Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 517, Issue 4, Pages 642-647Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2019.07.084
Keywords
PD cell model; Microglia-derived EVs; alpha-synuclein; MPP+; Mitochondrial fission/fusion
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Funding
- Natural Science Foundation of China [8167051152]
- National Key Technology Research and Development Program of China [2016YFC1306500]
- Beijing Municipal Science and Technology Commission [Z151100003915117, Z151100003915150]
- Beijing Natural Science Foundation [7164254, 7192095]
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Biological functions of extracellular vesicles (EVs) are being discovered to be critical in neurodegenerative disorders, including Parkinson's disease (PD). A previous study using cellular models of PD has suggested that EVs derived from microglia exposed to aggregated alpha-synuclein (alpha-Syn) leads to enhanced neurotoxicity. However, the function of EVs derived from microglia not treated with aggregated alpha-Syn or treated with monomeric alpha-Syn are unclear. Here, employing a widely used cellular model of PD, i.e. SH-SY5Y cells treated with MPP+, a well-established parkinsonian toxicant, we revealed that microglial EVs, when not stimulated by aggregated alpha-Syn, appeared to be protective, and the mechanisms, though remain to be defined further, appeared to involve mitochondrial dynamics, especially mitochondrial fission. (C) 2019 Elsevier Inc. All rights reserved.
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