Ageing and rejuvenation of tissue stem cells and their niches

TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity

(2022) Tomoya Muto et al.   Cell Stem Cell

4D imaging analysis of the aging mouse neural stem cell niche reveals a dramatic loss of progenitor cell dynamism regulated by the RHO-ROCK pathway

(2022) Xiuli Zhao et al.   Stem Cell Reports

Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming

(2022) Dafni Chondronasiou et al.   AGING CELL

Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling

(2022) Daniel I. Benjamin et al.   Cell Metabolism

Chemical reprogramming of human somatic cells to pluripotent stem cells

(2022) Jingyang Guan et al.   NATURE

Molecular hallmarks of heterochronic parabiosis at single-cell resolution

(2022) Róbert Pálovics et al.   NATURE

Metabolic regulation of somatic stem cells in vivo

(2022) Corbin E. Meacham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer’s disease

(2022) Jessica S. Sadick et al.   NEURON

APOE mediated neuroinflammation and neurodegeneration in Alzheimer’s disease

(2022) Samira Parhizkar et al.   SEMINARS IN IMMUNOLOGY

Adult neural stem cell activation in mice is regulated by the day/night cycle and intracellular calcium dynamics

(2021) Archana Gengatharan et al.   CELL

Chaperone-mediated autophagy sustains haematopoietic stem-cell function

(2021) Shuxian Dong et al.   NATURE

The distribution of cellular turnover in the human body

(2021) Ron Sender et al.   NATURE MEDICINE

Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis

(2021) Alexander Heyde et al.   CELL

Preclinical Efficacy and Safety of a Human Embryonic Stem Cell-Derived Midbrain Dopamine Progenitor Product, MSK-DA01

(2021) Jinghua Piao et al.   Cell Stem Cell

Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity

(2021) Muhammad Khadeesh bin Imtiaz et al.   Cell Stem Cell

Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population

(2021) Lachlan Harris et al.   Cell Stem Cell

A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis

(2021) Bo Shen et al.   NATURE

Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification

(2021) Inah Hwang et al.   Nature Communications

Adult hippocampal neurogenesis in aging and Alzheimer's disease

(2021) Kelsey R. Babcock et al.   Stem Cell Reports

A comprehensive transcriptome signature of murine hematopoietic stem cell aging

(2021) Arthur Flohr Svendsen et al.   BLOOD

Early stem cell aging in the mature brain

(2021) Albina Ibrayeva et al.   Cell Stem Cell

Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling

(2021) Daniel Hormaechea-Agulla et al.   Cell Stem Cell

Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging

(2021) Kira Young et al.   Cell Stem Cell

Positive Controls in Adults and Children Support That Very Few, If Any, New Neurons Are Born in the Adult Human Hippocampus

(2021) Shawn F. Sorrells et al.   JOURNAL OF NEUROSCIENCE

Engineering skeletal muscle: Building complexity to achieve functionality

(2021) Eszter Mihaly et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells

(2021) Qiaozhi Wei et al.   Nature Communications

Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging

(2021) Miriama Kruta et al.   Cell Stem Cell

Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions

(2021) Theodore T. Ho et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Aged skeletal stem cells generate an inflammatory degenerative niche

(2021) Thomas H. Ambrosi et al.   NATURE

Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility

(2021) Janis Koester et al.   NATURE CELL BIOLOGY

HIV is associated with an increased risk of age-related clonal hematopoiesis among older adults

(2021) Nila J. Dharan et al.   NATURE MEDICINE

Molecular mechanisms of dietary restriction promoting health and longevity

(2021) Cara L. Green et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche

(2021) Chao Wang et al.   Nature Communications

Persistent JunB activation in fibroblasts disrupts stem cell niche interactions enforcing skin aging

(2021) Pallab Maity et al.   Cell Reports

Extensive remodeling of the extracellular matrix during aging contributes to age-dependent impairments of muscle stem cell functionality

(2021) Svenja C. Schüler et al.   Cell Reports

Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging

(2021) Jacqueline A Larouche et al.   eLife

Association of Diet Quality With Prevalence of Clonal Hematopoiesis and Adverse Cardiovascular Events

(2021) Romit Bhattacharya et al.   JAMA Cardiology

Changing and stable chromatin accessibility supports transcriptional overhaul during neural stem cell activation and is altered with age

(2021) Sun Y. Maybury‐Lewis et al.   AGING CELL

Cells, scaffolds, and bioactive factors: Engineering strategies for improving regeneration following volumetric muscle loss

(2021) Ioannis Eugenis et al.   BIOMATERIALS

Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis

(2021) Yuhua Xie et al.   Cell Stem Cell

Cell–cell contact and signaling in the muscle stem cell niche

(2021) Allison P. Kann et al.   CURRENT OPINION IN CELL BIOLOGY

Exercise plasma boosts memory and dampens brain inflammation via clusterin

(2021) Zurine De Miguel et al.   NATURE

Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells

(2021) Daniel Franjic et al.   NEURON

Impact of neurodegenerative diseases on human adult hippocampal neurogenesis

(2021) J. Terreros-Roncal et al.   SCIENCE

CD4 + T cells contribute to neurodegeneration in Lewy body dementia

(2021) David Gate et al.   SCIENCE

Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging

(2020) Shuai Ma et al.   CELL

Defining the Adult Neural Stem Cell Niche Proteome Identifies Key Regulators of Adult Neurogenesis

(2020) Jacob Kjell et al.   Cell Stem Cell

Aging-associated decrease in the histone acetyltransferase KAT6B is linked to altered hematopoietic stem cell differentiation

(2020) Eraj Shafiq Khokhar et al.   EXPERIMENTAL HEMATOLOGY

Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease

(2020) David Gate et al.   NATURE

Single-cell analysis of olfactory neurogenesis and differentiation in adult humans

(2020) Michael A. Durante et al.   NATURE NEUROSCIENCE

The aging skin microenvironment dictates stem cell behavior

(2020) Yejing Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Aging-induced IL27Ra Signaling Impairs Hematopoietic Stem Cells

(2020) Hanqing He et al.   BLOOD

Extreme disruption of heterochromatin is required for accelerated haematopoietic aging

(2020) Christine R Keenan et al.   BLOOD

Aging induces aberrant state transition kinetics in murine muscle stem cells

(2020) Jacob C. Kimmel et al.   DEVELOPMENT

Differentiation Drives Widespread Rewiring of the Neural Stem Cell Chaperone Network

(2020) Willianne I.M. Vonk et al.   MOLECULAR CELL

The evolutionary dynamics and fitness landscape of clonal hematopoiesis

(2020) Caroline J. Watson et al.   SCIENCE

Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells

(2020) Tapash Jay Sarkar et al.   Nature Communications

Region-Specific Proteome Changes of the Intestinal Epithelium during Aging and Dietary Restriction

(2020) Nadja Gebert et al.   Cell Reports

The Autonomic Nervous System Pulls the Strings to Coordinate Circadian HSC Functions

(2020) Andrés García-García et al.   Frontiers in Immunology

The aged hematopoietic system promotes hippocampal‐dependent cognitive decline

(2020) Lucas K. Smith et al.   AGING CELL

CD8 + T cells are increased in the subventricular zone with physiological and pathological aging

(2020) Manuel Moreno‐Valladares et al.   AGING CELL

Distinct Spatiotemporally Dynamic Wnt-Secreting Niches Regulate Proximal Airway Regeneration and Aging

(2020) Cody J. Aros et al.   Cell Stem Cell

Aging and Rejuvenation of Neural Stem Cells and Their Niches

(2020) Paloma Navarro Negredo et al.   Cell Stem Cell

Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion

(2020) Ayala Tovy et al.   Cell Stem Cell

Proliferation: Driver of HSC aging phenotypes?

(2020) Yanai Hagai et al.   MECHANISMS OF AGEING AND DEVELOPMENT

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

(2020)   NATURE

Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain

(2020) Alana M. Horowitz et al.   SCIENCE

Glycogen accumulation, central carbon metabolism, and aging of hematopoietic stem and progenitor cells

(2020) Laura Poisa-Beiro et al.   Scientific Reports

Dissecting Murine Muscle Stem Cell Aging through Regeneration Using Integrative Genomic Analysis

(2020) Anna Shcherbina et al.   Cell Reports

Blood extracellular vesicles from healthy individuals regulate hematopoietic stem cells as humans age

(2020) Isabelle Grenier‐Pleau et al.   AGING CELL

Stem cell therapy for muscular dystrophies

(2020) Stefano Biressi et al.   JOURNAL OF CLINICAL INVESTIGATION

FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age

(2020) Laura García-Prat et al.   NATURE CELL BIOLOGY

Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation

(2020) Charles W. White et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing

(2020) Simona Valletta et al.   Nature Communications

In Vivo Reprogramming Ameliorates Aging Features in Dentate Gyrus Cells and Improves Memory in Mice

(2020) Alberto Rodríguez-Matellán et al.   Stem Cell Reports

Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging

(2020) Denis A. Mogilenko et al.   IMMUNITY

Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche

(2020) Wakako Kuribayashi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nociceptive nerves regulate haematopoietic stem cell mobilization

(2020) Xin Gao et al.   NATURE

Reprogramming to recover youthful epigenetic information and restore vision

(2020) Yuancheng Lu et al.   NATURE

NAD+ metabolism and its roles in cellular processes during ageing

(2020) Anthony J. Covarrubias et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Machine Learning of Hematopoietic Stem Cell Divisions from Paired Daughter Cell Expression Profiles Reveals Effects of Aging on Self-Renewal

(2020) Fumio Arai et al.   Cell Systems

UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes

(2020) Yasuyuki Sera et al.   BLOOD

Anti-human CD117 antibody-mediated bone marrow niche clearance in non-human primates and humanized NSG mice

(2019) Hye-Sook Kwon et al.   BLOOD

Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging

(2019) Hanzhi Luo et al.   Cell Reports

Recalibrating the Relevance of Adult Neurogenesis

(2019) Jason S. Snyder   TRENDS IN NEUROSCIENCES

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

(2019) Elena P. Moreno-Jiménez et al.   NATURE MEDICINE

Transforming growth factor-beta renders ageing microglia inhibitory to oligodendrocyte generation by CNS progenitors

(2019) Roey Baror et al.   GLIA

The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance

(2019) Nicola Vannini et al.   Cell Stem Cell

EGFR-Aurka Signaling Rescues Polarity and Regeneration Defects in Dystrophin-Deficient Muscle Stem Cells by Increasing Asymmetric Divisions

(2019) Yu Xin Wang et al.   Cell Stem Cell

Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors

(2019) Laura Lukjanenko et al.   Cell Stem Cell

Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain

(2019) Georgios Kalamakis et al.   CELL

NAD + supplementation rejuvenates aged gut adult stem cells

(2019) Masaki Igarashi et al.   AGING CELL

Phenotypical and functional heterogeneity of neural stem cells in the aged hippocampus

(2019) Soraya Martín‐Suárez et al.   AGING CELL

Lineage Tracing Reveals a Subset of Reserve Muscle Stem Cells Capable of Clonal Expansion under Stress

(2019) Annarita Scaramozza et al.   Cell Stem Cell

Spatial chromatin organization and gene regulation at the nuclear lamina

(2019) Isabel Guerreiro et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Stem cell competition orchestrates skin homeostasis and ageing

(2019) Nan Liu et al.   NATURE

Engineering a haematopoietic stem cell niche by revitalizing mesenchymal stromal cells

(2019) Fumio Nakahara et al.   NATURE CELL BIOLOGY

Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1

(2019) Hanadie Yousef et al.   NATURE MEDICINE

Mesenchymal Stromal Cells Are Required for Regeneration and Homeostatic Maintenance of Skeletal Muscle

(2019) Michael N. Wosczyna et al.   Cell Reports

FOXO3 directly regulates an autophagy network to functionally regulate proteostasis in adult neural stem cells

(2019) Amanda J. Audesse et al.   PLoS Genetics

BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis

(2019) Patrick-Simon Welz et al.   CELL

Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging

(2019) Ya-Hsuan Ho et al.   Cell Stem Cell

Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium

(2019) Nalle Pentinmikko et al.   NATURE

Single-cell analysis reveals T cell infiltration in old neurogenic niches

(2019) Ben W. Dulken et al.   NATURE

The transcription factor Slug represses p16Ink4a and regulates murine muscle stem cell aging

(2019) Pei Zhu et al.   Nature Communications

Glucose Metabolism Drives Histone Acetylation Landscape Transitions that Dictate Muscle Stem Cell Function

(2019) Nora Yucel et al.   Cell Reports

Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium

(2019) Kayla M. Gross et al.   Cell Reports

Daily light and darkness onset and circadian rhythms metabolically synchronize hematopoietic stem cell differentiation and maintenance: The role of bone marrow norepinephrine, tumor necrosis factor, and melatonin cycles

(2019) Karin Golan et al.   EXPERIMENTAL HEMATOLOGY

Transcription Factor-Directed Re-wiring of Chromatin Architecture for Somatic Cell Nuclear Reprogramming toward trans-Differentiation

(2019) Alessandra Dall’Agnese et al.   MOLECULAR CELL

Niche stiffness underlies the ageing of central nervous system progenitor cells

(2019) Michael Segel et al.   NATURE

Single-cell transcriptomic profiling of the aging mouse brain

(2019) Methodios Ximerakis et al.   NATURE NEUROSCIENCE

Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells

(2019) Björn Neumann et al.   Cell Stem Cell

Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain

(2019) Elizabeth G. Wheatley et al.   CURRENT BIOLOGY

The landscape of somatic mutation in normal colorectal epithelial cells

(2019) Henry Lee-Six et al.   NATURE

Haematopoietic stem cells in perisinusoidal niches are protected from ageing

(2019) Mehmet Saçma et al.   NATURE CELL BIOLOGY

Clonal hematopoiesis in human aging and disease

(2019) Siddhartha Jaiswal et al.   SCIENCE

Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells

(2019) Irene Hernando-Herraez et al.   Nature Communications

Stem cell-based therapies for Duchenne muscular dystrophy

(2019) Congshan Sun et al.   EXPERIMENTAL NEUROLOGY

The impact of aging on primate hematopoiesis as interrogated by clonal tracking

(2018) Kyung-Rok Yu et al.   BLOOD

Aged murine hematopoietic stem cells drive aging-associated immune remodeling

(2018) Hanna Leins et al.   BLOOD

NAD + Intermediates: The Biology and Therapeutic Potential of NMN and NR

(2018) Jun Yoshino et al.   Cell Metabolism

Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment

(2018) Ryo Yamamoto et al.   Cell Stem Cell

Muscle Stem Cells Exhibit Distinct Clonal Dynamics in Response to Tissue Repair and Homeostatic Aging

(2018) Matthew T. Tierney et al.   Cell Stem Cell

Epithelial Sodium Channel Regulates Adult Neural Stem Cell Proliferation in a Flow-Dependent Manner

(2018) David Petrik et al.   Cell Stem Cell

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging

(2018) Maria M. Mihaylova et al.   Cell Stem Cell

Human Hippocampal Neurogenesis Persists throughout Aging

(2018) Maura Boldrini et al.   Cell Stem Cell

Human Adult Neurogenesis: Evidence and Remaining Questions

(2018) Gerd Kempermann et al.   Cell Stem Cell

Adult Neurogenesis Is Sustained by Symmetric Self-Renewal and Differentiation

(2018) Kirsten Obernier et al.   Cell Stem Cell

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults

(2018) Shawn F. Sorrells et al.   NATURE

Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage

(2018) Paula Gutierrez-Martinez et al.   NATURE CELL BIOLOGY

Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche

(2018) Maria Maryanovich et al.   NATURE MEDICINE

Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging

(2018) Dena S. Leeman et al.   SCIENCE

Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M

(2018) Srinath C. Sampath et al.   Nature Communications

Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo

(2018) Mira Jeong et al.   Cell Reports

Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain

(2018) Geraldine Gontier et al.   Cell Reports

The AMPK/p27 Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells

(2018) James P. White et al.   Stem Cell Reports

Impaired Notch Signaling Leads to a Decrease in p53 Activity and Mitotic Catastrophe in Aged Muscle Stem Cells

(2018) Ling Liu et al.   Cell Stem Cell

Distinct metabolic states govern skeletal muscle stem cell fates during prenatal and postnatal myogenesis

(2018) Francesca Pala et al.   JOURNAL OF CELL SCIENCE

FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis

(2018) Iris Schäffner et al.   NEURON

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model

(2018) Se Hoon Choi et al.   SCIENCE

Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline

(2018) Marco L. Hennrich et al.   Nature Communications

Human neural stem cell transplantation improves cognition in a murine model of Alzheimer’s disease

(2018) Lisa M. McGinley et al.   Scientific Reports

Dual cholinergic signals regulate daily migration of hematopoietic stem cells and leukocytes

(2018) Andrés García-García et al.   BLOOD

Turning back time with emerging rejuvenation strategies

(2018) Salah Mahmoudi et al.   NATURE CELL BIOLOGY

Somatic mutant clones colonize the human esophagus with age

(2018) Iñigo Martincorena et al.   SCIENCE

Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli Are Altered with Age

(2018) Mati Mann et al.   Cell Reports

Increasing Neural Stem Cell Division Asymmetry and Quiescence Are Predicted to Contribute to the Age-Related Decline in Neurogenesis

(2018) Lisa Bast et al.   Cell Reports

Murine HSCs contribute actively to native hematopoiesis but with reduced differentiation capacity upon aging

(2018) Petter Säwen et al.   eLife

Heterogeneous Expression of SDF1 Retains Actively Proliferating Neural Progenitors in the Capillary Compartment of the Niche

(2018) Chang Zhu et al.   Stem Cell Reports

Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions

(2017) Amelie V. Guitart et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autophagy maintains the metabolism and function of young and old stem cells

(2017) Theodore T. Ho et al.   NATURE

Human umbilical cord plasma proteins revitalize hippocampal function in aged mice

(2017) Joseph M. Castellano et al.   NATURE

The diversity and disparity of the glial scar

(2017) Katrina L. Adams et al.   NATURE NEUROSCIENCE

Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis

(2017) Ruth Beckervordersandforth et al.   NEURON

Hypothalamic regulation of regionally distinct adult neural stem cells and neurogenesis

(2017) Alex Paul et al.   SCIENCE

A Single-Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche

(2017) Benedetta Artegiani et al.   Cell Reports

Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration

(2017) Wenxuan Liu et al.   eLife

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

(2016) Alejandro Ocampo et al.   CELL

Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML

(2016) Rishi V. Puram et al.   CELL

Why NAD + Declines during Aging: It’s Destroyed

(2016) Michael B. Schultz et al.   Cell Metabolism

Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging

(2016) Duozhuang Tang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

Tissue-specific mutation accumulation in human adult stem cells during life

(2016) Francis Blokzijl et al.   NATURE

Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing

(2016) Navdeep S. Chandel et al.   NATURE CELL BIOLOGY

3K3A–activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice

(2016) Yaoming Wang et al.   NATURE MEDICINE

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

(2016) H. Zhang et al.   SCIENCE

Hematopoietic stem cell transplantation in immunocompetent hosts without radiation or chemotherapy

(2016) Akanksha Chhabra et al.   Science Translational Medicine

A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood

(2016) Justin Rebo et al.   Nature Communications

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

(2015) Sebastian Brandhorst et al.   Cell Metabolism

Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits

(2015) P. Darrell Neufer et al.   Cell Metabolism

Aberrant Lipid Metabolism in the Forebrain Niche Suppresses Adult Neural Stem Cell Proliferation in an Animal Model of Alzheimer’s Disease

(2015) Laura K. Hamilton et al.   Cell Stem Cell

The NAD+-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells

(2015) James G. Ryall et al.   Cell Stem Cell

Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division

(2015) Nicolas A Dumont et al.   NATURE MEDICINE

Stem cells and healthy aging

(2015) M. A. Goodell et al.   SCIENCE

High burden and pervasive positive selection of somatic mutations in normal human skin

(2015) I. Martincorena et al.   SCIENCE

Neural stem cell transplantation at critical period improves learning and memory through restoring synaptic impairment in Alzheimer’s disease mouse model

(2015) J A Kim et al.   Cell Death & Disease

Numb is required to prevent p53-dependent senescence following skeletal muscle injury

(2015) Isabelle Le Roux et al.   Nature Communications

Exposure to a youthful circulation rejuvenates bone repair through modulation of β-catenin

(2015) Gurpreet S. Baht et al.   Nature Communications

Bystander Effect Fuels Human Induced Pluripotent Stem Cell-Derived Neural Stem Cells to Quickly Attenuate Early Stage Neurological Deficits After Stroke

(2015) Auston Eckert et al.   Stem Cells Translational Medicine

TRPV1 Pain Receptors Regulate Longevity and Metabolism by Neuropeptide Signaling

(2014) Céline E. Riera et al.   CELL

Testosterone is essential for skeletal muscle growth in aged mice in a heterochronic parabiosis model

(2014) Indranil Sinha et al.   CELL AND TISSUE RESEARCH

Epigenomic Profiling of Young and Aged HSCs Reveals Concerted Changes during Aging that Reinforce Self-Renewal

(2014) Deqiang Sun et al.   Cell Stem Cell

Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation

(2014) Ann H Tang et al.   EMBO JOURNAL

Geriatric muscle stem cells switch reversible quiescence into senescence

(2014) Pedro Sousa-Victor et al.   NATURE

Stem cell aging: mechanisms, regulators and therapeutic opportunities

(2014) Juhyun Oh et al.   NATURE MEDICINE

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

(2014) Saul A Villeda et al.   NATURE MEDICINE

Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia

(2014) Christopher S Fry et al.   NATURE MEDICINE

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

(2014) Giulio Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Aging-induced type I interferon response at the choroid plexus negatively affects brain function

(2014) K. Baruch et al.   SCIENCE

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

(2014) L. Katsimpardi et al.   SCIENCE

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

Human neural stem cells rapidly ameliorate symptomatic inflammation in early-stage ischemic-reperfusion cerebral injury

(2014) Lei Huang et al.   Stem Cell Research & Therapy

FOXO3 Promotes Quiescence in Adult Muscle Stem Cells during the Process of Self-Renewal

(2014) Suchitra D. Gopinath et al.   Stem Cell Reports

Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity

(2013) Michael J. Conboy et al.   AGING CELL

Systemic Regulation of the Age-Related Decline of Pancreatic β-Cell Replication

(2013) Seth J. Salpeter et al.   DIABETES

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Reprogramming in vivo produces teratomas and iPS cells with totipotency features

(2013) María Abad et al.   NATURE

Chromatin Modifications as Determinants of Muscle Stem Cell Quiescence and Chronological Aging

(2013) Ling Liu et al.   Cell Reports

Self-Renewing Human Bone Marrow Mesenspheres Promote Hematopoietic Stem Cell Expansion

(2013) Joan Isern et al.   Cell Reports

Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing

(2012) A. V. Ergen et al.   BLOOD

Conditional TRF1 knockout in the hematopoietic compartment leads to bone marrow failure and recapitulates clinical features of dyskeratosis congenita

(2012) F. Beier et al.   BLOOD

Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock

(2012) Thomas A. Rando et al.   CELL

A Subpopulation of Adult Skeletal Muscle Stem Cells Retains All Template DNA Strands after Cell Division

(2012) Pierre Rocheteau et al.   CELL

Rejuvenation of Regeneration in the Aging Central Nervous System

(2012) Julia M. Ruckh et al.   Cell Stem Cell

Reprogramming development and aging: cell differentiation as a malleable process

(2012) Juan Carlos Izpisua Belmonte   CURRENT OPINION IN CELL BIOLOGY

Aging and reprogramming: a two-way street

(2012) Salah Mahmoudi et al.   CURRENT OPINION IN CELL BIOLOGY

The aged niche disrupts muscle stem cell quiescence

(2012) Joe V. Chakkalakal et al.   NATURE

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Honoring Clive McCay and 75 Years of Calorie Restriction Research

(2010) Roger B. McDonald et al.   JOURNAL OF NUTRITION

FoxOs Cooperatively Regulate Diverse Pathways Governing Neural Stem Cell Homeostasis

(2009) Ji-hye Paik et al.   Cell Stem Cell

FoxO3 Regulates Neural Stem Cell Homeostasis

(2009) Valérie M. Renault et al.   Cell Stem Cell

Forebrain neurogenesis after focal Ischemic and traumatic brain injury

(2009) Steven G. Kernie et al.   NEUROBIOLOGY OF DISEASE

Foxo3 Is Essential for the Regulation of Ataxia Telangiectasia Mutated and Oxidative Stress-mediated Homeostasis of Hematopoietic Stem Cells

(2008) Safak Yalcin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY