Impacts of tissue-type plasminogen activator (tPA) on neuronal survival

Stressed neurons protect themselves by a tissue-type plasminogen activator-mediated EGFR-dependent mechanism

(2015) E Lemarchand et al.   CELL DEATH AND DIFFERENTIATION

The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration

(2015) E. Mantuano et al.   JOURNAL OF CELL SCIENCE

Randomized Assessment of Rapid Endovascular Treatment of Ischemic Stroke

(2015) Mayank Goyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Endovascular Therapy for Ischemic Stroke with Perfusion-Imaging Selection

(2015) Bruce C.V. Campbell et al.   NEW ENGLAND JOURNAL OF MEDICINE

Conformations of tissue plasminogen activator (tPA) orchestrate neuronal survival by a crosstalk between EGFR and NMDAR

(2015) T Bertrand et al.   Cell Death & Disease

Effect of neuroserpin in a neonatal hypoxic-ischemic injury model ex vivo

(2013) Jiao Ma et al.   BIOLOGICAL RESEARCH

Tissue-type plasminogen activator is an extracellular mediator of Purkinje cell damage and altered gait

(2013) Elisa J. Cops et al.   EXPERIMENTAL NEUROLOGY

LRP1 Assembles Unique Co-receptor Systems to Initiate Cell Signaling in Response to Tissue-type Plasminogen Activator and Myelin-associated Glycoprotein

(2013) Elisabetta Mantuano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tissue-Type Plasminogen Activator Mediates Neuronal Detection and Adaptation to Metabolic Stress

(2013) Fang Wu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

Hypoxia-Ischemia or Excitotoxin-Induced Tissue Plasminogen Activator- Dependent Gelatinase Activation in Mice Neonate Brain Microvessels

(2013) Priscilla L. Omouendze et al.   PLoS One

Tissue plasminogen activator regulates Purkinje neuron development and survival

(2013) J. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unveiling an exceptional zymogen: the single-chain form of tPA is a selective activator of NMDA receptor-dependent signaling and neurotoxicity

(2012) J Parcq et al.   CELL DEATH AND DIFFERENTIATION

Excessive Autophagy Contributes to Neuron Death in Cerebral Ischemia

(2012) Ruoyang Shi et al.   CNS Neuroscience & Therapeutics

Cleavage of the NR2B Subunit Amino Terminus ofN-Methyl-d-aspartate (NMDA) Receptor by Tissue Plasminogen Activator

(2012) Kay-Siong Ng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutamate Controls tPA Recycling by Astrocytes, Which in Turn Influences Glutamatergic Signals

(2012) F. Casse et al.   JOURNAL OF NEUROSCIENCE

Tissue-Type Plasminogen Activator Regulates the Neuronal Uptake of Glucose in the Ischemic Brain

(2012) F. Wu et al.   JOURNAL OF NEUROSCIENCE

Tissue-type plasminogen activator protects neurons from excitotoxin-induced cell death via activation of the ERK1/2–CREB–ATF3 signaling pathway

(2012) Fang Wu et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

High t-PA release by neonate brain microvascular endothelial cells under glutamate exposure affects neuronal fate

(2012) Vincent Jean Henry et al.   NEUROBIOLOGY OF DISEASE

Memantine Improves Safety of Thrombolysis for Stroke

(2012) Axel Montagne et al.   STROKE

Tissue plasminogen activator induces microglial inflammation via a noncatalytic molecular mechanism involving activation of mitogen-activated protein kinases and Akt signaling pathways and AnnexinA2 and Galectin-1 receptors

(2011) David Pineda et al.   GLIA

HMGB-1 promotes fibrinolysis and reduces neurotoxicity mediated by tissue plasminogen activator

(2011) B. D. Roussel et al.   JOURNAL OF CELL SCIENCE

Tissue-Type Plasminogen Activator has a Neuroprotective Effect in the Ischemic Brain Mediated by Neuronal TNF-α

(2011) Woldeab B Haile et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Tissue plasminogen activator prevents white matter damage following stroke

(2011) Fernando Correa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Functional Role for Nlrp6 in Intestinal Inflammation and Tumorigenesis

(2011) G. Y. Chen et al.   JOURNAL OF IMMUNOLOGY

First Structural Model of Full-Length Human Tissue-Plasminogen Activator: A SAXS Data-Based Modeling Study

(2011) Yogendra S. Rathore et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway

(2011) Huang Guo et al.   Molecular Neurodegeneration

Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo

(2011) Amandine Jullienne et al.   Molecular Neurodegeneration

Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12

(2011) N Badiola et al.   Cell Death & Disease

Neuroprotective effect of neuroserpin in rat primary cortical cultures after oxygen and glucose deprivation and tPA

(2010) Raquel Rodríguez-González et al.   NEUROCHEMISTRY INTERNATIONAL

Functional Occurrence of the Interaction of Tissue Plasminogen Activator With the NR1 Subunit of N -Methyl- d -Aspartate Receptors During Stroke

(2010) Richard Macrez et al.   STROKE

Antifibrinolytic agents reduce tissue plasminogen activator-mediated neuronal toxicityin vitro

(2009) H.-Y. SUN et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Characterization of Oligosaccharides in Recombinant Tissue Plasminogen Activator Produced in Chinese Hamster Ovary Cells: Two Decades of Analytical Technology Development

(2009) Oleg V. Borisov et al.   ANALYTICAL CHEMISTRY

Inhibition of p75 Neurotrophin Receptor Attenuates Isoflurane-mediated Neuronal Apoptosis in the Neonatal Central Nervous System

(2009) Brian P. Head et al.   ANESTHESIOLOGY

The Tissue-Type Plasminogen Activator Story

(2009) D. Collen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Age and albumin D site-binding protein control tissue plasminogen activator levels: neurotoxic impact

(2009) Benoit D. Roussel et al.   BRAIN

NR2D-containing NMDA receptors mediate tissue plasminogen activator-promoted neuronal excitotoxicity

(2009) A Baron et al.   CELL DEATH AND DIFFERENTIATION

The Serine Protease Plasmin Cleaves the Amino-terminal Domain of the NR2A Subunit to Relieve Zinc Inhibition of theN-Methyl-d-aspartate Receptors

(2009) Hongjie Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HtrA1-dependent proteolysis of TGF-β controls both neuronal maturation and developmental survival

(2008) S Launay et al.   CELL DEATH AND DIFFERENTIATION

The JNK Inhibitor XG-102 Protects from Ischemic Damage with Delayed Intravenous Administration Also in the Presence of Recombinant Tissue Plasminogen Activator

(2008) Karine Wiegler et al.   CEREBROVASCULAR DISEASES

The Functional Role of the Second NPXY Motif of the LRP1 β-Chain in Tissue-type Plasminogen Activator-mediated Activation ofN-Methyl-D-aspartate Receptors

(2008) Anne M. Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toward Safer Thrombolytic Agents in Stroke: Molecular Requirements for NMDA Receptor-Mediated Neurotoxicity

(2008) Jose P Lopez-Atalaya et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function

(2008) Andre L. Samson et al.   JOURNAL OF NEUROCHEMISTRY

Key role of tissue plasminogen activator in neurovascular coupling

(2008) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA