NADPH oxidases: an overview from structure to innate immunity-associated pathologies

NADPH oxidase 4 represents a potential target for the treatment of osteoporosis

(2014) Paula Hoff et al.   Cellular & Molecular Immunology

Oxidative Stress Mediated Mitochondrial and Vascular Lesions as Markers in the Pathogenesis of Alzheimer Disease

(2014) G. Aliev et al.   CURRENT MEDICINAL CHEMISTRY

Time to Smoke First Morning Cigarette and Lung Cancer in a Case–Control Study

(2014) Fangyi Gu et al.   JNCI-Journal of the National Cancer Institute

Roles of DUOX-Mediated Hydrogen Peroxide in Metabolism, Host Defense, and Signaling

(2013) Xavier De Deken et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of PKC-ζ in NADPH oxidase–PKCα–Giα axis dependent inhibition of β-adrenergic response by U46619 in pulmonary artery smooth muscle cells

(2013) Sajal Chakraborti et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Glutathione metabolism and Parkinson's disease

(2013) Michelle Smeyne et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tyrosine Sulfation of Chemokine Receptor CCR2 Enhances Interactions with Both Monomeric and Dimeric Forms of the Chemokine Monocyte Chemoattractant Protein-1 (MCP-1)

(2013) Joshua H. Y. Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FcγR-driven Release of IL-6 by Macrophages Requires NOX2-dependent Production of Reactive Oxygen Species

(2013) Anthony M. Franchini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinase A-dependent Phosphorylation of Rap1 Regulates Its Membrane Localization and Cell Migration

(2013) Maho Takahashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Red ginseng extract inhibits the expression of MCP-1 and iNOS in Helicobacter pylori-infected gastric epithelial cells by suppressing the activation of NADPH oxidase and Jak2/Stat3

(2013) Soon Ok Cho et al.   JOURNAL OF ETHNOPHARMACOLOGY

Xanthine Oxido-Reductase, Free Radicals and Cardiovascular Disease. A Critical Review

(2013) A. M. Robert et al.   PATHOLOGY & ONCOLOGY RESEARCH

Toll-like receptor signaling and regulation of intestinal immunity

(2013) Karishma Kamdar et al.   Virulence

NADPH Oxidase-Mediated Triggering of Inflammasome Activation in Mouse Podocytes and Glomeruli During Hyperhomocysteinemia

(2012) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

Increased Expression of NAD(P)H Oxidase Subunit p67phox in the Renal Medulla Contributes to Excess Oxidative Stress and Salt-Sensitive Hypertension

(2012) Di Feng et al.   Cell Metabolism

Strategies for identifying synthetic peptides to act as inhibitors of NADPH oxidases, or “All that you did and did not want to know about Nox inhibitory peptides”

(2012) Iris Dahan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Vascular Nox4

(2012) Rhian M. Touyz et al.   CIRCULATION RESEARCH

NOD2 Signaling Contributes to Host Defense in the Lungs against Escherichia coli Infection

(2012) Balamayooran Theivanthiran et al.   INFECTION AND IMMUNITY

Ethanol Induces Oxidative Stress in Alveolar Macrophages via Upregulation of NADPH Oxidases

(2012) S. M. Yeligar et al.   JOURNAL OF IMMUNOLOGY

Intrapulmonary G-CSF Rescues Neutrophil Recruitment to the Lung and Neutrophil Release to Blood in Gram-Negative Bacterial Infection in MCP-1-/- Mice

(2012) G. Balamayooran et al.   JOURNAL OF IMMUNOLOGY

Intrapulmonary Administration of Leukotriene B4 Augments Neutrophil Accumulation and Responses in the Lung to Klebsiella Infection in CXCL1 Knockout Mice

(2012) S. Batra et al.   JOURNAL OF IMMUNOLOGY

Congenital hypothyroidism caused by a novel mutation of the dual oxidase 2 (DUOX2) gene

(2012) Atsuko Yoshizawa-Ogasawara et al.   JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

Molecular analysis of the binding mode of Toll/interleukin-1 receptor (TIR) domain proteins during TLR2 signaling

(2012) Masatoshi Nada et al.   MOLECULAR IMMUNOLOGY

NADPH oxidases: novel therapeutic targets for neurodegenerative diseases

(2012) Hui-Ming Gao et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Dual Oxidase 2 is Essential for the Toll-Like Receptor 5-Mediated Inflammatory Response in Airway Mucosa

(2011) Jung-Hee Joo et al.   ANTIOXIDANTS & REDOX SIGNALING

SUMO1 Negatively Regulates Reactive Oxygen Species Production From NADPH Oxidases

(2011) Deepesh Pandey et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: Regulation of proinflammatory cytokines and hepatic steatosis in mice

(2011) Pranoti Mandrekar et al.   HEPATOLOGY

Up-regulation and Sustained Activation of Stat1 Are Essential for Interferon-γ (IFN-γ)-induced Dual Oxidase 2 (Duox2) and Dual Oxidase A2 (DuoxA2) Expression in Human Pancreatic Cancer Cell Lines

(2011) Yongzhong Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

(2011) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Oleic acid induces smooth muscle foam cell formation and enhances atherosclerotic lesion development via CD36

(2011) Shuangtao Ma et al.   Lipids in Health and Disease

NOX Isoforms and Reactive Oxygen Species in Vascular Health

(2011) R. M. Touyz et al.   MOLECULAR INTERVENTIONS

Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

(2011) Grant R. Drummond et al.   NATURE REVIEWS DRUG DISCOVERY

Cigarette smoke-induced kinin B1 receptor promotes NADPH oxidase activity in cultured human alveolar epithelial cells

(2011) Sébastien Talbot et al.   PEPTIDES

The effects of cigarette smoke on airway inflammation in asthma and COPD: Therapeutic implications

(2011) Asad Tamimi et al.   RESPIRATORY MEDICINE

Suppressing production of reactive oxygen species (ROS) for influenza A virus therapy

(2011) Ross Vlahos et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Involvement of RAGE, NADPH Oxidase, and Ras/Raf-1 Pathway in Glycated LDL-Induced Expression of Heat Shock Factor-1 and Plasminogen Activator Inhibitor-1 in Vascular Endothelial Cells

(2010) Ganesh V. Sangle et al.   ENDOCRINOLOGY

Protection of podocytes from hyperhomocysteinemia-induced injury by deletion of the gp91phox gene

(2010) Chun Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hepatocyte NAD(P)H oxidases as an endogenous source of reactive oxygen species during hepatitis C virus infection

(2010) Nabora Soledad Reyes de Mochel et al.   HEPATOLOGY

Oxidative Stress and Endothelial Dysfunction in Aortas of Aged Spontaneously Hypertensive Rats by NOX1/2 Is Reversed by NADPH Oxidase Inhibition

(2010) Sven Wind et al.   HYPERTENSION

TLR5 Signaling Stimulates the Innate Production of IL-17 and IL-22 by CD3negCD127+ Immune Cells in Spleen and Mucosa

(2010) L. Van Maele et al.   JOURNAL OF IMMUNOLOGY

First in Class, Potent, and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis

(2010) Benoı̂t Laleu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small-Molecule NOX Inhibitors: ROS-Generating NADPH Oxidases as Therapeutic Targets

(2009) Vincent Jaquet et al.   ANTIOXIDANTS & REDOX SIGNALING

Irreversibly glycated LDL induce oxidative and inflammatory state in human endothelial cells; added effect of high glucose

(2009) Laura Toma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of human vascular NADPH oxidase by apocynin derived oligophenols

(2009) Mauricio Mora-Pale et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Poldip2, a Novel Regulator of Nox4 and Cytoskeletal Integrity in Vascular Smooth Muscle Cells

(2009) Alicia N. Lyle et al.   CIRCULATION RESEARCH

Induction of COX-2/PGE2/IL-6 is crucial for cigarette smoke extract-induced airway inflammation: Role of TLR4-dependent NADPH oxidase activation

(2009) Chih-Chung Lin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pressure-Induced Vascular Oxidative Stress Is Mediated Through Activation of Integrin-Linked Kinase 1/βPIX/Rac-1 Pathway

(2009) Carmine Vecchione et al.   HYPERTENSION

Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors

(2009) Masayuki Fukata et al.   INFLAMMATORY BOWEL DISEASES

Molecular Mechanisms of Felodipine Suppressing Atherosclerosis in High-Cholesterol-Diet Apolipoprotein E-Knockout Mice

(2009) Rui Yao et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses

(2009) S. Lipinski et al.   JOURNAL OF CELL SCIENCE

NOD1 and NOD2 Mediate Sensing of Periodontal Pathogens

(2009) T. Okugawa et al.   JOURNAL OF DENTAL RESEARCH

Hepatitis C Virus (HCV) Proteins Induce NADPH Oxidase 4 Expression in a Transforming Growth Factor  -Dependent Manner: a New Contributor to HCV-Induced Oxidative Stress

(2009) H. E. Boudreau et al.   JOURNAL OF VIROLOGY

Antimicrobial mechanisms of phagocytes and bacterial evasion strategies

(2009) Ronald S. Flannagan et al.   NATURE REVIEWS MICROBIOLOGY

NADPH oxidases in the vasculature: Molecular features, roles in disease and pharmacological inhibition

(2008) Stavros Selemidis et al.   PHARMACOLOGY & THERAPEUTICS

Silica binding and toxicity in alveolar macrophages

(2007) Raymond F. Hamilton et al.   FREE RADICAL BIOLOGY AND MEDICINE

Apocynin, NADPH Oxidase, and Vascular Cells

(2007) Rhian M. Touyz   HYPERTENSION

The discovery of nitric oxide and its role in vascular biology

(2006) S Moncada et al.   BRITISH JOURNAL OF PHARMACOLOGY