UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes

LEFTY2 alleviates hepatic stellate cell activation and liver fibrosis by regulating the TGF-β1/Smad3 pathway

(2020) Ya-ru Yang et al.   MOLECULAR IMMUNOLOGY

The Histone Demethylase UTX/KDM6A in Cancer: Progress and Puzzles

(2019) Wolfgang A. Schulz et al.   INTERNATIONAL JOURNAL OF CANCER

UTX Mutations in Human Cancer

(2019) Lu Wang et al.   CANCER CELL

Loss of KDM6A confers drug resistance in acute myeloid leukemia

(2019) Sophie M. Stief et al.   LEUKEMIA

Epigenetic silencing of miR-125b is required for normal B-cell development

(2018) Guideng Li et al.   BLOOD

Loss of KDM6A Activates Super-Enhancers to Induce Gender-Specific Squamous-like Pancreatic Cancer and Confers Sensitivity to BET Inhibitors

(2018) Jaclyn Andricovich et al.   CANCER CELL

Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States

(2018) Mark P. Mattson et al.   Cell Metabolism

Canonical TGF-β Signaling Pathway Represses Human NK Cell Metabolism

(2018) Vanessa Zaiatz-Bittencourt et al.   JOURNAL OF IMMUNOLOGY

Utx loss causes myeloid transformation

(2018) Liting Zheng et al.   LEUKEMIA

UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs

(2018) Malgorzata Gozdecka et al.   NATURE GENETICS

Transforming Growth Factor-β and Interleukin-10 Synergistically Regulate Humoral Immunity via Modulating Metabolic Signals

(2018) Toshihiko Komai et al.   Frontiers in Immunology

X chromosome protects against bladder cancer in females via aKDM6A-dependent epigenetic mechanism

(2018) Satoshi Kaneko et al.   Science Advances

HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis

(2018) Yuqing Sun et al.   CANCER CELL

ChIP‐Atlas: a data‐mining suite powered by full integration of public ChIP‐seq data

(2018) Shinya Oki et al.   EMBO REPORTS

Copy number profiling of adult relapsed B-cell precursor acute lymphoblastic leukemia reveals potential leukemia progression mechanisms

(2017) Jordi Ribera et al.   GENES CHROMOSOMES & CANCER

The epigenetic basis of hematopoietic stem cell aging

(2017) Ashley Kramer et al.   SEMINARS IN HEMATOLOGY

The role of sirtuins in aging and age-related diseases

(2016) Mateusz Wątroba et al.   Advances in Medical Sciences

Epigenetic Mechanisms of Longevity and Aging

(2016) Payel Sen et al.   CELL

SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling

(2016) Hu Wang et al.   Cell Stem Cell

Blood stem cells: from beginning to end

(2016) Anna Bigas et al.   DEVELOPMENT

UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia

(2016) Aissa Benyoucef et al.   GENES & DEVELOPMENT

UTX demethylase activity is required for satellite cell–mediated muscle regeneration

(2016) Hervé Faralli et al.   JOURNAL OF CLINICAL INVESTIGATION

The loss of Ezh2 drives the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition

(2016) Goro Sashida et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals

(2016) Simon Schwörer et al.   NATURE

Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition

(2016) Anja F Hohmann et al.   Nature Chemical Biology

Synergistic action of master transcription factors controls epithelial-to-mesenchymal transition

(2016) Hongyuan Chang et al.   NUCLEIC ACIDS RESEARCH

DNA Damage Response in Hematopoietic Stem Cell Ageing

(2016) Tangliang Li et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner

(2015) M. Mochizuki-Kashio et al.   BLOOD

TGF-  signaling in the control of hematopoietic stem cells

(2015) U. Blank et al.   BLOOD

Epigenetic Control of Stem Cell Potential during Homeostasis, Aging, and Disease

(2015) Isabel Beerman et al.   Cell Stem Cell

Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects

(2015) Jerome Mertens et al.   Cell Stem Cell

PRC2 mediated H3K27 methylations in cellular identity and cancer

(2015) Eric Conway et al.   CURRENT OPINION IN CELL BIOLOGY

Skin aging, gene expression and calcium

(2015) Mark Rinnerthaler et al.   EXPERIMENTAL GERONTOLOGY

Oxidative Stress, Bone Marrow Failure, and Genome Instability in Hematopoietic Stem Cells

(2015) Christine Richardson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The chromatin remodeler Brg1 activates enhancer repertoires to establish B cell identity and modulate cell growth

(2015) Claudia Bossen et al.   NATURE IMMUNOLOGY

Stem cells and healthy aging

(2015) M. A. Goodell et al.   SCIENCE

A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

(2015) M. Mohrin et al.   SCIENCE

Emerging Strategies to Enhance Homing and Engraftment of Hematopoietic Stem Cells

(2015) Mariusz Z. Ratajczak et al.   Stem Cell Reviews and Reports

The cancer COMPASS: navigating the functions of MLL complexes in cancer

(2015) David J. Ford et al.   Cancer Genetics

Emerging Strategies to Enhance Homing and Engraftment of Hematopoietic Stem Cells

(2015) Mariusz Z. Ratajczak et al.   Stem Cell Reviews and Reports

The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia

(2014) Joni Van der Meulen et al.   BLOOD

The role of EVI1 in myeloid malignancies

(2014) Carolyn Glass et al.   BLOOD CELLS MOLECULES AND DISEASES

Epigenomic Profiling of Young and Aged HSCs Reveals Concerted Changes during Aging that Reinforce Self-Renewal

(2014) Deqiang Sun et al.   Cell Stem Cell

The H3K27me3 demethylase UTX in normal development and disease

(2014) Joni Van der Meulen et al.   Epigenetics

Human UTY(KDM6C) Is a Male-specificNϵ-Methyl Lysyl Demethylase

(2014) Louise J. Walport et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

(2014) Johanna Flach et al.   NATURE

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

(2014) Panagiotis Ntziachristos et al.   NATURE

KDM6 Demethylase Independent Loss of Histone H3 Lysine 27 Trimethylation during Early Embryonic Development

(2014) Karl B. Shpargel et al.   PLoS Genetics

Concise Review: Hematopoietic Stem Cell Aging and the Prospects for Rejuvenation

(2014) Martin Wahlestedt et al.   Stem Cells Translational Medicine

Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells

(2014) Pauline Rimmelé et al.   Stem Cell Reports

CD41 expression marks myeloid-biased adult hematopoietic stem cells and increases with age

(2013) C. Gekas et al.   BLOOD

The histone demethylase UTX regulates stem cell migration and hematopoiesis

(2013) S. Thieme et al.   BLOOD

Sox4 Is a Key Oncogenic Target in C/EBPα Mutant Acute Myeloid Leukemia

(2013) Hong Zhang et al.   CANCER CELL

Haploinsufficiency of SAMD9L, an Endosome Fusion Facilitator, Causes Myeloid Malignancies in Mice Mimicking Human Diseases with Monosomy 7

(2013) Akiko Nagamachi et al.   CANCER CELL

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation

(2013) J. Shi et al.   GENES & DEVELOPMENT

Utx Is Required for Proper Induction of Ectoderm and Mesoderm during Differentiation of Embryonic Stem Cells

(2013) Cristina Morales Torres et al.   PLoS One

Drosophila UTX Coordinates with p53 to Regulate ku80 Expression in Response to DNA Damage

(2013) Chengwan Zhang et al.   PLoS One

UTX coordinates steroid hormone-mediated autophagy and cell death

(2013) Donna Denton et al.   Nature Communications

Chromatin Modifications as Determinants of Muscle Stem Cell Quiescence and Chronological Aging

(2013) Ling Liu et al.   Cell Reports

SIRT3 Reverses Aging-Associated Degeneration

(2013) Katharine Brown et al.   Cell Reports

The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis

(2012) Ali Shilatifard   Annual Review of Biochemistry

Sox4 cooperates with CREB in myeloid transformation

(2012) S. Sandoval et al.   BLOOD

Targeting hedgehog in hematologic malignancy

(2012) D. A. Irvine et al.   BLOOD

Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway

(2012) Wei Jiang et al.   CELL RESEARCH

Sequencing histone-modifying enzymes identifies UTX mutations in acute lymphoblastic leukemia

(2012) B G Mar et al.   LEUKEMIA

Novel mutations target distinct subgroups of medulloblastoma

(2012) Giles Robinson et al.   NATURE

Dissecting the genomic complexity underlying medulloblastoma

(2012) David T. W. Jones et al.   NATURE

The mutational landscape of lethal castration-resistant prostate cancer

(2012) Catherine S. Grasso et al.   NATURE

The role of SRY-related HMG box transcription factor 4 (SOX4) in tumorigenesis and metastasis: friend or foe?

(2012) S J Vervoort et al.   ONCOGENE

UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity

(2012) C. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner

(2012) G. G. Welstead et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The C. elegans H3K27 Demethylase UTX-1 Is Essential for Normal Development, Independent of Its Enzymatic Activity

(2012) Julien Vandamme et al.   PLoS Genetics

UTX and UTY Demonstrate Histone Demethylase-Independent Function in Mouse Embryonic Development

(2012) Karl B. Shpargel et al.   PLoS Genetics

UTX, a Histone H3-Lysine 27 Demethylase, Acts as a Critical Switch to Activate the Cardiac Developmental Program

(2011) Seunghee Lee et al.   DEVELOPMENTAL CELL

Dynamic BRG1 Recruitment during T Helper Differentiation and Activation Reveals Distal Regulatory Elements

(2011) S. De et al.   MOLECULAR AND CELLULAR BIOLOGY

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

(2011) Ignacio Varela et al.   NATURE

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

(2011) Yaoting Gui et al.   NATURE GENETICS

UTX mediates demethylation of H3K27me3 at muscle-specific genes during myogenesis

(2010) Shayesta Seenundun et al.   EMBO JOURNAL

The histone demethylase UTX enables RB-dependent cell fate control

(2010) J. K. Wang et al.   GENES & DEVELOPMENT

Jmjd3 and UTX Play a Demethylase-Independent Role in Chromatin Remodeling to Regulate T-Box Family Member-Dependent Gene Expression

(2010) Sara A. Miller et al.   MOLECULAR CELL

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

(2009) Gijs van Haaften et al.   NATURE GENETICS

Mechanisms of Polycomb gene silencing: knowns and unknowns

(2009) Jeffrey A. Simon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

It's T-ALL about Notch

(2008) R M Demarest et al.   ONCOGENE