Roles of the tissue-type plasminogen activator in immune response

Plasminogen Receptors and Fibrinolysis

(2021) Lindsey A. Miles et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tissue plasminogen activator worsens experimental autoimmune encephalomyelitis by complementary actions on lymphoid and myeloid cell responses

(2021) Pauline Hélie et al.   Journal of Neuroinflammation

Role of tissue plasminogen activator in clinical aggravation of experimental autoimmune encephalomyelitis and its therapeutic potential

(2020) Tehila Mizrachi et al.   CELLULAR IMMUNOLOGY

Nonionotropic Action of Endothelial NMDA Receptors on Blood–Brain Barrier Permeability via Rho/ROCK-Mediated Phosphorylation of Myosin

(2020) Anupriya Mehra et al.   JOURNAL OF NEUROSCIENCE

A critical role for plasminogen in inflammation

(2020) Sarah K. Baker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tissue‐type plasminogen activator neutralizes LPS but not protease‐activated receptor‐mediated inflammatory responses to plasmin

(2019) Cristina Zalfa et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Diversity, Mechanisms, and Significance of Macrophage Plasticity

(2019) Massimo Locati et al.   Annual Review of Pathology-Mechanisms of Disease

Neuroserpin regulates human T cell‐T cell interactions and proliferation through inhibition of tissue plasminogen activator

(2019) Evert Jan Loef et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Tissue-type plasminogen activator selectively inhibits multiple toll-like receptors in CSF-1-differentiated macrophages

(2019) Lipsa Das et al.   PLoS One

IL-10-producing T cells and their dual functions

(2019) Tanja Bedke et al.   SEMINARS IN IMMUNOLOGY

An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1

(2018) Ze Zheng et al.   BLOOD

Paracrine costimulation of IFN-γ signaling by integrins modulates CD8 T cell differentiation

(2018) Matthew F. Krummel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue-type plasminogen activator modulates macrophage M2 to M1 phenotypic change through annexin A2-mediated NF-κB pathway

(2017) Ling Lin et al.   Oncotarget

Neuroendothelial NMDA receptors as therapeutic targets in experimental autoimmune encephalomyelitis

(2016) Richard Macrez et al.   BRAIN

Plasmin and regulators of plasmin activity control the migratory capacity and adhesion of human T cells and dendritic cells by regulating cleavage of the chemokine CCL21

(2016) Natalie Lorenz et al.   IMMUNOLOGY AND CELL BIOLOGY

The Influence of Differentially Expressed Tissue-Type Plasminogen Activator in Experimental Autoimmune Encephalomyelitis: Implications for Multiple Sclerosis

(2016) Lisa CM Dahl et al.   PLoS One

LDL receptor-related protein-1 regulates NFκB and microRNA-155 in macrophages to control the inflammatory response

(2016) Elisabetta Mantuano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue-type Plasminogen Activator (tPA) Promotes M1 Macrophage Survival through p90 Ribosomal S6 Kinase (RSK) and p38 Mitogen-activated Protein Kinase (MAPK) Pathway

(2015) Ling Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human T cell activation induces synaptic translocation and alters expression of the serine protease inhibitor neuroserpin and its target protease

(2015) Natalie Lorenz et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Tissue Plasminogen Activator Expression Is Restricted to Subsets of Excitatory Pyramidal Glutamatergic Neurons

(2015) Morgane Louessard et al.   MOLECULAR NEUROBIOLOGY

Conformations of tissue plasminogen activator (tPA) orchestrate neuronal survival by a crosstalk between EGFR and NMDAR

(2015) T Bertrand et al.   Cell Death & Disease

The Interplay Between Monocytes/Macrophages and CD4+ T Cell Subsets in Rheumatoid Arthritis

(2015) Ceri A. Roberts et al.   Frontiers in Immunology

Dendritic Cell-Mediated Phagocytosis but Not Immune Activation Is Enhanced by Plasmin

(2015) Rachael J. Borg et al.   PLoS One

Tissue Plasminogen Activator Promotes Postischemic Neutrophil Recruitment via Its Proteolytic and Nonproteolytic Properties

(2014) B. Uhl et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

t-PA acts as a cytokine to regulate lymphocyte–endothelium adhesion in experimental autoimmune encephalomyelitis

(2014) Jinghua Wang et al.   CLINICAL IMMUNOLOGY

Tissue plasminogen activator involvement in experimental autoimmune myasthenia gravis: Aggravation and therapeutic potential

(2014) Devorah Gur-Wahnon et al.   JOURNAL OF AUTOIMMUNITY

Tissue-Type Plasminogen Activator Is a Regulator of Monocyte Diapedesis through the Brain Endothelial Barrier

(2014) A. Reijerkerk et al.   JOURNAL OF IMMUNOLOGY

Human tissue-type plasminogen activator

(2014) Egbert K. O. Kruithof et al.   THROMBOSIS AND HAEMOSTASIS

Unique Macrophages Different from M1/M2 Macrophages Inhibit T Cell Mitogenesis while Upregulating Th17 Polarization

(2014) Yutaka Tatano et al.   Scientific Reports

Recruitment of CCR6-expressing Th17 cells by CCL20 secreted from plasmin-stimulated macrophages

(2013) Qun Li et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

ICAM-1-Dependent Homotypic Aggregates Regulate CD8 T Cell Effector Function and Differentiation during T Cell Activation

(2013) N. A. Zumwalde et al.   JOURNAL OF IMMUNOLOGY

Molecular requirements for safer generation of thrombolytics by bioengineering the tissue-type plasminogen activator A chain

(2013) J. Parcq et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Glutamate Controls tPA Recycling by Astrocytes, Which in Turn Influences Glutamatergic Signals

(2012) F. Casse et al.   JOURNAL OF NEUROSCIENCE

Tissue Plasminogen Activator Activates NF- B through a Pathway Involving Annexin A2/CD11b and Integrin-Linked Kinase

(2012) L. Lin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Impact of Tissue Plasminogen Activator on the Neurovascular Unit: From Clinical Data to Experimental Evidence

(2011) Denis Vivien et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Tissue plasminogen activator prevents white matter damage following stroke

(2011) Fernando Correa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Endogenous Matrix Metalloproteinases 2 and 9 Regulate Activation of CD4+and CD8+T cells

(2010) Heather L. Benson et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Plasmin Triggers Chemotaxis of Monocyte-Derived Dendritic Cells Through an Akt2-Dependent Pathway and Promotes a T-Helper Type-1 Response

(2010) Xuehua Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Breast cancer cell surface annexin II induces cell migration and neoangiogenesis via tPA dependent plasmin generation

(2010) Meena Sharma et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Role of plasminogen activator inhibitor-2 (PAI-2) in keratinocyte differentiation

(2010) Sunhyae Jang et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

The NR1 subunit of NMDA receptor regulates monocyte transmigration through the brain endothelial cell barrier

(2010) Arie Reijerkerk et al.   JOURNAL OF NEUROCHEMISTRY

The Low-Density Lipoprotein Receptor-Related Protein 1 Mediates Tissue-Type Plasminogen Activator-Induced Microglial Activation in the Ischemic Brain

(2009) Chen Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Proteomics-based discovery of a novel, structurally unique, and developmentally regulated plasminogen receptor, Plg-RKT, a major regulator of cell surface plasminogen activation

(2009) N. M. Andronicos et al.   BLOOD

Tissue-type plasminogen activator (t-PA) induces stromelysin-1 (MMP-3) in endothelial cells through activation of lipoprotein receptor-related protein

(2009) Y. Suzuki et al.   BLOOD

Macrophages and Platelets Are the Major Source of Protease Nexin-1 in Human Atherosclerotic Plaque

(2008) Silvana Mansilla et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Toward Safer Thrombolytic Agents in Stroke: Molecular Requirements for NMDA Receptor-Mediated Neurotoxicity

(2008) Jose P Lopez-Atalaya et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM