Conformations of tissue plasminogen activator (tPA) orchestrate neuronal survival by a crosstalk between EGFR and NMDAR

LRP1 Assembles Unique Co-receptor Systems to Initiate Cell Signaling in Response to Tissue-type Plasminogen Activator and Myelin-associated Glycoprotein

(2013) Elisabetta Mantuano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unveiling an exceptional zymogen: the single-chain form of tPA is a selective activator of NMDA receptor-dependent signaling and neurotoxicity

(2012) J Parcq et al.   CELL DEATH AND DIFFERENTIATION

Tissue-Type Plasminogen Activator Regulates the Neuronal Uptake of Glucose in the Ischemic Brain

(2012) F. Wu et al.   JOURNAL OF NEUROSCIENCE

Tissue-type plasminogen activator protects neurons from excitotoxin-induced cell death via activation of the ERK1/2–CREB–ATF3 signaling pathway

(2012) Fang Wu et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

High t-PA release by neonate brain microvascular endothelial cells under glutamate exposure affects neuronal fate

(2012) Vincent Jean Henry et al.   NEUROBIOLOGY OF DISEASE

Tissue-Type Plasminogen Activator has a Neuroprotective Effect in the Ischemic Brain Mediated by Neuronal TNF-α

(2011) Woldeab B Haile et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Tissue plasminogen activator prevents white matter damage following stroke

(2011) Fernando Correa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antibodies Preventing the Interaction of Tissue-Type Plasminogen Activator With N-Methyl- d -Aspartate Receptors Reduce Stroke Damages and Extend the Therapeutic Window of Thrombolysis

(2011) Richard Macrez et al.   STROKE

NR2D-containing NMDA receptors mediate tissue plasminogen activator-promoted neuronal excitotoxicity

(2009) A Baron et al.   CELL DEATH AND DIFFERENTIATION