Normal and Pathological NRF2 Signalling in the Central Nervous System

Combination of dasatinib and quercetin improves cognitive abilities in aged male Wistar rats, alleviates inflammation and changes hippocampal synaptic plasticity and histone H3 methylation profile

(2022) Adam Krzystyniak et al.   Aging-US

Targeting cellular senescence with senotherapeutics: senolytics and senomorphics

(2022) Lei Zhang et al.   FEBS Journal

Interplay of Ferritin Accumulation and Ferroportin Loss in Ageing Brain: Implication for Protein Aggregation in Down Syndrome Dementia, Alzheimer’s, and Parkinson’s Diseases

(2022) Animesh Alexander Raha et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Perspective on Nrf2 Signaling Pathway for Neuroinflammation: A Potential Therapeutic Target in Alzheimer's and Parkinson's Diseases

(2022) Sarmistha Saha et al.   Frontiers in Cellular Neuroscience

Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology

(2022) Zoeb Jiwaji et al.   Nature Communications

Dissecting the Crosstalk Between Nrf2 and NF-κB Response Pathways in Drug-Induced Toxicity

(2022) Wen Gao et al.   Frontiers in Cell and Developmental Biology

Nrf2 Inhibits the Progression of Parkinson’s Disease by Upregulating AABR07032261.5 to Repress Pyroptosis

(2022) Yunxiao Zhong et al.   Journal of Inflammation Research

Irisin protects against sepsis-associated encephalopathy by suppressing ferroptosis via activation of the Nrf2/GPX4 signal axis

(2022) Jin Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sodium arsenite accelerates D-galactose-induced aging in the testis of the rat: Evidence for mitochondrial oxidative damage, NF-kB, JNK, and apoptosis pathways

(2022) Sholeh Akbari et al.   TOXICOLOGY

Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis

(2022) Diego Sáenz de Urturi et al.   Nature Communications

Vitexin protects against high glucose-induced endothelial cell apoptosis and oxidative stress via Wnt/β-catenin and Nrf2 signalling pathway

(2022) Sheng Zhang et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Senescence Is the Main Trait Induced by Temozolomide in Glioblastoma Cells

(2022) Lea Beltzig et al.   Cancers

Chlorogenic acid exerts neuroprotective effect against hypoxia-ischemia brain injury in neonatal rats by activating Sirt1 to regulate the Nrf2-NF-κB signaling pathway

(2022) Yihui Zheng et al.   Cell Communication and Signaling

Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice

(2021) Mikolaj Ogrodnik et al.   AGING CELL

Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease

(2021) Wen-Dai Bao et al.   CELL DEATH AND DIFFERENTIATION

Single-Cell Sequencing of Brain Cell Transcriptomes and Epigenomes

(2021) Ethan J. Armand et al.   NEURON

Cellular Senescence in Brain Aging

(2021) Ewa Sikora et al.   Frontiers in Aging Neuroscience

Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex

(2021) John K. Mich et al.   Cell Reports

Challenges and Limitations of Targeting the Keap1-Nrf2 Pathway for Neurotherapeutics: Bach1 De-Repression to the Rescue

(2021) Dmitry M. Hushpulian et al.   Frontiers in Aging Neuroscience

Apomorphine Reduces A53T α-Synuclein-Induced Microglial Reactivity Through Activation of NRF2 Signalling Pathway

(2021) Tony Heurtaux et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Modulation of Nrf2 and NF-κB Signaling Pathways by Naturally Occurring Compounds in Relation to Cancer Prevention and Therapy. Are Combinations Better Than Single Compounds?

(2021) Violetta Krajka-Kuźniak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glutathione and Related Molecules in Parkinsonism

(2021) Masato Asanuma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Single-nuclei chromatin profiling of ventral midbrain reveals cell identity transcription factors and cell-type-specific gene regulatory variation

(2021) Yujuan Gui et al.   Epigenetics & Chromatin

The redox-senescence axis and its therapeutic targeting

(2021) Natalie YL. Ngoi et al.   Redox Biology

The Nrf2-NLRP3-caspase-1 axis mediates the neuroprotective effects of Celastrol in Parkinson's disease

(2021) Chenyu Zhang et al.   Redox Biology

α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response

(2021) Alberto Delaidelli et al.   Acta Neuropathologica Communications

High Density of NRF2 Expression in Malignant Cells Is Associated with Increased Risk of CNS Metastasis in Early-Stage NSCLC

(2021) Georgios Tsakonas et al.   Cancers

A Role of Stress Sensor Nrf2 in Stimulating Thermogenesis and Energy Expenditure

(2021) Seo-Hyuk Chang et al.   Biomedicines

Exploring the evidence for epigenetic regulation of environmental influences on child health across generations

(2021) Carrie V. Breton et al.   Communications Biology

Brain-Protective Mechanisms of Transcription Factor NRF2: Toward a Common Strategy for Neurodegenerative Diseases

(2021) Antonio Cuadrado   Annual Review of Pharmacology and Toxicology

Crosstalk between Neuron and Glial Cells in Oxidative Injury and Neuroprotection

(2021) Kyung Hee Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dimethyl Fumarate is a Potential Therapeutic Option for Alzheimer’s Disease

(2021) Xiaodi Sun et al.   JOURNAL OF ALZHEIMERS DISEASE

Impaired antioxidant KEAP1-NRF2 system in amyotrophic lateral sclerosis: NRF2 activation as a potential therapeutic strategy

(2021) Silvia Bono et al.   Molecular Neurodegeneration

Cell-type specialization is encoded by specific chromatin topologies

(2021) Warren Winick-Ng et al.   NATURE

Bach1 derepression is neuroprotective in a mouse model of Parkinson’s disease

(2021) Manuj Ahuja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mix of Dietary Fibres Changes Interorgan Nutrients Exchanges and Muscle-Adipose Energy Handling in Overfed Mini-Pigs

(2021) Ahmed Ben Mohamed et al.   Nutrients

Reactive Oxygen Species: Do They Play a Role in Adaptive Immunity?

(2021) Esen Yonca Bassoy et al.   Frontiers in Immunology

Drug Delivery Strategies for Curcumin and Other Natural Nrf2 Modulators of Oxidative Stress-Related Diseases

(2021) Nina Katarina Grilc et al.   Pharmaceutics

The KEAP1-NRF2 System in Healthy Aging and Longevity

(2021) Daisuke Matsumaru et al.   Antioxidants

The NRF2-Dependent Transcriptional Regulation of Antioxidant Defense Pathways: Relevance for Cell Type-Specific Vulnerability to Neurodegeneration and Therapeutic Intervention

(2021) Stephanie M. Boas et al.   Antioxidants

Hydrogen Attenuated Inflammation Response and Oxidative in Hypoxic Ischemic Encephalopathy via Nrf2 Mediated the Inhibition of NLRP3 and NF-κB

(2021) Yajiao Hu et al.   NEUROSCIENCE

NRF2 as a Therapeutic Target in Neurodegenerative Diseases

(2020) Mikah S. Brandes et al.   ASN Neuro

The role of astrocytes in oxidative stress of central nervous system: A mixed blessing

(2020) Yaxing Chen et al.   CELL PROLIFERATION

Cypermethrin-induced cortical neurons apoptosis via the Nrf2/ARE signaling pathway

(2020) Lihua Zhou et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Cellular Senescence in Neurodegenerative Diseases

(2020) Carmen Martínez-Cué et al.   Frontiers in Cellular Neuroscience

Heme Oxygenase Dependent Bilirubin Generation in Vascular Cells: A Role in Preventing Endothelial Dysfunction in Local Tissue Microenvironment?

(2020) Mariapaola Nitti et al.   Frontiers in Physiology

Benefits of Metformin in Attenuating the Hallmarks of Aging

(2020) Ameya S. Kulkarni et al.   Cell Metabolism

Missing heritability in Parkinson’s disease: the emerging role of non-coding genetic variation

(2020) Jochen Ohnmacht et al.   JOURNAL OF NEURAL TRANSMISSION

NF-κB and Keap1 Interaction Represses Nrf2-Mediated Antioxidant Response in Rabbit Hemorrhagic Disease Virus Infection

(2020) Bo Hu et al.   JOURNAL OF VIROLOGY

Nrf2 Ablation Promotes Alzheimer’s Disease-Like Pathology in APP/PS1 Transgenic Mice: The Role of Neuroinflammation and Oxidative Stress

(2020) Peng Ren et al.   Oxidative Medicine and Cellular Longevity

Protective effect of dimethyl fumarate for the development of pressure ulcers after cutaneous ischemia‐reperfusion injury

(2020) Yuta Inoue et al.   WOUND REPAIR AND REGENERATION

Reactive oxygen species in reproduction: harmful, essential or both?

(2020) M. Jamil et al.   ZYGOTE

Exacerbation of adverse cardiovascular effects of aircraft noise in an animal model of arterial hypertension

(2020) Sebastian Steven et al.   Redox Biology

FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake

(2020) Sharon O. Jensen-Cody et al.   Cell Metabolism

NFκB promotes oxidative stress-induced necrosis and ischemia/reperfusion injury by inhibiting Nrf2-ARE pathway

(2020) Xiaoyun Guo et al.   FREE RADICAL BIOLOGY AND MEDICINE

NRF2, a Transcription Factor for Stress Response and Beyond

(2020) Feng He et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nrf2 knockout dysregulates iron metabolism and increases the hemolysis through ROS in aging mice

(2020) Zhenzhen Liu et al.   LIFE SCIENCES

Current Landscape of NRF2 Biomarkers in Clinical Trials

(2020) Yoko Yagishita et al.   Antioxidants

ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease

(2020) Dominic S. A. Simpson et al.   Antioxidants

Salacia chinensis exerts its antidiabetic effect by modulating glucose‐regulated proteins and transcription factors in high‐fat diet fed‐streptozotocin‐induced type 2 diabetic rats

(2020) Fusun Erten et al.   JOURNAL OF FOOD BIOCHEMISTRY

Role of Nrf2 in cell senescence regulation

(2020) Huan Yuan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Protective Effects of Eicosapentaenoic Acid Plus Hydroxytyrosol Supplementation Against White Adipose Tissue Abnormalities in Mice Fed a High-Fat Diet

(2020) Paola Illesca et al.   MOLECULES

Dimethyl Fumarate Mitigates Tauopathy in Aβ-Induced Neuroblastoma SH-SY5Y Cells

(2020) Mithun Singh Rajput et al.   NEUROCHEMICAL RESEARCH

WIP Modulates Oxidative Stress through NRF2/KEAP1 in Glioblastoma Cells

(2020) Maribel Escoll et al.   Antioxidants

Natural Nrf2 Modulators for Skin Protection

(2020) Yong Chool Boo   Antioxidants

Nrf2: a dark horse in Alzheimer's disease treatment

(2020) Alsiddig Osama et al.   AGEING RESEARCH REVIEWS

Kaempferol Inhibits Zearalenone-Induced Oxidative Stress and Apoptosis via the PI3K/Akt-Mediated Nrf2 Signaling Pathway: In Vitro and In Vivo Studies

(2020) Peramaiyan Rajendran et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation

(2020) Sarmistha Saha et al.   MOLECULES

Nuclear Factor [Erythroid-derived 2]-like 2 and Mitochondrial Transcription Factor A Contribute to Moderate-intensity Swimming Effectiveness against Memory Impairment in Young Mice Induced by Concomitant Exposure to a High-calorie Diet during the Early Life Period

(2020) Natália Silva Jardim et al.   NEUROSCIENCE

Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers

(2020) Keito Okazaki et al.   Nature Communications

Revealing Temozolomide Resistance Mechanisms via Genome-Wide CRISPR Libraries

(2020) Clarissa Ribeiro Reily Rocha et al.   Cells

Nrf2 Mediates Metabolic Reprogramming in Non-Small Cell Lung Cancer

(2020) Jiangang Zhao et al.   Frontiers in Oncology

Redox regulation by NRF2 in aging and disease

(2019) Cody J. Schmidlin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Anti-Inflammatory Effect of Sulforaphane on LPS-Activated Microglia Potentially through JNK/AP-1/NF-κB Inhibition and Nrf2/HO-1 Activation

(2019) Lalita Subedi et al.   Cells

Nrf2/ARE Pathway Modulation by Dietary Energy Regulation in Neurological Disorders

(2019) Andrea Rodrigues Vasconcelos et al.   Frontiers in Pharmacology

Measuring the Interaction of Transcription Factor Nrf2 with Its Negative Regulator Keap1 in Single Live Cells by an Improved FRET/FLIM Analysis

(2019) Dina Dikovskaya et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Omega 3 rich diet modulates energy metabolism via GPR120-Nrf2 crosstalk in a novel antioxidant mouse model

(2019) Deborah Amos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Nrf2 in cancers: A double‐edged sword

(2019) Shijia Wu et al.   Cancer Medicine

ERK/Nrf2 pathway activation by caffeic acid in HepG2 cells alleviates its hepatocellular damage caused by t-butylhydroperoxide-induced oxidative stress

(2019) Sung-Yong Yang et al.   BMC Complementary and Alternative Medicine

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

(2019) Darina Czamara et al.   Nature Communications

Nrf2 Involvement in Chemical-Induced Skin Innate Immunity

(2019) Doumet Georges Helou et al.   Frontiers in Immunology

HO-1 overexpression and underexpression: Clinical implications

(2019) George S. Drummond et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment

(2019) Sergio Di Meo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma

(2019) Petri Pölönen et al.   ONCOGENE

ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells

(2019) Anastasiya V. Snezhkina et al.   Oxidative Medicine and Cellular Longevity

Light-induced Nrf2−/− mice as atrophic age-related macular degeneration model and treatment with nanoceria laden injectable hydrogel

(2019) Kai Wang et al.   Scientific Reports

The Critical Role of Bach2 in Shaping the Balance between CD4+ T Cell Subsets in Immune-Mediated Diseases

(2019) Lingyi Yang et al.   MEDIATORS OF INFLAMMATION

Chronic inflammation in the etiology of disease across the life span

(2019) David Furman et al.   NATURE MEDICINE

Dietary Curcumin Supplementation Increases Antioxidant Capacity, Upregulates Nrf2 and Hmox1 Levels in the Liver of Piglet Model with Intrauterine Growth Retardation

(2019) Yu Niu et al.   Nutrients

Nrf2: Molecular and epigenetic regulation during aging

(2018) A. Silva-Palacios et al.   AGEING RESEARCH REVIEWS

Low Oxidative Stress-Mediated Proliferation Via JNK-FOXO3a-Catalase Signaling in Transplanted Adult Stem Cells Promotes Wound Tissue Regeneration

(2018) Neha R. Dhoke et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2-Keap1 signaling in oxidative and reductive stress

(2018) Ilaria Bellezza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

Crucial role for Nox2 and sleep deprivation in aircraft noise-induced vascular and cerebral oxidative stress, inflammation, and gene regulation

(2018) Swenja Kröller-Schön et al.   EUROPEAN HEART JOURNAL

New application of the commercial sweetener rebaudioside a as a hepatoprotective candidate: Induction of the Nrf2 signaling pathway

(2018) Yuxin Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The role of Nrf2 signaling in counteracting neurodegenerative diseases

(2018) Albena T. Dinkova-Kostova et al.   FEBS Journal

Regulation of neuronal development and function by ROS

(2018) Matthew C. W. Oswald et al.   FEBS LETTERS

Oxidative stress predicts cognitive decline with aging in healthy adults: an observational study

(2018) Ihab Hajjar et al.   Journal of Neuroinflammation

Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant Therapy

(2018) Marco Malavolta et al.   MEDIATORS OF INFLAMMATION

Recombinant FGF21 Protects Against Blood-Brain Barrier Leakage Through Nrf2 Upregulation in Type 2 Diabetes Mice

(2018) Zhanyang Yu et al.   MOLECULAR NEUROBIOLOGY

Genetic mutations associated with lung cancer metastasis to the brain

(2018) Hashim M Aljohani et al.   MUTAGENESIS

Single-nucleus analysis of accessible chromatin in developing mouse forebrain reveals cell-type-specific transcriptional regulation

(2018) Sebastian Preissl et al.   NATURE NEUROSCIENCE

The Good, the Bad, and the Ugly of ROS: New Insights on Aging and Aging-Related Diseases from Eukaryotic and Prokaryotic Model Organisms

(2018) Ana L. Santos et al.   Oxidative Medicine and Cellular Longevity

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

(2018) Antonio Cuadrado et al.   PHARMACOLOGICAL REVIEWS

Niga-ichigoside F1 ameliorates high-fat diet-induced hepatic steatosis in male mice by Nrf2 activation

(2018) Shu-Fang Xia et al.   Food & Function

Autophagy and Alzheimer’s Disease: From Molecular Mechanisms to Therapeutic Implications

(2018) Md. Sahab Uddin et al.   Frontiers in Aging Neuroscience

Physical Activity, Lifestyle Factors and Oxidative Stress in Middle Age Healthy Subjects

(2018) Elisabetta Carraro et al.   International Journal of Environmental Research and Public Health

Oxidative stress, aging, and diseases

(2018) Ilaria Liguori et al.   Clinical Interventions in Aging

Oxidative Stress in Parkinson's Disease: A Systematic Review and Meta-Analysis

(2018) Zexu Wei et al.   Frontiers in Molecular Neuroscience

13 reasons why the brain is susceptible to oxidative stress

(2018) James Nathan Cobley et al.   Redox Biology

Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy

(2018) Ana I. Rojo et al.   Redox Biology

Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain

(2018) Arpiar Saunders et al.   CELL

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

(2018) Luigi Ferrucci et al.   Nature Reviews Cardiology

Astrocyte-specific overexpression of Nrf2 protects against optic tract damage and behavioural alterations in a mouse model of cerebral hypoperfusion

(2018) Emma Sigfridsson et al.   Scientific Reports

IL-1β, IL-6, TNF- α and CRP in Elderly Patients with Depression or Alzheimer’s disease: Systematic Review and Meta-Analysis

(2018) Ada Ng et al.   Scientific Reports

A distinct class of antioxidant response elements is consistently activated in tumors with NRF2 mutations

(2018) Daniel C. Levings et al.   Redox Biology

A systematic analysis of Nrf2 pathway activation dynamics during repeated xenobiotic exposure

(2018) Luc J. M. Bischoff et al.   ARCHIVES OF TOXICOLOGY

Hyperactivity of the transcription factor Nrf2 causes metabolic reprogramming in mouse esophagus

(2018) Junsheng Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bach1: Function, Regulation, and Involvement in Disease

(2018) Xinyue Zhang et al.   Oxidative Medicine and Cellular Longevity

Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice

(2018) Sho Matsui et al.   Nature Communications

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

(2018) Bee Ling Tan et al.   Frontiers in Pharmacology

NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: Molecular mechanisms and possible therapeutic approaches

(2018) Farzane Sivandzade et al.   Redox Biology

Genetic reduction of Nrf2 exacerbates cognitive deficits in a mouse model of Alzheimer’s disease

(2017) Caterina Branca et al.   HUMAN MOLECULAR GENETICS

Di(2-ethylhexyl)phthalate Alters the Synthesis and β-Oxidation of Fatty Acids and Hinders ATP Supply in Mouse Testes via UPLC-Q-Exactive Orbitrap MS-Based Metabonomics Study

(2017) Guolin Shen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Regulation of redox balance in cancer and T cells

(2017) Hyewon Kong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple mechanisms of dimethyl fumarate in amyloid β-induced neurotoxicity in human neuronal cells

(2017) Michela Campolo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood–Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype

(2017) Stefano Tarantini et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Blood-brain barrier disruption in diabetic mice is linked to Nrf2 signaling deficits: Role of ABCB10?

(2017) Ravi K. Sajja et al.   NEUROSCIENCE LETTERS

The hippocampus and the regulation of human food intake.

(2017) Richard J. Stevenson et al.   PSYCHOLOGICAL BULLETIN

IDH1 R132H mutation regulates glioma chemosensitivity through Nrf2 pathway

(2017) Kaishu Li et al.   Oncotarget

Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress

(2017) Yoko Yagishita et al.   Cell Reports

Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis

(2017) Z Fan et al.   Oncogenesis

Circulating FGF21 in humans is potently induced by short term overfeeding of carbohydrates

(2017) Anne-Marie Lundsgaard et al.   Molecular Metabolism

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors

(2016) Anju Singh et al.   ACS Chemical Biology

Activation of apoptosis signalling pathways by reactive oxygen species

(2016) Maureen Redza-Dutordoir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Genetics of Transcription Factor DNA Binding Variation

(2016) Bart Deplancke et al.   CELL

Repression of the Antioxidant NRF2 Pathway in Premature Aging

(2016) Nard Kubben et al.   CELL

Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework

(2016) Samantha M. Solon-Biet et al.   Cell Metabolism

SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2

(2016) Huize Pan et al.   CELL RESEARCH

p62/SQSTM1 is required for the protection against endoplasmic reticulum stress-induced apoptotic cell death

(2016) Jeong Su Park et al.   FREE RADICAL RESEARCH

BACH1, the master regulator gene: A novel candidate target for cancer therapy

(2016) Sadaf Davudian et al.   GENE

Nrf2 Transcription Factor Can Directly Regulate mTOR

(2016) Gabriel Bendavit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease

(2016) M. Ahuja et al.   JOURNAL OF NEUROSCIENCE

Role of ROS and RNS Sources in Physiological and Pathological Conditions

(2016) Sergio Di Meo et al.   Oxidative Medicine and Cellular Longevity

The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review

(2016) Shanmugam Manoharan et al.   Oxidative Medicine and Cellular Longevity

Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma

(2016) F Ahmad et al.   Cell Death & Disease

CRISPR/Cas9-Derived Mutations Both Inhibit HIV-1 Replication and Accelerate Viral Escape

(2016) Zhen Wang et al.   Cell Reports

Antioxidant Supplementation in the Treatment of Aging-Associated Diseases

(2016) Valeria Conti et al.   Frontiers in Pharmacology

The Regulation of NF-κB Subunits by Phosphorylation

(2016) Frank Christian et al.   Cells

GSK-3β downregulates Nrf2 in cultured cortical neurons and in a rat model of cerebral ischemia-reperfusion

(2016) Xi Chen et al.   Scientific Reports

Associations of metabolic, inflammatory and oxidative stress markers with total morbidity and multi-morbidity in a large cohort of older German adults

(2015) Ben Schöttker et al.   AGE AND AGEING

Attenuation of p38α MAPK stress response signaling delays the in vivo aging of skeletal muscle myofibers and progenitor cells

(2015) John Papaconstantinou et al.   Aging-US

Value of monitoring Nrf2 activity for the detection of chemical and oxidative stress

(2015) Fiona E. Mutter et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways

(2015) Joanna D. Wardyn et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Eicosanoids Derived From Arachidonic Acid and Their Family Prostaglandins and Cyclooxygenase in Psychiatric Disorders

(2015) Kunio Yui et al.   Current Neuropharmacology

Preventive effect of safranal against oxidative damage in aged male rat brain

(2015) Saeed SAMARGHANDIAN et al.   EXPERIMENTAL ANIMALS

Oxidative stress response and Nrf2 signaling in aging

(2015) Hongqiao Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

p62 links autophagy and Nrf2 signaling

(2015) Tao Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

(2015) Lauren E. Tebay et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Mediator Subunit MED16 Transduces NRF2-Activating Signals into Antioxidant Gene Expression

(2015) Hiroki Sekine et al.   MOLECULAR AND CELLULAR BIOLOGY

Increased Alzheimer's disease–like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy

(2015) Gururaj Joshi et al.   NEUROBIOLOGY OF AGING

Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson’s disease by enhancing Nrf2 activity

(2015) X. Jing et al.   NEUROSCIENCE

Relationship between Inflammation and Oxidative Stress and Cognitive Decline in the Institutionalized Elderly

(2015) Marília Baierle et al.   Oxidative Medicine and Cellular Longevity

Controlling Redox Status for Stem Cell Survival, Expansion, and Differentiation

(2015) Sébastien Sart et al.   Oxidative Medicine and Cellular Longevity

Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models

(2015) Danielle R. Bruns et al.   Oxidative Medicine and Cellular Longevity

PI3K-AKT Signaling via Nrf2 Protects against Hyperoxia-Induced Acute Lung Injury, but Promotes Inflammation Post-Injury Independent of Nrf2 in Mice

(2015) Narsa M. Reddy et al.   PLoS One

Regulation of Nrf2 signaling and longevity in naturally long-lived rodents

(2015) Kaitlyn N. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

(2015) Karen F.S. Bell et al.   Nature Communications

Understanding the role of NRF2-regulated miRNAs in human malignancies

(2015) Niraj M Shah et al.   Oncotarget

Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases

(2014) Li Gan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Monitoring Keap1–Nrf2 interactions in single live cells

(2014) Liam Baird et al.   BIOTECHNOLOGY ADVANCES

Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2

(2014) S. Tao et al.   CANCER RESEARCH

NADPH oxidases: an overview from structure to innate immunity-associated pathologies

(2014) Arvind Panday et al.   Cellular & Molecular Immunology

Nrf2 Knockout Attenuates the Anti-Inflammatory Effects of Phenethyl Isothiocyanate and Curcumin

(2014) Sarandeep S. S. Boyanapalli et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The polycomb group protein EZH2 inhibits lung cancer cell growth by repressing the transcription factor Nrf2

(2014) Ziming Li et al.   FEBS LETTERS

Nrf2 induces fibroblast growth factor 21 in diabetic mice

(2014) Yuki Furusawa et al.   GENES TO CELLS

FGF21 is an endocrine signal of protein restriction

(2014) Thomas Laeger et al.   JOURNAL OF CLINICAL INVESTIGATION

The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program

(2014) Ari Itoh-Nakadai et al.   NATURE IMMUNOLOGY

Polyunsaturated fatty acids and their metabolites in brain function and disease

(2014) Richard P. Bazinet et al.   NATURE REVIEWS NEUROSCIENCE

Activation of the NRF2 pathway and its impact on the prognosis of anaplastic glioma patients

(2014) Masayuki Kanamori et al.   NEURO-ONCOLOGY

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

(2014) Antonio Ayala et al.   Oxidative Medicine and Cellular Longevity

Identifying and mapping cell-type-specific chromatin programming of gene expression

(2014) Troels T. Marstrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Environmental pollutants and lifestyle factors induce oxidative stress and poor prenatal development

(2014) Kaïs H. Al-Gubory   REPRODUCTIVE BIOMEDICINE ONLINE

Effect of Antioxidants Supplementation on Aging and Longevity

(2014) Izabela Sadowska-Bartosz et al.   Biomed Research International

Nrf2 is required to maintain the self-renewal of glioma stem cells

(2013) Jianhong Zhu et al.   BMC CANCER

ROS Are Required for Mouse Spermatogonial Stem Cell Self-Renewal

(2013) Hiroko Morimoto et al.   Cell Stem Cell

Nrf2 and Nrf1 signaling and ER stress crosstalk: implication for proteasomal degradation and autophagy

(2013) Hadi Digaleh et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Environmental factors and unhealthy lifestyle influence oxidative stress in humans—an overview

(2013) G. Smilin Bell Aseervatham et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Knockdown of Nrf2 suppresses glioblastoma angiogenesis by inhibiting hypoxia-induced activation of HIF-1α

(2013) Xiangjun Ji et al.   INTERNATIONAL JOURNAL OF CANCER

Temozolomide and irradiation combined treatment-induced Nrf2 activation increases chemoradiation sensitivity in human glioblastoma cells

(2013) Zi-Xiang Cong et al.   JOURNAL OF NEURO-ONCOLOGY

Correlation of Nrf2 and HIF-1α in glioblastoma and their relationships to clinicopathologic features and survival

(2013) Xiangjun Ji et al.   NEUROLOGICAL RESEARCH

NRF2-regulation in brain health and disease: Implication of cerebral inflammation

(2013) Mats Sandberg et al.   NEUROPHARMACOLOGY

ERK and PI3K signaling cascades induce Nrf2 activation and regulate cell viability partly through Nrf2 in human glioblastoma cells

(2013) ZI-XIANG CONG et al.   ONCOLOGY REPORTS

Knockdown of NF-E2-related factor 2 inhibits the proliferation and growth of U251MG human glioma cells in a mouse xenograft model

(2013) XIANG-JUN JI et al.   ONCOLOGY REPORTS

Correction: Absence of Nrf2 or Its Selective Overexpression in Neurons and Muscle Does Not Affect Survival in ALS-Linked Mutant hSOD1 Mouse Models

(2013) Marcelo R. Vargas et al.   PLoS One

Bach2 maintains T cells in a naive state by suppressing effector memory-related genes

(2013) S.-i. Tsukumo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-125b transcriptionally increased by Nrf2 inhibits AhR repressor, which protects kidney from cisplatin-induced injury

(2013) M S Joo et al.   Cell Death & Disease

Potential therapeutic effects of the simultaneous targeting of the Nrf2 and NF-κB pathways in diabetic neuropathy

(2013) Veera Ganesh Yerra et al.   Redox Biology

Roles of Reactive Oxygen Species in the Fate of Stem Cells

(2012) Pooja Chaudhari et al.   ANTIOXIDANTS & REDOX SIGNALING

The high Nrf2 expression in human acute myeloid leukemia is driven by NF- B and underlies its chemo-resistance

(2012) S. A. Rushworth et al.   BLOOD

Energy Intake and Exercise as Determinants of Brain Health and Vulnerability to Injury and Disease

(2012) Mark P. Mattson   Cell Metabolism

Linking disease associations with regulatory information in the human genome

(2012) M. A. Schaub et al.   GENOME RESEARCH

α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease

(2012) Isabel Lastres-Becker et al.   HUMAN MOLECULAR GENETICS

Beneficial Effects of Nrf2 Overexpression in a Mouse Model of Alexander Disease

(2012) C. M. LaPash Daniels et al.   JOURNAL OF NEUROSCIENCE

Astrocyte-Specific Overexpression of Nrf2 Delays Motor Pathology and Synuclein Aggregation throughout the CNS in the Alpha-Synuclein Mutant (A53T) Mouse Model

(2012) L. Gan et al.   JOURNAL OF NEUROSCIENCE

The Absence of Nrf2 Enhances NF-B-Dependent Inflammation following Scratch Injury in Mouse Primary Cultured Astrocytes

(2012) Hao Pan et al.   MEDIATORS OF INFLAMMATION

The involvement of Nrf2–ARE pathway in regulation of apoptosis in human glioblastoma cell U251

(2012) Hao Pan et al.   NEUROLOGICAL RESEARCH

Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha

(2012) B. N. Chorley et al.   NUCLEIC ACIDS RESEARCH

The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains

(2012) J-H Kim et al.   ONCOGENE

Knockdown of Nrf2 enhances autophagy induced by temozolomide in U251 human glioma cell line

(2012) YUAN ZHOU et al.   ONCOLOGY REPORTS

Identification of Novel microRNAs in Post-Transcriptional Control of Nrf2 Expression and Redox Homeostasis in Neuronal, SH-SY5Y Cells

(2012) Madhusudhanan Narasimhan et al.   PLoS One

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

(2012) M. T. Maurano et al.   SCIENCE

A transgenic mouse model for monitoring oxidative stress

(2012) Daisuke Oikawa et al.   Scientific Reports

A New Definition of Aging?

(2012) Thomas Flatt   Frontiers in Genetics

Oxidative Stress and Antioxidant Defense

(2012) Esra Birben et al.   World Allergy Organization Journal

Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway

(2011) Miao Yu et al.   CELLULAR SIGNALLING

Free Radical Lipid Peroxidation: Mechanisms and Analysis

(2011) Huiyong Yin et al.   CHEMICAL REVIEWS

Development of Neh2-Luciferase Reporter and Its Application for High Throughput Screening and Real-Time Monitoring of Nrf2 Activators

(2011) Natalya A. Smirnova et al.   CHEMISTRY & BIOLOGY

Epigenetic Modifications

(2011) Diane E. Handy et al.   CIRCULATION

Enhancer and promoter interactions—long distance calls

(2011) Ivan Krivega et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease

(2011) M. C. Barone et al.   Disease Models & Mechanisms

Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage

(2011) Bing Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Making sense of chromatin states

(2011) Monya Baker   NATURE METHODS

Activated microglia decrease histone acetylation and Nrf2-inducible anti-oxidant defence in astrocytes: Restoring effects of inhibitors of HDACs, p38 MAPK and GSK3β

(2011) Fernando Correa et al.   NEUROBIOLOGY OF DISEASE

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

Oxidative stress in development: Nature or nurture?

(2010) Phyllis A. Dennery   FREE RADICAL BIOLOGY AND MEDICINE

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

(2010) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

(2010) Deepti Malhotra et al.   NUCLEIC ACIDS RESEARCH

Different Susceptibility to the Parkinson's Toxin MPTP in Mice Lacking the Redox Master Regulator Nrf2 or Its Target Gene Heme Oxygenase-1

(2010) Nadia G. Innamorato et al.   PLoS One

Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression

(2010) Ilaria Bellezza et al.   Cancers

Dopamine promotes striatal neuronal apoptotic death via ERK signaling cascades

(2009) Jun Chen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease

(2009) Ana I. Rojo et al.   GLIA

Critical Cysteine Residues of Kelch-Like ECH-Associated Protein 1 in Arsenic Sensing and Suppression of Nuclear Factor Erythroid 2-Related Factor 2

(2009) X. He et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Eicosanoids: essential mediators in health and disease / Eicosanoide: bedeutende Faktoren in der Homöostase und ihre Bedeutung in der Pathogenese multipler Erkrankungen

(2009) Mathias Bruegel et al.   LaboratoriumsMedizin-Journal of Laboratory Medicine

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

(2009) Mitchell Guttman et al.   NATURE

Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease

(2009) K. Kanninen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Absence of the Pro-antioxidant Transcription Factor Nrf2 Exacerbates Experimental Autoimmune Encephalomyelitis

(2009) Delinda A. Johnson et al.   TOXICOLOGICAL SCIENCES

Mitochondrial generation of free radicals and hypoxic signaling

(2009) Robert O. Poyton et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Heme Oxygenase-1: Its Therapeutic Roles in Inflammatory Diseases

(2009) Hyun-Ock Pae et al.   Immune Network

Activation of Nrf2-antioxidant signaling attenuates NFκB-inflammatory response and elicits apoptosis

(2008) Wenge Li et al.   BIOCHEMICAL PHARMACOLOGY

NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

(2008) Guang-Hui Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man

(2008) Cecilia Gälman et al.   Cell Metabolism

Physiological Significance of Reactive Cysteine Residues of Keap1 in Determining Nrf2 Activity

(2008) T. Yamamoto et al.   MOLECULAR AND CELLULAR BIOLOGY

Lipid signalling in disease

(2008) Matthias P. Wymann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY