Impaired antioxidant KEAP1-NRF2 system in amyotrophic lateral sclerosis: NRF2 activation as a potential therapeutic strategy

The acetyltransferase p300 regulates NRF2 stability and localization

(2020) Athina Ganner et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phase 2 randomized placebo controlled double blind study to assess the efficacy and safety of tecfidera in patients with amyotrophic lateral sclerosis (TEALS Study)

(2020) Steve Vucic et al.   MEDICINE

Study protocol for SFX-01 after subarachnoid haemorrhage (SAS): a multicentre randomised double-blinded, placebo controlled trial

(2020) Ardalan H Zolnourian et al.   BMJ Open

NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases

(2020) Ángel Cores et al.   Biomolecules

Tobacco Smoking Induces Cardiovascular Mitochondrial Oxidative Stress, Promotes Endothelial Dysfunction and Enhances Hypertension

(2019) Sergey Dikalov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

(2019) Antonio Cuadrado et al.   NATURE REVIEWS DRUG DISCOVERY

An Overview of MicroRNAs as Biomarkers of ALS

(2019) Greig Joilin et al.   Frontiers in Neurology

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

Edaravone for the treatment of amyotrophic lateral sclerosis

(2019) Hiide Yoshino   Expert Review of Neurotherapeutics

Oxidative Stress: A Key Modulator in Neurodegenerative Diseases

(2019) Anju Singh et al.   MOLECULES

Nrf2 in cancers: A double‐edged sword

(2019) Shijia Wu et al.   Cancer Medicine

ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway

(2019) Zhiqiang Deng et al.   Autophagy

Heavy metal toxicity: An update of chelating therapeutic strategies

(2019) Jong-Joo Kim et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

From discoveries in ageing research to therapeutics for healthy ageing

(2019) Judith Campisi et al.   NATURE

Lysine harvesting is an antioxidant strategy and triggers underground polyamine metabolism

(2019) Viridiana Olin-Sandoval et al.   NATURE

Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development

(2019) Natalia Robledinos-Antón et al.   Oxidative Medicine and Cellular Longevity

341PFinal results of the STEM trial: SFX-01 in the treatment and evaluation of ER+ Her2- metastatic breast cancer (mBC)

(2019) S J Howell et al.   ANNALS OF ONCOLOGY

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Decoding the relationship between ageing and amyotrophic lateral sclerosis: a cellular perspective

(2019) Virenkumar A Pandya et al.   BRAIN

Redox Mechanisms in Neurodegeneration: From Disease Outcomes to Therapeutic Opportunities

(2018) Juan I. Sbodio et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2 Pathway in Age-Related Neurological Disorders: Insights into MicroRNAs

(2018) Simona Paladino et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Two Decades-Long Journey from Riluzole to Edaravone: Revisiting the Clinical Pharmacokinetics of the Only Two Amyotrophic Lateral Sclerosis Therapeutics

(2018) Ranjeet Prasad Dash et al.   CLINICAL PHARMACOKINETICS

Metals and Parkinson's Disease: Mechanisms and Biochemical Processes

(2018) Geir Bjorklund et al.   CURRENT MEDICINAL CHEMISTRY

Targeted Nrf2 activation therapy with RTA 408 enhances regenerative capacity of diabetic wounds

(2018) Piul S. Rabbani et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

The role of Nrf2 signaling in counteracting neurodegenerative diseases

(2018) Albena T. Dinkova-Kostova et al.   FEBS Journal

Non-covalent Small-Molecule Kelch-like ECH-Associated Protein 1–Nuclear Factor Erythroid 2-Related Factor 2 (Keap1–Nrf2) Inhibitors and Their Potential for Targeting Central Nervous System Diseases

(2018) Jakob S. Pallesen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, phase 1/2 trial

(2018) Zhi-Wei Lai et al.   LANCET

Novel genes associated with amyotrophic lateral sclerosis: diagnostic and clinical implications

(2018) Ruth Chia et al.   LANCET NEUROLOGY

Rapamycin treatment for amyotrophic lateral sclerosis

(2018) Jessica Mandrioli et al.   MEDICINE

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

The discovery of nitro-fatty acids as products of metabolic and inflammatory reactions and mediators of adaptive cell signaling

(2018) Bruce A. Freeman et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Canonical and non-canonical mechanisms of Nrf2 activation

(2018) Carlos Alfredo Silva-Islas et al.   PHARMACOLOGICAL RESEARCH

Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine

(2018) Rafael Radi   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential expression of microRNAs and other small RNAs in muscle tissue of patients with ALS and healthy age-matched controls

(2018) Anja Kovanda et al.   Scientific Reports

Small RNA Sequencing of Sporadic Amyotrophic Lateral Sclerosis Cerebrospinal Fluid Reveals Differentially Expressed miRNAs Related to Neural and Glial Activity

(2018) Rachel Waller et al.   Frontiers in Neuroscience

Trehalose protects against oxidative stress by regulating the Keap1–Nrf2 and autophagy pathways

(2018) Yuhei Mizunoe et al.   Redox Biology

Phosphoinositide 3-Kinase/Akt Signaling and Redox Metabolism in Cancer

(2018) Nikos Koundouros et al.   Frontiers in Oncology

Modulating NRF2 in Disease: Timing Is Everything

(2018) Matthew Dodson et al.   Annual Review of Pharmacology and Toxicology

Electrophilic nitroalkene-tocopherol derivatives: synthesis, physicochemical characterization and evaluation of anti-inflammatory signaling responses

(2018) Jorge Rodriguez-Duarte et al.   Scientific Reports

MicroRNA expression analysis identifies a subset of downregulated miRNAs in ALS motor neuron progenitors

(2018) Mafalda Rizzuti et al.   Scientific Reports

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

(2018) Jeroen Baardman et al.   Cell Reports

Safety, pharmacodynamics, and potential benefit of omaveloxolone in Friedreich ataxia

(2018) David R. Lynch et al.   Annals of Clinical and Translational Neurology

MicroRNAs as Biomarkers in Amyotrophic Lateral Sclerosis

(2018) Claudia Ricci et al.   Cells

The novel Nrf2 inducer TFM-735 ameliorates experimental autoimmune encephalomyelitis in mice

(2017) Chika Higashi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Nrf2, the Master Regulator of Anti-Oxidative Responses

(2017) Sandra Vomund et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex

(2017) Shasha Tao et al.   MOLECULAR AND CELLULAR BIOLOGY

Implications of white matter damage in amyotrophic lateral sclerosis

(2017) Ting Zhou et al.   Molecular Medicine Reports

FDA approves first deuterated drug

(2017) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

ALS Pathogenesis and Therapeutic Approaches: The Role of Mesenchymal Stem Cells and Extracellular Vesicles

(2017) Roberta Bonafede et al.   Frontiers in Cellular Neuroscience

Activating de novo mutations in NFE2L2 encoding NRF2 cause a multisystem disorder

(2017) Peter Huppke et al.   Nature Communications

ALS Clinical Trials Review: 20 Years of Failure. Are We Any Closer to Registering a New Treatment?

(2017) Dmitry Petrov et al.   Frontiers in Aging Neuroscience

Oxidative stress and cellular pathologies in Parkinson’s disease

(2017) Lesly Puspita et al.   Molecular Brain

Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis

(2017) Z Fan et al.   Oncogenesis

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes

(2016) Marta Pajares et al.   Autophagy

Microglia antioxidant systems and redox signalling

(2016) F Vilhardt et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitochondria and Cancer

(2016) Sejal Vyas et al.   CELL

SIRT6, oxidative stress and aging

(2016) Chen-Yu Liao et al.   CELL RESEARCH

Comprehensive Landscape of Nrf2 and p53 Pathway Activation Dynamics by Oxidative Stress and DNA Damage

(2016) Steven Hiemstra et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Adaptive regulation of the brain’s antioxidant defences by neurons and astrocytes

(2016) Paul S. Baxter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative signature of cerebrospinal fluid from mild cognitive impairment and Alzheimer disease patients

(2016) Fabio Di Domenico et al.   FREE RADICAL BIOLOGY AND MEDICINE

Smoking and Cerebral Oxidative Stress and Air Pollution: A Dreadful Equation with Particulate Matter Involved and One More Powerful Reason Not to Smoke Anything!

(2016) Lilian Calderón-Garcidueñas   JOURNAL OF ALZHEIMERS DISEASE

Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery

(2016) Thomas G. Davies et al.   JOURNAL OF MEDICINAL CHEMISTRY

AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550

(2016) Min Sung Joo et al.   MOLECULAR AND CELLULAR BIOLOGY

Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism

(2016) Akira Uruno et al.   MOLECULAR AND CELLULAR BIOLOGY

ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling

(2016) Alice Goode et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Decoding ALS: from genes to mechanism

(2016) J. Paul Taylor et al.   NATURE

Nuclear DNA damage signalling to mitochondria in ageing

(2016) Evandro Fei Fang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Gene discovery in amyotrophic lateral sclerosis: implications for clinical management

(2016) Ammar Al-Chalabi et al.   Nature Reviews Neurology

Is Modulation of Oxidative Stress an Answer? The State of the Art of Redox Therapeutic Actions in Neurodegenerative Diseases

(2016) Valerio Chiurchiù et al.   Oxidative Medicine and Cellular Longevity

The Dual Roles of NRF2 in Cancer

(2016) Silvia Menegon et al.   TRENDS IN MOLECULAR MEDICINE

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

(2016) Eri H. Kobayashi et al.   Nature Communications

SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells

(2016) Cristina Talarico et al.   Oncotarget

Mitochondrial dysfunction and oxidative stress in aging and cancer

(2016) Anna V. Kudryavtseva et al.   Oncotarget

Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers

(2016) Leonard D. Goldstein et al.   Cell Reports

Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation

(2016) Sun Young Chung et al.   Stem Cell Reports

Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention

(2015) Bryan Harder et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Melatonin-sulforaphane hybrid ITH12674 induces neuroprotection in oxidative stress conditions by a ‘drug-prodrug’ mechanism of action

(2015) Javier Egea et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS

(2015) A. Emde et al.   EMBO JOURNAL

MicroRNA-7 activates Nrf2 pathway by targeting Keap1 expression

(2015) Savan Kabaria et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress response and Nrf2 signaling in aging

(2015) Hongqiao Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

(2015) Lauren E. Tebay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structural basis of Keap1 interactions with Nrf2

(2015) Peter Canning et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2—a therapeutic target for the treatment of neurodegenerative diseases

(2015) Delinda A. Johnson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cell-Permeable Peptide Targeting the Nrf2-Keap1 Interaction: A Potential Novel Therapy for Global Cerebral Ischemia

(2015) J. Tu et al.   JOURNAL OF NEUROSCIENCE

RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1

(2015) Nadine Bakkar et al.   MOLECULAR AND CELLULAR BIOLOGY

Oxidative Stress in Neurodegenerative Diseases

(2015) Ewa Niedzielska et al.   MOLECULAR NEUROBIOLOGY

Biogenesis of reactive sulfur species for signaling by hydrogen sulfide oxidation pathways

(2015) Tatiana V Mishanina et al.   Nature Chemical Biology

Increased oxidative stress is related to disease severity in the ALS motor cortex: A PET study

(2015) M. Ikawa et al.   NEUROLOGY

TORC1 Inhibition by Rapamycin Promotes Antioxidant Defences in a Drosophila Model of Friedreich’s Ataxia

(2015) Pablo Calap-Quintana et al.   PLoS One

Mechanisms for redox-regulation of protein kinase C

(2015) Susan F. Steinberg   Frontiers in Pharmacology

Myelination of the Nervous System: Mechanisms and Functions

(2014) Klaus-Armin Nave et al.   Annual Review of Cell and Developmental Biology

Sublime Microglia: Expanding Roles for the Guardians of the CNS

(2014) Michael W. Salter et al.   CELL

Alpha-lipoic acid affects the oxidative stress in various brain structures in mice with methionine and choline deficiency

(2014) Milena Veskovic et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis

(2014) T. Wu et al.   GENES & DEVELOPMENT

Organization of the Human Mitochondrial Hydrogen Sulfide Oxidation Pathway

(2014) Marouane Libiad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipopolysaccharide-Induced Expression of NAD(P)H:Quinone Oxidoreductase 1 and Heme Oxygenase-1 Protects against Excessive Inflammatory Responses in Human Monocytes

(2014) S. A. Rushworth et al.   JOURNAL OF IMMUNOLOGY

Motor Neuron Disease: A Chemical Perspective

(2014) Laura K. Wood et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effect of the human SOD1-G93A gene on the Nrf2/ARE signaling pathway in NSC-34 cells

(2014) FUMIN WANG et al.   Molecular Medicine Reports

Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases

(2014) Claudio Hetz et al.   NATURE REVIEWS NEUROSCIENCE

Motor cortex glutathione deficit in ALS measured in vivo with the J-editing technique

(2014) N. Weiduschat et al.   NEUROSCIENCE LETTERS

Structure of the BTB Domain of Keap1 and Its Interaction with the Triterpenoid Antagonist CDDO

(2014) Anne Cleasby et al.   PLoS One

Induction of Heme Oxygenase I (HMOX1) by HPP-4382: A Novel Modulator of Bach1 Activity

(2014) Otis C. Attucks et al.   PLoS One

Sulforaphane treatment of autism spectrum disorder (ASD)

(2014) K. Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosis

(2014) Eveliina Pollari et al.   Frontiers in Cellular Neuroscience

Nrf2 is associated with the regulation of basal transcription activity of the BRCA1 gene

(2013) Qiaoqiao Wang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Protein aggregation in amyotrophic lateral sclerosis

(2013) Anna M. Blokhuis et al.   ACTA NEUROPATHOLOGICA

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Proteomic Analysis of Ubiquitin Ligase KEAP1 Reveals Associated Proteins That Inhibit NRF2 Ubiquitination

(2013) B. E. Hast et al.   CANCER RESEARCH

RXR  Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2

(2013) H. Wang et al.   CANCER RESEARCH

MicroRNA-93 regulates NRF2 expression and is associated with breast carcinogenesis

(2013) B. Singh et al.   CARCINOGENESIS

SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration

(2013) Amit R. Reddi et al.   CELL

S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis

(2013) Richard J. Mead et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs

(2013) Takumi Satoh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of Nrf2—an update

(2013) Suryakant K. Niture et al.   FREE RADICAL BIOLOGY AND MEDICINE

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

(2013) M. C. Jaramillo et al.   GENES & DEVELOPMENT

Seven in Absentia Homolog 2 (Siah2) Protein Is a Regulator of NF-E2-related Factor 2 (Nrf2)

(2013) Kazunobu Baba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases

(2013) Peter Canning et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival

(2013) Chiara Gorrini et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The modest impact of transcription factor Nrf2 on the course of disease in an ALS animal model

(2013) Yansu Guo et al.   LABORATORY INVESTIGATION

Mitochondrial metabolism of reactive oxygen species

(2013) Paola Venditti et al.   MITOCHONDRION

Notch-Nrf2 Axis: Regulation of Nrf2 Gene Expression and Cytoprotection by Notch Signaling

(2013) N. Wakabayashi et al.   MOLECULAR AND CELLULAR BIOLOGY

Kinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1

(2013) Toshiaki Fukutomi et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulatory Nexus of Synthesis and Degradation Deciphers Cellular Nrf2 Expression Levels

(2013) T. Suzuki et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

Absence of Nrf2 or Its Selective Overexpression in Neurons and Muscle Does Not Affect Survival in ALS-Linked Mutant hSOD1 Mouse Models

(2013) Marcelo R. Vargas et al.   PLoS One

Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex

(2013) L. Baird et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics

(2013) Ryan J. Mailloux et al.   TRENDS IN BIOCHEMICAL SCIENCES

Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response

(2013) Sarah Schmidt Grant et al.   Virulence

The genetics and neuropathology of amyotrophic lateral sclerosis

(2012) Ammar Al-Chalabi et al.   ACTA NEUROPATHOLOGICA

Does Nrf2 Contribute to p53-Mediated Control of Cell Survival and Death?

(2012) Weimin Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondria as a Source of Reactive Oxygen and Nitrogen Species: From Molecular Mechanisms to Human Health

(2012) Tiago R. Figueira et al.   ANTIOXIDANTS & REDOX SIGNALING

The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation

(2012) Holly K. Bryan et al.   BIOCHEMICAL PHARMACOLOGY

The high Nrf2 expression in human acute myeloid leukemia is driven by NF- B and underlies its chemo-resistance

(2012) S. A. Rushworth et al.   BLOOD

Impaired antioxydative Keap1/Nrf2 system and the downstream stress protein responses in the motor neuron of ALS model mice

(2012) Takafumi Mimoto et al.   BRAIN RESEARCH

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

Caveolin-1 Inhibits Expression of Antioxidant Enzymes through Direct Interaction with Nuclear Erythroid 2 p45-related Factor-2 (Nrf2)

(2012) Wen Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Keap1 Is Localized in Neuronal and Glial Cytoplasmic Inclusions in Various Neurodegenerative Diseases

(2012) Kunikazu Tanji et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/ -TrCP Axis

(2012) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

PALB2 Interacts with KEAP1 To Promote NRF2 Nuclear Accumulation and Function

(2012) J. Ma et al.   MOLECULAR AND CELLULAR BIOLOGY

Nrf2–MafG heterodimers contribute globally to antioxidant and metabolic networks

(2012) Yosuke Hirotsu et al.   NUCLEIC ACIDS RESEARCH

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

(2012) S Chowdhry et al.   ONCOGENE

Identification of Novel microRNAs in Post-Transcriptional Control of Nrf2 Expression and Redox Homeostasis in Neuronal, SH-SY5Y Cells

(2012) Madhusudhanan Narasimhan et al.   PLoS One

A novel strategy to activate cytoprotective genes in the injured brain

(2011) Jing Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

MG132 enhances neurite outgrowth in neurons overexpressing mutant TAR DNA-binding protein-43 via increase of HO-1

(2011) Weisong Duan et al.   BRAIN RESEARCH

MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism

(2011) Muhua Yang et al.   BREAST CANCER RESEARCH AND TREATMENT

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

Dipeptidyl peptidase III: a multifaceted oligopeptide N-end cutter

(2011) Subhash C. Prajapati et al.   FEBS Journal

Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis

(2011) Arie Neymotin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2 degron-fused reporter system: a new tool for specific evaluation of Nrf2 inducers

(2011) Yosuke Hirotsu et al.   GENES TO CELLS

Acetylation-Deacetylation of the Transcription Factor Nrf2 (Nuclear Factor Erythroid 2-related Factor 2) Regulates Its Transcriptional Activity and Nucleocytoplasmic Localization

(2011) Yumiko Kawai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-200a Regulates Nrf2 Activation by TargetingKeap1mRNA in Breast Cancer Cells

(2011) Gabriel Eades et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Electrophilic Nitro-fatty Acids Activate NRF2 by a KEAP1 Cysteine 151-independent Mechanism

(2011) Emilia Kansanen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New Synthetic Triterpenoids: Potent Agents for Prevention and Treatment of Tissue Injury Caused by Inflammatory and Oxidative Stress

(2011) Michael B. Sporn et al.   JOURNAL OF NATURAL PRODUCTS

Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1

(2011) Na Li et al.   MECHANISMS OF AGEING AND DEVELOPMENT

KPNA6 (Importin  7)-Mediated Nuclear Import of Keap1 Represses the Nrf2-Dependent Antioxidant Response

(2011) Z. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner

(2011) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

Detoxification: A Novel Function of BRCA1 in Tumor Suppression?

(2011) Hyo Jin Kang et al.   TOXICOLOGICAL SCIENCES

microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease

(2010) C. Sangokoya et al.   BLOOD

Small molecule modulators of antioxidant response pathway

(2010) Wooyoung Hur et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Beta cell function during rapamycin monotherapy in long-term type 1 diabetes

(2010) L. Piemonti et al.   DIABETOLOGIA

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

CR6-interacting Factor 1 (CRIF1) Regulates NF-E2-related Factor 2 (NRF2) Protein Stability by Proteasome-mediated Degradation

(2010) Hyo Jin Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway

(2010) Ian M. Copple et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

(2010) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Time course of oxidant markers and antioxidant defenses in subgroups of amyotrophic lateral sclerosis patients

(2010) Emanuela Cova et al.   NEUROCHEMISTRY INTERNATIONAL

Mutant TAR DNA-binding protein-43 induces oxidative injury in motor neuron-like cell

(2010) W. Duan et al.   NEUROSCIENCE

NRF2, cancer and calorie restriction

(2010) A Martín-Montalvo et al.   ONCOGENE

Nrf2 Expression Is Regulated by Epigenetic Mechanisms in Prostate Cancer of TRAMP Mice

(2010) Siwang Yu et al.   PLoS One

Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

(2010) M. McMahon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains

(2010) T. Ogura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response

(2009) Z. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

(2009) Weimin Chen et al.   MOLECULAR CELL

Many roads to maturity: microRNA biogenesis pathways and their regulation

(2009) Julia Winter et al.   NATURE CELL BIOLOGY

Impaired Nuclear Nrf2 Translocation Undermines the Oxidative Stress Response in Friedreich Ataxia

(2009) Vincent Paupe et al.   PLoS One

Phosphorylation of Nrf2 at Multiple Sites by MAP Kinases Has a Limited Contribution in Modulating the Nrf2-Dependent Antioxidant Response

(2009) Zheng Sun et al.   PLoS One

Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

(2009) C. Vance et al.   SCIENCE

Structural analysis of the complex of Keap1 with a prothymosin α peptide

(2008) Balasundaram Padmanabhan et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Glycogen synthase kinase 3β (GSK3β) in tumorigenesis and cancer chemotherapy

(2008) Jia Luo   CANCER LETTERS

Possible Role of Oxidative Stress in the Pathogenesis of Hypertension

(2008) A. Ceriello   DIABETES CARE

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

(2008) Shih-Ching Lo et al.   EXPERIMENTAL CELL RESEARCH

Proteomic and oxidative stress analysis in human brain samples of Huntington disease

(2008) M Alba Sorolla et al.   FREE RADICAL BIOLOGY AND MEDICINE

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells

(2008) Patrick L. Apopa et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Multiple Nuclear Localization Signals Function in the Nuclear Import of the Transcription Factor Nrf2

(2008) Melanie Theodore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear Erythroid 2-Related Factor 2-Antioxidative Response Element Signaling Pathway in Motor Cortex and Spinal Cord in Amyotrophic Lateral Sclerosis

(2008) Alexander Sarlette et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis

(2008) M. R. Vargas et al.   JOURNAL OF NEUROSCIENCE

Oxidant–antioxidant imbalance in the erythrocytes of sporadic amyotrophic lateral sclerosis patients correlates with the progression of disease

(2008) G. Nagesh Babu et al.   NEUROCHEMISTRY INTERNATIONAL

Genetic disruption of the Nrf2 compromises cell-cycle progression by impairing GSH-induced redox signaling

(2008) N M Reddy et al.   ONCOGENE

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2008) J. Sreedharan et al.   SCIENCE

AMPK: a metabolic gauge regulating whole-body energy homeostasis

(2008) Ricardo Lage et al.   TRENDS IN MOLECULAR MEDICINE