The Critical Role of Bach2 in Shaping the Balance between CD4+ T Cell Subsets in Immune-Mediated Diseases

Bach2 Controls T Follicular Helper Cells by Direct Repression of Bcl-6

(2019) Annette Lahmann et al.   JOURNAL OF IMMUNOLOGY

Bach2 Negatively Regulates T Follicular Helper Cell Differentiation and Is Critical for CD4+ T Cell Memory

(2019) Jianlin Geng et al.   JOURNAL OF IMMUNOLOGY

Variants in the BACH2 and CLEC16A gene might be associated with susceptibility to insulin‐triggered type 1 diabetes

(2019) Hiroshi Onuma et al.   Journal of Diabetes Investigation

BATF-Interacting Proteins Dictate Specificity in Th Subset Activity

(2019) Yongyao Fu et al.   JOURNAL OF IMMUNOLOGY

Bach2 Deficiency Leads to Spontaneous Expansion of IL-4-Producing T Follicular Helper Cells and Autoimmunity

(2019) Heng Zhang et al.   Frontiers in Immunology

IL-17, IL-21 and IL-22 polymorphisms in rheumatoid arthritis: A systematic review and meta-analysis

(2019) Inês Agonia et al.   CYTOKINE

The critical role of Bach2 in regulating type-2 chronic airway inflammation

(2018) Masakatsu Yamashita et al.   INTERNATIONAL IMMUNOLOGY

The Balance of Th17 versus Treg Cells in Autoimmunity

(2018) Gap Lee   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A BACH2 Gene Variant Is Associated with Postoperative Recurrence of Crohn's Disease

(2018) Michael R. Laffin et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Multiple sclerosis

(2018) Alan J Thompson et al.   LANCET

Multiple Sclerosis: Mechanisms and Immunotherapy

(2018) Clare Baecher-Allan et al.   NEURON

The Footprints of Poly-Autoimmunity: Evidence for Common Biological Factors Involved in Multiple Sclerosis and Hashimoto’s Thyroiditis

(2018) Simona Perga et al.   Frontiers in Immunology

SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation

(2018) Xiaoyan Yu et al.   Nature Communications

Epigenetic and gene expression alterations of FOXP3 in the T cells of EAE mouse model of multiple sclerosis

(2017) Ali Noori-Zadeh et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Bach2 repression mediates Th17 cell induced inflammation and associates with clinical features of advanced disease in chronic pancreatitis

(2017) M Sasikala et al.   United European Gastroenterology Journal

Follicular Helper T Cells

(2016) Carola G. Vinuesa et al.   Annual Review of Immunology

Variants associated with autoimmune Type 1 diabetes in Japanese children: implications for age-specific effects of cis-regulatory haplotypes at 17q12-q21

(2016) T. Ayabe et al.   DIABETIC MEDICINE

T Cell Fates Zipped Up: How the Bach2 Basic Leucine Zipper Transcriptional Repressor Directs T Cell Differentiation and Function

(2016) Martin J. Richer et al.   JOURNAL OF IMMUNOLOGY

TFH cells progressively differentiate to regulate the germinal center response

(2016) Jason S Weinstein et al.   NATURE IMMUNOLOGY

T-Helper Cell–Mediated Islet Inflammation Contributes to β-Cell Dysfunction in Chronic Pancreatitis

(2016) Rupjyoti Talukdar et al.   PANCREAS

Bach2–Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop

(2016) Makoto Kuwahara et al.   Nature Communications

New candidates for CD4 T cell pathogenicity in experimental neuroinflammation and multiple sclerosis

(2015) Nicola Hoppmann et al.   BRAIN

Shared Genetic Basis for Type 1 Diabetes, Islet Autoantibodies, and Autoantibodies Associated With Other Immune-Mediated Diseases in Families With Type 1 Diabetes

(2015) Caroline A. Brorsson et al.   DIABETES CARE

Genetic link of type 1 diabetes susceptibility loci with rheumatoid arthritis in Pakistani patients

(2015) Aysha Karim Kiani et al.   IMMUNOGENETICS

Anti-inflammatory genes associated with multiple sclerosis: A gene expression study

(2015) S. Perga et al.   JOURNAL OF NEUROIMMUNOLOGY

Super-enhancers delineate disease-associated regulatory nodes in T cells

(2015) Golnaz Vahedi et al.   NATURE

BACH2, a Candidate Risk Gene for Type 1 Diabetes, Regulates Apoptosis in Pancreatic  -Cells via JNK1 Modulation and Crosstalk With the Candidate Gene PTPN2

(2014) L. Marroqui et al.   DIABETES

Blimp-1 Attenuates Th1 Differentiation by Repression of ifng, tbx21, and bcl6 Gene Expression

(2014) L. Cimmino et al.   JOURNAL OF IMMUNOLOGY

Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development

(2014) Xindong Liu et al.   NATURE

Brief Report: Identification ofBACH2andRAD51Bas Rheumatoid Arthritis Susceptibility Loci in a Meta-Analysis of Genome-Wide Data

(2013) Kate McAllister et al.   ARTHRITIS AND RHEUMATISM

Cooperative transcriptional repression by BCL6 and BACH2 in germinal center B-cell differentiation

(2013) C. Huang et al.   BLOOD

Transcription repressor Bach2 is required for pulmonary surfactant homeostasis and alveolar macrophage function

(2013) Atsushi Nakamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bach2 Regulates Homeostasis of Foxp3+ Regulatory T Cells and Protects against Fatal Lung Disease in Mice

(2013) E. H. Kim et al.   JOURNAL OF IMMUNOLOGY

BACH2 represses effector programs to stabilize Treg-mediated immune homeostasis

(2013) Rahul Roychoudhuri et al.   NATURE

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cells

(2013) Wim Pierson et al.   NATURE IMMUNOLOGY

Regulatory T cell proliferative potential is impaired in human autoimmune disease

(2013) Fortunata Carbone et al.   NATURE MEDICINE

Bach2 maintains T cells in a naive state by suppressing effector memory-related genes

(2013) S.-i. Tsukumo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From genetics of inflammatory bowel disease towards mechanistic insights

(2013) Daniel B. Graham et al.   TRENDS IN IMMUNOLOGY

Next generation exome sequencing of paediatric inflammatory bowel disease patients identifies rare and novel variants in candidate genes

(2012) Katja Christodoulou et al.   GUT

Preferential control of induced regulatory T cell homeostasis via a Bim/Bcl-2 axis

(2012) X Wang et al.   Cell Death & Disease

Heme regulates B-cell differentiation, antibody class switch, and heme oxygenase-1 expression in B cells as a ligand of Bach2

(2011) M. Watanabe-Matsui et al.   BLOOD

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic  -Cell Apoptosis via Regulation of the BH3-Only Protein Bim

(2011) I. Santin et al.   DIABETES

Chronic pancreatitis

(2011) Joan M Braganza et al.   LANCET

Understanding type 1 diabetes through genetics: advances and prospects

(2011) Constantin Polychronakos et al.   NATURE REVIEWS GENETICS

Genome-Wide Association Analysis of Autoantibody Positivity in Type 1 Diabetes Cases

(2011) Vincent Plagnol et al.   PLoS Genetics

Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch

(2010) Akihiko Muto et al.   EMBO JOURNAL

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation

(2010) Shane Crotty et al.   NATURE IMMUNOLOGY

Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease

(2010) Steve Eyre et al.   ARTHRITIS RESEARCH & THERAPY

Follow-Up Analysis of Genome-Wide Association Data Identifies Novel Loci for Type 1 Diabetes

(2008) S. F.A. Grant et al.   DIABETES

Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci

(2008) Jason D Cooper et al.   NATURE GENETICS