Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions

Adult hematopoietic stem cells lacking Hif-1  self-renew normally

(2016) M. Vukovic et al.   BLOOD

Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis

(2016) Jaclyn Andricovich et al.   JOURNAL OF CLINICAL INVESTIGATION

The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal in mice

(2015) M. H. Stewart et al.   BLOOD

Regulatory network control of blood stem cells

(2015) B. Gottgens   BLOOD

Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance

(2015) Milica Vukovic et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias

(2015) Vincent-Philippe Lavallée et al.   NATURE GENETICS

Highly proliferative primitive fetal liver hematopoietic stem cells are fueled by oxidative metabolic pathways

(2015) Javed K. Manesia et al.   Stem Cell Research

Fumarate induces redox-dependent senescence by modifying glutathione metabolism

(2015) Liang Zheng et al.   Nature Communications

HIF-1  can act as a tumor suppressor gene in murine acute myeloid leukemia

(2014) T. Velasco-Hernandez et al.   BLOOD

Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis

(2014) Ying-Hua Wang et al.   CELL

The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress

(2014) Peter van Galen et al.   NATURE

Haematopoietic stem cells require a highly regulated protein synthesis rate

(2014) Robert A. J. Signer et al.   NATURE

Statistical detection of quantitative protein biomarkers provides insights into signaling networks deregulated in acute myeloid leukemia

(2014) Laura L. Elo et al.   PROTEOMICS

Dppa5 Improves Hematopoietic Stem Cell Activity by Reducing Endoplasmic Reticulum Stress

(2014) Kenichi Miharada et al.   Cell Reports

Hif-2  is not essential for cell-autonomous hematopoietic stem cell maintenance

(2013) A. V. Guitart et al.   BLOOD

HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress

(2013) R. P. Singh et al.   BLOOD

SDH Mutations Establish a Hypermethylator Phenotype in Paraganglioma

(2013) Eric Letouzé et al.   CANCER CELL

Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells

(2013) Keiyo Takubo et al.   Cell Stem Cell

Metabolic Regulation by the Mitochondrial Phosphatase PTPMT1 Is Required for Hematopoietic Stem Cell Differentiation

(2013) Wen-Mei Yu et al.   Cell Stem Cell

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

(2013) Eleni D. Lagadinou et al.   Cell Stem Cell

Spare mitochondrial respiratory capacity permits human adipocytes to maintain ATP homeostasis under hypoglycemic conditions

(2013) Michaela Keuper et al.   FASEB JOURNAL

Germline mutations in FH confer predisposition to malignant pheochromocytomas and paragangliomas

(2013) Luis Jaime Castro-Vega et al.   HUMAN MOLECULAR GENETICS

Oncometabolites: linking altered metabolism with cancer

(2013) Ming Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling

(2013) Lucas B. Sullivan et al.   MOLECULAR CELL

Fumarase Deficiency in Dichorionic Diamniotic Twins

(2013) Simone Tregoning et al.   Twin Research and Human Genetics

A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia

(2013) Julie Adam et al.   Cell Reports

Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency

(2013) Nicola Ternette et al.   Cell Reports

Fumarate Is Cardioprotective via Activation of the Nrf2 Antioxidant Pathway

(2012) Houman Ashrafian et al.   Cell Metabolism

Inhibition of  -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

(2012) M. Xiao et al.   GENES & DEVELOPMENT

Cells Lacking the Fumarase Tumor Suppressor Are Protected from Apoptosis through a Hypoxia-Inducible Factor-Independent, AMPK-Dependent Mechanism

(2012) C. Bardella et al.   MOLECULAR AND CELLULAR BIOLOGY

Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

(2011) Julie Adam et al.   CANCER CELL

Functional Crosstalk between Bmi1 and MLL/Hoxa9 Axis in Establishment of Normal Hematopoietic and Leukemic Stem Cells

(2011) Lan-Lan Smith et al.   Cell Stem Cell

Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche

(2011) Toshio Suda et al.   Cell Stem Cell

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

(2011) Gerritje J.W. van der Windt et al.   IMMUNITY

The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance

(2011) Monika Mortensen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status

(2011) Chiara Bardella et al.   JOURNAL OF PATHOLOGY

β-Catenin Mediates the Establishment and Drug Resistance of MLL Leukemic Stem Cells

(2010) Jenny Yeung et al.   CANCER CELL

The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

(2010) Tugba Simsek et al.   Cell Stem Cell

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

(2010) Keiyo Takubo et al.   Cell Stem Cell

Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism

(2010) Linda O'Flaherty et al.   HUMAN MOLECULAR GENETICS

The Wnt/ -Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML

(2010) Y. Wang et al.   SCIENCE

Cited2 Is an Essential Regulator of Adult Hematopoietic Stem Cells

(2009) Kamil R. Kranc et al.   Cell Stem Cell

Mouse models of human AML accurately predict chemotherapy response

(2009) J. Zuber et al.   GENES & DEVELOPMENT

Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure

(2009) Sung W. Choi et al.   JOURNAL OF NEUROCHEMISTRY

AML1-ETO9a is correlated with C-KIT overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-M2

(2009) B Jiao et al.   LEUKEMIA

The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases

(2008) I. L. Weissman et al.   BLOOD

Advances in measuring cellular bioenergetics using extracellular flux

(2008) David A. Ferrick et al.   DRUG DISCOVERY TODAY