Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging

Autophagy maintains the metabolism and function of young and old stem cells

(2017) Theodore T. Ho et al.   NATURE

Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth

(2017) Chiara Di Malta et al.   SCIENCE

Single-Cell Transcriptomic Analysis Defines Heterogeneity and Transcriptional Dynamics in the Adult Neural Stem Cell Lineage

(2017) Ben W. Dulken et al.   Cell Reports

Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior

(2016) J. Tiago Gonçalves et al.   CELL

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

Near-optimal probabilistic RNA-seq quantification

(2016) Nicolas L Bray et al.   NATURE BIOTECHNOLOGY

The Adult Ventricular–Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis

(2016) Daniel A. Lim et al.   Cold Spring Harbor Perspectives in Biology

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

(2015) Sebastian Brandhorst et al.   Cell Metabolism

Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury

(2015) Enric Llorens-Bobadilla et al.   Cell Stem Cell

Robust enumeration of cell subsets from tissue expression profiles

(2015) Aaron M Newman et al.   NATURE METHODS

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation

(2014) Ann H Tang et al.   EMBO JOURNAL

Age-related changes in astrocytic and ependymal cells of the subventricular zone

(2014) Vivian Capilla-Gonzalez et al.   GLIA

Prospective Identification and Purification of Quiescent Adult Neural Stem Cells from Their In Vivo Niche

(2014) Paolo Codega et al.   NEURON

Proteostasis impairment in protein-misfolding and -aggregation diseases

(2014) Mark S. Hipp et al.   TRENDS IN CELL BIOLOGY

Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion

(2013) Jing Zhou et al.   CELL RESEARCH

Epigenomic enhancer annotation reveals a key role for NFIX in neural stem cell quiescence

(2013) B. Martynoga et al.   GENES & DEVELOPMENT

Rapalogs and mTOR inhibitors as anti-aging therapeutics

(2013) Dudley W. Lamming et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular Diversity Subdivides the Adult Forebrain Neural Stem Cell Population

(2013) Claudio Giachino et al.   STEM CELLS

Proteostasis and aging of stem cells

(2013) David Vilchez et al.   TRENDS IN CELL BIOLOGY

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

(2013) Louis R. Lapierre et al.   Nature Communications

The sva package for removing batch effects and other unwanted variation in high-throughput experiments

(2012) Jeffrey T. Leek et al.   BIOINFORMATICS

Staying alive

(2012) James R. Valcourt et al.   CELL CYCLE

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways

(2011) Michela Palmieri et al.   HUMAN MOLECULAR GENETICS

Novel Cell- and Tissue-Based Assays for Detecting Misfolded and Aggregated Protein Accumulation Within Aggresomes and Inclusion Bodies

(2010) Dee Shen et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise

(2010) G. Valdez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel classification of quiescent and transit amplifying adult neural stem cells by surface and metabolic markers permits a defined simultaneous isolation

(2010) Franz-Josef Obermair et al.   Stem Cell Research

Integration of Clearance Mechanisms: The Proteasome and Autophagy

(2010) E. Wong et al.   Cold Spring Harbor Perspectives in Biology

Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

(2010) Della C. David et al.   PLOS BIOLOGY

A scaling normalization method for differential expression analysis of RNA-seq data

(2010) Mark D Robinson et al.   GENOME BIOLOGY

A general modular framework for gene set enrichment analysis

(2009) Marit Ackermann et al.   BMC BIOINFORMATICS

A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins

(2009) Simon Alberti et al.   CELL

FoxO3 Regulates Neural Stem Cell Homeostasis

(2009) Valérie M. Renault et al.   Cell Stem Cell

Forebrain neurogenesis after focal Ischemic and traumatic brain injury

(2009) Steven G. Kernie et al.   NEUROBIOLOGY OF DISEASE

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE