NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

Metabotropic NMDA receptor function is required for  -amyloid-induced synaptic depression

(2013) H. W. Kessels et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disrupted surface cross-talk between NMDA and Ephrin-B2 receptors in anti-NMDA encephalitis

(2012) Lenka Mikasova et al.   BRAIN

Synaptic and Extrasynaptic NMDA Receptors Are Gated by Different Endogenous Coagonists

(2012) Thomas Papouin et al.   CELL

Synaptic plasticity of NMDA receptors: mechanisms and functional implications

(2012) David L Hunt et al.   CURRENT OPINION IN NEUROBIOLOGY

CaMKII binding to GluN2B is critical during memory consolidation

(2012) Amy R Halt et al.   EMBO JOURNAL

NMDA Receptors with Incomplete Mg2+ Block Enable Low-Frequency Transmission through the Cerebellar Cortex

(2012) E. J. Schwartz et al.   JOURNAL OF NEUROSCIENCE

Subunit-Selective Allosteric Inhibition of Glycine Binding to NMDA Receptors

(2012) K. B. Hansen et al.   JOURNAL OF NEUROSCIENCE

GluN1 splice variant control of GluN1/GluN2D NMDA receptors

(2012) Katie M. Vance et al.   JOURNAL OF PHYSIOLOGY-LONDON

Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial

(2012) Michael D Hill et al.   LANCET NEUROLOGY

Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain

(2012) Douglas J. Cook et al.   NATURE

Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function

(2012) Hyejung Won et al.   NATURE

A single GluN2 subunit residue controls NMDA receptor channel properties via intersubunit interaction

(2012) Beth Siegler Retchless et al.   NATURE NEUROSCIENCE

REST-dependent epigenetic remodeling promotes the developmental switch in synaptic NMDA receptors

(2012) Alma Rodenas-Ruano et al.   NATURE NEUROSCIENCE

The Subtype of GluN2 C-terminal Domain Determines the Response to Excitotoxic Insults

(2012) Marc-André Martel et al.   NEURON

Target-Specific Expression of Presynaptic NMDA Receptors in Neocortical Microcircuits

(2012) Katherine A. Buchanan et al.   NEURON

Diversity in NMDA Receptor Composition

(2012) Antonio Sanz-Clemente et al.   NEUROSCIENTIST

An Alternating GluN1-2-1-2 Subunit Arrangement in Mature NMDA Receptors

(2012) Morgane Riou et al.   PLoS One

Genetic Overexpression of NR2B Subunit Enhances Social Recognition Memory for Different Strains and Species

(2012) Stephanie A. Jacobs et al.   PLoS One

Genetic Deletion of NR3A Accelerates Glutamatergic Synapse Maturation

(2012) Maile A. Henson et al.   PLoS One

GluN3 subunit-containing NMDA receptors: not just one-trick ponies

(2012) Svenja Pachernegg et al.   TRENDS IN NEUROSCIENCES

Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist

(2011) S McKay et al.   BRITISH JOURNAL OF PHARMACOLOGY

New developments on the role of NMDA receptors in Alzheimer's disease

(2011) Roberto Malinow   CURRENT OPINION IN NEUROBIOLOGY

Metaplasticity gated through differential regulation of GluN2A versus GluN2B receptors by Src family kinases

(2011) Kai Yang et al.   EMBO JOURNAL

Molecular basis of positive allosteric modulation of GluN2B NMDA receptors by polyamines

(2011) Laetitia Mony et al.   EMBO JOURNAL

Molecular basis of NMDA receptor functional diversity

(2011) Pierre Paoletti   EUROPEAN JOURNAL OF NEUROSCIENCE

Structural and Mechanistic Determinants of a Novel Site for Noncompetitive Inhibition of GluN2D-Containing NMDA Receptors

(2011) K. B. Hansen et al.   JOURNAL OF NEUROSCIENCE

Arrangement of Subunits in Functional NMDA Receptors

(2011) C. L. Salussolia et al.   JOURNAL OF NEUROSCIENCE

Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

(2011) S. Li et al.   JOURNAL OF NEUROSCIENCE

Mechanisms underlying NMDA receptor synaptic/extrasynaptic distribution and function

(2011) Clare M. Gladding et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo

(2011) Amandine Jullienne et al.   Molecular Neurodegeneration

Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors

(2011) Erkan Karakas et al.   NATURE

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit

(2011) Chihiro Nozaki et al.   NATURE NEUROSCIENCE

NMDA receptor–dependent metaplasticity at hippocampal mossy fiber synapses

(2011) Nelson Rebola et al.   NATURE NEUROSCIENCE

NR3A-containing NMDARs promote neurotransmitter release and spike timing–dependent plasticity

(2011) Rylan S Larsen et al.   NATURE NEUROSCIENCE

In utero exposure to cocaine delays postnatal synaptic maturation of glutamatergic transmission in the VTA

(2011) Camilla Bellone et al.   NATURE NEUROSCIENCE

Targeting NR2A-containing NMDA receptors reduces L-DOPA-induced dyskinesias

(2011) Fabrizio Gardoni et al.   NEUROBIOLOGY OF AGING

mGluR5 and NMDA Receptors Drive the Experience- and Activity-Dependent NMDA Receptor NR2B to NR2A Subunit Switch

(2011) Jose A. Matta et al.   NEURON

Distinct Modes of AMPA Receptor Suppression at Developing Synapses by GluN2A and GluN2B: Single-Cell NMDA Receptor Subunit Deletion In Vivo

(2011) John A. Gray et al.   NEURON

A Critical Role for GluN2B-Containing NMDA Receptors in Cortical Development and Function

(2011) Chih-Chieh Wang et al.   NEURON

NMDA GluN2A and GluN2B receptors play separate roles in the induction of LTP and LTD in the amygdala and in the acquisition and extinction of conditioned fear

(2011) Gemma L. Dalton et al.   NEUROPHARMACOLOGY

From Revolution to Evolution: The Glutamate Hypothesis of Schizophrenia and its Implication for Treatment

(2011) Bita Moghaddam et al.   NEUROPSYCHOPHARMACOLOGY

NMDA receptor subunit composition controls synaptogenesis and synapse stabilization

(2011) A. C. Gambrill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamatergic mechanisms in the dyskinesias induced by pharmacological dopamine replacement and deep brain stimulation for the treatment of Parkinson's disease

(2011) Véronique Sgambato-Faure et al.   PROGRESS IN NEUROBIOLOGY

Emerging Models of Glutamate Receptor Ion Channel Structure and Function

(2011) Mark L. Mayer   STRUCTURE

Stroke intervention pathways: NMDA receptors and beyond

(2011) Ted Weita Lai et al.   TRENDS IN MOLECULAR MEDICINE

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke

(2010) Weihong Tu et al.   CELL

Impairment of CaMKII activation and attenuation of neuropathic pain in mice lacking NR2B phosphorylated at Tyr1472

(2010) Shinji Matsumura et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Triheteromeric NR1/NR2A/NR2B Receptors Constitute the MajorN-Methyl-d-aspartate Receptor Population in Adult Hippocampal Synapses

(2010) Claudia Rauner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of NR2A Receptors Induces Ischemic Tolerance through CREB Signaling

(2010) Yasukazu Terasaki et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Excitatory Glycine Responses of CNS Myelin Mediated by NR1/NR3 "NMDA" Receptor Subunits

(2010) J. C. Pina-Crespo et al.   JOURNAL OF NEUROSCIENCE

Distinct Roles of NR2A and NR2B Cytoplasmic Tails in Long-Term Potentiation

(2010) K. A. Foster et al.   JOURNAL OF NEUROSCIENCE

Loss of GluN2B-Containing NMDA Receptors in CA1 Hippocampus and Cortex Impairs Long-Term Depression, Reduces Dendritic Spine Density, and Disrupts Learning

(2010) J. L. Brigman et al.   JOURNAL OF NEUROSCIENCE

Activation of Extrasynaptic, But Not Synaptic, NMDA Receptors Modifies Amyloid Precursor Protein Expression Pattern and Increases Amyloid-  Production

(2010) K. Bordji et al.   JOURNAL OF NEUROSCIENCE

Memantine Preferentially Blocks Extrasynaptic over Synaptic NMDA Receptor Currents in Hippocampal Autapses

(2010) P. Xia et al.   JOURNAL OF NEUROSCIENCE

Cellular and Synaptic Mechanisms of Anti-NMDA Receptor Encephalitis

(2010) E. G. Hughes et al.   JOURNAL OF NEUROSCIENCE

Identification and Characterization of Novel NMDA Receptor Antagonists Selective for NR2A- over NR2B-Containing Receptors

(2010) E. Bettini et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The receptor subunits generating NMDA receptor mediated currents in oligodendrocytes

(2010) Valeria Burzomato et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes

(2010) Sabine Endele et al.   NATURE GENETICS

Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95

(2010) Jihoon Jo et al.   NATURE NEUROSCIENCE

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors

(2010) Raik Rönicke et al.   NEUROBIOLOGY OF AGING

GABAB Receptors Modulate NMDA Receptor Calcium Signals in Dendritic Spines

(2010) Jason R. Chalifoux et al.   NEURON

Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice

(2010) Austen J. Milnerwood et al.   NEURON

Metaplasticity at Single Glutamatergic Synapses

(2010) Ming-Chia Lee et al.   NEURON

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

Casein Kinase 2 Regulates the NR2 Subunit Composition of Synaptic NMDA Receptors

(2010) Antonio Sanz-Clemente et al.   NEURON

Organization of NMDA receptors at extrasynaptic locations

(2010) R.S. Petralia et al.   NEUROSCIENCE

NR2A subunit of the N-methyl d-aspartate receptors are required for potentiation at the mossy fiber to granule cell synapse and vestibulo-cerebellar motor learning

(2010) C.E. Andreescu et al.   NEUROSCIENCE

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

Dynamic and specific interaction between synaptic NR2-NMDA receptor and PDZ proteins

(2010) L. Bard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influence of the NR3A subunit on NMDA receptor functions

(2010) Maile A. Henson et al.   PROGRESS IN NEUROBIOLOGY

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors

(2010) Praseeda Mullasseril et al.   Nature Communications

Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential

(2009) Laetitia Mony et al.   BRITISH JOURNAL OF PHARMACOLOGY

Different Roles of C-terminal Cassettes in the Trafficking of Full-length NR1 Subunits to the Cell Surface

(2009) Martin Horak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Expression of Ligand-Gated Ion Channels in L5 Pyramidal Cell Axons

(2009) J. M. Christie et al.   JOURNAL OF NEUROSCIENCE

Control of NMDA Receptor Function by the NR2 Subunit Amino-Terminal Domain

(2009) H. Yuan et al.   JOURNAL OF NEUROSCIENCE

Decreased NR2B Subunit Synaptic Levels Cause Impaired Long-Term Potentiation But Not Long-Term Depression

(2009) F. Gardoni et al.   JOURNAL OF NEUROSCIENCE

Subunit- and Pathway-Specific Localization of NMDA Receptors and Scaffolding Proteins at Ganglion Cell Synapses in Rat Retina

(2009) J. Zhang et al.   JOURNAL OF NEUROSCIENCE

Metaplastic Regulation of Long-Term Potentiation/Long-Term Depression Threshold by Activity-Dependent Changes of NR2A/NR2B Ratio

(2009) Z. Xu et al.   JOURNAL OF NEUROSCIENCE

In Vivo Evidence for NMDA Receptor-Mediated Excitotoxicity in a Murine Genetic Model of Huntington Disease

(2009) M. Y. Heng et al.   JOURNAL OF NEUROSCIENCE

Mg2+ Imparts NMDA Receptor Subtype Selectivity to the Alzheimer's Drug Memantine

(2009) S. E. Kotermanski et al.   JOURNAL OF NEUROSCIENCE

Both NR2A and NR2B subunits of the NMDA receptor are critical for long-term potentiation and long-term depression in the lateral amygdala of horizontal slices of adult mice

(2009) T. Muller et al.   LEARNING & MEMORY

Mechanism of differential control of NMDA receptor activity by NR2 subunits

(2009) Marc Gielen et al.   NATURE

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

(2009) Alexander I. Sobolevsky et al.   NATURE

Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes

(2009) Juan E Belforte et al.   NATURE NEUROSCIENCE

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON

Burst-Timing-Dependent Plasticity of NMDA Receptor-Mediated Transmission in Midbrain Dopamine Neurons

(2009) Mark T. Harnett et al.   NEURON

Downregulation of NR3A-Containing NMDARs Is Required for Synapse Maturation and Memory Consolidation

(2009) Adam C. Roberts et al.   NEURON

Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain

(2009) Long-Jun Wu et al.   Neurotherapeutics

Genetic Enhancement of Memory and Long-Term Potentiation but Not CA1 Long-Term Depression in NR2B Transgenic Rats

(2009) Deheng Wang et al.   PLoS One

GluN2B subunit-containing NMDA receptor antagonists prevent A -mediated synaptic plasticity disruption in vivo

(2009) N.-W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule

(2009) C. Bidoret et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Group I mGluR-Dependent Long-Term Depression of NMDA Receptor–Mediated Transmission at Schaffer Collateral–CA1 Synapses

(2008) David R. Ireland et al.   JOURNAL OF NEUROPHYSIOLOGY

Synapse-Specific Expression of Functional Presynaptic NMDA Receptors in Rat Somatosensory Cortex

(2008) D. J. Brasier et al.   JOURNAL OF NEUROSCIENCE

NMDA Receptor Subunit NR2A Is Required for Rapidly Acquired Spatial Working Memory But Not Incremental Spatial Reference Memory

(2008) D. M. Bannerman et al.   JOURNAL OF NEUROSCIENCE

Extrasynaptic NR2D-Containing NMDARs Are Recruited to the Synapse during LTP of NMDAR-EPSCs

(2008) S. C. Harney et al.   JOURNAL OF NEUROSCIENCE

Functional contributions of synaptically localized NR2B subunits of the NMDA receptor to synaptic transmission and long-term potentiation in the adult mouse CNS

(2008) Hideki Miwa et al.   JOURNAL OF PHYSIOLOGY-LONDON

Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies

(2008) Josep Dalmau et al.   LANCET NEUROLOGY

Contribution of Hippocampal and Extra-Hippocampal NR2B-Containing NMDA Receptors to Performance on Spatial Learning Tasks

(2008) Jakob von Engelhardt et al.   NEURON

Long-Term Potentiation Selectively Expressed by NMDA Receptors at Hippocampal Mossy Fiber Synapses

(2008) Hyung-Bae Kwon et al.   NEURON

Adenosine A2A Receptors Are Essential for Long-Term Potentiation of NMDA-EPSCs at Hippocampal Mossy Fiber Synapses

(2008) Nelson Rebola et al.   NEURON

Structural Rearrangements of NR1/NR2A NMDA Receptors during Allosteric Inhibition

(2008) Marc Gielen et al.   NEURON

Regulation of NMDA receptor subunit expression and its implications for LTD, LTP, and metaplasticity

(2008) Koji Yashiro et al.   NEUROPHARMACOLOGY

Presynaptic NMDA Receptors: Newly Appreciated Roles in Cortical Synaptic Function and Plasticity

(2008) Rebekah Corlew et al.   NEUROSCIENTIST

Left-right asymmetry of the hippocampal synapses with differential subunit allocation of glutamate receptors

(2008) Y. Shinohara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Roles of NMDA Receptor Subtypes in Ischemic Neuronal Cell Death and Ischemic Tolerance

(2008) Min Chen et al.   STROKE

NR2B- and NR2D-containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones

(2007) S. L. C. Brothwell et al.   JOURNAL OF PHYSIOLOGY-LONDON