Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Rare coding variants in ten genes confer substantial risk for schizophrenia

(2022) Tarjinder Singh et al.   NATURE

Rare genetic variants affecting urine metabolite levels link population variation to inborn errors of metabolism

(2021) Yurong Cheng et al.   Nature Communications

Widespread signatures of natural selection across human complex traits and functional genomic categories

(2021) Jian Zeng et al.   Nature Communications

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

(2021) Urmo Võsa et al.   NATURE GENETICS

Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism

(2020) F. Kyle Satterstrom et al.   CELL

De novo mutations identified by exome sequencing implicate rare missense variants in SLC6A1 in schizophrenia

(2020) Elliott Rees et al.   NATURE NEUROSCIENCE

Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease

(2020) Julien Bryois et al.   NATURE GENETICS

Association between Mental Disorders and Subsequent Medical Conditions

(2020) Natalie C. Momen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evidence for 28 genetic disorders discovered by combining healthcare and research data

(2020) Joanna Kaplanis et al.   NATURE

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse

(2019) Frank Koopmans et al.   NEURON

RICOPILI: Rapid Imputation for COnsortias PIpeLIne

(2019) Max Lam et al.   BIOINFORMATICS

A comprehensive analysis of mortality-related health metrics associated with mental disorders: a nationwide, register-based cohort study

(2019) Oleguer Plana-Ripoll et al.   LANCET

Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry

(2019) Tim B. Bigdeli et al.   MOLECULAR PSYCHIATRY

Comparative genetic architectures of schizophrenia in East Asian and European populations

(2019) Max Lam et al.   NATURE GENETICS

Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits

(2019) Wen Zhang et al.   Nature Communications

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin

(2018) Laurie Galvan et al.   BRAIN

Genetic identification of brain cell types underlying schizophrenia

(2018) Nathan G. Skene et al.   NATURE GENETICS

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

(2018) Antonio F. Pardiñas et al.   NATURE GENETICS

Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

(2018) Hilary K. Finucane et al.   NATURE GENETICS

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

(2018) James J. Lee et al.   NATURE GENETICS

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder

(2018) Michael J. Gandal et al.   SCIENCE

Comprehensive functional genomic resource and integrative model for the human brain

(2018) Daifeng Wang et al.   SCIENCE

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7

(2017) Yang Luo et al.   NATURE GENETICS

The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability

(2017) Tarjinder Singh et al.   NATURE GENETICS

Massively parallel single-nucleus RNA-seq with DroNc-seq

(2017) Naomi Habib et al.   NATURE METHODS

FINEMAP: efficient variable selection using summary data from genome-wide association studies

(2016) Christian Benner et al.   BIOINFORMATICS

Schizophrenia

(2016) Michael J Owen et al.   LANCET

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

Reference-based phasing using the Haplotype Reference Consortium panel

(2016) Po-Ru Loh et al.   NATURE GENETICS

Haplotype estimation for biobank-scale data sets

(2016) Jared O'Connell et al.   NATURE GENETICS

A reference panel of 64,976 haplotypes for genotype imputation

(2016)   NATURE GENETICS

Next-generation genotype imputation service and methods

(2016) Sayantan Das et al.   NATURE GENETICS

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

(2016) Zhihong Zhu et al.   NATURE GENETICS

Integrative approaches for large-scale transcriptome-wide association studies

(2016) Alexander Gusev et al.   NATURE GENETICS

Increased burden of ultra-rare protein-altering variants among 4,877 individuals with schizophrenia

(2016) Giulio Genovese et al.   NATURE NEUROSCIENCE

Fully non-parametric receiver operating characteristic curve estimation for random-effects meta-analysis

(2016) Pablo Martínez-Camblor   STATISTICAL METHODS IN MEDICAL RESEARCH

Analysis of Intellectual Disability Copy Number Variants for Association With Schizophrenia

(2016) Elliott Rees et al.   JAMA Psychiatry

Novel Findings from CNVs Implicate Inhibitory and Excitatory Signaling Complexes in Schizophrenia

(2015) Andrew J. Pocklington et al.   NEURON

MAGMA: Generalized Gene-Set Analysis of GWAS Data

(2015) Christiaan A. de Leeuw et al.   PLoS Computational Biology

Second-generation PLINK: rising to the challenge of larger and richer datasets

(2015) Christopher C Chang et al.   GigaScience

Conducting Meta-Analyses inRwith themetaforPackage

(2015) Wolfgang Viechtbauer   Journal of Statistical Software

The association between Darier disease, bipolar disorder, and schizophrenia revisited: a population-based family study

(2014) Martin Cederlöf et al.   BIPOLAR DISORDERS

Cohort Profile: the Health and Retirement Study (HRS)

(2014) A. Sonnega et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

De novo mutations in schizophrenia implicate synaptic networks

(2014) Menachem Fromer et al.   NATURE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Specificity protein 4 functionally regulates the transcription of NMDA receptor subunits GluN1, GluN2A, and GluN2B

(2013) Anusha Priya et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

(2013) Linn Fagerberg et al.   MOLECULAR & CELLULAR PROTEOMICS

Genome-wide association analysis identifies 13 new risk loci for schizophrenia

(2013) Stephan Ripke et al.   NATURE GENETICS

A Better Coefficient of Determination for Genetic Profile Analysis

(2012) Sang Hong Lee et al.   GENETIC EPIDEMIOLOGY

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

(2012) Jian Yang et al.   NATURE GENETICS

A Systematic Review and Meta-Analysis of Recovery in Schizophrenia

(2012) E. Jaaskelainen et al.   SCHIZOPHRENIA BULLETIN

De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia

(2011) G Kirov et al.   MOLECULAR PSYCHIATRY

Genome-wide association study identifies five new schizophrenia loci

(2011)   NATURE GENETICS

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation

(2010) Daniele Merico et al.   PLoS One

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

(2009) Shaun M. Purcell et al.   NATURE

Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt

(2009) Steffen Durinck et al.   Nature Protocols