Molecular Mechanisms of Glutamate Toxicity in Parkinson’s Disease

The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: Potential targets for neurotherapeutics

(2019) Edward Pajarillo et al.   NEUROPHARMACOLOGY

Regulatory Mechanism of miR-543-3p on GLT-1 in a Mouse Model of Parkinson’s Disease

(2019) Xiaojuan Wu et al.   ACS Chemical Neuroscience

The Metabolic Disturbances of Motoneurons Exposed to Glutamate

(2018) Blandine Madji Hounoum et al.   MOLECULAR NEUROBIOLOGY

MicroRNA-219 alleviates glutamate-induced neurotoxicity in cultured hippocampal neurons by targeting calmodulin-dependent protein kinase II gamma

(2018) Feng Xu et al.   Neural Regeneration Research

Valproic acid attenuates manganese-induced reduction in expression of GLT-1 and GLAST with concomitant changes in murine dopaminergic neurotoxicity

(2018) James Johnson et al.   NEUROTOXICOLOGY

Suppression of microRNA-342-3p increases glutamate transporters and prevents dopaminergic neuron loss through activating the Wnt signaling pathway via p21-activated kinase 1 in mice with Parkinson's disease

(2018) Dong-Mei Wu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Stimulation of synaptoneurosome glutamate release by monomeric and fibrillated α-synuclein

(2017) Theodore A. Sarafian et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Targeting glutamate signalling in depression: progress and prospects

(2017) James W. Murrough et al.   NATURE REVIEWS DRUG DISCOVERY

Regulation of glutamate transporter trafficking by Nedd4-2 in a Parkinson’s disease model

(2017) Yunlong Zhang et al.   Cell Death & Disease

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Microglial Priming and Alzheimer’s Disease: A Possible Role for (Early) Immune Challenges and Epigenetics?

(2016) Lianne Hoeijmakers et al.   Frontiers in Human Neuroscience

Overexpression of α-synuclein simultaneously increases glutamate NMDA receptor phosphorylation and reduces glucocerebrosidase activity

(2016) Junfeng Yang et al.   NEUROSCIENCE LETTERS

Recent Advance in the Relationship between Excitatory Amino Acid Transporters and Parkinson’s Disease

(2016) Yunlong Zhang et al.   NEURAL PLASTICITY

The biomarkers of immune dysregulation and inflammation response in Parkinson disease

(2016) Li Chen et al.   Translational Neurodegeneration

How microglia kill neurons

(2015) Guy C. Brown et al.   BRAIN RESEARCH

Dynamics and modulation of metabotropic glutamate receptors

(2015) Philippe Rondard et al.   CURRENT OPINION IN PHARMACOLOGY

A complex relative motion between hairpin loop 2 and transmembrane domain 5 in the glutamate transporter GLT-1

(2015) Xiuliang Rong et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Invited review: Neuropathology of tauopathies: principles and practice

(2015) G. G. Kovacs   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease

(2015) Diana M. Norden et al.   NEUROPHARMACOLOGY

Neuroprotective effect of thalidomide on MPTP-induced toxicity

(2015) Guadalupe Palencia et al.   NEUROTOXICOLOGY

Glutamate transporters in brain ischemia: to modulate or not?

(2014) Weronika Krzyżanowska et al.   ACTA PHARMACOLOGICA SINICA

Cysteine mutagenesis reveals alternate proximity between transmembrane domain 2 and hairpin loop 1 of the glutamate transporter EAAT1

(2014) Yunlong Zhang et al.   AMINO ACIDS

Ubiquitination of α-synuclein and autophagy in Parkinson's disease

(2014) Simone Engelender   Autophagy

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Glutamate transporter EAAT2: a new target for the treatment of neurodegenerative diseases

(2012) Chien-Liang Glenn Lin et al.   Future Medicinal Chemistry

The CpG island shore of the GLT-1 gene acts as a methylation-sensitive enhancer

(2012) Tatjana Perisic et al.   GLIA

Valproic acid induces the glutamate transporter excitatory amino acid transporter-3 in human oligodendroglioma cells

(2012) M.G. Bianchi et al.   NEUROSCIENCE

The Accessibility in the External Part of the TM5 of the Glutamate Transporter EAAT1 Is Conformationally Sensitive during the Transport Cycle

(2012) Xiuping Zhang et al.   PLoS One

Inflammation after trauma: Microglial activation and traumatic brain injury

(2011) Anil F. Ramlackhansingh et al.   ANNALS OF NEUROLOGY

AMPA-receptor-mediated excitatory synaptic transmission is enhanced by iron-induced α-synuclein oligomers

(2011) Sandra Hüls et al.   JOURNAL OF NEUROCHEMISTRY

Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1β and NMDA stimulation

(2011) Fabrizio Gardoni et al.   Journal of Neuroinflammation

Overview of glutamatergic neurotransmission in the nervous system

(2011) Mark J. Niciu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

(2010) Colleen M. Niswender et al.   Annual Review of Pharmacology and Toxicology

Pathogenic Lysosomal Depletion in Parkinson's Disease

(2010) B. Dehay et al.   JOURNAL OF NEUROSCIENCE

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

Metabotropic glutamate receptors: From the workbench to the bedside

(2010) F. Nicoletti et al.   NEUROPHARMACOLOGY

Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis

(2010) Ranjan Dutta et al.   PROGRESS IN NEUROBIOLOGY

Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice

(2010) Xing-Long Gu et al.   Molecular Brain

Glutamate receptors on myelinated spinal cord axons: II. AMPA and GluR5 receptors

(2009) Mohamed Ouardouz et al.   ANNALS OF NEUROLOGY

Impaired glutamate homeostasis and programmed cell death in a chronic MPTP mouse model of Parkinson's disease

(2009) G.E. Meredith et al.   EXPERIMENTAL NEUROLOGY

12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress

(2009) Stefanie Pallast et al.   JOURNAL OF NEUROCHEMISTRY

Interplay between Cytosolic Dopamine, Calcium, and α-Synuclein Causes Selective Death of Substantia Nigra Neurons

(2009) Eugene V. Mosharov et al.   NEURON

Alterations in corticostriatal synaptic plasticity in mice overexpressing human α-synuclein

(2009) J.B. Watson et al.   NEUROSCIENCE

The equivalent of a thallium binding residue from an archeal homolog controls cation interactions in brain glutamate transporters

(2009) S. Teichman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inward-facing conformation of glutamate transporters as revealed by their inverted-topology structural repeats

(2009) T. J. Crisman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bid-induced release of AIF from mitochondria causes immediate neuronal cell death

(2008) S Landshamer et al.   CELL DEATH AND DIFFERENTIATION

Substrates and Non-transportable Analogues Induce Structural Rearrangements at the Extracellular Entrance of the Glial Glutamate Transporter GLT-1/EAAT2

(2008) Shaogang Qu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Downregulation of glial glutamate transporters after dopamine denervation in the striatum of 6-hydroxydopamine-lesioned rats

(2008) E.K.Y. Chung et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Sp1 is involved in H2O2-induced PUMA gene expression and apoptosis in colorectal cancer cells.

(2008) Xinying Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Parkinson's disease: clinical features and diagnosis

(2008) J Jankovic   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Astrocytes in the Epileptic Brain

(2008) Jonathon Wetherington et al.   NEURON