Nrf2 and Nrf1 signaling and ER stress crosstalk: implication for proteasomal degradation and autophagy

Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome

(2014) Wen-Xing Ding et al.   Autophagy

Autophagy activation by NFκB is essential for cell survival after heat shock

(2014) Mathieu Nivon et al.   Autophagy

Differential Involvement of I B Kinases   and   in Cytokine- and Insulin-Induced Mammalian Target of Rapamycin Activation Determined by Akt

(2014) H. C. Dan et al.   JOURNAL OF IMMUNOLOGY

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Reduction of Hippocampal Apoptosis by Intracerebroventricular Administration of Extracellular Signal-Regulated Protein Kinase and/or p38 Inhibitors in Amyloid Beta Rat Model of Alzheimer's Disease: Involvement of Nuclear-Related Factor-2 and Nuclear Facto

(2013) Ghorbangol Ashabi et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Molecular Mechanism Aspect of ER Stress in Alzheimer's Disease: Current Approaches and Future Strategies

(2013) Niloufar Ansari et al.   CURRENT DRUG TARGETS

Molecules and their functions in autophagy

(2012) Jong-Ok Pyo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Crosstalk between Nrf2 and the proteasome: Therapeutic potential of Nrf2 inducers in vascular disease and aging

(2012) Sarah J. Chapple et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Nrf2-dependent Induction of Proteasome and Pa28αβ Regulator Are Required for Adaptation to Oxidative Stress

(2012) Andrew M. Pickering et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Phosphorylation of JNK Suppresses Aβ-Induced ER Stress and Upregulates Prosurvival Mitochondrial Proteins in Rat Hippocampus

(2012) Parvin Yenki et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Reduced Calreticulin Levels Link Endoplasmic Reticulum Stress and Fas-Triggered Cell Death in Motoneurons Vulnerable to ALS

(2012) N. Bernard-Marissal et al.   JOURNAL OF NEUROSCIENCE

Increase of autophagy and attenuation of apoptosis by Salvigenin promote survival of SH-SY5Y cells following treatment with H2O2

(2012) Ghazaleh Rafatian et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Involvement of the Nrf2-proteasome pathway in the endoplasmic reticulum stress response in pancreatic β-cells

(2012) Sanghwan Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

H2O2 preconditioning modulates phase II enzymes through p38 MAPK and PI3K/Akt activation

(2011) Cristina Angeloni et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Genipin up-regulates heme oxygenase-1 via PI3-kinase-JNK1/2-Nrf2 signaling pathway to enhance the anti-inflammatory capacity in RAW264.7 macrophages

(2011) Woo-Kwang Jeon et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Autophagy inhibition engages Nrf2-p62 Ub-associated signaling

(2011) Brigit E. Riley et al.   Autophagy

Alginate oligosaccharide protects against endoplasmic reticulum- and mitochondrial-mediated apoptotic cell death and oxidative stress

(2011) Solaleh Khoramian Tusi et al.   BIOMATERIALS

Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis

(2011) Arie Neymotin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular cross-talk between the NRF2/KEAP1 signaling pathway, autophagy, and apoptosis

(2011) Tomasz M. Stępkowski et al.   FREE RADICAL BIOLOGY AND MEDICINE

IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux

(2011) Huikyong Lee et al.   HUMAN MOLECULAR GENETICS

p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway

(2011) Angeles Duran et al.   MOLECULAR CELL

Age-Related Retinopathy in NRF2-Deficient Mice

(2011) Zhenyang Zhao et al.   PLoS One

The Nrf1 CNC-bZIP Protein Is Regulated by the Proteasome and Activated by Hypoxia

(2011) Nikolai L. Chepelev et al.   PLoS One

When NRF2 Talks, Who's Listening?

(2010) Nobunao Wakabayashi et al.   ANTIOXIDANTS & REDOX SIGNALING

IL-1β induces ER stress in a JNK dependent manner that determines cell death in human pancreatic epithelial MIA PaCa-2 cells

(2010) Gaurav Verma et al.   APOPTOSIS

Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy

(2010) Weiliang Fan et al.   Autophagy

Identification of topological determinants in the N-terminal domain of transcription factor Nrf1 that control its orientation in the endoplasmic reticulum membrane

(2010) Yiguo Zhang et al.   BIOCHEMICAL JOURNAL

Amyloid β-induced FOXRED2 mediates neuronal cell death via inhibition of proteasome activity

(2010) SangMi Shim et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hsp90 Interaction with INrf2(Keap1) Mediates Stress-induced Nrf2 Activation

(2010) Suryakant K. Niture et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Antioxidant Transcription Factor Nrf2 Negatively Regulates Autophagy and Growth Arrest Induced by the Anticancer Redox Agent Mitoquinone

(2010) V. Ashutosh Rao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection

(2010) Brigit E. Riley et al.   JOURNAL OF CELL BIOLOGY

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

(2010) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcription Factor Nrf1 Mediates the Proteasome Recovery Pathway after Proteasome Inhibition in Mammalian Cells

(2010) Senthil K. Radhakrishnan et al.   MOLECULAR CELL

Proteasomal Degradation Is Transcriptionally Controlled by TCF11 via an ERAD-Dependent Feedback Loop

(2010) Janos Steffen et al.   MOLECULAR CELL

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

IKK-dependent, NF-κB-independent control of autophagic gene expression

(2010) W C Comb et al.   ONCOGENE

Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease

(2010) G. P. Sykiotis et al.   Science Signaling

Integration of Clearance Mechanisms: The Proteasome and Autophagy

(2010) E. Wong et al.   Cold Spring Harbor Perspectives in Biology

The IKK complex contributes to the induction of autophagy

(2009) Alfredo Criollo et al.   EMBO JOURNAL

The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease

(2009) Antonio Cuadrado et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

(2009) C. Hetz et al.   GENES & DEVELOPMENT

p65/RelA Modulates BECN1 Transcription and Autophagy

(2009) T. Copetti et al.   MOLECULAR AND CELLULAR BIOLOGY

Neuroprotective Effects of the Triterpenoid, CDDO Methyl Amide, a Potent Inducer of Nrf2-Mediated Transcription

(2009) Lichuan Yang et al.   PLoS One

ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells

(2009) Q. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Nrf1 in antioxidant response element-mediated gene expression and beyond

(2009) Madhurima Biswas et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The IKK Complex, a Central Regulator of NF- B Activation

(2009) A. Israel   Cold Spring Harbor Perspectives in Biology

The Nrf1 CNC/bZIP protein is a nuclear envelope-bound transcription factor that is activated by t-butyl hydroquinone but not by endoplasmic reticulum stressors

(2008) Yiguo Zhang et al.   BIOCHEMICAL JOURNAL

The Signaling Adaptor p62 Is an Important NF-κB Mediator in Tumorigenesis

(2008) Angeles Duran et al.   CANCER CELL

Nrf1 and Nrf2 Play Distinct Roles in Activation of Antioxidant Response Element-dependent Genes

(2008) Makiko Ohtsuji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY

One step at a time: endoplasmic reticulum-associated degradation

(2008) Shruthi S. Vembar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cigarette Smoke Induces an Unfolded Protein Response in the Human Lung

(2007) Steven G. Kelsen et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY