The Good, the Bad, and the Ugly of ROS: New Insights on Aging and Aging-Related Diseases from Eukaryotic and Prokaryotic Model Organisms

Protein and exercise in the prevention of sarcopenia and aging

(2017) Manal A. Naseeb et al.   NUTRITION RESEARCH

Protein Posttranslational Modifications: Roles in Aging and Age-Related Disease

(2017) Ana L. Santos et al.   Oxidative Medicine and Cellular Longevity

Caloric restriction extends yeast chronological lifespan via a mechanism linking cellular aging to cell cycle regulation, maintenance of a quiescent state, entry into a non-quiescent state and survival in the non-quiescent state

(2017) Anna Leonov et al.   Oncotarget

PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila

(2017) Martin Borch Jensen et al.   eLife

A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1−/ − mice is correlated to increased cellular senescence

(2017) Yiqiang Zhang et al.   Redox Biology

Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan

(2016) Filippo Scialò et al.   Cell Metabolism

The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4′-hydroxystilbene and trans-2,4′,5-trihydroxystilbene decrease oxidative stress and prolong lifespan inCaenorhabditis elegans

(2016) Nadine Fischer et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Orchestrating the network of molecular pathways affecting aging: Role of nonselective autophagy and mitophagy

(2016) Laura Knuppertz et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

(2016) Michael S. Bonkowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nuclear DNA damage signalling to mitochondria in ageing

(2016) Evandro Fei Fang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases

(2016) Pierpaola Davalli et al.   Oxidative Medicine and Cellular Longevity

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

(2016) H. Zhang et al.   SCIENCE

mTOR's role in ageing: protein synthesis or autophagy?

(2016) Sarah L. Hands et al.   Aging-US

Ubiquitin over-expression phenotypes and ubiquitin gene molecular misreading during aging in Drosophila melanogaster

(2016) Nicholas Hoe et al.   Aging-US

Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf

(2016) Takahiro Ogawa et al.   Scientific Reports

Specific protein homeostatic functions of small heat-shock proteins increase lifespan

(2015) Michel J. Vos et al.   AGING CELL

Significant life extension by ten percent dietary restriction

(2015) Arlan Richardson et al.   Annals of the New York Academy of Sciences

Asymmetric damage segregation at cell division via protein aggregate fusion and attachment to organelles

(2015) Miguel Coelho et al.   BIOESSAYS

Poly(ADP-ribose)polymerase 1 inhibition protects against age-dependent endothelial dysfunction

(2015) Guang-hao Zhang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice

(2015) Karim Gariani et al.   HEPATOLOGY

Mitochondria Retrograde Signaling and the UPRmt: Where Are We in Mammals?

(2015) Thierry Arnould et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Defective Repair of Uracil Causes Telomere Defects in Mouse Hematopoietic Cells

(2015) Haritha Vallabhaneni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nicotinamide Exerts Antioxidative Effects on Senescent Cells

(2015) Ju Yeon Kwak et al.   MOLECULES AND CELLS

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

Proteostasis and aging

(2015) Susmita Kaushik et al.   NATURE MEDICINE

Exercise Attenuates the Major Hallmarks of Aging

(2015) Nuria Garatachea et al.   REJUVENATION RESEARCH

Metformin for cancer and aging prevention: is it a time to make the long story short?

(2015) Vladimir N. Anisimov   Oncotarget

Lifespan and Stress Resistance in Drosophila with Overexpressed DNA Repair Genes

(2015) Mikhail Shaposhnikov et al.   Scientific Reports

Mitochondrial and Cytoplasmic ROS Have Opposing Effects on Lifespan

(2015) Claire E. Schaar et al.   PLoS Genetics

The Critical Need to Promote Research of Aging and Aging-related Diseases to Improve Health and Longevity of the Elderly Population

(2015) Kunlin Jin et al.   Aging and Disease

Caloric restriction induces energy-sparing alterations in skeletal muscle contraction, fiber composition and local thyroid hormone metabolism that persist during catch-up fat upon refeeding

(2015) Paula B. M. De Andrade et al.   Frontiers in Physiology

Teaching the fundamentals of electron transfer reactions in mitochondria and the production and detection of reactive oxygen species

(2015) Ryan J. Mailloux   Redox Biology

Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

(2014) Evandro Fei Fang et al.   CELL

Mitochondrial Proteostasis in the Control of Aging and Longevity

(2014) Martin Borch Jensen et al.   Cell Metabolism

NAD+ Deficiency in Age-Related Mitochondrial Dysfunction

(2014) Tomas A. Prolla et al.   Cell Metabolism

Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)

(2014) Michael Ristow et al.   Dose-Response

Role of asymmetric cell division in lifespan control inSaccharomyces cerevisiae

(2014) Ryo Higuchi-Sanabria et al.   FEMS YEAST RESEARCH

Ubiquitin sets the timer: impacts on aging and longevity

(2014) Éva Kevei et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

A Krüppel-like factor downstream of the E3 ligase WWP-1 mediates dietary-restriction-induced longevity in Caenorhabditis elegans

(2014) Andrea C. Carrano et al.   Nature Communications

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

(2014) Ricki J. Colman et al.   Nature Communications

Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice

(2013) Anthony J. Donato et al.   AGING CELL

Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts

(2013) Chad Lerner et al.   AGING CELL

Malfunction of Nuclease ERCC1-XPF Results in Diverse Clinical Manifestations and Causes Cockayne Syndrome, Xeroderma Pigmentosum, and Fanconi Anemia

(2013) Kazuya Kashiyama et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

Dietary restriction attenuates the accelerated aging phenotype of Sod1−/− mice

(2013) Yiqiang Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cellular metabolic and autophagic pathways: Traffic control by redox signaling

(2013) Matthew Dodson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Do sirtuins promote mammalian longevity?: A Critical review on its relevance to the longevity effect induced by calorie restriction

(2013) Seongjoon Park et al.   MOLECULES AND CELLS

Mutation in E1, the Ubiquitin Activating Enzyme, Reduces Drosophila Lifespan and Results in Motor Impairment

(2013) Hsiu-Yu Liu et al.   PLoS One

Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan

(2013) A. Rana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleotide Excision Repair in Eukaryotes

(2013) O. D. Scharer   Cold Spring Harbor Perspectives in Biology

Base Excision Repair

(2013) H. E. Krokan et al.   Cold Spring Harbor Perspectives in Biology

DNA-dependent protein kinase and DNA repair: relevance to Alzheimer's disease

(2013) Jyotshna Kanungo   Alzheimers Research & Therapy

Localization of Protein Aggregation in Escherichia coli Is Governed by Diffusion and Nucleoid Macromolecular Crowding Effect

(2013) Anne-Sophie Coquel et al.   PLoS Computational Biology

Defective Repair of Oxidative Base Lesions by the DNA Glycosylase Nth1 Associates with Multiple Telomere Defects

(2013) Haritha Vallabhaneni et al.   PLoS Genetics

Dietary Restriction Induced Longevity Is Mediated by Nuclear Receptor NHR-62 in Caenorhabditis elegans

(2013) Bree N. Heestand et al.   PLoS Genetics

Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD

(2012) Young C. Jang et al.   AGING CELL

Wavelength dependence of biological damage induced by UV radiation on bacteria

(2012) Ana L. Santos et al.   ARCHIVES OF MICROBIOLOGY

Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan

(2012) Sören Mai et al.   Autophagy

Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease

(2012) Cora O'Neill et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice

(2012) Vladimir N. Anisimov et al.   CELL CYCLE

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

(2012) Stacey Robida-Stubbs et al.   Cell Metabolism

Pten Positively Regulates Brown Adipose Function, Energy Expenditure, and Longevity

(2012) Ana Ortega-Molina et al.   Cell Metabolism

Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain

(2012) Si-Eun Yoo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pleiotropic Cellular Functions of PARP1 in Longevity and Aging: Genome Maintenance Meets Inflammation

(2012) Aswin Mangerich et al.   Oxidative Medicine and Cellular Longevity

A Molecular Mechanism for Direct Sirtuin Activation by Resveratrol

(2012) Melanie Gertz et al.   PLoS One

Superoxide dismutase is dispensable for normal animal lifespan

(2012) J. M. Van Raamsdonk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caloric Restriction Extends Yeast Chronological Lifespan by Altering a Pattern of Age-Related Changes in Trehalose Concentration

(2012) Pavlo Kyryakov et al.   Frontiers in Physiology

dFOXO-independent effects of reduced insulin-like signaling inDrosophila

(2011) Cathy Slack et al.   AGING CELL

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

Antioxidant defense and aging inC. elegans: Is the oxidative damage theory of aging wrong?

(2011) David Gems et al.   CELL CYCLE

Calorie restriction: Decelerating mTOR-driven aging from cells to organisms (including humans)

(2011) Mikhail V Blagosklonny   CELL CYCLE

PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

(2011) Péter Bai et al.   Cell Metabolism

Extending life span by increasing oxidative stress

(2011) Michael Ristow et al.   FREE RADICAL BIOLOGY AND MEDICINE

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

Reduction of Age-Associated Pathology in Old Mice by Overexpression of Catalase in Mitochondria

(2011) P. M. Treuting et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Thioredoxin 1 Overexpression Extends Mainly the Earlier Part of Life Span in Mice

(2011) V. I. Perez et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity

(2011) Vittorio Calabrese et al.   MOLECULAR ASPECTS OF MEDICINE

A review and appraisal of the DNA damage theory of ageing

(2011) Alex A. Freitas et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan

(2011) Silvestre Alavez et al.   NATURE

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Asymmetry and Aging of Mycobacterial Cells Lead to Variable Growth and Antibiotic Susceptibility

(2011) B. B. Aldridge et al.   SCIENCE

Overview of Base Excision Repair Biochemistry

(2011) Yun-Jeong Kim et al.   Current Molecular Pharmacology

Genome-wide screen identifies Escherichia coli TCA-cycle-related mutants with extended chronological lifespan dependent on acetate metabolism and the hypoxia-inducible transcription factor ArcA

(2010) Stavros Gonidakis et al.   AGING CELL

Autophagy in health and disease. 5. Mitophagy as a way of life

(2010) Roberta A. Gottlieb et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

The RpoS-Mediated General Stress Response inEscherichia coli

(2010) Aurelia Battesti et al.   Annual Review of Microbiology

E. coli hypoxia-inducible factor ArcA mediates lifespan extension in a lipoic acid synthase mutant by suppressing acetyl-CoA synthetase

(2010) Stavros Gonidakis et al.   BIOLOGICAL CHEMISTRY

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

Quantitative and spatio-temporal features of protein aggregation in Escherichia coli and consequences on protein quality control and cellular ageing

(2010) Juliane Winkler et al.   EMBO JOURNAL

Protein oxidation and aggregation in UVA-irradiated Escherichia coli cells as signs of accelerated cellular senescence

(2010) Franziska Bosshard et al.   ENVIRONMENTAL MICROBIOLOGY

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

(2010) Michael Ristow et al.   EXPERIMENTAL GERONTOLOGY

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Decreased Energy Metabolism Extends Life Span in Caenorhabditis elegans Without Reducing Oxidative Damage

(2010) J. M. Van Raamsdonk et al.   GENETICS

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

(2010) Richard A. Miller et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1

(2010) Brian Onken et al.   PLoS One

Insulin Signaling, Lifespan and Stress Resistance Are Modulated by Metabotropic GABA Receptors on Insulin Producing Cells in the Brain of Drosophila

(2010) Lina E. Enell et al.   PLoS One

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling

(2010) Eric Verdin et al.   TRENDS IN BIOCHEMICAL SCIENCES

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

(2010) Wen Yang et al.   PLOS BIOLOGY

Protein Carbonylation

(2009) Yuichiro J. Suzuki et al.   ANTIOXIDANTS & REDOX SIGNALING

Is the oxidative stress theory of aging dead?

(2009) Viviana I. Pérez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16

(2009) Teppei Hashimoto et al.   BIOGERONTOLOGY

Calories and carcinogenesis: lessons learned from 30 years of calorie restriction research

(2009) S. D. Hursting et al.   CARCINOGENESIS

When a theory of aging ages badly

(2009) Jérôme Lapointe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Checkpoint mechanisms at the intersection between DNA damage and repair

(2009) Federico Lazzaro et al.   DNA REPAIR

Cell Stress and Aging: New Emphasis on Multiplex Resistance Mechanisms

(2009) R. A. Miller   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Mice Deficient in Both Mn Superoxide Dismutase and Glutathione Peroxidase-1 Have Increased Oxidative Damage and a Greater Incidence of Pathology but No Reduction in Longevity

(2009) Y. Zhang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The Mn-superoxide dismutase single nucleotide polymorphism rs4880 and the glutathione peroxidase 1 single nucleotide polymorphism rs1050450 are associated with aging and longevity in the oldest old

(2009) Mette Soerensen et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The Vitamin Nicotinamide: Translating Nutrition into Clinical Care

(2009) Kenneth Maiese et al.   MOLECULES

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

AMPK in Health and Disease

(2009) Gregory R. Steinberg et al.   PHYSIOLOGICAL REVIEWS

The proteasome: Overview of structure and functions

(2009) Keiji TANAKA   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans

(2009) Jeremy M. Van Raamsdonk et al.   PLoS Genetics

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

(2008) Viviana I. Pérez et al.   AGING CELL

Replicative Aging in Yeast: The Means to the End

(2008) K.A. Steinkraus et al.   Annual Review of Cell and Developmental Biology

Resveratrol protects against oxidative injury induced by H2O2 in acute hippocampal slice preparations from Wistar rats

(2008) Lúcia Maria Vieira de Almeida et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Enzymes of glycerol and glyceraldehyde metabolism in mouse liver: effects of caloric restriction and age on activities.

(2008) Kevork Hagopian et al.   BIOSCIENCE REPORTS

Mechanisms Underlying Caloric Restriction and Lifespan Regulation

(2008) Zoltan Ungvari et al.   CIRCULATION RESEARCH

Sirtuin gene expression in human mononuclear cells is modulated by caloric restriction

(2008) A. B. Crujeiras et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Base excision repair, aging and health span

(2008) Guogang Xu et al.   MECHANISMS OF AGEING AND DEVELOPMENT

ATR: an essential regulator of genome integrity

(2008) Karlene A. Cimprich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Early Events in UV Carcinogenesis—DNA Damage, Target Cells and Mutant p53 Foci

(2008) Frank R. de Gruijl et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Bet-hedging and epigenetic inheritance in bacterial cell development

(2008) J.-W. Veening et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Asymmetric segregation of protein aggregates is associated with cellular aging and rejuvenation

(2008) A. B. Lindner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exercise, oxidative stress and hormesis

(2007) Zsolt Radak et al.   AGEING RESEARCH REVIEWS

Thrifty metabolism that favors fat storage after caloric restriction: a role for skeletal muscle phosphatidylinositol-3-kinase activity and AMP-activated protein kinase

(2007) S. Summermatter et al.   FASEB JOURNAL

Thioredoxin 2 haploinsufficiency in mice results in impaired mitochondrial function and increased oxidative stress

(2007) Viviana I. Pérez et al.   FREE RADICAL BIOLOGY AND MEDICINE