NMDA Receptors in Astrocytes: In Search for Roles in Neurotransmission and Astrocytic Homeostasis

In the Telencephalon, GluN2C NMDA Receptor Subunit mRNA is Predominately Expressed in Glial Cells and GluN2D mRNA in Interneurons

(2018) Hassan A. Alsaad et al.   NEUROCHEMICAL RESEARCH

Region-specific Expression of NMDA Receptor GluN2C Subunit in Parvalbumin-Positive Neurons and Astrocytes: Analysis of GluN2C Expression using a Novel Reporter Model

(2018) Aparna Ravikrishnan et al.   NEUROSCIENCE

Physiology of Astroglia

(2018) Alexei Verkhratsky et al.   PHYSIOLOGICAL REVIEWS

Persistent Overexposure to N-Methyl-d-Aspartate (NMDA) Calcium-Dependently Downregulates Glutamine Synthetase, Aquaporin 4, and Kir4.1 Channel in Mouse Cortical Astrocytes

(2018) Katarzyna Skowrońska et al.   NEUROTOXICITY RESEARCH

Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence

(2017) Hua Chai et al.   NEURON

Structure and symmetry inform gating principles of ionotropic glutamate receptors

(2017) Shujia Zhu et al.   NEUROPHARMACOLOGY

Astrocytic GluN2A and GluN2B Oppose the Synaptotoxic Effects of Amyloid-β1-40 in Hippocampal Cells

(2016) Yan Li et al.   JOURNAL OF ALZHEIMERS DISEASE

Ionotropic glutamate receptors: Which ones, when, and where in the mammalian neocortex

(2016) Minela Hadzic et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Postsynaptic, not presynaptic NMDA receptors are required for spike-timing-dependent LTD induction

(2016) Brett C Carter et al.   NATURE NEUROSCIENCE

Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity

(2016) Nicholas L Weilinger et al.   NATURE NEUROSCIENCE

Emerging roles of GluN3-containing NMDA receptors in the CNS

(2016) Isabel Pérez-Otaño et al.   NATURE REVIEWS NEUROSCIENCE

Neurotoxicity of Ammonia

(2016) Simo S. Oja et al.   NEUROCHEMICAL RESEARCH

Cytokine regulation by modulation of the NMDA receptor on astrocytes

(2016) Kurt-Wolfram Sühs et al.   NEUROSCIENCE LETTERS

Astrocytes regulate heterogeneity of presynaptic strengths in hippocampal networks

(2016) Mathieu Letellier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physiological Roles of Non-Neuronal NMDA Receptors

(2016) Adam D. Hogan-Cann et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5–Nrf2 pathway

(2015) D Jimenez-Blasco et al.   CELL DEATH AND DIFFERENTIATION

Quantitative Analysis of Glutamate Receptors in Glial Cells from the Cortex of GFAP/EGFP Mice Following Ischemic Injury: Focus on NMDA Receptors

(2015) David Dzamba et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Non-Ionotropic NMDA Receptor Signaling Drives Activity-Induced Dendritic Spine Shrinkage

(2015) I. S. Stein et al.   JOURNAL OF NEUROSCIENCE

Astroglial NMDA receptors inhibit expression of Kir4.1 channels in glutamate-overexposed astrocytes in vitro and in the brain of rats with acute liver failure

(2015) Marta Obara-Michlewska et al.   NEUROCHEMISTRY INTERNATIONAL

A Metabotropic-Like Flux-Independent NMDA Receptor Regulates Ca2+ Exit from Endoplasmic Reticulum and Mitochondrial Membrane Potential in Cultured Astrocytes

(2015) Pavel Montes de Oca Balderas et al.   PLoS One

Agonist binding to the NMDA receptor drives movement of its cytoplasmic domain without ion flow

(2015) Kim Dore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss

(2015) J H Birnbaum et al.   Cell Death & Disease

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Astrocyte-encoded positional cues maintain sensorimotor circuit integrity

(2014) Anna V. Molofsky et al.   NATURE

Precipitants of hepatic encephalopathy induce rapid astrocyte swelling in an oxidative stress dependent manner

(2013) Vera Lachmann et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Glutamate, Glutamate Receptors, and Downstream Signaling Pathways

(2013) Stacey S. Willard et al.   International Journal of Biological Sciences

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice

(2013) Marie Orre et al.   NEUROBIOLOGY OF AGING

NMDA-Receptor Activation but Not Ion Flux Is Required for Amyloid-Beta Induced Synaptic Depression

(2013) Albert Tamburri et al.   PLoS One

Heterogeneity of Astrocytes: From Development to Injury – Single Cell Gene Expression

(2013) Vendula Rusnakova et al.   PLoS One

Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression

(2013) S. Nabavi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabotropic NMDA receptor function is required for  -amyloid-induced synaptic depression

(2013) H. W. Kessels et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GluN3A: An NMDA Receptor Subunit with Exquisite Properties and Functions

(2013) Laura A. Kehoe et al.   NEURAL PLASTICITY

Inflammatory activation enhances NMDA-triggered Ca2+ signalling and IL-1β secretion in primary cultures of rat astrocytes

(2012) Franck Gérard et al.   BRAIN RESEARCH

Ammonia upregulates kynurenine aminotransferase II mRNA expression in rat brain: a role for astrocytic NMDA receptors?

(2012) Marta Obara-Michlewska et al.   METABOLIC BRAIN DISEASE

GluN3 subunit-containing NMDA receptors: not just one-trick ponies

(2012) Svenja Pachernegg et al.   TRENDS IN NEUROSCIENCES

Distinct pharmacological and functional properties of NMDA receptors in mouse cortical astrocytes

(2011) Oleg Palygin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Molecular basis of NMDA receptor functional diversity

(2011) Pierre Paoletti   EUROPEAN JOURNAL OF NEUROSCIENCE

Ionotropic receptors in neuronal–astroglial signalling: What is the role of “excitable” molecules in non-excitable cells

(2010) Ulyana Lalo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ionotropic NMDA and P2X1/5 receptors mediate synaptically induced Ca2+ signalling in cortical astrocytes

(2010) Oleg Palygin et al.   CELL CALCIUM

Subunit Arrangement inN-Methyl-d-aspartate (NMDA) Receptors

(2010) Anu Rambhadran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New Insights into the Not-So-New NR3 Subunits of N-Methyl-D-aspartate Receptor: Localization, Structure, and Function

(2010) C.-M. Low et al.   MOLECULAR PHARMACOLOGY

Do astrocytes really exocytose neurotransmitters?

(2010) Nicola B. Hamilton et al.   NATURE REVIEWS NEUROSCIENCE

Astrocytes Express N-Methyl-D-Aspartate Receptor Subunits in Development, Ischemia and Post-Ischemia

(2010) Ye Zhou et al.   NEUROCHEMICAL RESEARCH

Inhibition of nitric oxide-induced nuclear localization of CAPON by NMDA receptor antagonist in cultured rat primary astrocytes

(2010) Jing Jiang et al.   NEUROCHEMISTRY INTERNATIONAL

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

Characterisation of the Expression of NMDA Receptors in Human Astrocytes

(2010) Ming-Chak Lee et al.   PLoS One

Influence of the NR3A subunit on NMDA receptor functions

(2010) Maile A. Henson et al.   PROGRESS IN NEUROBIOLOGY

Effect of quinolinic acid on human astrocytes morphology and functions: implications in Alzheimer's disease

(2009) Ka Ting et al.   Journal of Neuroinflammation

Neuroprotection by the NR3A Subunit of the NMDA Receptor

(2009) N. Nakanishi et al.   JOURNAL OF NEUROSCIENCE

Novel Neuroprotective Mechanisms of Memantine: Increase in Neurotrophic Factor Release from Astroglia and Anti-Inflammation by Preventing Microglial Activation

(2009) Hung-Ming Wu et al.   NEUROPSYCHOPHARMACOLOGY

Tripartite synapses: astrocytes process and control synaptic information

(2009) Gertrudis Perea et al.   TRENDS IN NEUROSCIENCES

A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

(2008) J. D. Cahoy et al.   JOURNAL OF NEUROSCIENCE

Shuffling the Deck Anew: How NR3 Tweaks NMDA Receptor Function

(2008) Nora A. Cavara et al.   MOLECULAR NEUROBIOLOGY

Modulation of NMDA Receptor Properties and Synaptic Transmission by the NR3A Subunit in Mouse Hippocampal and Cerebrocortical Neurons

(2007) Gary Tong et al.   JOURNAL OF NEUROPHYSIOLOGY