NAD + supplementation rejuvenates aged gut adult stem cells

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging

(2018) Maria M. Mihaylova et al.   Cell Stem Cell

Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells

(2017) Kodandaramireddy Nalapareddy et al.   Cell Reports

mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction

(2016) Masaki Igarashi et al.   CELL

Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing

(2016) Navdeep S. Chandel et al.   NATURE CELL BIOLOGY

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

(2016) H. Zhang et al.   SCIENCE

A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

(2015) M. Mohrin et al.   SCIENCE

The non-muscle-myosin-II heavy chain Myh9 mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells

(2015) Bing Zhao et al.   Nature Communications

Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

(2014) Evandro Fei Fang et al.   CELL

Lgr proteins in epithelial stem cell biology

(2013) N. Barker et al.   DEVELOPMENT

Calorie restriction and sirtuins revisited

(2013) L. Guarente   GENES & DEVELOPMENT

Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny

(2013) Xiaolei Yin et al.   NATURE METHODS

SIRT3 Reverses Aging-Associated Degeneration

(2013) Katharine Brown et al.   Cell Reports

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

(2012) Carles Cantó et al.   Cell Metabolism

Identifying the Stem Cell of the Intestinal Crypt: Strategies and Pitfalls

(2012) Nick Barker et al.   Cell Stem Cell

Ageing as a Risk Factor for Disease

(2012) Teresa Niccoli et al.   CURRENT BIOLOGY

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

(2012) Ömer H. Yilmaz et al.   NATURE

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell

(2012) Shiro Yui et al.   NATURE MEDICINE

Paneth Cells in Intestinal Homeostasis and Tissue Injury

(2012) Sabrina Roth et al.   PLoS One

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

(2011) Jun Yoshino et al.   Cell Metabolism

Redox Regulation by Keap1 and Nrf2 Controls Intestinal Stem Cell Proliferation in Drosophila

(2011) Christine E. Hochmuth et al.   Cell Stem Cell

Maintaining Tissue Homeostasis: Dynamic Control of Somatic Stem Cell Activity

(2011) Benoit Biteau et al.   Cell Stem Cell

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate

(2009) Laurens G. van der Flier et al.   CELL

OLFM4 Is a Robust Marker for Stem Cells in Human Intestine and Marks a Subset of Colorectal Cancer Cells

(2009) Laurens G. van der Flier et al.   GASTROENTEROLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor

(2008) Na-Hyun Choi et al.   AGING CELL

JNK Activity in Somatic Stem Cells Causes Loss of Tissue Homeostasis in the Aging Drosophila Gut

(2008) Benoît Biteau et al.   Cell Stem Cell