(2013) L.-L. Li et al.   JOURNAL OF NEUROSCIENCE

Critical Role of Increased PTEN Nuclear Translocation in Excitotoxic and Ischemic Neuronal Injuries

(2013) S. Zhang et al.   JOURNAL OF NEUROSCIENCE

Immunosuppression byN-Methyl-d-Aspartate Receptor Antagonists Is Mediated through Inhibition of Kv1.3 and KCa3.1 Channels in T Cells

(2013) Sascha Kahlfuß et al.   MOLECULAR AND CELLULAR BIOLOGY

NMDA receptor as a newly identified member of the metabotropic glutamate receptor family: Clinical implications for neurodegenerative diseases

(2013) ChiHye Chung   MOLECULES AND CELLS

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

Allosteric signaling and dynamics of the clamshell-like NMDA receptor GluN1 N-terminal domain

(2013) Shujia Zhu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Withdrawing amantadine in dyskinetic patients with Parkinson disease: The AMANDYSK trial

(2013) F. Ory-Magne et al.   NEUROLOGY

NMDA receptors in nervous system diseases

(2013) Qiang Zhou et al.   NEUROPHARMACOLOGY

Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression

(2013) S. Nabavi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Excitotoxicity and stroke: Identifying novel targets for neuroprotection

(2013) Ted Weita Lai et al.   PROGRESS IN NEUROBIOLOGY

NMDA receptor-mediated excitotoxicity depends on the coactivation of synaptic and extrasynaptic receptors

(2013) X Zhou et al.   Cell Death & Disease

Pericyte loss influences Alzheimer-like neurodegeneration in mice

(2013) Abhay P. Sagare et al.   Nature Communications

Increased Prevalence of Diverse N -Methyl-D-Aspartate Glutamate Receptor Antibodies in Patients With an Initial Diagnosis of Schizophrenia

(2013) Johann Steiner et al.   JAMA Psychiatry

Serum IgG Antibodies Against the NR1Subunit of the NMDA Receptor Not Detected in Schizophrenia

(2012) Joseph C. Masdeu et al.   AMERICAN JOURNAL OF PSYCHIATRY

Activation of microglial N-methyl-D-aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain

(2012) Angela M. Kaindl et al.   ANNALS OF NEUROLOGY

Role of the N-methyl-d-aspartate receptors complex in amyotrophic lateral sclerosis

(2012) Alida Spalloni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Anti-NMDA-receptor antibody detected in encephalitis, schizophrenia, and narcolepsy with psychotic features

(2012) Ko Tsutsui et al.   BMC Psychiatry

Deficiency in Mural Vascular Cells Coincides with Blood-Brain Barrier Disruption in Alzheimer's Disease

(2012) Jesse D. Sengillo et al.   BRAIN PATHOLOGY

Synaptic and Extrasynaptic NMDA Receptors Are Gated by Different Endogenous Coagonists

(2012) Thomas Papouin et al.   CELL

Involvement and interplay of Parkin, PINK1, and DJ1 in neurodegenerative and neuroinflammatory disorders

(2012) Micha M.M. Wilhelmus et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glutamate Controls tPA Recycling by Astrocytes, Which in Turn Influences Glutamatergic Signals

(2012) F. Casse et al.   JOURNAL OF NEUROSCIENCE

GluN1 splice variant control of GluN1/GluN2D NMDA receptors

(2012) Katie M. Vance et al.   JOURNAL OF PHYSIOLOGY-LONDON

Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial

(2012) Michael D Hill et al.   LANCET NEUROLOGY

Tissue-type plasminogen activator protects neurons from excitotoxin-induced cell death via activation of the ERK1/2–CREB–ATF3 signaling pathway

(2012) Fang Wu et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Immunotherapy blocking the tissue plasminogen activator-dependent activation of N-methyl-d-aspartate glutamate receptors improves hemorrhagic stroke outcome

(2012) Thomas Gaberel et al.   NEUROPHARMACOLOGY

Delayed administration of a PTEN inhibitor BPV improves functional recovery after experimental stroke

(2012) L. Mao et al.   NEUROSCIENCE

A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

(2012) A. Bach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Memantine Improves Safety of Thrombolysis for Stroke

(2012) Axel Montagne et al.   STROKE

A Randomized, Double-blind, Placebo-Controlled Study of Latrepirdine in Patients With Mild to Moderate Huntington Disease

(2012)   JAMA Neurology

Evaluation of the neuroprotective effect of dextromethorphan in the acute phase of ischaemic stroke

(2011) Seyed Ali Mousavi et al.   Archives of Medical Science

Distinct pharmacological and functional properties of NMDA receptors in mouse cortical astrocytes

(2011) Oleg Palygin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Changes in Nursing Burden Following Memantine for Agitation and Aggression in Long-Term Care Residents with Moderate to Severe Alzheimerʼs Disease

(2011) Nathan Herrmann et al.   CNS DRUGS

Neural differentiation of rat aorta pericyte cells

(2011) Enrique Montiel-Eulefi et al.   CYTOMETRY PART A

Molecular basis of positive allosteric modulation of GluN2B NMDA receptors by polyamines

(2011) Laetitia Mony et al.   EMBO JOURNAL

Molecular basis of NMDA receptor functional diversity

(2011) Pierre Paoletti   EUROPEAN JOURNAL OF NEUROSCIENCE

N-Methyl-d-aspartate Receptor Mechanosensitivity Is Governed by C Terminus of NR2B Subunit

(2011) Pallab Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tissue plasminogen activator prevents white matter damage following stroke

(2011) Fernando Correa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Compartment- and context-specific changes in tissue-type plasminogen activator (tPA) activity following brain injury and pharmacological stimulation

(2011) Maithili Sashindranath et al.   LABORATORY INVESTIGATION

Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo

(2011) Amandine Jullienne et al.   Molecular Neurodegeneration

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

Stroke research at a crossroad: asking the brain for directions

(2011) Costantino Iadecola et al.   NATURE NEUROSCIENCE

Analysis of complement and plasma cells in the brain of patients with anti-NMDAR encephalitis

(2011) E. Martinez-Hernandez et al.   NEUROLOGY

From Revolution to Evolution: The Glutamate Hypothesis of Schizophrenia and its Implication for Treatment

(2011) Bita Moghaddam et al.   NEUROPSYCHOPHARMACOLOGY

Oligodendrocytes as Regulators of Neuronal Networks during Early Postnatal Development

(2011) Sandrine Doretto et al.   PLoS One

Antibodies Preventing the Interaction of Tissue-Type Plasminogen Activator With N-Methyl- d -Aspartate Receptors Reduce Stroke Damages and Extend the Therapeutic Window of Thrombolysis

(2011) Richard Macrez et al.   STROKE

Stroke intervention pathways: NMDA receptors and beyond

(2011) Ted Weita Lai et al.   TRENDS IN MOLECULAR MEDICINE

A Randomized, Placebo-Controlled Trial of Latrepirdine in Huntington Disease

(2010) Karl Kieburtz   ARCHIVES OF NEUROLOGY

Decreased serotonin levels associated with behavioral disinhibition in tissue plasminogen activator deficient (tPA−/−) mice

(2010) Konstantinos Pothakos et al.   BRAIN RESEARCH

Sustained calcium signalling and caspase-3 activation involve NMDA receptors in thymocytes in contact with dendritic cells

(2010) P Affaticati et al.   CELL DEATH AND DIFFERENTIATION

Neu2000, an NR2B-selective, moderate NMDA receptor antagonist and potent spin trapping molecule for stroke

(2010) S.J. Cho et al.   DRUG NEWS & PERSPECTIVES

PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression

(2010) Sandra Jurado et al.   EMBO JOURNAL

The NR1 subunit of NMDA receptor regulates monocyte transmigration through the brain endothelial cell barrier

(2010) Arie Reijerkerk et al.   JOURNAL OF NEUROCHEMISTRY

Excitatory Glycine Responses of CNS Myelin Mediated by NR1/NR3 "NMDA" Receptor Subunits

(2010) J. C. Pina-Crespo et al.   JOURNAL OF NEUROSCIENCE

Memantine Preferentially Blocks Extrasynaptic over Synaptic NMDA Receptor Currents in Hippocampal Autapses

(2010) P. Xia et al.   JOURNAL OF NEUROSCIENCE

Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis

(2010) Josep Dalmau et al.   LANCET NEUROLOGY

Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95

(2010) Jihoon Jo et al.   NATURE NEUROSCIENCE

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

Long-term depression in the CNS

(2010) Graham L. Collingridge et al.   NATURE REVIEWS NEUROSCIENCE

Glutamate transporter variants reduce glutamate uptake in Alzheimer's disease

(2010) Heather A. Scott et al.   NEUROBIOLOGY OF AGING

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

Essential Role of NMDA Receptor Channel ε4 Subunit (GluN2D) in the Effects of Phencyclidine, but Not Methamphetamine

(2010) Yoko Hagino et al.   PLoS One

Characterisation of the Expression of NMDA Receptors in Human Astrocytes

(2010) Ming-Chak Lee et al.   PLoS One

Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase

(2010) J. Mitchell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic and specific interaction between synaptic NR2-NMDA receptor and PDZ proteins

(2010) L. Bard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of tissue plasminogen activator in stress responsivity during acute cocaine withdrawal in mice

(2010) Yan Zhou et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential

(2009) Laetitia Mony et al.   BRITISH JOURNAL OF PHARMACOLOGY

NR2D-containing NMDA receptors mediate tissue plasminogen activator-promoted neuronal excitotoxicity

(2009) A Baron et al.   CELL DEATH AND DIFFERENTIATION

NKCC1-mediated traumatic brain injury-induced brain edema and neuron death via Raf/MEK/MAPK cascade

(2009) Kwok-Tung Lu et al.   CRITICAL CARE MEDICINE

Microglial Low-Density Lipoprotein Receptor-Related Protein 1 Mediates the Effect of Tissue-Type Plasminogen Activator on Matrix Metalloproteinase-9 Activity in the Ischemic Brain

(2009) Chen Zhang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Memantine Augmentation in Treatment-Resistant Obsessive-Compulsive Disorder

(2009) Elias Aboujaoude et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Long-term Neurologic Outcomes After Traumatic Brain Injury

(2009) Jeffrey J. Bazarian et al.   JOURNAL OF HEAD TRAUMA REHABILITATION

Common circuit defect of excitatory-inhibitory balance in mouse models of autism

(2009) Nadine Gogolla et al.   Journal of Neurodevelopmental Disorders

Synaptic Activity-Mediated Suppression of p53 and Induction of Nuclear Calcium-Regulated Neuroprotective Genes Promote Survival through Inhibition of Mitochondrial Permeability Transition

(2009) D. Lau et al.   JOURNAL OF NEUROSCIENCE

Matrix Metalloproteinase-9 Controls NMDA Receptor Surface Diffusion through Integrin  1 Signaling

(2009) P. Michaluk et al.   JOURNAL OF NEUROSCIENCE

In Vivo Evidence for NMDA Receptor-Mediated Excitotoxicity in a Murine Genetic Model of Huntington Disease

(2009) M. Y. Heng et al.   JOURNAL OF NEUROSCIENCE

Alterations in Blood-Brain Barrier Permeability to Large and Small Molecules and Leukocyte Accumulation after Traumatic Brain Injury: Effects of Post-Traumatic Hypothermia

(2009) George Lotocki et al.   JOURNAL OF NEUROTRAUMA

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

(2009) Shu-ichi Okamoto et al.   NATURE MEDICINE

Cerebromicrovascular endothelial cells are resistant to l-glutamate

(2008) Ferenc Domoki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Toward Safer Thrombolytic Agents in Stroke: Molecular Requirements for NMDA Receptor-Mediated Neurotoxicity

(2008) Jose P Lopez-Atalaya et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Prevalence of Long-Term Disability From Traumatic Brain Injury in the Civilian Population of the United States, 2005

(2008) Eduard Zaloshnja et al.   JOURNAL OF HEAD TRAUMA REHABILITATION

Down-regulation of astrocytic GLAST by microglia-related inflammation is abrogated in dibutyryl cAMP-differentiated cultures

(2008) Sébastien Tilleux et al.   JOURNAL OF NEUROCHEMISTRY

Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function

(2008) Andre L. Samson et al.   JOURNAL OF NEUROCHEMISTRY

Activation of recombinant NR1/NR2C NMDA receptors

(2008) Shashank M. Dravid et al.   JOURNAL OF PHYSIOLOGY-LONDON

NMDA receptors in clinical neurology: excitatory times ahead

(2008) Lorraine V Kalia et al.   LANCET NEUROLOGY

Measurement and characteristics of neurotransmitter receptor surface trafficking (Review)

(2008) Laurent Groc et al.   MOLECULAR MEMBRANE BIOLOGY

Presynaptic glutamate receptors: physiological functions and mechanisms of action

(2008) Paulo S. Pinheiro et al.   NATURE REVIEWS NEUROSCIENCE

Regulation of N-methyl-d-aspartate receptors by astrocytic d-serine

(2008) S.H.R. Oliet et al.   NEUROSCIENCE

Presynaptic NMDA Receptors: Newly Appreciated Roles in Cortical Synaptic Function and Plasticity

(2008) Rebekah Corlew et al.   NEUROSCIENTIST

Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression

(2008) Anteneh M. Feyissa et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Differential Roles of NMDA Receptor Subtypes in Ischemic Neuronal Cell Death and Ischemic Tolerance

(2008) Min Chen et al.   STROKE

Beyond NMDA and AMPA glutamate receptors: emerging mechanisms for ionic imbalance and cell death in stroke

(2008) Elaine Besancon et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Modulation of NMDA Receptor Properties and Synaptic Transmission by the NR3A Subunit in Mouse Hippocampal and Cerebrocortical Neurons

(2007) Gary Tong et al.   JOURNAL OF NEUROPHYSIOLOGY