Article
Biochemistry & Molecular Biology
Amanda J. Croft, Conagh Kelly, Dongqing Chen, Tatt Jhong Haw, Aaron L. Sverdlov, Doan T. M. Ngo
Summary: Obesity is associated with various metabolic disorders and cardiovascular diseases, causing increased hospitalizations, morbidity, and mortality. Dysfunction of adipose tissue due to chronic nutrient stress can lead to oxidative stress, mitochondrial dysfunction, inflammation, hypoxia, and insulin resistance. This study aimed to reduce adipose tissue oxidative stress by overexpressing the antioxidant mitochondrial catalase (mCAT) in adipose tissue to improve systemic metabolic function. The results showed that the AdipoQ-mCAT mice were protected from further metabolic impairment under obesogenic dietary conditions compared to obese wild-type mice, highlighting the critical role of physiological H2O2 signaling in metabolism and adipose tissue function.
Article
Biochemistry & Molecular Biology
Pilar Fernandez-Mateos, Pilar Cano-Barquilla, Vanesa Jimenez-Ortega, Leire Virto, Juliana Perez-Miguelsanz, Ana I. Esquifino
Summary: Increased adiposity is associated with oxidative stress, inflammation, and metabolic disorders. Melatonin has been shown to prevent the negative effects of obesity on neuroendocrine and inflammatory parameters related to oxidative stress. This study examines the effects of a high-fat diet (HFD) on the gene expression of redox balance enzymes in subcutaneous (SAT) and perirenal (PRAT) adipose tissue of male Wistar rats and the potential preventive role of melatonin. The results indicate that HFD disrupts the normal gene expression patterns of redox enzymes in both SAT and PRAT, with PRAT being more susceptible to oxidative stress induced by obesity. However, melatonin administration along with HFD partially prevents the changes in gene expression of redox enzymes in both SAT and PRAT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Seyyed Mohammad Reza Hashemnia, Reza Meshkani, Fahimeh Zamani-Garmsiri, Maryam Shabani, Maryam Tajabadi-Ebrahimi, Iraj Ragerdi Kashani, Seyed Davar Siadat, Samaneh Mohassel Azadi, Solaleh Emamgholipour
Summary: New evidence suggests that B. coagulans can be a promising alternative for treating metabolic disorders. However, its effects on obesity-induced adipose tissue inflammation are still unknown.
Article
Hematology
Mark Colin Gissler, Nathaly Anto-Michel, Jan Pennig, Philipp Scherrer, Xiaowei Li, Timoteo Marchini, Katharina Pfeiffer, Carmen Haerdtner, Tijani Abogunloko, Timothy Mwinyella, Lucia Sol Mitre, Lisa Spiga, Christoph Koentges, Christian Smolka, Dominik von Elverfeldt, Natalie Hoppe, Peter Stachon, Bianca Dufner, Timo Heidt, Sven Piepenburg, Ingo Hilgendorf, Jan-Inge Bjune, Simon N. Dankel, Gunnar Mellgren, Gabriel Seifert, Steffen U. Eisenhardt, Heiko Bugger, Constantin von zur Muhlen, Christoph Bode, Andreas Zirlik, Dennis Wolf, Florian Willecke
Summary: Genetic deficiency of TRAF5 exacerbates diet-induced obesity and metabolic dysregulation by promoting a proinflammatory response in adipocytes, indicating a potential role of TRAF5 in anti-inflammatory and obesity-preventing signaling events in adipose tissue.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Nutrition & Dietetics
Yu Wang, Xuyang Gao, Xiaoyou Chen, Qiang Li, Xinrui Li, Junxing Zhao
Summary: Sea buckthorn powder intake has a preventive effect on high-fat diet-induced obesity, reducing body weight, fat mass, and circulating lipid levels, and improving insulin sensitivity. Additionally, it alleviates hepatic steatosis and lipid accumulation, exhibits anti-inflammatory capacity in white adipose tissue, promotes thermogenesis in brown adipose tissue, and induces beige adipocyte formation.
Article
Plant Sciences
Eun A. Kim, Ju-Hwan Yang, Eun-Hye Byeon, Woong Kim, Dawon Kang, Jaehee Han, Seong-Geun Hong, Deok-Ryong Kim, Sang-Je Park, Jae-Won Huh, Hyeonsook Cheong, Seung-Pil Yun, Dong-Kun Lee
Summary: The study demonstrates that pine needle extract inhibits obesity by increasing hypothalamic POMC neuronal activity and improving physiological conditions after high-fat diet-induced obesity. Additionally, PNE also suppresses lipogenesis in white adipose tissue.
Review
Nutrition & Dietetics
Muhammed Mustafa Atakan, Sukran Nazan Kosar, Yasemin Guzel, Hiu Tung Tin, Xu Yan
Summary: Calorie restriction, regular exercise, or a combination of the two are accepted as effective strategies in preventing or treating obesity. The benefits of exercise in combating obesity are not only attributed to reducing adiposity but also to releasing proteins, peptides, enzymes, and metabolites that are beneficial for overall health.
Article
Biochemistry & Molecular Biology
Sara Becerril, Carlota Tuero, Javier A. Cienfuegos, Amaia Rodriguez, Victoria Catalan, Beatriz Ramirez, Victor Valenti, Rafael Moncada, Xabier Unamuno, Javier Gomez-Ambrosi, Gema Fruhbeck
Summary: This study compares Sleeve Gastrectomy (SG) and Single Anastomosis Duodenoileal Bypass with SG (SADI-S) in obese rats and finds that SADI-S surgery results in better control of lipid and glucose metabolism and improved adipose tissue function compared to SG surgery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Yen-Ju Chiu, Ho-Hsiang Tu, Mei-Lang Kung, Hung-Ju Wu, Yun-Wen Chen
Summary: Patients with type 2 diabetes mellitus have a higher risk of developing depression, and fluoxetine (FLX) has been shown to alleviate high fat diet-induced metabolic dysfunctions and depressive phenotypes in mice. FLX improves systemic glucose homeostasis by enhancing insulin signaling in visceral white adipose tissue (vWAT), and reduces circulating plasma leptin levels as well as the expression of adipose triglyceride lipase (ATGL) and peroxisome proliferator-activated receptor gamma (PPAR gamma) in vWAT.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Sabrina Folie, Bernhard Radlinger, Georg Goebel, Karin Salzmann, Gabriele Staudacher, Claudia Ress, Herbert Tilg, Susanne Kaser
Summary: The study suggests that switching from a metabolically harmful Western diet to a balanced standard diet can improve adipose tissue inflammation, while long-term consumption of a Western diet negatively impacts the thermogenic capacity of brown adipose tissue and inhibits beiging of white adipose tissue.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Bynvant Sandhu, Maria C. Perez-Matos, Stephanie Tran, Garima Singhal, Ismail Syed, Linda Feldbruegge, Shuji Mitsuhashi, Julie Pelletier, Jinhe Huang, Yusuf Yalcin, Eva Csizmadia, Shilpa Tiwari-Heckler, Keiichi Enjyoji, Jean Sevigny, Eleftheria Maratos-Flier, Simon C. Robson, Z. Gordon Jiang
Summary: This study investigated the impact of NTPDase3 deficiency on diet-induced obesity and metabolism in mice. The results showed that global NTPDase3 deletion led to resistance to obesity and glucose intolerance, with metabolic changes in adipocytes playing a key role rather than NTPDase3 expression in pancreatic beta-cells.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Food Science & Technology
Hsin-Lin Cheng, Wei-Tang Chang, Jiun-Ling Lin, Chun-Tse Tsai, Ming-Ching Cheng, Shih-Chien Huang, Yue-Ching Wong, Chin-Lin Hsu
Summary: This study confirms the anti-obesity effects of the Mei-Gin formula (MGF) in obese rats induced by a high-fat diet. MGF intake significantly suppressed body weight, fat mass, and lipid levels while increasing fecal lipid excretion. The study also reveals the potential molecular mechanisms of MGF in regulating lipid metabolism pathways and promoting lipolysis, fatty acid oxidation, and thermogenesis.
Article
Biochemistry & Molecular Biology
M. Carmen Navarro-Ruiz, M. Carmen Soler-Vazquez, Alberto Diaz-Ruiz, Juan R. Peinado, Andrea Nieto Calonge, Julia Sanchez-Ceinos, Carmen Tercero-Alcazar, Jaime Lopez-Alcala, Oriol A. Rangel-Zuniga, Antonio Membrives, Jose Lopez-Miranda, Maria M. Malagon, Rocio Guzman-Ruiz
Summary: This study investigated the carbonylome of subcutaneous and omental human adipose tissue in obesity-associated insulin resistance. The results showed differences in carbonylated proteins between different fat depots, highlighting the complexity of oxidative stress at the metabolic level. Furthermore, the study revealed the altered expression and function of carbonylated transferrin, linking oxidative stress to metabolic dysfunction. This research provides insights into the molecular mechanisms underlying adipocyte dysfunction in obesity and identifies potential targets for therapeutic intervention.
Article
Pharmacology & Pharmacy
Zhuohui Luo, Jiawen Huang, Zhiping Li, Zhiwen Liu, Linchun Fu, Yingjie Hu, Xiaoling Shen
Summary: The study showed that CLA can prevent high-fat diet-induced obesity by reducing energy intake, mainly through the inhibition of orexigenic gene expression in the hypothalamus, reducing fat accumulation, and protecting adipose tissues and the liver from mitochondrial dysfunction induced by lipid.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Engineering, Environmental
Ho Ting Shiu, Xiaohan Pan, Qing Liu, KeKao Long, Kenneth King Yip Cheng, Ben Chi-Bun Ko, James Kar-Hei Fang, Yuyan Zhu
Summary: The health concerns of microplastics (MPs) and nanoplastics (NPs) have been increasing, but there is still a lack of key indicators to evaluate the adverse risks of MPs/NPs. This study demonstrates that fluorescent polystyrene nanoplastics (nPS) can distribute in white adipose tissue (WAT) of mice and reduce lipolysis under stimulation in vitro and ex vivo. Chronic oral exposure to nPS at relevant concentrations impairs lipid mobilization in obese mice, leading to larger adipocytes in WAT. Additionally, nPS exposure induces macrophage infiltration in the small intestine and increases lipid accumulation in the liver, disrupting systemic metabolism. These findings highlight the potential obesogenic role of nPS via diminishing lipid mobilization in WAT and suggest using lipolysis relevant parameters for evaluating the adverse effect of MPs/NPs in clinics.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Pharmacology & Pharmacy
James W. Walters, Deborah Amos, Kristeena Ray, Nalini Santanam
CURRENT OPINION IN PHARMACOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Caitlin Kocher, Matthew Christiansen, Sarah Martin, Christopher Adams, Paulette Wehner, Todd Gress, Nalini Santanam
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2017)
Article
Obstetrics & Gynecology
Nalini Santanam, Nathaniel Zoneraich, Sampath Parthasarathy
REPRODUCTIVE SCIENCES
(2017)
Article
Biochemistry & Molecular Biology
Kristeena Ray Wright, Brenda Mitchell, Nalini Santanam
Editorial Material
Oncology
Sarah Brunty, Nalini Santanam
ANNALS OF TRANSLATIONAL MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Sabel Meadows, Abbagael Seidler, Madison Wall, Jamika Page, Cara Taylor, Brendin Flinn, Robin Turner, Nalini Santanam
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Sarah Brunty, Kristeena Ray Wright, Brenda Mitchell, Nalini Santanam
Summary: Activation of trimethylation of histone 3 lysine 27 (H3K27me3) by EZH2 plays a role in endometriosis, with higher expression of PRC2 complex components like JARID2, miR-155, and FOXP3 noted in patient tissues. MiR-155 affects the PRC2 complex but has minimal impact on JARID2 expression, suggesting alternative pathways may be involved. A novel crosstalk between miR-155, the PRC2 complex, JARID2, and PHF19 has been identified, providing potential epigenetic targets for further study in endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Jeremy R. Chen See, Deborah Amos, Justin Wright, Regina Lamendella, Nalini Santanam
Summary: The study revealed a synergistic beneficial influence of antioxidant overexpression and exercise on the gut microbiome, potentially affecting diversity through enrichment of specific metabolic pathways, with a synergistic relationship between exercise and genotypic traits.
ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Brendin Flinn, Christopher Adams, Nepal Chowdhury, Todd Gress, Nalini Santanam
Summary: Epicardial fat plays a key role in cardiovascular diseases, and the non-coding RNA and transcriptomic alterations of epicardial fat in coronary artery disease have been found to be unique. Analysis of microRNA and long non-coding RNA revealed sex-dependent mi/lncRNA changes in epicardial fat of patients with coronary artery disease. These changes are associated with inflammation, adipogenesis, cardiomyocyte apoptosis, atherosclerosis, and myocardial infarction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Lauren Clower, Taylor Fleshman, Werner J. Geldenhuys, Nalini Santanam
Summary: Endometriosis is a common gynecological disorder characterized by chronic pelvic pain and infertility. The pathophysiology of this disorder involves oxidative stress and inflammation. Targeting oxidative stress may offer potential treatment options, although further research is needed.
Article
Endocrinology & Metabolism
Mose July, Saba Faiz, Abid Yaqub, Prasanna Santhanam, Jillian Douglas, Ronald Stanek, Todd Gress, Omolola Olajide, Henry Driscoll, Nalini Santanam
MINERVA ENDOCRINOLOGICA
(2018)
Review
Clinical Neurology
PaulD Chantler, Emily Burrage, KentL Marshall, Nalini Santanam
Article
Biochemistry & Molecular Biology
Deborah L. Amos, Tanner Robinson, Melissa B. Massie, Carla Cook, Alexis Hoffsted, Courtney Crain, Nalini Santanam
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2017)
Article
Endocrinology & Metabolism
Nalini Santanam, Yoram Elitsur, Ronald Stanek, Mateen Hotiana, Jennifer Wheaton, Reem Kheetan, Randa Aljayoussi, Todd Gress, Abid Yaqub
MINERVA ENDOCRINOLOGICA
(2016)
Article
Biochemistry & Molecular Biology
Chenchen Bian, Xiangtong Yuan, Caihong Zeng, Jian Sun, Gen Kaneko, Hong Ji
Summary: This study investigated the mechanism of docosahexaenoic acid (DHA)-induced apoptosis mediated by mitophagy, using grass carp as an animal model. The results showed that inhibition of mitophagy alleviated apoptosis and eliminated the inhibition of lipid accumulation induced by DHA. Mechanistically, DHA induced mitophagy by activating the PPAR gamma-LC3-BNIP3 pathway. Inhibition of PPAR gamma decreased autophagy-related gene expression and prevented BNIP3/NIX-mediated mitophagy-induced apoptosis, thereby alleviating the inhibition of lipid accumulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Venkatesan Ramya, Karuppiah Prakash Shyam, Arulanandu Angelmary, Balamuthu Kadalmani
Summary: This study reveals that Lauric acid (LA) exerts an epigenetic regulation and metabolic reprogramming on SH-SY5Y neuroblastoma cells through modulation of lncRNA HOTAIR, remodeling of chromatin H3K4 tri-methylation and regulation of glucose uptake by controlling NF-kappa B activation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Sreelekshmi Sreekumar, Karyath Palliyath Gangaraj, Manikantan Syamala Kiran
Summary: This study investigates the intricate interplay between angiogenic regulation and the browning of white adipocytes. The findings reveal that concurrent activation of angiogenesis is necessary for inducing browning of white adipocytes. The study also highlights the role of Vascular endothelial growth factor (VEGF) in promoting angiogenesis and triggering the browning process through the activation of Estrogen receptor alpha (ER alpha) signaling pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Zanxia Cao, Liling Zhao, Mingcui Chen, Zhihong Shi, Lei Liu
Summary: This study investigated the translocation process of cholesterol/calcitriol in bacterial membranes and their effects on membrane structure. Calcitriol facilitated water transport across the membrane, while cholesterol had the opposite effect. These findings contribute to a better understanding of the relationship between cholesterol/calcitriol concentrations, lipid bilayer structure, and water permeation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Xiaozhen Guo, Jiawen Wang, Hualing Xu, Yangyang Wang, Yutang Cao, Yingquan Wen, Jiaqi Li, Yameng Liu, Kanglong Wang, Jue Wang, Xianchun Zhong, Chuying Sun, Yongxin Zhang, Jingyi Xu, Cuina Li, Pengxiang Mu, Lingyan Xu, Cen Xie
Summary: This study aims to investigate the role of the gut microbiota-bile acid axis in regulating the diurnal rhythms of metabolic homeostasis and assess the impact of obesity on them. The results show that high fat diet feeding and Leptin gene deficiency disrupt the rhythmic patterns of insulin sensitivity and serum total cholesterol levels. The study provides compelling evidence for the association between diurnal rhythm of insulin sensitivity and gut microbiota-bile acid axis, and elucidates the deleterious effects of obesity on gut microbiome-bile acid metabolism.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Giuseppe Pepe, Maria Cotugno, Federico Marracino, Luca Capocci, Ludovica Pizzati, Maurizio Forte, Rosita Stanzione, Pamela Scarselli, Alba Di Pardo, Sebastiano Sciarretta, Massimo Volpe, Speranza Rubattu, Vittorio Maglione
Summary: The study found that enzymes involved in sphingolipid metabolism show abnormal expression in the cardiac tissue of hypertensive rat models, which may be related to the susceptibility to cardiac damage.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)