A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

Cell-Permeable and Plasma-Stable Peptidomimetic Inhibitors of the Postsynaptic Density-95/N-Methyl-d-Aspartate Receptor Interaction

(2011) Anders Bach et al.   JOURNAL OF MEDICINAL CHEMISTRY

Perturbing PSD-95 Interactions With NR2B-subtype Receptors Attenuates Spinal Nociceptive Plasticity and Neuropathic Pain

(2011) Richard D'Mello et al.   MOLECULAR THERAPY

Emerging mechanisms of disrupted cellular signaling in brain ischemia

(2011) Michael Tymianski   NATURE NEUROSCIENCE

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Deciphering the Kinetic Binding Mechanism of Dimeric Ligands Using a Potent Plasma-stable Dimeric Inhibitor of Postsynaptic Density Protein-95 as an Example

(2010) Celestine N. Chi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biomimetic divalent ligands for the acute disruption of synaptic AMPAR stabilization

(2010) Matthieu Sainlos et al.   Nature Chemical Biology

A cyclic peptide targeted against PSD-95 blocks central sensitization and attenuates thermal hyperalgesia

(2010) B.W. LeBlanc et al.   NEUROSCIENCE

Design and Synthesis of Highly Potent and Plasma-Stable Dimeric Inhibitors of the PSD-95-NMDA Receptor Interaction

(2009) Anders Bach et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Microglia Protect Neurons against Ischemia by Synthesis of Tumor Necrosis Factor

(2009) K. L. Lambertsen et al.   JOURNAL OF NEUROSCIENCE

Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density

(2009) Wei Feng et al.   NATURE REVIEWS NEUROSCIENCE

MAGUK proteins: New targets for pharmacological intervention in the glutamatergic synapse

(2008) Fabrizio Gardoni   EUROPEAN JOURNAL OF PHARMACOLOGY

Modified Peptides as Potent Inhibitors of the Postsynaptic Density-95/N-Methyl-d-Aspartate Receptor Interaction

(2008) Anders Bach et al.   JOURNAL OF MEDICINAL CHEMISTRY

Specific Targeting of Pro-Death NMDA Receptor Signals with Differing Reliance on the NR2B PDZ Ligand

(2008) F. X. Soriano et al.   JOURNAL OF NEUROSCIENCE

Creating Conformational Entropy by Increasing Interdomain Mobility in Ligand Binding Regulation: A Revisit to N-Terminal Tandem PDZ Domains of PSD-95

(2008) Wenning Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cell-permeable Peptide Tat-PSD-95 PDZ2 Inhibits Chronic Inflammatory Pain Behaviors in Mice

(2008) Feng Tao et al.   MOLECULAR THERAPY

Small Molecule Protein–Protein Interaction Inhibitors as CNS Therapeutic Agents: Current Progress and Future Hurdles

(2008) Levi L Blazer et al.   NEUROPSYCHOPHARMACOLOGY

Effectiveness of PSD95 Inhibitors in Permanent and Transient Focal Ischemia in the Rat

(2008) Hong-Shuo Sun et al.   STROKE