Excitotoxicity in the pathogenesis of neurological and psychiatric disorders: Therapeutic implications

CNS inflammation and neurodegeneration

(2017) Tanuja Chitnis et al.   JOURNAL OF CLINICAL INVESTIGATION

Current view and perspectives in amyotrophic lateral sclerosis

(2017) Stéphane Mathis et al.   Neural Regeneration Research

ALS Pathogenesis and Therapeutic Approaches: The Role of Mesenchymal Stem Cells and Extracellular Vesicles

(2017) Roberta Bonafede et al.   Frontiers in Cellular Neuroscience

APP as a Protective Factor in Acute Neuronal Insults

(2017) Dimitri Hefter et al.   Frontiers in Molecular Neuroscience

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Mechanisms of tau and Aβ-induced excitotoxicity

(2016) Susanne P. Pallo et al.   BRAIN RESEARCH

Serum levels of SOD and risk of autism spectrum disorder: A case-control study

(2016) Lixuan Wang et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis

(2016) Emiliano Trias et al.   Journal of Neuroinflammation

Oral Inosine Persistently Elevates Plasma antioxidant capacity in Parkinson's disease

(2016) Shamik Bhattacharyya et al.   MOVEMENT DISORDERS

Molecular mechanisms of NMDA receptor-mediated excitotoxicity: implications for neuroprotective therapeutics for stroke

(2016) YuTian Wang et al.   Neural Regeneration Research

Elevated plasma levels of glutamate in children with autism spectrum disorders

(2016) Jing Cai et al.   NEUROREPORT

Fingolimod: A Disease-Modifier Drug in a Mouse Model of Amyotrophic Lateral Sclerosis

(2016) Rosa Luisa Potenza et al.   Neurotherapeutics

Adult Neurogenesis and Psychiatric Disorders

(2016) Eunchai Kang et al.   Cold Spring Harbor Perspectives in Biology

An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation

(2016) L Brundin et al.   Translational Psychiatry

Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer’s disease mouse model

(2015) Romain Fol et al.   ACTA NEUROPATHOLOGICA

Altered kynurenine pathway metabolism in autism: Implication for immune-induced glutamatergic activity

(2015) Chai K. Lim et al.   Autism Research

Dynamics and modulation of metabotropic glutamate receptors

(2015) Philippe Rondard et al.   CURRENT OPINION IN PHARMACOLOGY

Striatal astrocytes produce neuroblasts in an excitotoxic model of Huntington's disease

(2015) G. Nato et al.   DEVELOPMENT

Stroke Prevalence, Mortality and Disability-Adjusted Life Years in Adults Aged 20-64 Years in 1990-2013: Data from the Global Burden of Disease 2013 Study

(2015) Rita V. Krishnamurthi et al.   NEUROEPIDEMIOLOGY

Mechanisms of Neuronal Protection against Excitotoxicity, Endoplasmic Reticulum Stress, and Mitochondrial Dysfunction in Stroke and Neurodegenerative Diseases

(2015) Howard Prentice et al.   Oxidative Medicine and Cellular Longevity

Adult Neurogenesis in Neurodegenerative Diseases: Figure 1.

(2015) Beate Winner et al.   Cold Spring Harbor Perspectives in Biology

The Global Burden of Mental, Neurological and Substance Use Disorders: An Analysis from the Global Burden of Disease Study 2010

(2015) Harvey A. Whiteford et al.   PLoS One

Quinolinic Acid Responses during Interferon-α-Induced Depressive Symptomatology in Patients with Chronic Hepatitis C Infection - A Novel Aspect for Depression and Inflammatory Hypothesis

(2015) Andreas Baranyi et al.   PLoS One

Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death

(2014) A. Martorell-Riera et al.   EMBO JOURNAL

Glutamate-mediated excitotoxicity in schizophrenia: A review

(2014) Eric Plitman et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

The global prevalence of common mental disorders: a systematic review and meta-analysis 1980–2013

(2014) Zachary Steel et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Is there a role for glutamate-mediated excitotoxicity in inflammation-induced depression?

(2014) Robert Dantzer et al.   JOURNAL OF NEURAL TRANSMISSION

GABAergic/glutamatergic imbalance relative to excessive neuroinflammation in autism spectrum disorders

(2014) Afaf El-Ansary et al.   Journal of Neuroinflammation

Mechanism of Oxidative Stress and Synapse Dysfunction in the Pathogenesis of Alzheimer’s Disease: Understanding the Therapeutics Strategies

(2014) Pradip K. Kamat et al.   MOLECULAR NEUROBIOLOGY

Perspectives on neuroinflammation and excitotoxicity: A neurotoxic conspiracy?

(2014) Barbara Viviani et al.   NEUROTOXICOLOGY

A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease

(2014) et al.   JAMA Neurology

Mitochondrial permeability transition pore is a potential drug target for neurodegeneration

(2013) Valasani Koteswara Rao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Activation of Mammalian Target of Rapamycin and Synaptogenesis: Role in the Actions of Rapid-Acting Antidepressants

(2013) Jason M. Dwyer et al.   BIOLOGICAL PSYCHIATRY

Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex

(2013) W. Zhou et al.   EUROPEAN PSYCHIATRY

Neuroinflammation and psychiatric illness

(2013) Souhel Najjar et al.   Journal of Neuroinflammation

Phase II safety, tolerability, and dose selection study of isradipine as a potential disease-modifying intervention in early Parkinson's disease (STEADY-PD)

(2013)   MOVEMENT DISORDERS

Connecting inflammation with glutamate agonism in suicidality

(2013) Sophie Erhardt et al.   NEUROPSYCHOPHARMACOLOGY

Conceptual Confluence: The Kynurenine Pathway as a Common Target for Ketamine and the Convergence of the Inflammation and Glutamate Hypotheses of Depression

(2013) Andrew H Miller   NEUROPSYCHOPHARMACOLOGY

Inflammatory cytokines in depression: Neurobiological mechanisms and therapeutic implications

(2013) J.C. Felger et al.   NEUROSCIENCE

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

Increased Hippocampal Glutamate and Volumetric Deficits in Unmedicated Patients With Schizophrenia

(2013) Nina V. Kraguljac et al.   JAMA Psychiatry

Elevated Prefrontal Cortex γ-Aminobutyric Acid and Glutamate-Glutamine Levels in Schizophrenia Measured In Vivo With Proton Magnetic Resonance Spectroscopy

(2012) Xiangling Mao   ARCHIVES OF GENERAL PSYCHIATRY

Increased Glutamate Concentration in the Auditory Cortex of Persons With Autism and First-Degree Relatives: A1H-MRS Study

(2012) Mark S. Brown et al.   Autism Research

Matrix Metalloproteinases, New Insights into the Understanding of Neurodegenerative Disorders

(2012) Yoon-Seong Kim et al.   Biomolecules & Therapeutics

Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine - searching for the connections

(2012) Wojciech Danysz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Quinolinic acid, the inescapable neurotoxin

(2012) Gilles J. Guillemin   FEBS Journal

Memantine as adjunctive treatment to risperidone in children with autistic disorder: a randomized, double-blind, placebo-controlled trial

(2012) Ali Ghaleiha et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Calcium, Bioenergetics, and Neuronal Vulnerability in Parkinson's Disease

(2012) D. James Surmeier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ketamine effects on brain GABA and glutamate levels with 1H-MRS: relationship to ketamine-induced psychopathology

(2012) J M Stone et al.   MOLECULAR PSYCHIATRY

Kynurenines in the mammalian brain: when physiology meets pathology

(2012) Robert Schwarcz et al.   NATURE REVIEWS NEUROSCIENCE

Excitotoxicity in the Pathogenesis of Autism

(2012) M. M. Essa et al.   NEUROTOXICITY RESEARCH

Synapses and Alzheimer's Disease

(2012) M. Sheng et al.   Cold Spring Harbor Perspectives in Biology

Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation

(2012) Demian Obregon et al.   Nature Communications

Metabotropic Glutamate Receptor 5 Upregulation in Children with Autism is Associated with Underexpression of Both Fragile X Mental Retardation Protein and GABAA Receptor Beta 3 in Adults with Autism

(2011) S. Hossein Fatemi et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Meta-Analysis of the Efficacy of Adjunctive NMDA Receptor Modulators in Chronic Schizophrenia

(2011) Surendra P. Singh et al.   CNS DRUGS

Tolerability and efficacy of memantine add-on therapy to rivastigmine transdermal patches in mild to moderate Alzheimer's disease: a multicenter, randomized, open-label, parallel-group study

(2011) Seong Hye Choi et al.   CURRENT MEDICAL RESEARCH AND OPINION

Nitric oxide signaling: Classical, less classical, and nonclassical mechanisms

(2011) Antonio Martínez-Ruiz et al.   FREE RADICAL BIOLOGY AND MEDICINE

The role of the kynurenine metabolism in major depression

(2011) Aye-Mu Myint et al.   JOURNAL OF NEURAL TRANSMISSION

Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission?

(2011) Johann Steiner et al.   Journal of Neuroinflammation

Amyloid- /Fyn-Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

(2011) E. D. Roberson et al.   JOURNAL OF NEUROSCIENCE

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

GABAergic interneuron origin of schizophrenia pathophysiology

(2011) Kazu Nakazawa et al.   NEUROPHARMACOLOGY

Oxidative stress caused by mitochondrial calcium overload

(2010) Tsung-I Peng et al.   Annals of the New York Academy of Sciences

Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

(2010) Colleen M. Niswender et al.   Annual Review of Pharmacology and Toxicology

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Pathogenic Lysosomal Depletion in Parkinson's Disease

(2010) B. Dehay et al.   JOURNAL OF NEUROSCIENCE

A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease

(2010) Barry J. Snow et al.   MOVEMENT DISORDERS

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

(2010) Jaime N. Guzman et al.   NATURE

Glutamate receptors, neurotoxicity and neurodegeneration

(2010) Anthony Lau et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Family-based association testing of glutamate transporter genes in autism

(2010) Suma Jacob et al.   PSYCHIATRIC GENETICS

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Interferon-  and Tumor Necrosis Factor-  Mediate the Upregulation of Indoleamine 2,3-Dioxygenase and the Induction of Depressive-Like Behavior in Mice in Response to Bacillus Calmette-Guerin

(2009) J. C. O'Connor et al.   JOURNAL OF NEUROSCIENCE

NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation

(2009) Angela M Brennan et al.   NATURE NEUROSCIENCE

Interplay between Cytosolic Dopamine, Calcium, and α-Synuclein Causes Selective Death of Substantia Nigra Neurons

(2009) Eugene V. Mosharov et al.   NEURON

Novel Neuroprotective Mechanisms of Memantine: Increase in Neurotrophic Factor Release from Astroglia and Anti-Inflammation by Preventing Microglial Activation

(2009) Hung-Ming Wu et al.   NEUROPSYCHOPHARMACOLOGY

Neurochemical changes in the rat prefrontal cortex following acute phencyclidine treatment: anin vivolocalized1H MRS study

(2009) Isabelle Iltis et al.   NMR IN BIOMEDICINE

Linking Aβ and Tau in Late-Onset Alzheimer's Disease: A Dual Pathway Hypothesis

(2008) Scott A. Small et al.   NEURON

Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks

(2008) Kishore V. Kuchibhotla et al.   NEURON

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease

(2008) M. A. Busche et al.   SCIENCE