The KEAP1-NRF2 System in Healthy Aging and Longevity

The Role of Nrf2 in Hearing Loss

(2021) Dafei Li et al.   Frontiers in Pharmacology

Inflammation, Nitro-Oxidative Stress, Impaired Autophagy, and Insulin Resistance as a Mechanistic Convergence Between Arterial Stiffness and Alzheimer’s Disease

(2021) Jhana O. Hendrickx et al.   Frontiers in Molecular Biosciences

Skeletal muscle-specific Keap1 disruption modulates fatty acid utilization and enhances exercise capacity in female mice

(2021) Takahiro Onoki et al.   Redox Biology

Brain-Protective Mechanisms of Transcription Factor NRF2: Toward a Common Strategy for Neurodegenerative Diseases

(2021) Antonio Cuadrado   Annual Review of Pharmacology and Toxicology

Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-In Alzheimer’s Disease Model Mice

(2020) Akira Uruno et al.   MOLECULAR AND CELLULAR BIOLOGY

Adaptation of the master antioxidant response connects metabolism, lifespan and feather development pathways in birds

(2020) Gianni M. Castiglione et al.   Nature Communications

Oxidative Stress in Cognitive and Epigenetic Aging: A Retrospective Glance

(2020) Aditi Kandlur et al.   Frontiers in Molecular Neuroscience

Age-Related Hearing Loss Is Dominated by Damage to Inner Ear Sensory Cells, Not the Cellular Battery That Powers Them

(2020) Pei-zhe Wu et al.   JOURNAL OF NEUROSCIENCE

Senolytic CAR T cells reverse senescence-associated pathologies

(2020) Corina Amor et al.   NATURE

Sulforaphane prevents age‐associated cardiac and muscular dysfunction through Nrf2 signaling

(2020) Chhanda Bose et al.   AGING CELL

A Cellular Mechanism to Detect and Alleviate Reductive Stress

(2020) Andrew G. Manford et al.   CELL

NRF2 pathway activation by KEAP1 inhibition attenuates the manifestation of aging phenotypes in salivary glands

(2020) Sisca Meida Wati et al.   Redox Biology

High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance

(2020) David B. Lombard et al.   Science Advances

Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers

(2020) Keito Okazaki et al.   Nature Communications

Modulation of Oxidative Stress and Inflammation in the Aged Lacrimal Gland

(2020) Rodrigo G. de Souza et al.   AMERICAN JOURNAL OF PATHOLOGY

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

(2019) Antonio Cuadrado et al.   NATURE REVIEWS DRUG DISCOVERY

Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis

(2019) Christopher M. Henstridge et al.   NATURE REVIEWS NEUROSCIENCE

Mitochondria as a Target for Mitigating Sarcopenia

(2019) Paul M. Coen et al.   Frontiers in Physiology

Age-Related Hearing Loss Is Accelerated by Repeated Short-Duration Loud Sound Stimulation

(2019) Juan Carlos Alvarado et al.   Frontiers in Neuroscience

p62/SQSTM1 and Nrf2 are essential for exercise-mediated enhancement of antioxidant protein expression in oxidative muscle

(2019) Mami Yamada et al.   FASEB JOURNAL

Nrf2 deficiency exacerbates frailty and sarcopenia by impairing skeletal muscle mitochondrial biogenesis and dynamics in an age-dependent manner

(2019) Dong-Dong Huang et al.   EXPERIMENTAL GERONTOLOGY

Senolytic therapies for healthy longevity

(2019) Jan M. van Deursen   SCIENCE

Drosophila Nrf2/Keap1 Mediated Redox Signaling Supports Synaptic Function and Longevity and Impacts on Circadian Activity

(2019) Jereme G. Spiers et al.   Frontiers in Molecular Neuroscience

The Contribution of Ototoxic Medications to Hearing Loss Among Older Adults

(2019) Yoonmee Joo et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development

(2019) Natalia Robledinos-Antón et al.   Oxidative Medicine and Cellular Longevity

Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1

(2019) Takafumi Suzuki et al.   Cell Reports

Reduced NRF2 expression suppresses endothelial progenitor cell function and induces senescence during aging

(2019) Ruiyun Wang et al.   Aging-US

Role of KEAP1/NFE2L2 mutations in the chemotherapeutic response of non-small cell lung cancer patients

(2019) Youngtae Jeong et al.   CLINICAL CANCER RESEARCH

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Systemic activation of Nrf2 pathway in Parkinson's disease

(2019) Sara Petrillo et al.   MOVEMENT DISORDERS

Impacts of NRF2 activation in non–small‐cell lung cancer cell lines on extracellular metabolites

(2019) Daisuke Saigusa et al.   CANCER SCIENCE

Immunohistochemical localization of Nrf2 in the human cochlea

(2018) Kumiko Hosokawa et al.   BRAIN RESEARCH

NRF2 addiction in cancer cells

(2018) Hiroshi Kitamura et al.   CANCER SCIENCE

Nrf2-Mediated Fibroblast Reprogramming Drives Cellular Senescence by Targeting the Matrisome

(2018) Paul Hiebert et al.   DEVELOPMENTAL CELL

Hyperactivation of Nrf2 leads to hypoplasia of bone in vivo

(2018) Eiki Yoshida et al.   GENES TO CELLS

Oxidative stress is increased in sarcopenia and associated with cardiovascular disease risk in sarcopenic obesity

(2018) Francesco Bellanti et al.   MATURITAS

The physiopathologic role of oxidative stress in skeletal muscle

(2018) Bianca Maria Scicchitano et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

(2018) Antonio Cuadrado et al.   PHARMACOLOGICAL REVIEWS

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

(2018) Masayuki Yamamoto et al.   PHYSIOLOGICAL REVIEWS

Partial involvement of Nrf2 in skeletal muscle mitohormesis as an adaptive response to mitochondrial uncoupling

(2018) Verena Coleman et al.   Scientific Reports

Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice

(2018) Karessa White et al.   Scientific Reports

Association of Cardiovascular Comorbidities With Hearing Loss in the Older Old

(2018) Kapil Wattamwar et al.   JAMA Otolaryngology-Head & Neck Surgery

Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy

(2018) Antonio Cuadrado et al.   Redox Biology

Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy

(2018) Ana I. Rojo et al.   Redox Biology

MicroRNAs mediate the senescence-associated decline of NRF2 in endothelial cells

(2018) Suvi M. Kuosmanen et al.   Redox Biology

Next-generation sequencing identified SPATC1L as a possible candidate gene for both early-onset and age-related hearing loss

(2018) Anna Morgan et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Evidence supporting oxidative stress in a moderately affected area of the brain in Alzheimer’s disease

(2018) Priscilla Youssef et al.   Scientific Reports

Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation

(2018) Eleni N. Tsakiri et al.   AGING CELL

Curcumin Improves Exercise Performance of Mice with Coronary Artery Ligation Induced HFrEF: Nrf2 and Antioxidant Mechanisms in Skeletal Muscle

(2018) Ahmed M. Wafi et al.   JOURNAL OF APPLIED PHYSIOLOGY

Sarcopenia: Aging-Related Loss of Muscle Mass and Function

(2018) Lars Larsson et al.   PHYSIOLOGICAL REVIEWS

Age-Related Hearing Loss

(2018) Michael R. Bowl et al.   Cold Spring Harbor Perspectives in Medicine

Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation

(2018) Gabor A. Fulop et al.   GeroScience

Dynamic activation of basilar membrane macrophages in response to chronic sensory cell degeneration in aging mouse cochleae

(2017) Mitchell D. Frye et al.   HEARING RESEARCH

Genetic reduction of Nrf2 exacerbates cognitive deficits in a mouse model of Alzheimer’s disease

(2017) Caterina Branca et al.   HUMAN MOLECULAR GENETICS

Zinc L-carnosine suppresses inflammatory responses in lipopolysaccharide-induced RAW 264.7 murine macrophages cell line via activation of Nrf2/HO-1 signaling pathway

(2017) Theng Choon Ooi et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Meta-Analysis of Parkinson’s Disease and Alzheimer’s Disease Revealed Commonly Impaired Pathways and Dysregulation of NRF2-Dependent Genes

(2017) Qian Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Relationship between hyposalivation and oxidative stress in aging mice

(2017) Yoshitaka Yamauchi et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Systemic Activation of NRF2 Alleviates Lethal Autoimmune Inflammation in Scurfy Mice

(2017) Takuma Suzuki et al.   MOLECULAR AND CELLULAR BIOLOGY

NRF2 Activation Impairs Quiescence and Bone Marrow Reconstitution Capacity of Hematopoietic Stem Cells

(2017) Shohei Murakami et al.   MOLECULAR AND CELLULAR BIOLOGY

Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis

(2017) Rodrigo Romero et al.   NATURE MEDICINE

IL-11 contribution to tumorigenesis in an NRF2 addiction cancer model

(2017) H Kitamura et al.   ONCOGENE

Skeletal muscle aging: influence of oxidative stress and physical exercise

(2017) Mariana Janini Gomes et al.   Oncotarget

Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress

(2017) Yoko Yagishita et al.   Cell Reports

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

(2017) Ana I. Rojo et al.   Redox Biology

Redox control of senescence and age-related disease

(2017) Akshaya Chandrasekaran et al.   Redox Biology

Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation

(2017) Erika Castillo et al.   Scientific Reports

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Degeneration of stria vascularis in age-related hearing loss; a corrosion cast study in a mouse model

(2016) Mattia Carraro et al.   ACTA OTO-LARYNGOLOGICA

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer

(2016) Randy Strong et al.   AGING CELL

Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease

(2016) Isabel Lastres-Becker et al.   ANTIOXIDANTS & REDOX SIGNALING

The role of Nrf2 in skeletal muscle contractile and mitochondrial function

(2016) Matthew J. Crilly et al.   JOURNAL OF APPLIED PHYSIOLOGY

Astaxanthin affects oxidative stress and hyposalivation in aging mice

(2016) Manatsu Kuraji et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism

(2016) Akira Uruno et al.   MOLECULAR AND CELLULAR BIOLOGY

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

(2016) Eri H. Kobayashi et al.   Nature Communications

Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis

(2016) Jorge Iván Castillo-Quan et al.   Cell Reports

Nrf2 mediates redox adaptations to exercise

(2016) Aaron J. Done et al.   Redox Biology

NRF2 Is a Key Target for Prevention of Noise-Induced Hearing Loss by Reducing Oxidative Damage of Cochlea

(2016) Yohei Honkura et al.   Scientific Reports

The Effect of Nrf2 Knockout on Ocular Surface Protection from Acute Tobacco Smoke Exposure

(2015) Takashi Kojima et al.   AMERICAN JOURNAL OF PATHOLOGY

Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators

(2015) Atul D. Jain et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Age-related loss of hepatic Nrf2 protein homeostasis: Potential role for heightened expression of miR-146a

(2015) Eric J. Smith et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress response and Nrf2 signaling in aging

(2015) Hongqiao Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sulforaphane alleviates muscular dystrophy in mdx mice by activation of Nrf2

(2015) Chengcao Sun et al.   JOURNAL OF APPLIED PHYSIOLOGY

Meta-Analysis of Salivary Flow Rates in Young and Older Adults

(2015) Rebecca H. Affoo et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Increased Alzheimer's disease–like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy

(2015) Gururaj Joshi et al.   NEUROBIOLOGY OF AGING

Regulation of Nrf2 signaling and longevity in naturally long-lived rodents

(2015) Kaitlyn N. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

(2015) Karen F.S. Bell et al.   Nature Communications

Inflammation in Parkinson’s disease: role of glucocorticoids

(2015) María-Trinidad Herrero et al.   Frontiers in Neuroanatomy

The Role of Oxidative Stress in Neurodegenerative Diseases

(2015) Geon Ha Kim et al.   Experimental Neurobiology

Neuroprotection by 6-(methylsulfinyl)hexyl isothiocyanate in a 6-hydroxydopamine mouse model of Parkinson׳s disease

(2014) Fabiana Morroni et al.   BRAIN RESEARCH

Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis

(2014) T. Wu et al.   GENES & DEVELOPMENT

Mitochondrial free radical theory of aging: Who moved my premise?

(2014) Ye Liu et al.   Geriatrics & Gerontology International

Inflammation is associated with a worsening of presbycusis: Evidence from the MRC national study of hearing

(2014) Carl Verschuur et al.   INTERNATIONAL JOURNAL OF AUDIOLOGY

Oxidative Stress in Alzheimer’s Disease: Why Did Antioxidant Therapy Fail?

(2014) Torbjörn Persson et al.   Oxidative Medicine and Cellular Longevity

Oxidative Stresses and Mitochondrial Dysfunction in Age-Related Hearing Loss

(2014) Chisato Fujimoto et al.   Oxidative Medicine and Cellular Longevity

Effect of Antioxidants Supplementation on Aging and Longevity

(2014) Izabela Sadowska-Bartosz et al.   Biomed Research International

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Nrf2 signaling is impaired in the aging RPE given an oxidative insult

(2013) Mira M. Sachdeva et al.   EXPERIMENTAL EYE RESEARCH

Nrf2 deficiency leads to behavioral, neurochemical and transcriptional changes in mice

(2013) Hiroyuki Muramatsu et al.   GENES TO CELLS

Regulatory Nexus of Synthesis and Degradation Deciphers Cellular Nrf2 Expression Levels

(2013) T. Suzuki et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

Expression and localization of aging markers in lacrimal gland of chronic graft-versus-host disease

(2013) Masataka Kawai et al.   Scientific Reports

Muscle Changes in Aging

(2013) Patrick N. Siparsky et al.   Sports Health-A Multidisciplinary Approach

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

Somatic mutations of the KEAP1 gene in common solid cancers

(2012) Nam Jin Yoo et al.   HISTOPATHOLOGY

Cellular and molecular mechanisms of antioxidants in Parkinson's disease

(2012) Jhon Jairo Sutachan et al.   NUTRITIONAL NEUROSCIENCE

The Aging Lacrimal Gland: Changes in Structure and Function

(2012) Eduardo M. Rocha et al.   Ocular Surface

Correction: Impaired Transcriptional Activity of Nrf2 in Age-Related Myocardial Oxidative Stress Is Reversible by Moderate Exercise Training

(2012) Sellamuthu S. Gounder et al.   PLoS One

Oxidative Stress Induced Inflammation Initiates Functional Decline of Tear Production

(2012) Yuichi Uchino et al.   PLoS One

Protective role of Nrf2 in age-related hearing loss and gentamicin ototoxicity

(2011) Tomofumi Hoshino et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Involvement of heme oxygenase-1 induction via Nrf2/ARE activation in protection against H2O2-induced PC12 cell death by a metabolite of sesamin contained in sesame seeds

(2011) Nanako Hamada et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

Dynamics of Nrf2 and Keap1 in ARE-MediatedNQO1Expression by Wasabi 6-(Methylsulfinyl)hexyl Isothiocyanate

(2011) De-Xing Hou et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

Separate and combined effects of Sod1 and Cdh23 mutations on age-related hearing loss and cochlear pathology in C57BL/6J mice

(2010) Kenneth R. Johnson et al.   HEARING RESEARCH

Nuclear Erythroid Factor 2-mediated Proteasome Activation Delays Senescence in Human Fibroblasts

(2010) Suzanne Kapeta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex

(2010) Mubeen A. Ansari et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Lifespan extension in genetically modified mice

(2009) Warren Ladiges et al.   AGING CELL

DNA damage response and cellular senescence in tissues of aging mice

(2009) Chunfang Wang et al.   AGING CELL

Is the oxidative stress theory of aging dead?

(2009) Viviana I. Pérez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Relationship of Type 2 diabetes to the prevalence, incidence and progression of age-related hearing loss

(2009) P. Mitchell et al.   DIABETIC MEDICINE

Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease

(2009) Ana I. Rojo et al.   GLIA

Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer’s disease

(2009) Magali Dumont et al.   JOURNAL OF NEUROCHEMISTRY

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Neuroprotective Effects of the Triterpenoid, CDDO Methyl Amide, a Potent Inducer of Nrf2-Mediated Transcription

(2009) Lichuan Yang et al.   PLoS One

Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease

(2009) K. Kanninen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

(2009) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration

(2009) Marisol Cano et al.   VISION RESEARCH

Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

(2008) Jennifer M.A. Tullet et al.   CELL

Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila

(2008) Gerasimos P. Sykiotis et al.   DEVELOPMENTAL CELL

Nuclear factor erythroid 2-related factor 2 protects against beta amyloid

(2008) Katja Kanninen et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production

(2008) Scott K. Powers et al.   PHYSIOLOGICAL REVIEWS

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

(2008) T. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY