Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling

The ketogenic diet preserves skeletal muscle with aging in mice

(2021) Marita A. Wallace et al.   AGING CELL

p53 β-hydroxybutyrylation attenuates p53 activity

(2019) Kun Liu et al.   Cell Death & Disease

Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses

(2019) Motoyoshi Nagai et al.   CELL

The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction

(2019) Nicholas Collins et al.   CELL

Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool

(2019) Stefan Jordan et al.   CELL

Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet

(2019) Chia-Wei Cheng et al.   CELL

Graded regulation of cellular quiescence depth between proliferation and senescence by a lysosomal dimmer switch

(2019) Kotaro Fujimaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem cell-based therapies for Duchenne muscular dystrophy

(2019) Congshan Sun et al.   EXPERIMENTAL NEUROLOGY

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging

(2018) Maria M. Mihaylova et al.   Cell Stem Cell

Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension

(2018) James H. Catterson et al.   CURRENT BIOLOGY

Targeting p53-dependent stem cell loss for intestinal chemoprotection

(2018) Brian J. Leibowitz et al.   Science Translational Medicine

Calorie Restriction Governs Intestinal Epithelial Regeneration through Cell-Autonomous Regulation of mTORC1 in Reserve Stem Cells

(2018) Maryam Yousefi et al.   Stem Cell Reports

Impaired Notch Signaling Leads to a Decrease in p53 Activity and Mitotic Catastrophe in Aged Muscle Stem Cells

(2018) Ling Liu et al.   Cell Stem Cell

β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4

(2018) Young-min Han et al.   MOLECULAR CELL

Liver p53 is stabilized upon starvation and required for amino acid catabolism and gluconeogenesis

(2017) Andreas Prokesch et al.   FASEB JOURNAL

The ketone body metabolite β-hydroxybutyrate induces an antidepression-associated ramification of microglia via HDACs inhibition-triggered Akt-small RhoGTPase activation

(2017) Chao Huang et al.   GLIA

Ketone bodies mimic the life span extending properties of caloric restriction

(2017) Richard L. Veech et al.   IUBMB LIFE

Staufen1 inhibits MyoD translation to actively maintain muscle stem cell quiescence

(2017) Antoine de Morrée et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pten is necessary for the quiescence and maintenance of adult muscle stem cells

(2017) Feng Yue et al.   Nature Communications

Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss

(2017) Marco Quarta et al.   Nature Communications

The effect of calorie restriction on mouse skeletal muscle is sex, strain and time-dependent

(2017) Luisa Boldrin et al.   Scientific Reports

Controlling Depth of Cellular Quiescence by an Rb-E2F Network Switch

(2017) Jungeun Sarah Kwon et al.   Cell Reports

Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode

(2016) Donglai Wang et al.   NATURE

An artificial niche preserves the quiescence of muscle stem cells and enhances their therapeutic efficacy

(2016) Marco Quarta et al.   NATURE BIOTECHNOLOGY

Inhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent mTOR repression

(2016) Cyndi R. Morales et al.   Science Signaling

p53 Regulates Progenitor Cell Quiescence and Differentiation in the Airway

(2016) Alicia M. McConnell et al.   Cell Reports

Inhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent mTOR repression

(2016) Cyndi R. Morales et al.   Science Signaling

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

(2015) Sebastian Brandhorst et al.   Cell Metabolism

Acetoacetate Accelerates Muscle Regeneration and Ameliorates Muscular Dystrophy in Mice

(2015) Xiaoting Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ProLuCID: An improved SEQUEST-like algorithm with enhanced sensitivity and specificity

(2015) T. Xu et al.   Journal of Proteomics

A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity

(2015) Eric Ravussin et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Isolation of skeletal muscle stem cells by fluorescence-activated cell sorting

(2015) Ling Liu et al.   Nature Protocols

Ex Vivo Expansion and In Vivo Self-Renewal of Human Muscle Stem Cells

(2015) Gregory W. Charville et al.   Stem Cell Reports

Suppression of histone deacetylation promotes the differentiation of human pluripotent stem cells towards neural progenitor cells

(2014) Juan Yang et al.   BMC BIOLOGY

Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression

(2014) Chia-Wei Cheng et al.   Cell Stem Cell

mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert

(2014) Joseph T. Rodgers et al.   NATURE

Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia

(2014) Christopher S Fry et al.   NATURE MEDICINE

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

(2014) Ricki J. Colman et al.   Nature Communications

Specific Acetylation of p53 by HDAC Inhibition Prevents DNA Damage-Induced Apoptosis in Neurons

(2013) C. Brochier et al.   JOURNAL OF NEUROSCIENCE

Molecular regulation of stem cell quiescence

(2013) Tom H. Cheung et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ketone bodies as signaling metabolites

(2013) John C. Newman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Successful adaptation to ketosis by mice with tissue-specific deficiency of ketone body oxidation

(2012) David G. Cotter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A Subpopulation of Adult Skeletal Muscle Stem Cells Retains All Template DNA Strands after Cell Division

(2012) Pierre Rocheteau et al.   CELL

Short-Term Calorie Restriction Enhances Skeletal Muscle Stem Cell Function

(2012) Massimiliano Cerletti et al.   Cell Stem Cell

Constitutive Notch Activation Upregulates Pax7 and Promotes the Self-Renewal of Skeletal Muscle Satellite Cells

(2012) Y. Wen et al.   MOLECULAR AND CELLULAR BIOLOGY

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle regeneration

(2011) C. Lepper et al.   DEVELOPMENT

Low Level of c-Kit Expression Marks Deeply Quiescent Murine Hematopoietic Stem Cells

(2011) Yoshikazu Matsuoka et al.   STEM CELLS

A Critical Requirement for Notch Signaling in Maintenance of the Quiescent Skeletal Muscle Stem Cell State

(2011) Philippos Mourikis et al.   STEM CELLS

Notch Signaling Is Necessary to Maintain Quiescence in Adult Muscle Stem Cells

(2011) Christopher R.R. Bjornson et al.   STEM CELLS

p73 regulates maintenance of neural stem cell

(2010) Massimiliano Agostini et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metabolic Control of Vesicular Glutamate Transport and Release

(2010) Narinobu Juge et al.   NEURON

Absence of CD34 on Murine Skeletal Muscle Satellite Cells Marks a Reversible State of Activation during Acute Injury

(2010) Nicholas Ieronimakis et al.   PLoS One

Short-term dietary restriction and fasting precondition against ischemia reperfusion injury in mice

(2009) James R. Mitchell et al.   AGING CELL

p53 Regulates Hematopoietic Stem Cell Quiescence

(2009) Yan Liu et al.   Cell Stem Cell

Biomarker system for studying muscle, stem cells, and cancer in vivo

(2009) Koichi Nishijo et al.   FASEB JOURNAL

Strategies to promote donor cell survival: Combining preconditioning approach with stem cell transplantation

(2008) Husnain Kh Haider et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Self-renewal and expansion of single transplanted muscle stem cells

(2008) Alessandra Sacco et al.   NATURE

Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy

(2008) L. Raffaghello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA