The Role of NMDA Receptors in Alzheimer’s Disease

N-methyl-D-aspartate receptor–mediated calcium influx connects amyloid-β oligomers to ectopic neuronal cell cycle reentry in Alzheimer's disease

(2018) Erin J. Kodis et al.   Alzheimers & Dementia

Therapeutic peptides for CNS indications: Progress and challenges

(2018) Bruce H. Morimoto   BIOORGANIC & MEDICINAL CHEMISTRY

Towards resolving the presynaptic NMDA receptor debate

(2018) Guy Bouvier et al.   CURRENT OPINION IN NEUROBIOLOGY

Long-Term Depression Is Independent of GluN2 Subunit Composition

(2018) Jonathan M. Wong et al.   JOURNAL OF NEUROSCIENCE

Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors

(2018) Michael C. Regan et al.   NEURON

Triheteromeric GluN1/GluN2A/GluN2C NMDARs with Unique Single-Channel Properties Are the Dominant Receptor Population in Cerebellar Granule Cells

(2018) Subhrajit Bhattacharya et al.   NEURON

Glutamate and Glycine Binding to the NMDA Receptor

(2018) Alvin Yu et al.   STRUCTURE

Aβ and the dementia syndrome: simple versus complex perspectives

(2018) Sally Hunter et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Memantine and Brain Atrophy in Alzheimer's Disease: A 1-Year Randomized Controlled Trial

(2018) David Wilkinson et al.   JOURNAL OF ALZHEIMERS DISEASE

Impaired Transcription in Alzheimer's Disease: Key Role in Mitochondrial Dysfunction and Oxidative Stress

(2018) Gladys L. Caldeira et al.   JOURNAL OF ALZHEIMERS DISEASE

Mechanism of NMDA receptor channel block by MK-801 and memantine

(2018) Xianqiang Song et al.   NATURE

Imaging the evolution and pathophysiology of Alzheimer disease

(2018) William Jagust   NATURE REVIEWS NEUROSCIENCE

N-Methyl-D-Aspartate Receptor Link to the MAP Kinase Pathway in Cortical and Hippocampal Neurons and Microglia Is Dependent on Calcium Sensors and Is Blocked by α-Synuclein, Tau, and Phospho-Tau in Non-transgenic and Transgenic APPSw,Ind Mice

(2018) Rafael Franco et al.   Frontiers in Molecular Neuroscience

Questions concerning the role of amyloid-β in the definition, aetiology and diagnosis of Alzheimer’s disease

(2018) Gary P. Morris et al.   ACTA NEUROPATHOLOGICA

Whole brain imaging reveals distinct spatial patterns of amyloid beta deposition in three mouse models of Alzheimer's disease

(2018) Jennifer D. Whitesell et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The diagnostic value of FDG and amyloid PET in Alzheimer’s disease—A systematic review

(2017) Louise Rice et al.   EUROPEAN JOURNAL OF RADIOLOGY

Role of Glutamate and NMDA Receptors in Alzheimer’s Disease

(2017) Rui Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Unconventional NMDA Receptor Signaling

(2017) Kim Dore et al.   JOURNAL OF NEUROSCIENCE

In vivo staging of regional amyloid deposition

(2017) Michel J. Grothe et al.   NEUROLOGY

Allosteric Interactions between NMDA Receptor Subunits Shape the Developmental Shift in Channel Properties

(2017) Weinan Sun et al.   NEURON

Differential Regulation of Evoked and Spontaneous Release by Presynaptic NMDA Receptors

(2017) Therése Abrahamsson et al.   NEURON

Diverse modes of NMDA receptor positive allosteric modulation: Mechanisms and consequences

(2017) David H. Hackos et al.   NEUROPHARMACOLOGY

Modulating synaptic NMDA receptors

(2017) Kenneth R. Tovar et al.   NEUROPHARMACOLOGY

Cognitive Decline in Neuronal Aging and Alzheimer's Disease: Role of NMDA Receptors and Associated Proteins

(2017) Jesús Avila et al.   Frontiers in Neuroscience

Amyloid-β Induces Caspase-Dependent Loss of PSD-95 and Synaptophysin Through NMDA Receptors

(2017) Jinping Liu et al.   JOURNAL OF ALZHEIMERS DISEASE

Icariin, a major constituent from Epimedium brevicornum , attenuates ibotenic acid-induced excitotoxicity in rat hippocampus

(2016) Nan Zong et al.   BEHAVIOURAL BRAIN RESEARCH

Expression of A152T human tau causes age‐dependent neuronal dysfunction and loss in transgenic mice

(2016) Sumihiro Maeda et al.   EMBO REPORTS

The Tau/A152T mutation, a risk factor for frontotemporal‐spectrum disorders, leads to NR2B receptor‐mediated excitotoxicity

(2016) Jochen Martin Decker et al.   EMBO REPORTS

Beyond immunotherapy: new approaches for disease modifying treatments for early Alzheimer’s disease

(2016) Myuri Ruthirakuhan et al.   EXPERT OPINION ON PHARMACOTHERAPY

Pharmacotherapeutic strategies in the treatment of severe Alzheimer’s disease

(2016) William James Deardorff et al.   EXPERT OPINION ON PHARMACOTHERAPY

Differential Regulation of N-Methyl-D-Aspartate Receptor Subunits is An Early Event in the Actions of Soluble Amyloid-β1-40 Oligomers on Hippocampal Neurons

(2016) Lirong Chang et al.   JOURNAL OF ALZHEIMERS DISEASE

Astrocytic GluN2A and GluN2B Oppose the Synaptotoxic Effects of Amyloid-β1-40 in Hippocampal Cells

(2016) Yan Li et al.   JOURNAL OF ALZHEIMERS DISEASE

Blocking the Interaction between EphB2 and ADDLs by a Small Peptide Rescues Impaired Synaptic Plasticity and Memory Deficits in a Mouse Model of Alzheimer's Disease

(2016) Xiao-Dong Shi et al.   JOURNAL OF NEUROSCIENCE

Proton-gated Ca2+-permeable TRP channels damage myelin in conditions mimicking ischaemia

(2016) Nicola B. Hamilton et al.   NATURE

Postsynaptic, not presynaptic NMDA receptors are required for spike-timing-dependent LTD induction

(2016) Brett C Carter et al.   NATURE NEUROSCIENCE

Emerging roles of GluN3-containing NMDA receptors in the CNS

(2016) Isabel Pérez-Otaño et al.   NATURE REVIEWS NEUROSCIENCE

Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors

(2016) Feng Yi et al.   NEURON

NMDA Receptor-Dependent LTD Requires Transient Synaptic Incorporation of Ca 2+ -Permeable AMPARs Mediated by AKAP150-Anchored PKA and Calcineurin

(2016) Jennifer L. Sanderson et al.   NEURON

The N-terminal domain of the GluN3A subunit determines the efficacy of glycine-activated NMDA receptors

(2016) Ivana Mesic et al.   NEUROPHARMACOLOGY

Roles of Presynaptic NMDA Receptors in Neurotransmission and Plasticity

(2016) Abhishek Banerjee et al.   TRENDS IN NEUROSCIENCES

Physiological Roles of Non-Neuronal NMDA Receptors

(2016) Adam D. Hogan-Cann et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Extrasynaptic NMDA receptor-induced tau overexpression mediates neuronal death through suppressing survival signaling ERK phosphorylation

(2016) Xu-Ying Sun et al.   Cell Death & Disease

NMDA receptors mediate contractile responses in human airway smooth muscle cells

(2015) Vidyanand Anaparti et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

NR2B antagonist CP-101,606 inhibits NR2B phosphorylation at tyrosine-1472 and its interactions with Fyn in levodopa-induced dyskinesia rat model

(2015) Min Kong et al.   BEHAVIOURAL BRAIN RESEARCH

Effect of acute NR2B antagonist treatment on long-term potentiation in the rat hippocampus

(2015) John D Graef et al.   BRAIN RESEARCH

Long-term potentiation and the role of N -methyl- d -aspartate receptors

(2015) Arturas Volianskis et al.   BRAIN RESEARCH

Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5–Nrf2 pathway

(2015) D Jimenez-Blasco et al.   CELL DEATH AND DIFFERENTIATION

Allosteric modulators of NMDA receptors: multiple sites and mechanisms

(2015) Shujia Zhu et al.   CURRENT OPINION IN PHARMACOLOGY

A structural biology perspective on NMDA receptor pharmacology and function

(2015) Michael C Regan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Inhibition of in vivo [3H]MK-801 binding by NMDA receptor open channel blockers and GluN2B antagonists in rats and mice

(2015) Alda Fernandes et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

ER stress response in NG108-15 cells involves upregulation of syntaxin 5 expression and reduced amyloid β peptide secretion

(2015) Kei Suga et al.   EXPERIMENTAL CELL RESEARCH

Non-Ionotropic NMDA Receptor Signaling Drives Activity-Induced Dendritic Spine Shrinkage

(2015) I. S. Stein et al.   JOURNAL OF NEUROSCIENCE

Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment

(2015) Jan Marquard et al.   NATURE MEDICINE

The mechanisms and functions of spontaneous neurotransmitter release

(2015) Ege T. Kavalali   NATURE REVIEWS NEUROSCIENCE

Aβ and NMDAR activation cause mitochondrial dysfunction involving ER calcium release

(2015) Ildete Luísa Ferreira et al.   NEUROBIOLOGY OF AGING

Presynaptic NMDA receptors: Roles and rules

(2015) G. Bouvier et al.   NEUROSCIENCE

A Metabotropic-Like Flux-Independent NMDA Receptor Regulates Ca2+ Exit from Endoplasmic Reticulum and Mitochondrial Membrane Potential in Cultured Astrocytes

(2015) Pavel Montes de Oca Balderas et al.   PLoS One

Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss

(2015) J H Birnbaum et al.   Cell Death & Disease

Endoplasmic reticulum stress promotes amyloid-beta peptides production in RGC-5 cells

(2014) Bingqian Liu et al.   CELL STRESS & CHAPERONES

Therapeutic Molecules and Endogenous Ligands Regulate the Interaction between Brain Cellular Prion Protein (PrPC) and Metabotropic Glutamate Receptor 5 (mGluR5)

(2014) Laura T. Haas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ionotropic NMDA Receptor Signaling Is Required for the Induction of Long-Term Depression in the Mouse Hippocampal CA1 Region

(2014) W. E. Babiec et al.   JOURNAL OF NEUROSCIENCE

Controlling NMDA Receptor Subunit Composition Using Ectopic Retention Signals

(2014) D. Stroebel et al.   JOURNAL OF NEUROSCIENCE

NMDA receptor structures reveal subunit arrangement and pore architecture

(2014) Chia-Hsueh Lee et al.   NATURE

Synapse-Specific Control of Experience-Dependent Plasticity by Presynaptic NMDA Receptors

(2014) Rylan S. Larsen et al.   NEURON

Essential Role of Presynaptic NMDA Receptors in Activity-Dependent BDNF Secretion and Corticostriatal LTP

(2014) Hyungju Park et al.   NEURON

Distinct Functional and Pharmacological Properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA Receptors

(2014) Kasper B. Hansen et al.   NEURON

Study of the interaction of glutamatergic and nitrergic signalling in conditions of the experimental airways hyperreactivity

(2014) Martina Antošová et al.   Pharmacological Reports

Crystal structure of a heterotetrameric NMDA receptor ion channel

(2014) E. Karakas et al.   SCIENCE

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

GRIN2Amutation and early-onset epileptic encephalopathy: personalized therapy with memantine

(2014) Tyler Mark Pierson et al.   Annals of Clinical and Translational Neurology

CORM-A1 prevents blood-brain barrier dysfunction caused by ionotropic glutamate receptor-mediated endothelial oxidative stress and apoptosis

(2013) Shyamali Basuroy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Activation of the endoplasmic reticulum stress response by the amyloid-beta 1–40 peptide in brain endothelial cells

(2013) Ana Catarina R.G. Fonseca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

NMDA Receptors in Glial Cells: Pending Questions

(2013) David Dzamba et al.   Current Neuropharmacology

A functional role of NMDA receptor in regulating the differentiation of oligodendrocyte precursor cells and remyelination

(2013) Cui Li et al.   GLIA

Involvement of the GluN2A and GluN2B Subunits in Synaptic and Extrasynaptic N -methyl-d-aspartate Receptor Function and Neuronal Excitotoxicity

(2013) Xianju Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Presynaptic NMDA Receptor Mechanisms for Enhancing Spontaneous Neurotransmitter Release

(2013) P. A. Kunz et al.   JOURNAL OF NEUROSCIENCE

NMDA receptor as a newly identified member of the metabotropic glutamate receptor family: Clinical implications for neurodegenerative diseases

(2013) ChiHye Chung   MOLECULES AND CELLS

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein

(2013) Ji Won Um et al.   NEURON

Structure-based discovery of antagonists for GluN3-containing N-methyl-d-aspartate receptors

(2013) Trine Kvist et al.   NEUROPHARMACOLOGY

Dysfunctional synapse in Alzheimer's disease – A focus on NMDA receptors

(2013) Sandra I. Mota et al.   NEUROPHARMACOLOGY

Microtubule-associated protein tau is essential for long-term depression in the hippocampus

(2013) T. Kimura et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

NMDA-Receptor Activation but Not Ion Flux Is Required for Amyloid-Beta Induced Synaptic Depression

(2013) Albert Tamburri et al.   PLoS One

Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression

(2013) S. Nabavi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabotropic NMDA receptor function is required for  -amyloid-induced synaptic depression

(2013) H. W. Kessels et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NMDA receptor-mediated excitotoxicity depends on the coactivation of synaptic and extrasynaptic receptors

(2013) X Zhou et al.   Cell Death & Disease

Dysregulation of synaptic and extrasynaptic N-methyl-D-aspartate receptors induced by amyloid-β

(2013) Zhi-Cong Wang et al.   Neuroscience Bulletin

Endoplasmic reticulum stress occurs downstream of GluN2B subunit ofN-methyl-D-aspartate receptor in mature hippocampal cultures treated with amyloid-β oligomers

(2012) Rui O. Costa et al.   AGING CELL

Activation of microglial N-methyl-D-aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain

(2012) Angela M. Kaindl et al.   ANNALS OF NEUROLOGY

Inflammatory activation enhances NMDA-triggered Ca2+ signalling and IL-1β secretion in primary cultures of rat astrocytes

(2012) Franck Gérard et al.   BRAIN RESEARCH

Presynaptic NMDA receptors: Are they dendritic receptors in disguise?

(2012) Ian C. Duguid   BRAIN RESEARCH BULLETIN

Role of nonsynaptic GluN2B-containing NMDA receptors in excitotoxicity: Evidence that fluoxetine selectively inhibits these receptors and may have neuroprotective effects

(2012) E.S. Vizi et al.   BRAIN RESEARCH BULLETIN

Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine - searching for the connections

(2012) Wojciech Danysz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Synaptic and Extrasynaptic NMDA Receptors Are Gated by Different Endogenous Coagonists

(2012) Thomas Papouin et al.   CELL

Amyloid-Beta Peptide 1-42 Causes Microtubule Deregulation through N-methyl-D-aspartate Receptors in Mature Hippocampal Cultures

(2012) Sandra I. Mota et al.   Current Alzheimer Research

Multiple Defects in Energy Metabolism in Alzheimers Disease

(2012) I. L. Ferreira et al.   CURRENT DRUG TARGETS

G-Protein-Coupled Receptor 30 Mediates Rapid Neuroprotective Effects of Estrogen via Depression of NR2B-Containing NMDA Receptors

(2012) S.-b. Liu et al.   JOURNAL OF NEUROSCIENCE

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

(2012) Ji Won Um et al.   NATURE NEUROSCIENCE

The NMDA receptor subunit GluN3A protects against 3-nitroproprionic-induced striatal lesions via inhibition of calpain activation

(2012) Rebeca Martínez-Turrillas et al.   NEUROBIOLOGY OF DISEASE

Tau protein is involved in morphological plasticity in hippocampal neurons in response to BDNF

(2012) Qian Chen et al.   NEUROCHEMISTRY INTERNATIONAL

Pre- and postsynaptic localization of NMDA receptor subunits at hippocampal mossy fibre synapses

(2012) L.K. Berg et al.   NEUROSCIENCE

Diversity in NMDA Receptor Composition

(2012) Antonio Sanz-Clemente et al.   NEUROSCIENTIST

Selective Regulation of NR2B by Protein Phosphatase-1 for the Control of the NMDA Receptor in Neuroprotection

(2012) Mélissa Farinelli et al.   PLoS One

Efficacy of Memantine for Agitation in Alzheimer’s Dementia: A Randomised Double-Blind Placebo Controlled Trial

(2012) Chris Fox et al.   PLoS One

Current and Calcium Responses to Local Activation of Axonal NMDA Receptors in Developing Cerebellar Molecular Layer Interneurons

(2012) Bénédicte Rossi et al.   PLoS One

Genetic Deletion of NR3A Accelerates Glutamatergic Synapse Maturation

(2012) Maile A. Henson et al.   PLoS One

GluN3 subunit-containing NMDA receptors: not just one-trick ponies

(2012) Svenja Pachernegg et al.   TRENDS IN NEUROSCIENCES

NMDA Receptor-Dependent Long-Term Potentiation and Long-Term Depression (LTP/LTD)

(2012) C. Luscher et al.   Cold Spring Harbor Perspectives in Biology

Multiple signaling pathways involved in stimulation of osteoblast differentiation by N-methyl-D-aspartate receptors activation in vitro

(2011) Jie-li Li et al.   ACTA PHARMACOLOGICA SINICA

New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs

(2011) Salvatore Salomone et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Distinct pharmacological and functional properties of NMDA receptors in mouse cortical astrocytes

(2011) Oleg Palygin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Amyloid β peptide oligomers directly activate NMDA receptors

(2011) Laura Texidó et al.   CELL CALCIUM

Amyloid beta peptide 1–42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-d-aspartate receptors in cortical cultures

(2011) I.L. Ferreira et al.   CELL CALCIUM

New developments on the role of NMDA receptors in Alzheimer's disease

(2011) Roberto Malinow   CURRENT OPINION IN NEUROBIOLOGY

Combination Therapy for Alzheimerʼs Disease

(2011) Laxeshkumar Patel et al.   DRUGS & AGING

Molecular basis of NMDA receptor functional diversity

(2011) Pierre Paoletti   EUROPEAN JOURNAL OF NEUROSCIENCE

Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau

(2011) Alessia Usardi et al.   FEBS Journal

The regulation of N-methyl-d-aspartate receptors by Src kinase

(2011) Bradley R. Groveman et al.   FEBS Journal

Expression of N-methyl D-aspartate receptor subunits in amoeboid microglia mediates production of nitric oxide via NF-κB signaling pathway and oligodendrocyte cell death in hypoxic postnatal rats

(2011) Madhuvika Murugan et al.   GLIA

The ER stress factor XBP1s prevents amyloid-β neurotoxicity

(2011) Sergio Casas-Tinto et al.   HUMAN MOLECULAR GENETICS

Opposing Synaptic Regulation of Amyloid-  Metabolism by NMDA Receptors In Vivo

(2011) D. K. Verges et al.   JOURNAL OF NEUROSCIENCE

Mechanisms underlying NMDA receptor synaptic/extrasynaptic distribution and function

(2011) Clare M. Gladding et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

NR3A-containing NMDARs promote neurotransmitter release and spike timing–dependent plasticity

(2011) Rylan S Larsen et al.   NATURE NEUROSCIENCE

GluN2B-containing NMDA receptors as possible targets for the neuroprotective and antidepressant effects of fluoxetine

(2011) Janos P. Kiss et al.   NEUROCHEMISTRY INTERNATIONAL

NMDA receptors: Recent insights and clinical correlations

(2011) E. E. Benarroch   NEUROLOGY

Pharmacotherapies for Alzheimer's disease: Beyond cholinesterase inhibitors

(2011) Haythum O. Tayeb et al.   PHARMACOLOGY & THERAPEUTICS

Control of Local Protein Synthesis and Initial Events in Myelination by Action Potentials

(2011) H. Wake et al.   SCIENCE

Functional NMDA receptors with atypical properties are expressed in podocytes

(2010) Marc Anderson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Aberrant subcellular neuronal calcium regulation in aging and Alzheimer's disease

(2010) Simonetta Camandola et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Residues at the tip of the pore loop of NR3B-containing NMDA receptors determine Ca2+ permeability and Mg2+ block

(2010) Nora A Cavara et al.   BMC NEUROSCIENCE

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Activation of Extrasynaptic, But Not Synaptic, NMDA Receptors Modifies Amyloid Precursor Protein Expression Pattern and Increases Amyloid-  Production

(2010) K. Bordji et al.   JOURNAL OF NEUROSCIENCE

A -Mediated NMDA Receptor Endocytosis in Alzheimer's Disease Involves Ubiquitination of the Tyrosine Phosphatase STEP61

(2010) P. Kurup et al.   JOURNAL OF NEUROSCIENCE

Amyloid   Induces the Morphological Neurodegenerative Triad of Spine Loss, Dendritic Simplification, and Neuritic Dystrophies through Calcineurin Activation

(2010) H.-Y. Wu et al.   JOURNAL OF NEUROSCIENCE

A  Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

(2010) H. Zempel et al.   JOURNAL OF NEUROSCIENCE

The receptor subunits generating NMDA receptor mediated currents in oligodendrocytes

(2010) Valeria Burzomato et al.   JOURNAL OF PHYSIOLOGY-LONDON

New Insights into the Not-So-New NR3 Subunits of N-Methyl-D-aspartate Receptor: Localization, Structure, and Function

(2010) C.-M. Low et al.   MOLECULAR PHARMACOLOGY

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

(2010) Jorge J Palop et al.   NATURE NEUROSCIENCE

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors

(2010) Raik Rönicke et al.   NEUROBIOLOGY OF AGING

Presynaptic NMDARs in the Hippocampus Facilitate Transmitter Release at Theta Frequency

(2010) Lindsay McGuinness et al.   NEURON

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

Characterisation of the Expression of NMDA Receptors in Human Astrocytes

(2010) Ming-Chak Lee et al.   PLoS One

Influence of the NR3A subunit on NMDA receptor functions

(2010) Maile A. Henson et al.   PROGRESS IN NEUROBIOLOGY

Regulation of NMDA receptor Ca2+signalling and synaptic plasticity

(2009) C. Geoffrey Lau et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Phosphorylation status of the NR2B subunit of NMDA receptor regulates its interaction with calcium/calmodulin-dependent protein kinase II

(2009) Rajeevkumar Raveendran et al.   JOURNAL OF NEUROCHEMISTRY

Effect of quinolinic acid on human astrocytes morphology and functions: implications in Alzheimer's disease

(2009) Ka Ting et al.   Journal of Neuroinflammation

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

Neuroprotection by the NR3A Subunit of the NMDA Receptor

(2009) N. Nakanishi et al.   JOURNAL OF NEUROSCIENCE

Synaptic NMDA Receptor Activation Stimulates  -Secretase Amyloid Precursor Protein Processing and Inhibits Amyloid-  Production

(2009) S. E. Hoey et al.   JOURNAL OF NEUROSCIENCE

Both NR2A and NR2B subunits of the NMDA receptor are critical for long-term potentiation and long-term depression in the lateral amygdala of horizontal slices of adult mice

(2009) T. Muller et al.   LEARNING & MEMORY

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON

Downregulation of NR3A-Containing NMDARs Is Required for Synapse Maturation and Memory Consolidation

(2009) Adam C. Roberts et al.   NEURON

Novel Neuroprotective Mechanisms of Memantine: Increase in Neurotrophic Factor Release from Astroglia and Anti-Inflammation by Preventing Microglial Activation

(2009) Hung-Ming Wu et al.   NEUROPSYCHOPHARMACOLOGY

Circadian and developmental regulation of N-methyl-d-aspartate-receptor 1 mRNA splice variants and N-methyl-d-aspartate-receptor 3 subunit expression within the rat suprachiasmatic nucleus

(2009) Z. Bendová et al.   NEUROSCIENCE

Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule

(2009) C. Bidoret et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors

(2008) Yongneng Yao et al.   EMBO JOURNAL

Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors

(2008) F. Léveillé et al.   FASEB JOURNAL

Phosphorylation Regulates Tau Interactions with Src Homology 3 Domains of Phosphatidylinositol 3-Kinase, Phospholipase Cγ1, Grb2, and Src Family Kinases

(2008) C. Hugh Reynolds et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Classification of Toxic Amyloid Oligomers

(2008) Charles G. Glabe   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunolocalization of NMDA receptor subunit NR3B in selected structures in the rat forebrain, cerebellum, and lumbar spinal cord

(2008) Karen S.-L. Wee et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Synapse-Specific Expression of Functional Presynaptic NMDA Receptors in Rat Somatosensory Cortex

(2008) D. J. Brasier et al.   JOURNAL OF NEUROSCIENCE

Mobility of NMDA autoreceptors but not postsynaptic receptors at glutamate synapses in the rat entorhinal cortex

(2008) Jian Yang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Glutamate Receptor Dynamics in Dendritic Microdomains

(2008) Thomas M. Newpher et al.   NEURON

Regulation of NMDA receptor subunit expression and its implications for LTD, LTP, and metaplasticity

(2008) Koji Yashiro et al.   NEUROPHARMACOLOGY

In developing hippocampal neurons, NR2B-containing N-methyl-d-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death

(2008) M.-A. Martel et al.   NEUROSCIENCE

The amyloid  -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

(2008) C. A. Hansson Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid beta peptides and glutamatergic synaptic dysregulation

(2007) Kodeeswaran Parameshwaran et al.   EXPERIMENTAL NEUROLOGY

Recruiting Extrasynaptic NMDA Receptors Augments Synaptic Signaling

(2007) Alexander Z. Harris et al.   JOURNAL OF NEUROPHYSIOLOGY

Tyrosine phosphorylation of ionotropic glutamate receptors by Fyn or Src differentially modulates their susceptibility to calpain and enhances their binding to spectrin and PSD-95

(2003) Yongqi Rong et al.   JOURNAL OF NEUROCHEMISTRY