Turning back time with emerging rejuvenation strategies

The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon

(2018) Luigi Fontana et al.   AGING CELL

Resveratrol, an Nrf2 activator, ameliorates aging-related progressive renal injury

(2018) Eun Nim Kim et al.   Aging-US

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging

(2018) Dena S. Leeman et al.   SCIENCE

Hallmarks of Cellular Senescence

(2018) Alejandra Hernandez-Segura et al.   TRENDS IN CELL BIOLOGY

Supraphysiologic Administration of GDF11 Induces Cachexia in Part by Upregulating GDF15

(2018) Juli E. Jones et al.   Cell Reports

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration

(2017) Birgit Ritschka et al.   GENES & DEVELOPMENT

Endothelial transplantation rejuvenates aged hematopoietic stem cell function

(2017) Michael G. Poulos et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy maintains the metabolism and function of young and old stem cells

(2017) Theodore T. Ho et al.   NATURE

Human umbilical cord plasma proteins revitalize hippocampal function in aged mice

(2017) Joseph M. Castellano et al.   NATURE

Hypothalamic stem cells control ageing speed partly through exosomal miRNAs

(2017) Yalin Zhang et al.   NATURE

Targeting cellular senescence prevents age-related bone loss in mice

(2017) Joshua N Farr et al.   NATURE MEDICINE

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Ageing: Old bone removal

(2017) M. Teresa Villanueva   NATURE REVIEWS DRUG DISCOVERY

Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease

(2017) Min Wei et al.   Science Translational Medicine

The Fountain of Youth by Targeting Senescent Cells?

(2017) Peter L.J. de Keizer   TRENDS IN MOLECULAR MEDICINE

Identification of HSP90 inhibitors as a novel class of senolytics

(2017) Heike Fuhrmann-Stroissnigg et al.   Nature Communications

Cellular senescence drives age-dependent hepatic steatosis

(2017) Mikolaj Ogrodnik et al.   Nature Communications

Regulation of life span by the gut microbiota in the short-lived African turquoise killifish

(2017) Patrick Smith et al.   eLife

Short-term calorie restriction ameliorates genomewide, age-related alterations in DNA methylation

(2016) Chul Hong Kim et al.   AGING CELL

AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD+elevation

(2016) Xiaojuan Han et al.   AGING CELL

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

(2016) Carolyn M. Roos et al.   AGING CELL

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

(2016) Yi Zhu et al.   AGING CELL

Bursts of Reprogramming: A Path to Extend Lifespan?

(2016) Salah Mahmoudi et al.   CELL

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

(2016) Alejandro Ocampo et al.   CELL

Metformin as a Tool to Target Aging

(2016) Nir Barzilai et al.   Cell Metabolism

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Influence of donor age on induced pluripotent stem cells

(2016) Valentina Lo Sardo et al.   NATURE BIOTECHNOLOGY

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

(2016) Michael S. Bonkowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protective effects of resveratrol on aging-induced cognitive impairment in rats

(2016) Semil Selcen Gocmez et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo

(2016) Lluc Mosteiro et al.   SCIENCE

A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood

(2016) Justin Rebo et al.   Nature Communications

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

(2016) Reut Yosef et al.   Nature Communications

GDF11 administration does not extend lifespan in a mouse model of premature aging

(2016) Sandra Freitas-Rodríguez et al.   Oncotarget

D-beta-hydroxybutyrate extends lifespan in C. elegans

(2016) Clare Edwards et al.   Aging-US

Increased gene dosage ofInk4/Arfandp53delays age-associated central nervous system functional decline

(2015) Estefania Carrasco-Garcia et al.   AGING CELL

The rejuvenating effect of pregnancy on muscle regeneration

(2015) Tal Falick Michaeli et al.   AGING CELL

Interventions to Slow Aging in Humans: Are We Ready?

(2015) Valter D. Longo et al.   AGING CELL

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Systemic Problems: A perspective on stem cell aging and rejuvenation

(2015) Irina M. Conboy et al.   Aging-US

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

(2015) Sebastian Brandhorst et al.   Cell Metabolism

GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration

(2015) Marc A. Egerman et al.   Cell Metabolism

Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects

(2015) Jerome Mertens et al.   Cell Stem Cell

Circulating Growth Differentiation Factor 11/8 Levels Decline With AgeNovelty and Significance

(2015) Tommaso Poggioli et al.   CIRCULATION RESEARCH

GDF11 Does Not Rescue Aging-Related Pathological HypertrophyNovelty and Significance

(2015) Shavonn C. Smith et al.   CIRCULATION RESEARCH

NF-κB activation impairs somatic cell reprogramming in ageing

(2015) Clara Soria-Valles et al.   NATURE CELL BIOLOGY

Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming

(2015) Yasong Wu et al.   NATURE CELL BIOLOGY

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

(2015) Nicolás Herranz et al.   NATURE CELL BIOLOGY

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis

(2015) Lucas K Smith et al.   NATURE MEDICINE

Epigenetic regulation of ageing: linking environmental inputs to genomic stability

(2015) Bérénice A. Benayoun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

(2015) Ming Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal

(2015) Hanadie Yousef et al.   Oncotarget

Environmental Temperature Differentially Modulates C. elegans Longevity through a Thermosensitive TRP Channel

(2015) Bi Zhang et al.   Cell Reports

Targeting senescent cells enhances adipogenesis and metabolic function in old age

(2015) Ming Xu et al.   eLife

Metformin Acts on Two Different Molecular Pathways to Enhance Adult Neural Precursor Proliferation/Self-Renewal and Differentiation

(2015) Michael Fatt et al.   Stem Cell Reports

Insulin-like growth factor-1 regulates the SIRT1-p53 pathway in cellular senescence

(2014) Duc Tran et al.   AGING CELL

Metformin and Cancer Risk and Mortality: A Systematic Review and Meta-analysis Taking into Account Biases and Confounders

(2014) S. Gandini et al.   Cancer Prevention Research

The Search for Antiaging Interventions: From Elixirs to Fasting Regimens

(2014) Rafael de Cabo et al.   CELL

Premature Termination of Reprogramming In Vivo Leads to Cancer Development through Altered Epigenetic Regulation

(2014) Kotaro Ohnishi et al.   CELL

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle

(2014) Isabel Beerman et al.   Cell Stem Cell

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Geriatric muscle stem cells switch reversible quiescence into senescence

(2014) Pedro Sousa-Victor et al.   NATURE

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

(2014) Saul A Villeda et al.   NATURE MEDICINE

Influence of a ketogenic diet, fish-oil, and calorie restriction on plasma metabolites and lipids in C57BL/6J mice

(2014) Joshua J Meidenbauer et al.   Nutrition & Metabolism

Aging-induced type I interferon response at the choroid plexus negatively affects brain function

(2014) K. Baruch et al.   SCIENCE

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

(2014) L. Katsimpardi et al.   SCIENCE

Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle

(2014) M. Sinha et al.   SCIENCE

mTOR inhibition improves immune function in the elderly

(2014) J. B. Mannick et al.   Science Translational Medicine

Cell Senescence Abrogates the Therapeutic Potential of Human Mesenchymal Stem Cells in the Lethal Endotoxemia Model

(2014) Juan Carlos Sepúlveda et al.   STEM CELLS

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration

(2014) Christian Elabd et al.   Nature Communications

Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity

(2013) Michael J. Conboy et al.   AGING CELL

Autophagy and senescence

(2013) David A. Gewirtz   Autophagy

Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model

(2013) Christin E. Burd et al.   CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

Epigenetics of Reprogramming to Induced Pluripotency

(2013) Bernadett Papp et al.   CELL

Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling

(2013) Edward Owusu-Ansah et al.   CELL

Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy

(2013) Francesco S. Loffredo et al.   CELL

Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

(2013) Yun-Hee Youm et al.   Cell Metabolism

Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

(2013) Justine D. Miller et al.   Cell Stem Cell

Chronic resistance training activates autophagy and reduces apoptosis of muscle cells by modulating IGF-1 and its receptors, Akt/mTOR and Akt/FOXO3a signaling in aged rats

(2013) Li Luo et al.   EXPERIMENTAL GERONTOLOGY

Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway

(2013) Qin-Li Wan et al.   EXPERIMENTAL GERONTOLOGY

Rapamycin extends murine lifespan but has limited effects on aging

(2013) Frauke Neff et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Reprogramming in vivo produces teratomas and iPS cells with totipotency features

(2013) María Abad et al.   NATURE

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

(2013) Guo Zhang et al.   NATURE

Early role for IL-6 signalling during generation of induced pluripotent stem cells revealed by heterokaryon RNA-Seq

(2013) Jennifer J. Brady et al.   NATURE CELL BIOLOGY

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

Increased dosage ofInk4/Arfprotects against glucose intolerance and insulin resistance associated with aging

(2012) Herminia González-Navarro et al.   AGING CELL

Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts

(2012) David Gems et al.   Annual Review of Physiology

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock

(2012) Thomas A. Rando et al.   CELL

Activation of Innate Immunity Is Required for Efficient Nuclear Reprogramming

(2012) Jieun Lee et al.   CELL

A Molecular Roadmap of Reprogramming Somatic Cells into iPS Cells

(2012) Jose M. Polo et al.   CELL

Short-Term Calorie Restriction Enhances Skeletal Muscle Stem Cell Function

(2012) Massimiliano Cerletti et al.   Cell Stem Cell

mTOR Inhibition Prevents Epithelial Stem Cell Senescence and Protects from Radiation-Induced Mucositis

(2012) Ramiro Iglesias-Bartolome et al.   Cell Stem Cell

Rejuvenation of Regeneration in the Aging Central Nervous System

(2012) Julia M. Ruckh et al.   Cell Stem Cell

Aging and reprogramming: a two-way street

(2012) Salah Mahmoudi et al.   CURRENT OPINION IN CELL BIOLOGY

Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer

(2012) Bruno Bernardes de Jesus et al.   EMBO Molecular Medicine

Independence of Repressive Histone Marks and Chromatin Compaction during Senescent Heterochromatic Layer Formation

(2012) Tamir Chandra et al.   MOLECULAR CELL

Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates

(2012) Gregory Hannum et al.   MOLECULAR CELL

Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

(2012) Mason A. Israel et al.   NATURE

Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells

(2011) Taotao Chen et al.   AGING CELL

Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

(2011) S. M. Schoenwaelder et al.   BLOOD

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Rapamycin decelerates cellular senescence

(2011) Zoya N. Demidenko et al.   CELL CYCLE

Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state

(2011) L. Lapasset et al.   GENES & DEVELOPMENT

Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome

(2011) Guang-Hui Liu et al.   NATURE

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Mitochondrial-Associated Cell Death Mechanisms Are Reset to an Embryonic-Like State in Aged Donor-Derived iPS Cells Harboring Chromosomal Aberrations

(2011) Alessandro Prigione et al.   PLoS One

Short-term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress

(2010) Catarina Rippe et al.   AGING CELL

Resveratrol Inhibits mTOR Signaling by Promoting the Interaction between mTOR and DEPTOR

(2010) Meilian Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

(2010) Wyndham H Wilson et al.   LANCET ONCOLOGY

Upregulation of DNA Methyltransferase-Mediated Gene Silencing, Anchorage-Independent Growth, and Migration of Colon Cancer Cells by Interleukin-6

(2010) E. Foran et al.   MOLECULAR CANCER RESEARCH

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Rejuvenation After Induced Pluripotency

(2010) Steven T. Suhr et al.   PLoS One

Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise

(2010) G. Valdez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression ofp16INK4ain peripheral blood T-cells is a biomarker of human aging

(2009) Yan Liu et al.   AGING CELL

Anti-aging activity of theInk4/Arflocus

(2009) Ander Matheu et al.   AGING CELL

Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain

(2009) Jeffrey M. Copeland et al.   CURRENT BIOLOGY

Senescence impairs successful reprogramming to pluripotent stem cells

(2009) A. Banito et al.   GENES & DEVELOPMENT

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

The Ink4/Arf locus is a barrier for iPS cell reprogramming

(2009) Han Li et al.   NATURE

Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

(2008) Randy  Strong et al.   AGING CELL

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

(2008) Kevin J. Pearson et al.   Cell Metabolism

A Temporal Switch from Notch to Wnt Signaling in Muscle Stem Cells Is Necessary for Normal Adult Myogenesis

(2008) Andrew S. Brack et al.   Cell Stem Cell

10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes

(2008) Rury R. Holman et al.   NEW ENGLAND JOURNAL OF MEDICINE