Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer’s disease

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Spatial transcriptomics at subspot resolution with BayesSpace

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Neurotoxic reactive astrocytes induce cell death via saturated lipids

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Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

(2020) Yingyue Zhou et al.   NATURE MEDICINE

Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration

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Depletion of LncRNA NEAT1 Rescues Mitochondrial Dysfunction Through NEDD4L-Dependent PINK1 Degradation in Animal Models of Alzheimer’s Disease

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Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

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CD49f Is a Novel Marker of Functional and Reactive Human iPSC-Derived Astrocytes

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Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model

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Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease

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Dual-Specificity Phosphatases in Neuroblastoma Cell Growth and Differentiation

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Single-cell transcriptomic analysis of Alzheimer’s disease

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Comprehensive Integration of Single-Cell Data

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ADAMTS13 maintains cerebrovascular integrity to ameliorate Alzheimer-like pathology

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A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain

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Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy

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Blood transcriptomic biomarker as a surrogate of ischemic brain gene expression

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Fast, sensitive and accurate integration of single-cell data with Harmony

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A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation

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Brain cell type–specific enhancer–promoter interactome maps and disease-risk association

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Astrocyte molecular signatures in Huntington’s disease

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Orchestrating single-cell analysis with Bioconductor

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Novel Phosphodiesterase Inhibitors for Cognitive Improvement in Alzheimer’s Disease

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A general and flexible method for signal extraction from single-cell RNA-seq data

(2018) Davide Risso et al.   Nature Communications

The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain

(2018) Matthew M. Boisvert et al.   Cell Reports

SALM/Lrfn Family Synaptic Adhesion Molecules

(2018) Eunkyung Lie et al.   Frontiers in Molecular Neuroscience

The Emerging Role of Mechanics in Synapse Formation and Plasticity

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Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer’s disease

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ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

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Astrocytic neuroligins control astrocyte morphogenesis and synaptogenesis

(2017) Jeff A. Stogsdill et al.   NATURE

Neurotoxic reactive astrocytes are induced by activated microglia

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Heparan sulfate proteoglycans and heparanases in Alzheimer's disease: current outlook and potential therapeutic targets

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Involvement of Astrocytes in Alzheimer’s Disease from a Neuroinflammatory and Oxidative Stress Perspective

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White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network

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Role of P-glycoprotein in mediating rivastigmine effect on amyloid-β brain load and related pathology in Alzheimer's disease mouse model

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Complex heatmaps reveal patterns and correlations in multidimensional genomic data

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The Cellular Phase of Alzheimer’s Disease

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The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting

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Selective vulnerability in neurodegeneration: insights from clinical variants of Alzheimer's disease

(2016) Niklas Mattsson et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

(2016) H. Lian et al.   JOURNAL OF NEUROSCIENCE

A rapid and cost-effective method for genotyping apolipoprotein E gene polymorphism

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Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism

(2016) Aiman S. Saab et al.   NEURON

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

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Complement and microglia mediate early synapse loss in Alzheimer mouse models

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Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

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Galantamine attenuates amyloid-β deposition and astrocyte activation in APP/PS1 transgenic mice

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The promise of stem cells in the therapy of Alzheimer’s disease

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Targeted quantitative analysis of synaptic proteins in Alzheimer’s disease brain

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Inhibition of phosphodiesterase-4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination

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White matter abnormalities associated with Alzheimer’s disease and mild cognitive impairment: a critical review of MRI studies

(2013) Marcia Radanovic et al.   Expert Review of Neurotherapeutics

APOE-ε2 and APOE-ε4 Correlate With Increased Amyloid Accumulation in Cerebral Vasculature

(2013) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

MAP Kinase Phosphatase 1 (MKP-1/DUSP1) Is Neuroprotective in Huntington's Disease via Additive Effects of JNK and p38 Inhibition

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Mitogen-Activated Protein Kinase Phosphatase (MKP)-1 as a Neuroprotective Agent: Promotion of the Morphological Development of Midbrain Dopaminergic Neurons

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Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease

(2012) Azeb Tadesse Argaw et al.   JOURNAL OF CLINICAL INVESTIGATION

Genomic Analysis of Reactive Astrogliosis

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Evidence for Astrocytosis in Prodromal Alzheimer Disease Provided by 11C-Deuterium-L-Deprenyl: A Multitracer PET Paradigm Combining 11C-Pittsburgh Compound B and 18F-FDG

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Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

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Fiji: an open-source platform for biological-image analysis

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Cerebral amyloid angiopathy in the elderly

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Cholesterol Level and Statin Use in Alzheimer Disease

(2011) Nina E. Shepardson   ARCHIVES OF NEUROLOGY

Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study

(2011) Melissa E Murray et al.   LANCET NEUROLOGY

Cholesterol: A Novel Regulatory Role in Myelin Formation

(2011) Gesine Saher et al.   NEUROSCIENTIST

High Degree of Heterogeneity in Alzheimer's Disease Progression Patterns

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N-cadherin Regulates p38 MAPK Signaling via Association with JNK-associated Leucine Zipper Protein

(2010) Koichi Ando et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DISC1 regulates N-cadherin and β1-integrin expression in neurons

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Polyamine pathway contributes to the pathogenesis of Parkinson disease

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(2009) Steffen Durinck et al.   Nature Protocols

Biochemical and physiological function of stearoyl-CoA desaturase

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Proteomics-Determined Differences in the Concanavalin-A-Fractionated Proteome of Hippocampus and Inferior Parietal Lobule in Subjects with Alzheimer’s Disease and Mild Cognitive Impairment: Implications for Progression of AD

(2008) Joshua B. Owen et al.   JOURNAL OF PROTEOME RESEARCH

Mitogen-Activated Protein (MAP) Kinase/MAP Kinase Phosphatase Regulation: Roles in Cell Growth, Death, and Cancer

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Phosphodiesterase inhibitors

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