Alpha-Synuclein Targeting Therapeutics for Parkinson's Disease and Related Synucleinopathies
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Title
Alpha-Synuclein Targeting Therapeutics for Parkinson's Disease and Related Synucleinopathies
Authors
Keywords
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Journal
Frontiers in Neurology
Volume 13, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2022-05-09
DOI
10.3389/fneur.2022.852003
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Note: Only part of the references are listed.- Alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy
- (2022) Ivan Martinez-Valbuena et al. Translational Neurodegeneration
- Spermidine and Rapamycin Reveal Distinct Autophagy Flux Response and Cargo Receptor Clearance Profile
- (2021) Sholto de Wet et al. Cells
- Blood-brain barrier opening with focused ultrasound in Parkinson’s disease dementia
- (2021) Carmen Gasca-Salas et al. Nature Communications
- Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies
- (2021) Inês C. Brás et al. Cells
- α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson’s disease
- (2021) Tracy A. Cole et al. JCI Insight
- Therapeutic Agent Delivery Across the Blood–Brain Barrier Using Focused Ultrasound
- (2021) Dallan McMahon et al. Annual Review of Biomedical Engineering
- Reactive microglia enhance the transmission of exosomal alpha-synuclein via toll-like receptor 2
- (2021) Yun Xia et al. BRAIN
- Role of MicroRNAs, Aptamers in Neuroinflammation and Neurodegenerative Disorders
- (2021) Islauddin Khan et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- α‐Synuclein in Plasma‐Derived Extracellular Vesicles Is a Potential Biomarker of Parkinson's Disease
- (2021) Anne Stuendl et al. MOVEMENT DISORDERS
- Lentiviral mediated gene delivery as an effective therapeutic approach for Parkinson disease
- (2021) Violina Kakoty et al. NEUROSCIENCE LETTERS
- Non-viral Vectors in Gene Therapy: Recent Development, Challenges, and Prospects
- (2021) Hui Zu et al. AAPS Journal
- Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes
- (2021) Hannah Scheiblich et al. CELL
- Autophagy in major human diseases
- (2021) Daniel J Klionsky et al. EMBO JOURNAL
- LAG3 is not expressed in human and murine neurons and does not modulate α‐synucleinopathies
- (2021) Marc Emmenegger et al. EMBO Molecular Medicine
- Investigation of α-Synuclein Species in Plasma Exosomes and the Oligomeric and Phosphorylated α-Synuclein as Potential Peripheral Biomarker of Parkinson’s Disease
- (2021) Hengxing Zheng et al. NEUROSCIENCE
- Safety and Tolerability of Active Immunotherapy Targeting α-Synuclein with PD03A in Patients with Early Parkinson’s Disease: A Randomized, Placebo-Controlled, Phase 1 Study
- (2021) Werner Poewe et al. Journal of Parkinsons Disease
- Amyloid-β and α-Synuclein Immunotherapy: From Experimental Studies to Clinical Trials
- (2021) Jacqui Taryn Nimmo et al. Frontiers in Neuroscience
- Toward Development of Neuron Specific Transduction After Systemic Delivery of Viral Vectors
- (2021) Dylan J. Finneran et al. Frontiers in Neurology
- Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer’s disease alleviates amyloid-related pathologies in mice
- (2021) Yangyang Duan et al. Nature Biomedical Engineering
- Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies
- (2021) Kristiana Xhima et al. BRAIN
- Differentially targeted seeding reveals unique pathological alpha-synuclein propagation patterns
- (2021) Shady Rahayel et al. BRAIN
- Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans
- (2021) Kevin S. Chen et al. Molecular Neurodegeneration
- AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset
- (2021) David Goertsen et al. NATURE NEUROSCIENCE
- Rescue of α-synuclein aggregation in Parkinson’s patient neurons by synergistic enhancement of ER proteostasis and protein trafficking
- (2021) Iva Stojkovska et al. NEURON
- Preclinical pharmacology of glucosylceramide synthase inhibitor venglustat in a GBA-related synucleinopathy model
- (2021) Catherine Viel et al. Scientific Reports
- The Compound ATH434 Prevents Alpha-Synuclein Toxicity in a Murine Model of Multiple System Atrophy
- (2021) David I. Finkelstein et al. Journal of Parkinsons Disease
- Extensive frontal focused ultrasound mediated blood–brain barrier opening for the treatment of Alzheimer’s disease: a proof-of-concept study
- (2021) So Hee Park et al. Translational Neurodegeneration
- Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophy
- (2020) Mohammad Shahnawaz et al. NATURE
- Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA
- (2020) Peiyuan Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Blood-Brain Barrier and Delivery of Protein and Gene Therapeutics to Brain
- (2020) William M. Pardridge Frontiers in Aging Neuroscience
- Ambroxol for the Treatment of Patients With Parkinson Disease With and Without Glucocerebrosidase Gene Mutations
- (2020) Stephen Mullin et al. JAMA Neurology
- Focused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in a mouse model of Alzheimer’s disease
- (2020) K. Xhima et al. Science Advances
- Microglial exosomes facilitate α-synuclein transmission in Parkinson’s disease
- (2020) Min Guo et al. BRAIN
- A longitudinal study on α‐synuclein in plasma neuronal exosomes as a biomarker for Parkinson’s disease development and progression
- (2020) M. Niu et al. EUROPEAN JOURNAL OF NEUROLOGY
- Pharmacological inhibition and knockdown of O‐GlcNAcase reduces cellular internalization of α‐synuclein pre‐formed‐fibrils
- (2020) Omid Tavassoly et al. FEBS Journal
- Structures of α-synuclein filaments from multiple system atrophy
- (2020) Manuel Schweighauser et al. NATURE
- Identifying drugs with disease‐modifying potential in Parkinson's disease using artificial intelligence and pharmacoepidemiology
- (2020) Laura C. Maclagan et al. PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
- Noninvasive hippocampal blood−brain barrier opening in Alzheimer’s disease with focused ultrasound
- (2020) Ali R. Rezai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration
- (2020) Insup Choi et al. Nature Communications
- Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity
- (2020) Vijay Gupta et al. Scientific Reports
- Role of Connexins 30, 36, and 43 in Brain Tumors, Neurodegenerative Diseases, and Neuroprotection
- (2020) Oscar F. Sánchez et al. Cells
- Safety and immunogenicity of the α-synuclein active immunotherapeutic PD01A in patients with Parkinson's disease: a randomised, single-blinded, phase 1 trial
- (2020) Dieter Volc et al. LANCET NEUROLOGY
- Lymphocyte-Activation Gene 3 (LAG3) Protein as a Possible Therapeutic Target for Parkinson’s Disease: Molecular Mechanisms Connecting Neuroinflammation to α-Synuclein Spreading Pathology
- (2020) Efthalia Angelopoulou et al. Biology-Basel
- Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns
- (2020) David M Asher et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Blinded RT‐QuIC Analysis of α‐Synuclein Biomarker in Skin Tissue from Parkinson's Disease Patients
- (2020) Sireesha Manne et al. MOVEMENT DISORDERS
- A Phase 1 Randomized Trial of Specific Active α‐Synuclein Immunotherapies PD01A and PD03A in Multiple System Atrophy
- (2020) Wassilios G. Meissner et al. MOVEMENT DISORDERS
- Applications of focused ultrasound in the brain: from thermoablation to drug delivery
- (2020) Ying Meng et al. Nature Reviews Neurology
- CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease
- (2020) Nora Bengoa-Vergniory et al. Nature Communications
- Treating Parkinson’s Disease with Antibodies: Previous Studies and Future Directions
- (2020) Anne-Marie Castonguay et al. Journal of Parkinsons Disease
- Skin α-Synuclein Aggregation Seeding Activity as a Novel Biomarker for Parkinson Disease
- (2020) Zerui Wang et al. JAMA Neurology
- Anti-α-synuclein ASO delivered to monoamine neurons prevents α-synuclein accumulation in a Parkinson's disease-like mouse model and in monkeys
- (2020) Diana Alarcón-Arís et al. EBioMedicine
- PHP.B/eB Vectors Bring New Successes to Gene Therapy for Brain Diseases
- (2020) Robin Reynaud-Dulaurier et al. Frontiers in Bioengineering and Biotechnology
- Exosome-mediated delivery of antisense oligonucleotides targeting α-synuclein ameliorates the pathology in a mouse model of Parkinson's disease
- (2020) Jiaolong Yang et al. NEUROBIOLOGY OF DISEASE
- Using artificial intelligence to identify anti‐hypertensives as possible disease modifying agents in Parkinson's disease
- (2020) Naomi P. Visanji et al. PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
- Novel antibodies detect additional α-synuclein pathology in synucleinopathies: potential development for immunotherapy
- (2020) Jacqui T. Nimmo et al. Alzheimers Research & Therapy
- Current Status and Challenges Associated with CNS-Targeted Gene Delivery across the BBB
- (2020) Seigo Kimura et al. Pharmaceutics
- Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter
- (2020) Roxine Staats et al. Communications Chemistry
- Long-term RNAi knockdown of α-synuclein in the adult rat substantia nigra without neurodegeneration
- (2019) Alevtina Zharikov et al. NEUROBIOLOGY OF DISEASE
- α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson’s disease
- (2019) Paul M. Levine et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Novel Immunotherapeutic Approaches to Target Alpha-Synuclein and Related Neuroinflammation in Parkinson’s Disease
- (2019) Maria Zella et al. Cells
- Plant Extracts and Phytochemicals Targeting α-Synuclein Aggregation in Parkinson's Disease Models
- (2019) Hayate Javed et al. Frontiers in Pharmacology
- Microglia as modulators of exosomal alpha-synuclein transmission
- (2019) Yun Xia et al. Cell Death & Disease
- Intrinsically disordered proteins in synaptic vesicle trafficking and release
- (2019) David Snead et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Selective vulnerability in α-synucleinopathies
- (2019) Javier Alegre-Abarrategui et al. ACTA NEUROPATHOLOGICA
- Binding of α-synuclein oligomers to Cx32 facilitates protein uptake and transfer in neurons and oligodendrocytes
- (2019) Juan F. Reyes et al. ACTA NEUROPATHOLOGICA
- Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA)
- (2019) Philip Wing-Lok Ho et al. Autophagy
- Targeting α-Synuclein in Parkinson’s Disease: Progress Towards the Development of Disease-Modifying Therapeutics
- (2019) Daniel Savitt et al. DRUGS
- Connexin 43 hemichannels and pannexin‐1 channels contribute to the α‐synuclein‐induced dysfunction and death of astrocytes
- (2019) Esteban F. Díaz et al. GLIA
- Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson’s disease model
- (2019) Michal Wegrzynowicz et al. ACTA NEUROPATHOLOGICA
- Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes
- (2019) Sarah H. Shahmoradian et al. NATURE NEUROSCIENCE
- Systemic peptide mediated delivery of an siRNA targeting α-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy body disease
- (2019) Brian Spencer et al. NEUROBIOLOGY OF DISEASE
- Identification of N-linked glycans as specific mediators of neuronal uptake of acetylated α-Synuclein
- (2019) Melissa Birol et al. PLOS BIOLOGY
- Autophagy in Synucleinopathy: The Overwhelmed and Defective Machinery
- (2019) Marie-Laure Arotcarena et al. Cells
- Calling α-synuclein a prion is scientifically justifiable
- (2019) Joel C. Watts ACTA NEUROPATHOLOGICA
- Challenges of gene delivery to the central nervous system and the growing use of biomaterial vectors
- (2019) Devan L. Puhl et al. BRAIN RESEARCH BULLETIN
- Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies
- (2019) Harold G. Selnick et al. JOURNAL OF MEDICINAL CHEMISTRY
- Safety and efficacy of epigallocatechin gallate in multiple system atrophy (PROMESA): a randomised, double-blind, placebo-controlled trial
- (2019) Johannes Levin et al. LANCET NEUROLOGY
- Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology
- (2019) María Izco et al. MOLECULAR THERAPY
- Update of the MDS research criteria for prodromal Parkinson's disease
- (2019) Sebastian Heinzel et al. MOVEMENT DISORDERS
- Human NPCs can degrade α–syn fibrils and transfer them preferentially in a cell contact-dependent manner possibly through TNT-like structures
- (2019) Clara Grudina et al. NEUROBIOLOGY OF DISEASE
- Detection of alpha-synuclein aggregates in gastrointestinal biopsies by protein misfolding cyclic amplification
- (2019) Alexis Fenyi et al. NEUROBIOLOGY OF DISEASE
- Extracellular microvesicles-derived from microglia treated with unaggregated α-synuclein attenuate mitochondrial fission and toxicity-induced by Parkinsonian toxin MPP+
- (2019) Na Li et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The Wnt/Ca 2+ pathway is involved in interneuronal communication mediated by tunneling nanotubes
- (2019) Jessica Y Vargas et al. EMBO JOURNAL
- Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids
- (2019) Qin Huang et al. PLoS One
- First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound
- (2019) Agessandro Abrahao et al. Nature Communications
- Contribution of syndecans to cellular uptake and fibrillation of α-synuclein and tau
- (2019) Anett Hudák et al. Scientific Reports
- Targeting Microglial and Neuronal Toll-like Receptor 2 in Synucleinopathies
- (2019) Somin Kwon et al. Experimental Neurobiology
- α-Synuclein strains target distinct brain regions and cell types
- (2019) Angus Lau et al. NATURE NEUROSCIENCE
- Optimizing intracellular antibodies (intrabodies/nanobodies) to treat neurodegenerative disorders
- (2019) Anne Messer et al. NEUROBIOLOGY OF DISEASE
- Advances and considerations in AD tau-targeted immunotherapy
- (2019) Alice Bittar et al. NEUROBIOLOGY OF DISEASE
- Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo
- (2019) Darren J. Schofield et al. NEUROBIOLOGY OF DISEASE
- Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease
- (2019) Michael X. Henderson et al. NEUROBIOLOGY OF DISEASE
- Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein
- (2019) Leah K. Cuddy et al. NEURON
- Focused ultrasound enhanced intranasal delivery of brain derived neurotrophic factor produces neurorestorative effects in a Parkinson’s disease mouse model
- (2019) Robin Ji et al. Scientific Reports
- Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy
- (2019) Ricardo Guerrero-Ferreira et al. eLife
- Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine
- (2018) Michele Perni et al. ACS Chemical Biology
- The concept of alpha-synuclein as a prion-like protein: ten years after
- (2018) Jennifer A. Steiner et al. CELL AND TISSUE RESEARCH
- GBA-Associated Parkinson’s Disease and Other Synucleinopathies
- (2018) Ziv Gan-Or et al. Current Neurology and Neuroscience Reports
- Selective α-Synuclein Knockdown in Monoamine Neurons by Intranasal Oligonucleotide Delivery: Potential Therapy for Parkinson’s Disease
- (2018) Diana Alarcón-Arís et al. MOLECULAR THERAPY
- Neuroprotective effect of gold nanoparticles composites in Parkinson's disease model
- (2018) Kaikai Hu et al. Nanomedicine-Nanotechnology Biology and Medicine
- Repurposing drugs to treat l -DOPA-induced dyskinesia in Parkinson's disease
- (2018) Tom H. Johnston et al. NEUROPHARMACOLOGY
- Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound
- (2018) Nir Lipsman et al. Nature Communications
- Prion-like Propagation of α-Synuclein Is Regulated by the FcγRIIB-SHP-1/2 Signaling Pathway in Neurons
- (2018) Yu Ree Choi et al. Cell Reports
- Safety and Tolerability of Multiple Ascending Doses of PRX002/RG7935, an Anti–α-Synuclein Monoclonal Antibody, in Patients With Parkinson Disease
- (2018) Joseph Jankovic et al. JAMA Neurology
- Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent Toxicity
- (2018) Matthew J. Benskey et al. Frontiers in Molecular Neuroscience
- Import and Export of Misfolded α-Synuclein
- (2018) Lilia Rodriguez et al. Frontiers in Neuroscience
- Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease
- (2018) Géraldine Gelders et al. Journal of Immunology Research
- Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC
- (2018) Bradley R. Groveman et al. Acta Neuropathologica Communications
- β2-adrenoreceptor medications and risk of Parkinson disease
- (2018) Susan Searles Nielsen et al. ANNALS OF NEUROLOGY
- Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD
- (2018) Boris Kantor et al. MOLECULAR THERAPY
- Noninvasive delivery of an α-synuclein gene silencing vector with magnetic resonance-guided focused ultrasound
- (2018) Kristiana Xhima et al. MOVEMENT DISORDERS
- Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons
- (2018) Jordi Pujols et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel
- (2018) Binsen Li et al. Nature Communications
- The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson’s disease
- (2018) Diana L. Price et al. Scientific Reports
- Anle138b modulates α-synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy
- (2018) Antonio Heras-Garvin et al. MOVEMENT DISORDERS
- Therapeutic activation of autophagy by combined treatment with rapamycin and trehalose in a mouse MPTP-induced model of Parkinson's disease
- (2018) Alexander B. Pupyshev et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models
- (2018) Andreas Weihofen et al. NEUROBIOLOGY OF DISEASE
- Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies
- (2017) Richard J. Karpowicz et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes
- (2017) Jinar Rostami et al. JOURNAL OF NEUROSCIENCE
- Prying into the Prion Hypothesis for Parkinson's Disease
- (2017) Patrik Brundin et al. JOURNAL OF NEUROSCIENCE
- Epigallocatechin Gallate Has a Neurorescue Effect in a Mouse Model of Parkinson Disease
- (2017) Qi Xu et al. JOURNAL OF NUTRITION
- Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems
- (2017) Ken Y Chan et al. NATURE NEUROSCIENCE
- Selective neuronal vulnerability in Parkinson disease
- (2017) D. James Surmeier et al. NATURE REVIEWS NEUROSCIENCE
- Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy
- (2017) Omar El-Agnaf et al. NEUROBIOLOGY OF DISEASE
- A Molecular Tweezer Ameliorates Motor Deficits in Mice Overexpressing α-Synuclein
- (2017) Franziska Richter et al. Neurotherapeutics
- Preclinical development of a vaccine against oligomeric alpha-synuclein based on virus-like particles
- (2017) Marika Doucet et al. PLoS One
- A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
- (2017) Michele Perni et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Autophagic flux control in neurodegeneration: Progress and precision targeting—Where do we stand?
- (2017) Dumisile Lumkwana et al. PROGRESS IN NEUROBIOLOGY
- β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease
- (2017) Shuchi Mittal et al. SCIENCE
- Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates
- (2017) Peizhou Jiang et al. Scientific Reports
- Cell Biology and Pathophysiology of α-Synuclein
- (2017) Jacqueline Burré et al. Cold Spring Harbor Perspectives in Medicine
- Polyethylenimine Nanoparticle-Mediated siRNA Delivery to Reduce α-Synuclein Expression in a Model of Parkinson’s Disease
- (2017) Christin Helmschrodt et al. Molecular Therapy-Nucleic Acids
- Parkinson disease
- (2017) Werner Poewe et al. Nature Reviews Disease Primers
- Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy
- (2017) Brian Spencer et al. Acta Neuropathologica Communications
- α-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson’s disease patients
- (2017) Birger Victor Dieriks et al. Scientific Reports
- Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1
- (2016) Michel Brahic et al. ACTA NEUROPATHOLOGICA
- Ade novocompound targeting α-synuclein improves deficits in models of Parkinson’s disease
- (2016) Wolfgang Wrasidlo et al. BRAIN
- Dedicated SNAREs and specialized TRIM cargo receptors mediate secretory autophagy
- (2016) Tomonori Kimura et al. EMBO JOURNAL
- Tunneling nanotubes spread fibrillar α‐synuclein by intercellular trafficking of lysosomes
- (2016) Saïda Abounit et al. EMBO JOURNAL
- Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson’s disease
- (2016) Edward Rockenstein et al. HUMAN MOLECULAR GENETICS
- Camelid single-domain antibodies: A versatile tool for in vivo imaging of extracellular and intracellular brain targets
- (2016) Tengfei Li et al. JOURNAL OF CONTROLLED RELEASE
- Non-invasive, neuron-specific gene therapy by focused ultrasound-induced blood-brain barrier opening in Parkinson's disease mouse model
- (2016) Chung-Yin Lin et al. JOURNAL OF CONTROLLED RELEASE
- Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson’s disease
- (2016) Nolwen L. Rey et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Proteolysis of α-synuclein fibrils in the lysosomal pathway limits induction of inclusion pathology
- (2016) Amanda N. Sacino et al. JOURNAL OF NEUROCHEMISTRY
- Development of Nonviral Vectors Targeting the Brain as a Therapeutic Approach For Parkinson's Disease and Other Brain Disorders
- (2016) Hayate Javed et al. MOLECULAR THERAPY
- Bifunctional Anti-Non-Amyloid Component α-Synuclein Nanobodies Are Protective In Situ
- (2016) David C. Butler et al. PLoS One
- Pathological -synuclein transmission initiated by binding lymphocyte-activation gene 3
- (2016) X. Mao et al. SCIENCE
- Focused ultrasound-enhanced intranasal brain delivery of brain-derived neurotrophic factor
- (2016) Hong Chen et al. Scientific Reports
- Noninvasive, Targeted and Non-Viral Ultrasound-Mediated GDNF-Plasmid Delivery for Treatment of Parkinson’s Disease
- (2016) Ching-Hsiang Fan et al. Scientific Reports
- Is Alpha-Synuclein Loss-of-Function a Contributor to Parkinsonian Pathology? Evidence from Non-human Primates
- (2016) Timothy J. Collier et al. Frontiers in Neuroscience
- MicroRNA-214 participates in the neuroprotective effect of Resveratrol via inhibiting α-synuclein expression in MPTP-induced Parkinson’s disease mouse
- (2015) Zhao-Hui Wang et al. BIOMEDICINE & PHARMACOTHERAPY
- Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization
- (2015) Filsy Samuel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson’s disease
- (2015) Elvira Valera et al. Journal of Neuroinflammation
- Hypoestoxide reduces neuroinflammation and α-synuclein accumulation in a mouse model of Parkinson’s disease
- (2015) Changyoun Kim et al. Journal of Neuroinflammation
- Treatment with Trehalose Prevents Behavioral and Neurochemical Deficits Produced in an AAV α-Synuclein Rat Model of Parkinson’s Disease
- (2015) Qing He et al. MOLECULAR NEUROBIOLOGY
- α-Synuclein strains cause distinct synucleinopathies after local and systemic administration
- (2015) W. Peelaerts et al. NATURE
- A cell culture model for monitoring α-synuclein cell-to-cell transfer
- (2015) Juan F. Reyes et al. NEUROBIOLOGY OF DISEASE
- Ambroxol-induced rescue of defective glucocerebrosidase is associated with increased LIMP-2 and saposin C levels in GBA1 mutant Parkinson's disease cells
- (2015) Giulia Ambrosi et al. NEUROBIOLOGY OF DISEASE
- Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons
- (2015) Emily M. Rocha et al. NEUROBIOLOGY OF DISEASE
- Tea polyphenols alleviate motor impairments, dopaminergic neuronal injury, and cerebral α-synuclein aggregation in MPTP-intoxicated parkinsonian monkeys
- (2015) M. Chen et al. NEUROSCIENCE
- Propagation of prions causing synucleinopathies in cultured cells
- (2015) Amanda L. Woerman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders
- (2015) Stefano G. Daniele et al. Science Signaling
- Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease
- (2015) YaXing Gui et al. Oncotarget
- Evaluation of an α synuclein sensitized dendritic cell based vaccine in a transgenic mouse model of Parkinson disease
- (2015) Kenneth E Ugen et al. Human Vaccines & Immunotherapeutics
- Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders
- (2015) Stefano G. Daniele et al. Science Signaling
- Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injury
- (2015) Ayse Ulusoy et al. Acta Neuropathologica Communications
- Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease
- (2014) Min Shi et al. ACTA NEUROPATHOLOGICA
- Next-generation active immunization approach for synucleinopathies: implications for Parkinson’s disease clinical trials
- (2014) Markus Mandler et al. ACTA NEUROPATHOLOGICA
- Antibodies and protein misfolding: From structural research tools to therapeutic strategies
- (2014) Erwin De Genst et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells
- (2014) Alisdair McNeill et al. BRAIN
- Targeting alpha-synuclein with a microRNA-embedded silencing vector in the rat substantia nigra: Positive and negative effects
- (2014) Christina E. Khodr et al. BRAIN RESEARCH
- Autosis and autophagic cell death: the dark side of autophagy
- (2014) Y Liu et al. CELL DEATH AND DIFFERENTIATION
- Acceleration of α-Synuclein Aggregation by Exosomes
- (2014) Marie Grey et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Brain Injection of -Synuclein Induces Multiple Proteinopathies, Gliosis, and a Neuronal Injury Marker
- (2014) A. N. Sacino et al. JOURNAL OF NEUROSCIENCE
- Reducing C-Terminal-Truncated Alpha-Synuclein by Immunotherapy Attenuates Neurodegeneration and Propagation in Parkinson's Disease-Like Models
- (2014) D. Games et al. JOURNAL OF NEUROSCIENCE
- Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice
- (2014) J. Mark Cooper et al. MOVEMENT DISORDERS
- The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse
- (2014) Mari H. Savolainen et al. NEUROBIOLOGY OF DISEASE
- miR-16-1 Promotes the Aberrantα-Synuclein Accumulation in Parkinson Disease via Targeting Heat Shock Protein 70
- (2014) Zhelin Zhang et al. TheScientificWorldJOURNAL
- Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation
- (2014) Luis Fonseca-Ornelas et al. Nature Communications
- α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration
- (2014) Hien T. Tran et al. Cell Reports
- Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease
- (2013) Jens Wagner et al. ACTA NEUROPATHOLOGICA
- Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice
- (2013) Nolwen L. Rey et al. ACTA NEUROPATHOLOGICA
- Nanobodies: Natural Single-Domain Antibodies
- (2013) Serge Muyldermans Annual Review of Biochemistry
- Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound
- (2013) Jessica F. Jordão et al. EXPERIMENTAL NEUROLOGY
- Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of -synuclein in Parkinson's disease models
- (2013) M. L. Hebron et al. HUMAN MOLECULAR GENETICS
- A Blood-Brain Barrier (BBB) Disrupter Is Also a Potent α-Synuclein (α-syn) Aggregation Inhibitor
- (2013) Ronit Shaltiel-Karyo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy
- (2013) Selcuk A. Tanik et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nanobodies Raised against Monomeric α-Synuclein Distinguish between Fibrils at Different Maturation Stages
- (2013) Tim Guilliams et al. JOURNAL OF MOLECULAR BIOLOGY
- α-Synuclein Vaccination Prevents the Accumulation of Parkinson Disease-Like Pathologic Inclusions in Striatum in Association With Regulatory T Cell Recruitment in a Rat Model
- (2013) Vanesa Sanchez-Guajardo et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- The protective role of AMP-activated protein kinase in alpha-synuclein neurotoxicity in vitro
- (2013) Marija Dulovic et al. NEUROBIOLOGY OF DISEASE
- Exosomes of BV-2 cells induced by alpha-synuclein: Important mediator of neurodegeneration in PD
- (2013) Chongwang Chang et al. NEUROSCIENCE LETTERS
- Intrabodies as Neuroprotective Therapeutics
- (2013) Anne Messer et al. Neurotherapeutics
- Alpha-Synuclein Induces Lysosomal Rupture and Cathepsin Dependent Reactive Oxygen Species Following Endocytosis
- (2013) David Freeman et al. PLoS One
- Transmission of multiple system atrophy prions to transgenic mice
- (2013) J. C. Watts et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TFEB-mediated autophagy rescues midbrain dopamine neurons from -synuclein toxicity
- (2013) M. Decressac et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds
- (2013) B. B. Holmes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural and functional characterization of two alpha-synuclein strains
- (2013) Luc Bousset et al. Nature Communications
- Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia
- (2013) Changyoun Kim et al. Nature Communications
- Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport
- (2012) Eric C. Freundt et al. ANNALS OF NEUROLOGY
- Lipid Peroxidation Product 4-Hydroxy-2-Nonenal Promotes Seeding-Capable Oligomer Formation and Cell-to-Cell Transfer of α-Synuclein
- (2012) Eun-Jin Bae et al. ANTIOXIDANTS & REDOX SIGNALING
- A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease
- (2012) TT Myöhänen et al. BRITISH JOURNAL OF PHARMACOLOGY
- The molecular basis of induction and formation of tunneling nanotubes
- (2012) Shunsuke Kimura et al. CELL AND TISSUE RESEARCH
- Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia
- (2012) Lisa Fellner et al. GLIA
- Targeted Delivery of Self-Complementary Adeno-Associated Virus Serotype 9 to the Brain, Using Magnetic Resonance Imaging-Guided Focused Ultrasound
- (2012) Emmanuel Thévenot et al. HUMAN GENE THERAPY
- Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
- (2012) Kelvin C. Luk et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Adrenergic and Dopaminergic Modulation of Immunity in Multiple Sclerosis: Teaching Old Drugs New Tricks?
- (2012) Marco Cosentino et al. Journal of Neuroimmune Pharmacology
- Antibody-Aided Clearance of Extracellular -Synuclein Prevents Cell-to-Cell Aggregate Transmission
- (2012) E.-J. Bae et al. JOURNAL OF NEUROSCIENCE
- Fusion to a highly charged proteasomal retargeting sequence increases soluble cytoplasmic expression and efficacy of diverse anti-synuclein intrabodies
- (2012) Shubhada N. Joshi et al. mAbs
- Targeting the Chameleon: a Focused Look at α-Synuclein and Its Roles in Neurodegeneration
- (2012) Blanca A. Silva et al. MOLECULAR NEUROBIOLOGY
- Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy
- (2012) Masatoshi Konno et al. Molecular Neurodegeneration
- Exosomal cell-to-cell transmission of alpha synuclein oligomers
- (2012) Karin M Danzer et al. Molecular Neurodegeneration
- 100 years of Lewy pathology
- (2012) Michel Goedert et al. Nature Reviews Neurology
- A Novel “Molecular Tweezer” Inhibitor of α-Synuclein Neurotoxicity in Vitro and in Vivo
- (2012) Shubhangi Prabhudesai et al. Neurotherapeutics
- Alpha-Synuclein Cell-to-Cell Transfer and Seeding in Grafted Dopaminergic Neurons In Vivo
- (2012) Elodie Angot et al. PLoS One
- Sodium Phenylbutyrate Controls Neuroinflammatory and Antioxidant Activities and Protects Dopaminergic Neurons in Mouse Models of Parkinson’s Disease
- (2012) Avik Roy et al. PLoS One
- A microRNA embedded AAV alpha-synuclein gene silencing vector for dopaminergic neurons
- (2011) Ye Han et al. BRAIN RESEARCH
- An alpha-synuclein AAV gene silencing vector ameliorates a behavioral deficit in a rat model of Parkinson's disease, but displays toxicity in dopamine neurons
- (2011) Christina E. Khodr et al. BRAIN RESEARCH
- Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations
- (2011) Frank Soldner et al. CELL
- Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies
- (2011) Joseph R. Mazzulli et al. CELL
- Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers
- (2011) He-Jin Lee et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Phenylbutyrate Up-regulates the DJ-1 Protein and Protects Neurons in Cell Culture and in Animal Models of Parkinson Disease
- (2011) Wenbo Zhou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
- (2011) Christian Hansen et al. JOURNAL OF CLINICAL INVESTIGATION
- β2-Adrenergic Receptor Activation Prevents Rodent Dopaminergic Neurotoxicity by Inhibiting Microglia via a Novel Signaling Pathway
- (2011) Li Qian et al. JOURNAL OF IMMUNOLOGY
- Prion-like acceleration of a synucleinopathy in a transgenic mouse model
- (2011) Anne-Laure Mougenot et al. NEUROBIOLOGY OF AGING
- Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission
- (2011) Lydia Alvarez-Erviti et al. NEUROBIOLOGY OF DISEASE
- Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
- (2011) Laura A. Volpicelli-Daley et al. NEURON
- Transmigration of beta amyloid specific heavy chain antibody fragments across the in vitro blood–brain barrier
- (2011) K.S. Rutgers et al. NEUROSCIENCE
- Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease
- (2011) Eliezer Masliah et al. PLoS One
- Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders
- (2010) Thomas G. Beach et al. ACTA NEUROPATHOLOGICA
- Chaperone-Mediated Autophagy Markers in Parkinson Disease Brains
- (2010) Lydia Alvarez-Erviti et al. ARCHIVES OF NEUROLOGY
- Post-transcriptional Regulation of α-Synuclein Expression by mir-7 and mir-153
- (2010) Epaminondas Doxakis JOURNAL OF BIOLOGICAL CHEMISTRY
- Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies
- (2010) He-Jin Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Non-classical exocytosis of α-synuclein is sensitive to folding states and promoted under stress conditions
- (2010) Ara Jang et al. JOURNAL OF NEUROCHEMISTRY
- Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson's Disease
- (2010) C. Malagelada et al. JOURNAL OF NEUROSCIENCE
- Cell-Produced -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival
- (2010) E. Emmanouilidou et al. JOURNAL OF NEUROSCIENCE
- Exosomes: Extracellular organelles important in intercellular communication
- (2010) Suresh Mathivanan et al. Journal of Proteomics
- In Vivo RNAi-Mediated α-Synuclein Silencing Induces Nigrostriatal Degeneration
- (2010) Oleg S Gorbatyuk et al. MOLECULAR THERAPY
- Emergence of orphan drugs in the United States: a quantitative assessment of the first 25 years
- (2010) M. Miles Braun et al. NATURE REVIEWS DRUG DISCOVERY
- On the mechanism of internalization of α-synuclein into microglia: roles of ganglioside GM1 and lipid raft
- (2009) Ji-Young Park et al. JOURNAL OF NEUROCHEMISTRY
- Rapamycin protects against rotenone-induced apoptosis through autophagy induction
- (2009) T. Pan et al. NEUROSCIENCE
- Inclusion formation and neuronal cell death through neuron-to-neuron transmission of -synuclein
- (2009) P. Desplats et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Repression of -synuclein expression and toxicity by microRNA-7
- (2009) E. Junn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Exogenous -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
- (2009) K. C. Luk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Assembly-dependent endocytosis and clearance of extracellular a-synuclein
- (2008) He-Jin Lee et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Exosomes: The Trojan horses of neurodegeneration
- (2008) Roberta Ghidoni et al. MEDICAL HYPOTHESES
- In vivo silencing of alpha-synuclein using naked siRNA
- (2008) Jada Lewis et al. Molecular Neurodegeneration
- Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
- (2008) Jia-Yi Li et al. NATURE MEDICINE
- Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease
- (2008) Jeffrey H Kordower et al. NATURE MEDICINE
- EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
- (2008) Dagmar E Ehrnhoefer et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
- (2008) Berislav V. Zlokovic NEURON
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