Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

(2019) Elena P. Moreno-Jiménez et al.   NATURE MEDICINE

Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer’s Disease Patients

(2019) Matthew K. Tobin et al.   Cell Stem Cell

SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells

(2019) Christopher D. Wiley et al.   Cell Reports

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults

(2018) Shawn F. Sorrells et al.   NATURE

Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain

(2018) Geraldine Gontier et al.   Cell Reports

Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer’s disease

(2018) Sarah K. Baker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model

(2018) Se Hoon Choi et al.   SCIENCE

Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease

(2018) Stephan Müller et al.   Alzheimers & Dementia

Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris

(2018) et al.   NATURE

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Gpr158 mediates osteocalcin’s regulation of cognition

(2017) Lori Khrimian et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Plasminogen Deficiency Delays the Onset and Protects from Demyelination and Paralysis in Autoimmune Neuroinflammatory Disease

(2017) Maureen A. Shaw et al.   JOURNAL OF NEUROSCIENCE

Human umbilical cord plasma proteins revitalize hippocampal function in aged mice

(2017) Joseph M. Castellano et al.   NATURE

Continuous daily assessment of multiple sclerosis disability using remote step count monitoring

(2016) V. J. Block et al.   JOURNAL OF NEUROLOGY

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

(2016) Stefka Tyanova et al.   Nature Protocols

Quantitative proteomic analyses of mammary organoids reveals distinct signatures after exposure to environmental chemicals

(2016) Katherine E. Williams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GPI-AP release in cellular, developmental, and reproductive biology

(2015) Yoshitaka Fujihara et al.   JOURNAL OF LIPID RESEARCH

Life Extension Factor Klotho Prevents Mortality and Enhances Cognition in hAPP Transgenic Mice

(2015) D. B. Dubal et al.   JOURNAL OF NEUROSCIENCE

β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis

(2015) Lucas K Smith et al.   NATURE MEDICINE

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Exposure to a youthful circulation rejuvenates bone repair through modulation of β-catenin

(2015) Gurpreet S. Baht et al.   Nature Communications

APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction

(2015) Ileana Soto et al.   PLOS BIOLOGY

Vascular hippocampal plasticity after aerobic exercise in older adults

(2014) A Maass et al.   MOLECULAR PSYCHIATRY

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

(2014) Saul A Villeda et al.   NATURE MEDICINE

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

(2014) L. Katsimpardi et al.   SCIENCE

Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle

(2014) M. Sinha et al.   SCIENCE

Transient Expression of Proteins by Hydrodynamic Gene Delivery in Mice

(2014) Daniella Kovacsics et al.   Jove-Journal of Visualized Experiments

Daily exercise improves memory, stimulates hippocampal neurogenesis and modulates immune and neuroimmune cytokines in aging rats

(2012) Rachel B. Speisman et al.   BRAIN BEHAVIOR AND IMMUNITY

Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes

(2012) Atsuhiko T. Naito et al.   CELL

Exercise counteracts declining hippocampal function in aging and Alzheimer's disease

(2012) Karlie A. Intlekofer et al.   NEUROBIOLOGY OF DISEASE

The Urokinase Receptor System, A Key Regulator at the Intersection between Inflammation, Immunity, and Coagulation

(2011) Mario Del Rosso et al.   CURRENT PHARMACEUTICAL DESIGN

How many steps/day are enough? For older adults and special populations

(2011) Catrine Tudor-Locke et al.   International Journal of Behavioral Nutrition and Physical Activity

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Influence of late-life exposure to environmental enrichment or exercise on hippocampal function and CA1 senescent physiology

(2011) Ashok Kumar et al.   NEUROBIOLOGY OF AGING

Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology

(2011) Karim Belarbi et al.   NEUROBIOLOGY OF DISEASE

Exercise training increases size of hippocampus and improves memory

(2011) K. I. Erickson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physical Exercise, Aging, and Mild Cognitive Impairment

(2010) Yonas E. Geda et al.   ARCHIVES OF NEUROLOGY

Quiescent and Active Hippocampal Neural Stem Cells with Distinct Morphologies Respond Selectively to Physiological and Pathological Stimuli and Aging

(2010) Sebastian Lugert et al.   Cell Stem Cell

Running enhances spatial pattern separation in mice

(2010) D. J. Creer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The urokinase receptor: Focused cell surface proteolysis, cell adhesion and signaling

(2009) Francesco Blasi et al.   FEBS LETTERS

Practical Implementation of 2D HPLC Scheme with Accurate Peptide Retention Prediction in Both Dimensions for High-Throughput Bottom-Up Proteomics

(2008) Ravi C. Dwivedi et al.   ANALYTICAL CHEMISTRY

Effect of Physical Activity on Cognitive Function in Older Adults at Risk for Alzheimer Disease

(2008) Nicola T. Lautenschlager et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Exercise enhances the proliferation of neural stem cells and neurite growth and survival of neuronal progenitor cells in dentate gyrus of middle-aged mice

(2008) Chih-Wei Wu et al.   JOURNAL OF APPLIED PHYSIOLOGY

Nonlinear Fitting Method for Determining Local False Discovery Rates from Decoy Database Searches

(2008) Wilfred H. Tang et al.   JOURNAL OF PROTEOME RESEARCH