ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

(2020) Julia Marschallinger et al.   NATURE NEUROSCIENCE

Nox2 dependent redox-regulation of microglial response to amyloid-β stimulation and microgliosis in aging

(2020) Li Geng et al.   Scientific Reports

Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage‐gated calcium channels and NADPH oxidase

(2020) Noemi Esteras et al.   FEBS Journal

Advanced oxidation protein products induce microglia-mediated neuroinflammation via MAPKs-NF-κB signaling pathway and pyroptosis after secondary spinal cord injury

(2020) Zhongyuan Liu et al.   Journal of Neuroinflammation

Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation

(2020) Andrew S. Mendiola et al.   NATURE IMMUNOLOGY

Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease

(2020) Simon Dujardin et al.   NATURE MEDICINE

Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivo

(2020) Eyiyemisi C. Damisah et al.   Science Advances

Carnosine Prevents Aβ-Induced Oxidative Stress and Inflammation in Microglial Cells: A Key Role of TGF-β1

(2019) Giuseppe Caruso et al.   Cells

Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer’s Disease Model

(2019) Mario Merlini et al.   NEURON

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

(2019) Takahiro Masuda et al.   NATURE

Rapid clearance of cellular debris by microglia limits secondary neuronal cell death after brain injury in vivo

(2019) Chiara Herzog et al.   DEVELOPMENT

CX3CR1-deficient microglia shows impaired signalling of the transcription factor NRF2: Implications in tauopathies

(2019) Sara Castro-Sánchez et al.   Redox Biology

Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice

(2019) Jiayi Zhao et al.   Scientific Reports

Cellular Specificity of NF-κB Function in the Nervous System

(2019) Erica C. Dresselhaus et al.   Frontiers in Immunology

Lipid droplet biogenesis

(2019) Catherine L Jackson   CURRENT OPINION IN CELL BIOLOGY

Microglial regional heterogeneity and its role in the brain

(2019) Yun-Long Tan et al.   MOLECULAR PSYCHIATRY

NLRP3 inflammasome activation drives tau pathology

(2019) Christina Ising et al.   NATURE

Mapping microglia states in the human brain through the integration of high-dimensional techniques

(2019) Roman Sankowski et al.   NATURE NEUROSCIENCE

The Beta Amyloid Dysfunction (BAD) Hypothesis for Alzheimer’s Disease

(2019) Heinz Hillen   Frontiers in Neuroscience

Loss of Oxidation Resistance 1, OXR1, Is Associated with an Autosomal-Recessive Neurological Disease with Cerebellar Atrophy and Lysosomal Dysfunction

(2019) Julia Wang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A novel Tmem119-tdTomato reporter mouse model for studying microglia in the central nervous system

(2019) Chunsheng Ruan et al.   BRAIN BEHAVIOR AND IMMUNITY

Heterozygous CX3CR1 Deficiency in Microglia Restores Neuronal β-Amyloid Clearance Pathways and Slows Progression of Alzheimer's Like-Disease in PS1-APP Mice

(2019) Suzanne E. Hickman et al.   Frontiers in Immunology

A role for peroxiredoxins in H2O2- and MEKK-dependent activation of the p38 signaling pathway

(2019) Ana G. Barata et al.   Redox Biology

Oncogenic Signaling Pathways in The Cancer Genome Atlas

(2018) Francisco Sanchez-Vega et al.   CELL

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

(2018) Aleksandra Deczkowska et al.   CELL

AMPK/Nrf2 signaling is involved in the anti-neuroinflammatory action of Petatewalide B from Petasites japonicus against lipopolysaccharides in microglia

(2018) Sun Young Park et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Activation of Nrf2 Pathway Contributes to Neuroprotection by the Dietary Flavonoid Tiliroside

(2018) Ravikanth Velagapudi et al.   MOLECULAR NEUROBIOLOGY

Using ROS as a Second Messenger, NADPH Oxidase 2 Mediates Macrophage Senescence via Interaction with NF-κB during Pseudomonas aeruginosa Infection

(2018) Hui Li et al.   Oxidative Medicine and Cellular Longevity

Amyloid toxicity in Alzheimer’s disease

(2018) Allison B. Reiss et al.   REVIEWS IN THE NEUROSCIENCES

Complement receptor 3 mediates NADPH oxidase activation and dopaminergic neurodegeneration through a Src-Erk-dependent pathway

(2018) Liyan Hou et al.   Redox Biology

13 reasons why the brain is susceptible to oxidative stress

(2018) James Nathan Cobley et al.   Redox Biology

Alzheimer’s disease hypothesis and related therapies

(2018) Xiaoguang Du et al.   Translational Neurodegeneration

AT2R Activation Prevents Microglia Pro-inflammatory Activation in a NOX-Dependent Manner: Inhibition of PKC Activation and p47phox Phosphorylation by PP2A

(2018) Shahnawaz Ali Bhat et al.   MOLECULAR NEUROBIOLOGY

Facing up to the global challenges of ageing

(2018) Linda Partridge et al.   NATURE

Microglia in neurodegeneration

(2018) Suzanne Hickman et al.   NATURE NEUROSCIENCE

The Contribution and Therapeutic Potential of Epigenetic Modifications in Alzheimer’s Disease

(2018) Ian C. Wood   Frontiers in Neuroscience

Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) Emma Nichols et al.   LANCET NEUROLOGY

New insights into the role of TREM2 in Alzheimer’s disease

(2018) Maud Gratuze et al.   Molecular Neurodegeneration

Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer’s human brains

(2018) Hans-Ulrich Klein et al.   NATURE NEUROSCIENCE

The interferon-inducible isoform of NCOA7 inhibits endosome-mediated viral entry

(2018) Tomas Doyle et al.   Nature Microbiology

Why do trials for Alzheimer’s disease drugs keep failing? A discontinued drug perspective for 2010-2015

(2017) Dev Mehta et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

(2017) Eric Tönnies et al.   JOURNAL OF ALZHEIMERS DISEASE

Understanding the functions and relationships of the glymphatic system and meningeal lymphatics

(2017) Antoine Louveau et al.   JOURNAL OF CLINICAL INVESTIGATION

TLDc proteins: new players in the oxidative stress response and neurological disease

(2017) Mattéa J. Finelli et al.   MAMMALIAN GENOME

Microglia limit the expansion of β-amyloid plaques in a mouse model of Alzheimer’s disease

(2017) Ruohe Zhao et al.   Molecular Neurodegeneration

NADPH oxidase in brain injury and neurodegenerative disorders

(2017) Merry W. Ma et al.   Molecular Neurodegeneration

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

(2017) Carmen Venegas et al.   NATURE

Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases

(2017) Michael G. Erkkinen et al.   Cold Spring Harbor Perspectives in Biology

Involvement of Astrocytes in Alzheimer’s Disease from a Neuroinflammatory and Oxidative Stress Perspective

(2017) Rodrigo E. González-Reyes et al.   Frontiers in Molecular Neuroscience

NOX2 drives M1-like microglial/macrophage activation and neurodegeneration following experimental traumatic brain injury

(2016) Alok Kumar et al.   BRAIN BEHAVIOR AND IMMUNITY

NADPH oxidase isoform expression is temporally regulated and may contribute to microglial/macrophage polarization after spinal cord injury

(2016) Sara Bermudez et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Minimally Toxic Dose of Lipopolysaccharide and α-Synuclein Oligomer Elicit Synergistic Dopaminergic Neurodegeneration: Role and Mechanism of Microglial NOX2 Activation

(2016) Wei Zhang et al.   MOLECULAR NEUROBIOLOGY

Anti-neuroinflammatory Effect of Emodin in LPS-Stimulated Microglia: Involvement of AMPK/Nrf2 Activation

(2016) Sun Young Park et al.   NEUROCHEMICAL RESEARCH

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

ROS and ROS-Mediated Cellular Signaling

(2016) Jixiang Zhang et al.   Oxidative Medicine and Cellular Longevity

Targeting Oxidative Stress in Central Nervous System Disorders

(2016) Manisha Patel   TRENDS IN PHARMACOLOGICAL SCIENCES

CYB5R3: a key player in aerobic metabolism and aging?

(2016) Rafael de Cabo et al.   Aging-US

The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation

(2016) Anja Henn   ALTEX-Alternatives to Animal Experimentation

Neuron-specific antioxidant OXR1 extends survival of a mouse model of amyotrophic lateral sclerosis

(2015) Kevin X. Liu et al.   BRAIN

Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration

(2015) Lucy Liu et al.   CELL

Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease

(2015) Paul D. Wes et al.   GLIA

The Evolutionarily Conserved Tre2/Bub2/Cdc16 (TBC), Lysin Motif (LysM), Domain Catalytic (TLDc) Domain Is Neuroprotective against Oxidative Stress

(2015) Mattéa J. Finelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression dynamics of NADPH oxidases during early zebrafish development

(2015) Cory J. Weaver et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Induction of a Unique Isoform of theNCOA7Oxidation Resistance Gene by Interferon β-1b

(2015) Lijian Yu et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

β-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microglia

(2015) Eun-Jung Lee et al.   Journal of Neuroinflammation

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-κB pathways

(2015) Junghyung Park et al.   NEUROSCIENCE LETTERS

Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice

(2015) Byung Hee Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revisiting the Mechanisms of CNS Immune Privilege

(2015) Antoine Louveau et al.   TRENDS IN IMMUNOLOGY

Transcriptional profiling of macrophages derived from monocytes and iPS cells identifies a conserved response to LPS and novel alternative transcription

(2015) Kaur Alasoo et al.   Scientific Reports

UK research spend in 2008 and 2012: comparing stroke, cancer, coronary heart disease and dementia

(2015) R. Luengo-Fernandez et al.   BMJ Open

Nox4: A Hydrogen Peroxide-Generating Oxygen Sensor

(2014) Yukio Nisimoto et al.   BIOCHEMISTRY

NADPH oxidase- and mitochondria-derived reactive oxygen species in proinflammatory microglial activation: a bipartisan affair?

(2014) Evan A. Bordt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Macrophage Antigen Complex-1 Mediates Reactive Microgliosis and Progressive Dopaminergic Neurodegeneration in the MPTP Model of Parkinson's Disease

(2014) X. Hu et al.   JOURNAL OF IMMUNOLOGY

The Transcription Factor Nrf2 Is a Therapeutic Target against Brain Inflammation

(2014) N. G. Innamorato et al.   JOURNAL OF IMMUNOLOGY

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

DAMP-Mediated Activation of NLRP3-Inflammasome in Brain Sterile Inflammation: The Fine Line between Healing and Neurodegeneration

(2014) Anna Rubartelli   Frontiers in Immunology

New Insights on NOX Enzymes in the Central Nervous System

(2013) Zeynab Nayernia et al.   ANTIOXIDANTS & REDOX SIGNALING

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

Toll-Like Receptor 4-Dependent Microglial Activation Mediates Spinal Cord Ischemia-Reperfusion Injury

(2013) M. T. Bell et al.   CIRCULATION

The role of MAC1 in diesel exhaust particle-induced microglial activation and loss of dopaminergic neuron function

(2013) Shannon Levesque et al.   JOURNAL OF NEUROCHEMISTRY

Cellular and temporal expression of NADPH oxidase (NOX) isotypes after brain injury

(2013) Sean J Cooney et al.   Journal of Neuroinflammation

Microglial CD33-Related Siglec-E Inhibits Neurotoxicity by Preventing the Phagocytosis-Associated Oxidative Burst

(2013) J. Claude et al.   JOURNAL OF NEUROSCIENCE

JNK and NADPH Oxidase Involved in Fluoride-Induced Oxidative Stress in BV-2 Microglia Cells

(2013) Ling Yan et al.   MEDIATORS OF INFLAMMATION

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Reactive Oxygen Species from Human Astrocytes Induced Functional Impairment and Oxidative Damage

(2013) Wen S. Sheng et al.   NEUROCHEMICAL RESEARCH

Novel immune genes associated with excessive inflammatory and antiviral responses to rhinovirus in COPD

(2013) Katherine J Baines et al.   RESPIRATORY RESEARCH

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

(2013) Changyoun Kim et al.   Nature Communications

Dynamics and regulation of lipid droplet formation in lipopolysaccharide (LPS)-stimulated microglia

(2012) Armen Khatchadourian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The NOX toolbox: validating the role of NADPH oxidases in physiology and disease

(2012) Sebastian Altenhöfer et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aβ by microglia

(2012) Hongjun Fu et al.   GLIA

NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration

(2012) Liya Qin et al.   Journal of Neuroinflammation

Neuroinflammation and Blood-Brain Barrier Changes in Capillary Amyloid Angiopathy

(2012) Anna Carrano et al.   Neurodegenerative Diseases

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Transcriptional Specificity of NF-κB Dimers Is Coded within the κB DNA Response Elements

(2012) Vivien Ya-Fan Wang et al.   Cell Reports

NLRP3-Inflammasome Activating DAMPs Stimulate an Inflammatory Response in Glia in the Absence of Priming Which Contributes to Brain Inflammation after Injury

(2012) Catherine Diane Savage et al.   Frontiers in Immunology

Reactive Glia not only Associates with Plaques but also Parallels Tangles in Alzheimer's Disease

(2011) Alberto Serrano-Pozo et al.   AMERICAN JOURNAL OF PATHOLOGY

Pharmacological Targeting of the Transcription Factor Nrf2 at the Basal Ganglia Provides Disease Modifying Therapy for Experimental Parkinsonism

(2011) Agnieszka Jazwa et al.   ANTIOXIDANTS & REDOX SIGNALING

Amyloid Beta Induces Oxidative Stress-Mediated Blood–Brain Barrier Changes in Capillary Amyloid Angiopathy

(2011) Anna Carrano et al.   ANTIOXIDANTS & REDOX SIGNALING

Unraveling the Biological Roles of Reactive Oxygen Species

(2011) Michael P. Murphy et al.   Cell Metabolism

NADPH-oxidase activation and cognition in Alzheimer disease progression

(2011) Mubeen A. Ansari et al.   FREE RADICAL BIOLOGY AND MEDICINE

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Amyloid-β-induced reactive oxygen species production and priming are differentially regulated by ion channels in microglia

(2011) Tom Schilling et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inhibition of NADPH oxidase promotes alternative and anti-inflammatory microglial activation during neuroinflammation

(2011) Sang-Ho Choi et al.   JOURNAL OF NEUROCHEMISTRY

Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity

(2011) Dan Zhang et al.   Journal of Neuroinflammation

HMGB1 Acts on Microglia Mac1 to Mediate Chronic Neuroinflammation That Drives Progressive Neurodegeneration

(2011) H.-M. Gao et al.   JOURNAL OF NEUROSCIENCE

Cognitive impairment in humanized APP×PS1 mice is linked to Aβ1–42 and NOX activation

(2011) Annadora J. Bruce-Keller et al.   NEUROBIOLOGY OF DISEASE

Apocynin administration does not improve behavioral and neuropathological deficits in a transgenic mouse model of Alzheimer's disease

(2011) Magali Dumont et al.   NEUROSCIENCE LETTERS

CX3CR1 Deficiency Alters Microglial Activation and Reduces Beta-Amyloid Deposition in Two Alzheimer's Disease Mouse Models

(2010) Sungho Lee et al.   AMERICAN JOURNAL OF PATHOLOGY

The Spectrum of Mutations in Progranulin

(2010) Chang-En Yu et al.   ARCHIVES OF NEUROLOGY

Comparative pharmacology of chemically distinct NADPH oxidase inhibitors

(2010) S Wind et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structural studies of NF-κB signaling

(2010) Chao Zheng et al.   CELL RESEARCH

Differential interferon signaling in liver lobule and portal area cells under treatment for chronic hepatitis C

(2010) Masao Honda et al.   JOURNAL OF HEPATOLOGY

LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice

(2010) Daniel C Lee et al.   Journal of Neuroinflammation

Alzheimer's disease: clinical trials and drug development

(2010) Francesca Mangialasche et al.   LANCET NEUROLOGY

Multiphoton in vivo imaging of amyloid in animal models of Alzheimer’s disease

(2010) Jinghui Dong et al.   NEUROPHARMACOLOGY

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Prevalence of dementia – a rising challenge among ageing populations

(2010) I. Winblad et al.   European Geriatric Medicine

MAPK Signal Transduction Underlying Brain Inflammation and Gliosis as Therapeutic Target

(2009) Bozena Kaminska et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

NOX Enzymes in the Central Nervous System: From Signaling to Disease

(2009) Silvia Sorce et al.   ANTIOXIDANTS & REDOX SIGNALING

NOX Activity Is Increased in Mild Cognitive Impairment

(2009) Annadora J. Bruce-Keller et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease

(2009) Ana I. Rojo et al.   GLIA

IL-13-Induced Oxidative Stress via Microglial NADPH Oxidase Contributes to Death of Hippocampal Neurons In Vivo

(2009) K. W. Park et al.   JOURNAL OF IMMUNOLOGY

NOX4 Expression in Human Microglia Leads to Constitutive Generation of Reactive Oxygen Species and to Constitutive IL-6 Expression

(2009) Bin Li et al.   Journal of Innate Immunity

Gene Expression Profiling Reveals Similarities between the In vitro and In vivo Responses of Immune Effector Cells to IFN- 

(2008) J. M. Zimmerer et al.   CLINICAL CANCER RESEARCH

The non-provitamin A carotenoid, lutein, inhibits NF-κB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-κB-inducing kinase pathways: Role of H2O2 in NF-κB activation

(2008) Ji-Hee Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Biological Roles for the NOX Family NADPH Oxidases

(2008) William M. Nauseef   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurotoxic Activation of Microglia Is Promoted by a Nox1-Dependent NADPH Oxidase

(2008) C. Cheret et al.   JOURNAL OF NEUROSCIENCE

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Molecular characterization and bioinformatics analysis of Ncoa7B, a novel ovulation-associated and reproduction system-specific Ncoa7 isoform

(2008) Ketty Shkolnik et al.   REPRODUCTION

Synuclein activates microglia in a model of Parkinson's disease

(2007) Xiaomin Su et al.   NEUROBIOLOGY OF AGING