Ischemia and reperfusion—from mechanism to translation

Toll-Like Receptor 4 Inhibitor TAK-242 Attenuates Acute Kidney Injury in Endotoxemic Sheep

(2011) Johan Fenhammar et al.   ANESTHESIOLOGY

Targeting iNKT cells for the treatment of sickle cell disease

(2011) Joshua J. Field et al.   CLINICAL IMMUNOLOGY

Paneth cell-derived interleukin-17A causes multiorgan dysfunction after hepatic ischemia and reperfusion injury

(2011) Sang Won Park et al.   HEPATOLOGY

Nitric Oxide for Inhalation in the Acute Treatment of Sickle Cell Pain Crisis

(2011) Mark T. Gladwin   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Intravenous Erythropoietin in Patients With ST-Segment Elevation Myocardial Infarction

(2011) Samer S. Najjar   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes

(2011) Li Qian et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hypoxia-Inducible Factor-1α–Dependent Protection from Intestinal Ischemia/Reperfusion Injury Involves Ecto-5′-Nucleotidase (CD73) and the A2B Adenosine Receptor

(2011) Melanie L. Hart et al.   JOURNAL OF IMMUNOLOGY

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Adenosine receptor crossroads in sickle cell disease

(2011) Mark T Gladwin   NATURE MEDICINE

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Extracellular Adenosine: A Safety Signal That Dampens Hypoxia-Induced Inflammation During Ischemia

(2010) Almut Grenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Selective induction of endothelial P2Y6 nucleotide receptor promotes vascular inflammation

(2010) A.-K. Riegel et al.   BLOOD

Adenosine A2A receptors induced on iNKT and NK cells reduce pulmonary inflammation and injury in mice with sickle cell disease

(2010) K. L. Wallace et al.   BLOOD

Profound Cardioprotection With Chloramphenicol Succinate in the Swine Model of Myocardial Ischemia-Reperfusion Injury

(2010) J. A. Sala-Mercado et al.   CIRCULATION

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis*

(2010) Todd W. Rice et al.   CRITICAL CARE MEDICINE

A Role of Erythrocytes in Adenosine Monophosphate Initiation of Hypometabolism in Mammals

(2010) Isadora Susan Daniels et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion

(2010) Zubin M. Bamboat et al.   JOURNAL OF CLINICAL INVESTIGATION

Bcl3 prevents acute inflammatory lung injury in mice by restraining emergency granulopoiesis

(2010) Daniel Kreisel et al.   JOURNAL OF CLINICAL INVESTIGATION

Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3β phosphorylation

(2010) Zhongshu Tang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SP1-Dependent Induction of CD39 Facilitates Hepatic Ischemic Preconditioning

(2010) M. L. Hart et al.   JOURNAL OF IMMUNOLOGY

Inhibition of Prolyl Hydroxylases Increases Erythropoietin Production in ESRD

(2010) W. M. Bernhardt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial

(2010) Hans Erik Bøtker et al.   LANCET

Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

(2010) Faraaz B. Chekeni et al.   NATURE

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1

(2010) Jian-Xun Wang et al.   NATURE MEDICINE

In vivo prevention of transplant arteriosclerosis by ex vivo–expanded human regulatory T cells

(2010) Satish N Nadig et al.   NATURE MEDICINE

Detrimental effects of adenosine signaling in sickle cell disease

(2010) Yujin Zhang et al.   NATURE MEDICINE

The therapeutic potential of carbon monoxide

(2010) Roberto Motterlini et al.   NATURE REVIEWS DRUG DISCOVERY

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

(2010) B. McDonald et al.   SCIENCE

Inhaled Hydrogen Sulfide

(2009) Gian Paolo Volpato et al.   ANESTHESIOLOGY

Adenosine: An Old Drug Newly Discovered

(2009) Holger K. Eltzschig   ANESTHESIOLOGY

Complement-Mediated Ischemia-Reperfusion Injury

(2009) Gwendolyn M. P. Diepenhorst et al.   ANNALS OF SURGERY

Platelet Polyphosphates Are Proinflammatory and Procoagulant Mediators In Vivo

(2009) Felicitas Müller et al.   CELL

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

(2009) Massimiliano Mazzone et al.   CELL

CD4 T cells promote tissue inflammation via CD40 signaling without de novo activation in a murine model of liver ischemia/reperfusion injury

(2009) Xiuda Shen et al.   HEPATOLOGY

Cardiac macrophage migration inhibitory factor inhibits JNK pathway activation and injury during ischemia/reperfusion

(2009) Dake Qi et al.   JOURNAL OF CLINICAL INVESTIGATION

The Role for T Cell Repertoire/Antigen-Specific Interactions in Experimental Kidney Ischemia Reperfusion Injury

(2009) S. R. Satpute et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: A2B Adenosine Receptor Signaling Provides Potent Protection during Intestinal Ischemia/Reperfusion Injury

(2009) M. L. Hart et al.   JOURNAL OF IMMUNOLOGY

Pathogenic Natural Antibodies Recognizing Annexin IV Are Required to Develop Intestinal Ischemia-Reperfusion Injury

(2009) L. Kulik et al.   JOURNAL OF IMMUNOLOGY

Effect of Intravenous FX06 as an Adjunct to Primary Percutaneous Coronary Intervention for Acute ST-Segment Elevation Myocardial Infarction

(2009) Dan Atar et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Hypoxia-inducible factor–dependent induction of netrin-1 dampens inflammation caused by hypoxia

(2009) Peter Rosenberger et al.   NATURE IMMUNOLOGY

When integrins fail to integrate

(2009) Andrés Hidalgo et al.   NATURE MEDICINE

Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery

(2009) Muge Yemisci et al.   NATURE MEDICINE

Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury

(2009) Takashi Shichita et al.   NATURE MEDICINE

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

(2009) Arthur Liesz et al.   NATURE MEDICINE

Cell Death

(2009) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Peptide Bβ15-42 Preserves Endothelial Barrier Function in Shock

(2009) Marion Gröger et al.   PLoS One

Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury

(2009) W. Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation

(2009) B. Kruger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

(2009) S. S. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-92a Controls Angiogenesis and Functional Recovery of Ischemic Tissues in Mice

(2009) A. Bonauer et al.   SCIENCE

Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection

(2009) R. E. Lanford et al.   SCIENCE

Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites

(2009) F. K. Swirski et al.   SCIENCE

Role of the Peroxynitrite-Poly(ADP-Ribose) Polymerase Pathway in Human Disease

(2008) Pal Pacher et al.   AMERICAN JOURNAL OF PATHOLOGY

Use of a hanging-weight system for liver ischemic preconditioning in mice

(2008) Melanie L. Hart et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak

(2008) J. C. Morote-Garcia et al.   BLOOD

Central role of Sp1-regulated CD39 in hypoxia/ischemia protection

(2008) H. K. Eltzschig et al.   BLOOD

Hypoxia-Inducible Factor-1 Is Central to Cardioprotection

(2008) Tobias Eckle et al.   CIRCULATION

Long-Term Benefit of Postconditioning

(2008) Hélène Thibault et al.   CIRCULATION

Role of extracellular nucleotide phosphohydrolysis in intestinal ischemia-reperfusion injury

(2008) Melanie L. Hart et al.   FASEB JOURNAL

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PMNs facilitate translocation of platelets across human and mouse epithelium and together alter fluid homeostasis via epithelial cell–expressed ecto-NTPDases

(2008) Thomas Weissmüller et al.   JOURNAL OF CLINICAL INVESTIGATION

TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events

(2008) Karen A. Cavassani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of Hypoxia Inducible Factor Hydroxylases Protects Against Renal Ischemia-Reperfusion Injury

(2008) P. Hill et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart

(2008) Edward J. Miller et al.   NATURE

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

(2008) Julián Aragonés et al.   NATURE GENETICS

Kindlin-3 is essential for integrin activation and platelet aggregation

(2008) Markus Moser et al.   NATURE MEDICINE

The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics

(2008) Jon O. Lundberg et al.   NATURE REVIEWS DRUG DISCOVERY

Time to Take Myocardial Reperfusion Injury Seriously

(2008) Derek J. Hausenloy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infarction

(2008) Christophe Piot et al.   NEW ENGLAND JOURNAL OF MEDICINE

Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the Heart

(2008) Che-Hong Chen et al.   SCIENCE

The Reno-Vascular A2B Adenosine Receptor Protects the Kidney from Ischemia

(2008) Almut Grenz et al.   PLOS MEDICINE