Cellular Senescence in Brain Aging

Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice

(2021) Mikolaj Ogrodnik et al.   AGING CELL

FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice

(2020) Chi Zhang et al.   Aging-US

Dystrophic microglia in late‐onset Alzheimer's disease

(2020) Wolfgang J. Streit et al.   GLIA

Astrocyte senescence promotes glutamate toxicity in cortical neurons

(2020) Chandani Limbad et al.   PLoS One

Astrocyte Support for Oligodendrocyte Differentiation can be Conveyed via Extracellular Vesicles but Diminishes with Age

(2020) Cory M. Willis et al.   Scientific Reports

Lysosome biology in autophagy

(2020) Willa Wen-You Yim et al.   Cell Discovery

Estradiol-induced senescence of hypothalamic astrocytes contributes to aging-related reproductive function declines in female mice

(2020) Xiaoman Dai et al.   Aging-US

Senescence in Post-Mitotic Cells: A Driver of Aging?

(2020) Thomas von Zglinicki et al.   ANTIOXIDANTS & REDOX SIGNALING

When function follows form: Nuclear compartment structure and the epigenetic landscape of the aging neuron

(2020) Johannes C.M. Schlachetzki et al.   EXPERIMENTAL GERONTOLOGY

Phorbol myristate acetate induces cellular senescence in rat microglia in�vitro

(2020) Dan Cao et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Long-lived post-mitotic cell aging: is a telomere clock at play?

(2020) Maria Sol Jacome-Burbano et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons

(2020) A. Negrete-Hurtado et al.   Nature Communications

Senolytic drugs: from discovery to translation

(2020) J. L. Kirkland et al.   JOURNAL OF INTERNAL MEDICINE

Epigenetic Clock: DNA Methylation in Aging

(2020) Shuang Jiang et al.   Stem Cells International

Effects of Physical Exercise on Autophagy and Apoptosis in Aged Brain: Human and Animal Studies

(2020) Diana Zukas Andreotti et al.   Frontiers in Nutrition

Anti‐inflammatory treatment rescues memory deficits during aging in nfkb1 −/− mice

(2020) Edward Fielder et al.   AGING CELL

ATM-deficient neural precursors develop senescence phenotype with disturbances in autophagy

(2020) Piotr Sunderland et al.   MECHANISMS OF AGEING AND DEVELOPMENT

SIRT1 is downregulated by autophagy in senescence and ageing

(2020) Caiyue Xu et al.   NATURE CELL BIOLOGY

Glia: victims or villains of the aging brain?

(2020) Isabel H. Salas et al.   NEUROBIOLOGY OF DISEASE

Depletion of senescent-like neuronal cells alleviates cisplatin-induced peripheral neuropathy in mice

(2020) Scarlett Acklin et al.   Scientific Reports

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

(2019) Mikolaj Ogrodnik et al.   Cell Metabolism

Autophagy Is Required for Memory Formation and Reverses Age-Related Memory Decline

(2019) Mélissa Glatigny et al.   CURRENT BIOLOGY

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

(2019) Jamie N. Justice et al.   EBioMedicine

Senolytics and senostatics as adjuvant tumour therapy

(2019) Susan Short et al.   EBioMedicine

Influence of Normal Aging on Brain Autophagy: A Complex Scenario

(2019) David A. Loeffler   Frontiers in Aging Neuroscience

Astrocyte senescence: Evidence and significance

(2019) Justin Cohen et al.   AGING CELL

Epigenetic mechanisms related to cognitive decline during aging

(2019) María F. Harman et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

(2019) Peisu Zhang et al.   NATURE NEUROSCIENCE

Old age increases microglial senescence, exacerbates secondary neuroinflammation, and worsens neurological outcomes after acute traumatic brain injury in mice

(2019) Rodney M. Ritzel et al.   NEUROBIOLOGY OF AGING

Platelet‐derived extracellular vesicles convey mitochondrial DAMPs in platelet concentrates and their levels are associated with adverse reactions

(2019) Genevieve Marcoux et al.   TRANSFUSION

Activated cholangiocytes release macrophage-polarizing extracellular vesicles bearing the DAMP S100A11

(2019) Tomohiro Katsumi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Molecular Signatures of the Aging Brain: Finding the Links Between Genes and Phenotypes

(2019) Giuseppe Lupo et al.   Neurotherapeutics

Slowing Down Ageing: The Role of Nutrients and Microbiota in Modulation of the Epigenome

(2019) Agnieszka Gadecka et al.   Nutrients

Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons

(2019) Andrea KH Stavoe et al.   eLife

Cortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy

(2019) Daniel Moreno-Blas et al.   Aging-US

Single-cell transcriptomic profiling of the aging mouse brain

(2019) Methodios Ximerakis et al.   NATURE NEUROSCIENCE

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

(2019) LaTonya J. Hickson et al.   EBioMedicine

Targeting normal and cancer senescent cells as a strategy of senotherapy

(2019) Ewa Sikora et al.   AGEING RESEARCH REVIEWS

Proteostasis failure and cellular senescence in long‐term cultured postmitotic rat neurons

(2019) Shoma Ishikawa et al.   AGING CELL

Etoposide Induces Mitochondrial Dysfunction and Cellular Senescence in Primary Cultured Rat Astrocytes

(2019) Minji Bang et al.   Biomolecules & Therapeutics

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Amitosenescence and Pseudomitosenescence: Putative New Players in the Aging Process

(2019) Diane Wengerodt et al.   Cells

Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses

(2019) Marta Maglione et al.   Scientific Reports

Stress and aging act through common mechanisms to elicit neuroinflammatory priming

(2018) Laura K. Fonken et al.   BRAIN BEHAVIOR AND IMMUNITY

Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States

(2018) Mark P. Mattson et al.   Cell Metabolism

Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives

(2018) Darren J. Baker et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms and functions of cellular senescence

(2018) Nicolás Herranz et al.   JOURNAL OF CLINICAL INVESTIGATION

Is DNA damage indispensable for stress-induced senescence?

(2018) Anna Bielak-Zmijewska et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Mitochondria at the neuronal presynapse in health and disease

(2018) Michael J. Devine et al.   NATURE REVIEWS NEUROSCIENCE

Aging in the Brain: New Roles of Epigenetics in Cognitive Decline

(2018) Jolie D. Barter et al.   NEUROSCIENTIST

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging

(2018) Dena S. Leeman et al.   SCIENCE

Endoplasmic reticulum stress stimulates the release of extracellular vesicles carrying danger-associated molecular pattern (DAMP) molecules

(2018) Gavin P. Collett et al.   Oncotarget

Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease

(2018) Shankar J. Chinta et al.   Cell Reports

An Overview of the Role of Lipofuscin in Age-Related Neurodegeneration

(2018) Alexandra Moreno-García et al.   Frontiers in Neuroscience

Brain Mitochondria, Aging, and Parkinson’s Disease

(2018) Mario Rango et al.   Genes

Tau protein aggregation is associated with cellular senescence in the brain

(2018) Nicolas Musi et al.   AGING CELL

Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes

(2018) Minji Bang et al.   Biomolecules & Therapeutics

Ageing, Cellular Senescence and Neurodegenerative Disease

(2018) Marios Kritsilis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Fisetin is a senotherapeutic that extends health and lifespan

(2018) Matthew J. Yousefzadeh et al.   EBioMedicine

The senescent cell epigenome

(2018) Na Yang et al.   Aging-US

The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial

(2018) Miranka Wirth et al.   CORTEX

p53-Sensitive Epileptic Behavior and Inflammation in Ft1 Hypomorphic Mice

(2018) Romina Burla et al.   Frontiers in Genetics

Monitoring and Measuring Autophagy

(2017) Saori R. Yoshii et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Senescent cells: an emerging target for diseases of ageing

(2017) Bennett G. Childs et al.   NATURE REVIEWS DRUG DISCOVERY

Inflammaging and ‘Garb-aging’

(2017) Claudio Franceschi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies

(2017) Miranda E. Orr et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Identification of HSP90 inhibitors as a novel class of senolytics

(2017) Heike Fuhrmann-Stroissnigg et al.   Nature Communications

Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging

(2017) Lilach Soreq et al.   Cell Reports

Age-Dependent Protein Aggregation Initiates Amyloid-β Aggregation

(2017) Nicole Groh et al.   Frontiers in Aging Neuroscience

Aging Microglia—Phenotypes, Functions and Implications for Age-Related Neurodegenerative Diseases

(2017) Björn Spittau   Frontiers in Aging Neuroscience

Impact of lysosome status on extracellular vesicle content and release

(2016) Erez Eitan et al.   AGEING RESEARCH REVIEWS

Lysosomal cathepsins and their regulation in aging and neurodegeneration

(2016) Veronika Stoka et al.   AGEING RESEARCH REVIEWS

Lysosomal cell death mechanisms in aging

(2016) Raquel Gómez-Sintes et al.   AGEING RESEARCH REVIEWS

Spermidine boosts autophagy to protect from synapse aging

(2016) Anuradha Bhukel et al.   Autophagy

Is senescence-associated β-galactosidase a marker of neuronal senescence?

(2016) Malgorzata Piechota et al.   Oncotarget

Epigenetics and aging

(2016) S. Pal et al.   Science Advances

Telomerase Dysregulation in the Hippocampus of a Rat Model of Depression: Normalization by Lithium

(2015) Y. B. Wei et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Aging-Related Hyperexcitability in CA3 Pyramidal Neurons Is Mediated by Enhanced A-Type K+ Channel Function and Expression

(2015) D. Simkin et al.   JOURNAL OF NEUROSCIENCE

Long-term Neuroglial Cocultures as a Brain Aging Model: Hallmarks of Senescence, MicroRNA Expression Profiles, and Comparison With In Vivo Models

(2015) Elisabetta Bigagli et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease

(2015) Hong Lian et al.   NEURON

Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease

(2015) Diana M. Norden et al.   NEUROPHARMACOLOGY

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

Neurocognitive Aging and the Hippocampus across Species

(2015) Stephanie L. Leal et al.   TRENDS IN NEUROSCIENCES

Impact of age-related neuroglial cell responses on hippocampal deterioration

(2015) Joseph O. Ojo et al.   Frontiers in Aging Neuroscience

Communication breakdown: The impact of ageing on synapse structure

(2014) Ronald S. Petralia et al.   AGEING RESEARCH REVIEWS

Are there roles for brain cell senescence in aging and neurodegenerative disorders?

(2014) Florence C. C. Tan et al.   BIOGERONTOLOGY

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Ammonia-induced senescence in cultured rat astrocytes and in human cerebral cortex in hepatic encephalopathy

(2014) Boris Görg et al.   GLIA

REST and stress resistance in ageing and Alzheimer’s disease

(2014) Tao Lu et al.   NATURE

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

The behavioral, pathological and therapeutic features of the senescence-accelerated mouse prone 8 strain as an Alzheimer's disease animal model

(2013) Xiao-rui Cheng et al.   AGEING RESEARCH REVIEWS

Inhibition of mTOR Signaling by Quercetin in Cancer Treatment and Prevention

(2013) Ansgar Bruning   Anti-Cancer Agents in Medicinal Chemistry

Autophagy and senescence

(2013) David A. Gewirtz   Autophagy

A comparison of replicative senescence and doxorubicin-induced premature senescence of vascular smooth muscle cells isolated from human aorta

(2013) Anna Bielak-Zmijewska et al.   BIOGERONTOLOGY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Normal Cognitive Aging

(2013) Caroline N. Harada et al.   CLINICS IN GERIATRIC MEDICINE

p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes

(2013) Albert R. Davalos et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial dysfunction in long-term neuronal cultures mimics changes with aging

(2013) Weiguo Dong et al.   MEDICAL SCIENCE MONITOR

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenation

(2013) Wai T. Wong   Frontiers in Cellular Neuroscience

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

(2012) Diana Jurk et al.   AGING CELL

Fisetin: A Dietary Antioxidant for Health Promotion

(2012) Naghma Khan et al.   ANTIOXIDANTS & REDOX SIGNALING

Rejuvenation of senescent cells—The road to postponing human aging and age-related disease?

(2012) Ewa Sikora   EXPERIMENTAL GERONTOLOGY

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Dendritic spine changes associated with normal aging

(2012) D.L. Dickstein et al.   NEUROSCIENCE

Astrocyte Senescence as a Component of Alzheimer’s Disease

(2012) Rekha Bhat et al.   PLoS One

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

Inhibition of Src Family Kinases and Receptor Tyrosine Kinases by Dasatinib: Possible Combinations in Solid Tumors

(2011) J. C. Montero et al.   CLINICAL CANCER RESEARCH

Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype

(2011) Antero Salminen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The role of ubiquitin–proteasome system in ageing

(2011) Peter Löw   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Evidence for Reduced Experience-Dependent Dendritic Spine Plasticity in the Aging Prefrontal Cortex

(2011) E. B. Bloss et al.   JOURNAL OF NEUROSCIENCE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype

(2011) Julie E. Simpson et al.   NEUROBIOLOGY OF AGING

Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

(2011) M. Narita et al.   SCIENCE

Age-related alterations in the dynamic behavior of microglia

(2010) Mausam R. Damani et al.   AGING CELL

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Senescence-associated beta-galactosidase activity expression in aging hippocampal neurons

(2010) Yi-Qun Geng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Senescent cells as a source of inflammatory factors for tumor progression

(2010) Albert R. Davalos et al.   CANCER AND METASTASIS REVIEWS

The Promise of Slow Down Ageing May Come from Curcumin

(2010) E. Sikora et al.   CURRENT PHARMACEUTICAL DESIGN

Stress-induced senescence in human and rodent astrocytes

(2010) Alessandro Bitto et al.   EXPERIMENTAL CELL RESEARCH

Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases

(2010) Moonhee Lee et al.   FASEB JOURNAL

TGFβ signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke

(2010) Kristian P Doyle et al.   Journal of Neuroinflammation

Cortical DNA methylation maintains remote memory

(2010) Courtney A Miller et al.   NATURE NEUROSCIENCE

Age-related synapse loss in hippocampal CA3 is not reversed by caloric restriction

(2010) M.M. Adams et al.   NEUROSCIENCE

Astrocytes in Alzheimer’s disease

(2010) Alexei Verkhratsky et al.   Neurotherapeutics

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

(2010) M. M. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cultured cerebellar granule neurons as an in vitro aging model: Topoisomerase IIβ as an additional biomarker in DNA repair and aging

(2010) M. Uday Bhanu et al.   TOXICOLOGY IN VITRO

Age-related neuroinflammatory changes negatively impact on neuronal function

(2010) Marina A. Lynch   Frontiers in Aging Neuroscience

Autophagy mediates the mitotic senescence transition

(2009) A. R.J. Young et al.   GENES & DEVELOPMENT

Update on Slow Aging and Negligible Senescence – A Mini-Review

(2009) Caleb E. Finch   GERONTOLOGY

Tangle-Bearing Neurons Survive Despite Disruption of Membrane Integrity in a Mouse Model of Tauopathy

(2009) Alix de Calignon et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Genetic variation in the interleukin-1 -converting enzyme associates with cognitive function. The PROSPER study

(2008) S. Trompet et al.   BRAIN

Monocyte Chemoattractant Protein-1 Plays a Dominant Role in the Chronic Inflammation Observed in Alzheimer's Disease

(2008) Anna Sokolova et al.   BRAIN PATHOLOGY

Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system

(2008) Ryan N. Dilger et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Blood–brain barrier: Ageing and microvascular disease – systematic review and meta-analysis

(2007) Andrew J. Farrall et al.   NEUROBIOLOGY OF AGING