Current Status and Challenges Associated with CNS-Targeted Gene Delivery across the BBB

Systemic Brain Delivery of Antisense Oligonucleotides across the Blood-Brain Barrier with a Glucose-Coated Polymeric Nanocarrier

(2020) Hyun Su Min et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

ANG1005, a brain penetrating peptide-drug conjugate, shows activity in patients with breast cancer with leptomeningeal carcinomatosis and recurrent brain metastases

(2020) Priya Kumthekar et al.   CLINICAL CANCER RESEARCH

Nose-to-brain Delivery of Natural Compounds for the Treatment of Central Nervous System Disorders

(2020) Joana Bicker et al.   CURRENT PHARMACEUTICAL DESIGN

Engineering adeno-associated virus vectors for gene therapy

(2020) Chengwen Li et al.   NATURE REVIEWS GENETICS

Immune cell regulation of glia during CNS injury and disease

(2020) Andrew D. Greenhalgh et al.   NATURE REVIEWS NEUROSCIENCE

Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood–brain barrier

(2020) Oscar A. Marcos-Contreras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blood-Brain Barrier and Delivery of Protein and Gene Therapeutics to Brain

(2020) William M. Pardridge   Frontiers in Aging Neuroscience

Effect of Protein Corona on The Transfection Efficiency of Lipid-Coated Graphene Oxide-Based Cell Transfection Reagents

(2020) Erica Quagliarini et al.   Pharmaceutics

Efficient neuronal targeting and transfection using RVG and transferrin-conjugated liposomes

(2020) Bruna dos Santos Rodrigues et al.   BRAIN RESEARCH

Recent strategies and advances in the fabrication of nano lipid carriers and their application towards brain targeting

(2020) Mukta Agrawal et al.   JOURNAL OF CONTROLLED RELEASE

Does the protein corona take over the selectivity of molecularly imprinted nanoparticles? The biological challenges to recognition

(2020) Annalaura Capriotti et al.   Journal of Proteomics

An Analysis of the Binding Function and Structural Organization of the Protein Corona

(2020) Yuwei Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multiplexed Cre-dependent selection yields systemic AAVs for targeting distinct brain cell types

(2020) Sripriya Ravindra Kumar et al.   NATURE METHODS

Machine learning predicts the functional composition of the protein corona and the cellular recognition of nanoparticles

(2020) Zhan Ban et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Influence of Nanoparticle Shape on Protein Corona Formation

(2020) Rahul Madathiparambil Visalakshan et al.   Small

Regulating Protein Corona Formation and Dynamic Protein Exchange by Controlling Nanoparticle Hydrophobicity

(2020) Qianhui Yu et al.   Frontiers in Bioengineering and Biotechnology

Recent Advances in Understanding the Protein Corona of Nanoparticles and in the Formulation of “Stealthy” Nanomaterials

(2020) Riccardo Rampado et al.   Frontiers in Bioengineering and Biotechnology

Protein Corona-Enabled Systemic Delivery and Targeting of Nanoparticles

(2020) Dongyu Chen et al.   AAPS Journal

The Biomolecular Corona of Lipid Nanoparticles for Gene Therapy

(2020) Valentina Francia et al.   BIOCONJUGATE CHEMISTRY

Intertwined mechanisms define transport of anti-ICAM nanocarriers across the endothelium and brain delivery of a therapeutic enzyme

(2020) Rachel L. Manthe et al.   JOURNAL OF CONTROLLED RELEASE

Nanoparticles in the Biological Context: Surface Morphology and Protein Corona Formation

(2020) Walter Richtering et al.   Small

Microbubbles and Nanobubbles with Ultrasound for Systemic Gene Delivery

(2020) Yoko Endo-Takahashi et al.   Pharmaceutics

Design concepts of polyplex micelles for in vivo therapeutic delivery of plasmid DNA and messenger RNA

(2019) Satoshi Uchida et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Distribution of insulin in trigeminal nerve and brain after intranasal administration

(2019) Jeffrey J. Lochhead et al.   Scientific Reports

The GPI-Linked Protein LY6A Drives AAV-PHP.B Transport across the Blood-Brain Barrier

(2019) Juliette Hordeaux et al.   MOLECULAR THERAPY

Blood-brain barrier receptors and transporters: an insight on their function and how to exploit them through nanotechnology

(2019) Rui Pedro Moura et al.   Expert Opinion on Drug Delivery

Liposome protein corona characterization as a new approach in nanomedicine

(2019) Anna Laura Capriotti et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Survival, Motor Function, and Motor Milestones: Comparison of AVXS-101 Relative to Nusinersen for the Treatment of Infants with Spinal Muscular Atrophy Type 1

(2019) Omar Dabbous et al.   ADVANCES IN THERAPY

Lipid-Based DNA Therapeutics – Hallmarks of Non-Viral Gene Delivery

(2019) Jonas Buck et al.   ACS Nano

Focused ultrasound-induced blood brain-barrier opening enhanced vascular permeability for GDNF delivery in Huntington's disease mouse model

(2019) Chung-Yin Lin et al.   Brain Stimulation

Astrocyte-selective AAV gene therapy through the endogenous GFAP promoter results in robust transduction in the rat spinal cord following injury

(2019) Jarred M. Griffin et al.   GENE THERAPY

Combining vascular targeting and the local first pass provides 100-fold higher uptake of ICAM-1-targeted vs untargeted nanocarriers in the inflamed brain

(2019) Oscar A. Marcos-Contreras et al.   JOURNAL OF CONTROLLED RELEASE

Neural stimulations regulate the infiltration of immune cells into the CNS

(2019) D. Kamimura et al.   JOURNAL OF INTERNAL MEDICINE

Onasemnogene Abeparvovec: First Global Approval

(2019) Sheridan M. Hoy   DRUGS

Targeting the transferrin receptor for brain drug delivery

(2019) Kasper Bendix Johnsen et al.   PROGRESS IN NEUROBIOLOGY

Gene Therapy Tools for Brain Diseases

(2019) Selene Ingusci et al.   Frontiers in Pharmacology

AAV-PHP.B Administration Results in a Differential Pattern of CNS Biodistribution in Non-human Primates Compared with Mice

(2019) William A. Liguore et al.   MOLECULAR THERAPY

Regulators' Advice Can Make a Difference: European Medicines Agency Approval of Zynteglo for Beta Thalassemia

(2019) Martina Schuessler‐Lenz et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood–brain barrier dysfunction module

(2019) Roeben Nocon Munji et al.   NATURE NEUROSCIENCE

Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids

(2019) Qin Huang et al.   PLoS One

Brain-targeted drug delivery by manipulating protein corona functions

(2019) Zui Zhang et al.   Nature Communications

Recent Advances in the Use of Focused Ultrasound for Magnetic Resonance Image-Guided Therapeutic Nanoparticle Delivery to the Central Nervous System

(2019) Delaney G. Fisher et al.   Frontiers in Pharmacology

Active targeting towards and inside the brain based on nanoparticles: A Review

(2019) Morteza Rabiei et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Ly6a Differential Expression in Blood–Brain Barrier Is Responsible for Strain Specific Central Nervous System Transduction Profile of AAV-PHP.B

(2019) Ana Rita Batista et al.   HUMAN GENE THERAPY

Protein corona impact on nanoparticle-cell interactions: toward an energy-based model of endocytosis

(2019) P Shadmani et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

The global burden of neurological disorders: translating evidence into policy

(2019) Valery L Feigin et al.   LANCET NEUROLOGY

Dual microglia effects on blood brain barrier permeability induced by systemic inflammation

(2019) Koichiro Haruwaka et al.   Nature Communications

Brain targeting by liposome-biomolecular corona boosts anti-cancer efficacy of Temozolomide in glioblastoma cells

(2018) Antonietta Arcella et al.   ACS Chemical Neuroscience

Differential Recognition of Nanoparticle Protein Corona and Modified Low-Density Lipoprotein by Macrophage Receptor with Collagenous Structure

(2018) Sandra Lara et al.   ACS Nano

Quantitative Assessment of Nanoparticle Biodistribution by Fluorescence Imaging, Revisited

(2018) Fanfei Meng et al.   ACS Nano

Transferrin and transferrin receptors update

(2018) Hiroshi Kawabata   FREE RADICAL BIOLOGY AND MEDICINE

Severe Toxicity in Nonhuman Primates and Piglets Following High-Dose Intravenous Administration of an Adeno-Associated Virus Vector Expressing Human SMN

(2018) Christian Hinderer et al.   HUMAN GENE THERAPY

Micro-Dystrophin Gene Therapy Goes Systemic in Duchenne Muscular Dystrophy Patients

(2018) Dongsheng Duan   HUMAN GENE THERAPY

The Role and Mechanism of Borneol to Open the Blood-Brain Barrier

(2018) Tao Wu et al.   INTEGRATIVE CANCER THERAPIES

Protein corona–mediated targeting of nanocarriers to B cells allows redirection of allergic immune responses

(2018) Limei Shen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Gene therapy clinical trials worldwide to 2017: An update

(2018) Samantha L. Ginn et al.   JOURNAL OF GENE MEDICINE

High-Throughput Dissection of AAV–Host Interactions: The Fast and the Curious

(2018) Anne-Kathrin Herrmann et al.   JOURNAL OF MOLECULAR BIOLOGY

Targeted transport of nanocarriers into brain for theranosis with rabies virus glycoprotein-derived peptide

(2018) Chen Fu et al.   Materials Science & Engineering C-Materials for Biological Applications

Selective α-Synuclein Knockdown in Monoamine Neurons by Intranasal Oligonucleotide Delivery: Potential Therapy for Parkinson’s Disease

(2018) Diana Alarcón-Arís et al.   MOLECULAR THERAPY

Artificial apolipoprotein corona enables nanoparticle brain targeting

(2018) Roberta Dal Magro et al.   Nanomedicine-Nanotechnology Biology and Medicine

The spread and evolution of rabies virus: conquering new frontiers

(2018) Christine R. Fisher et al.   NATURE REVIEWS MICROBIOLOGY

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Microglia in the Neurovascular Unit: Blood–Brain Barrier–microglia Interactions After Central Nervous System Disorders

(2018) Hannah Thurgur et al.   NEUROSCIENCE

Intravenous administration of the adeno-associated virus-PHP.B capsid fails to upregulate transduction efficiency in the marmoset brain

(2018) Yasunori Matsuzaki et al.   NEUROSCIENCE LETTERS

Gene therapy comes of age

(2018) Cynthia E. Dunbar et al.   SCIENCE

Antibody affinity and valency impact brain uptake of transferrin receptor-targeted gold nanoparticles

(2018) Kasper Bendix Johnsen et al.   Theranostics

Patisiran: First Global Approval

(2018) Sheridan M. Hoy   DRUGS

Delivery of immunoglobulin G antibodies to the rat nervous system following intranasal administration: Distribution, dose-response, and mechanisms of delivery

(2018) Niyanta N. Kumar et al.   JOURNAL OF CONTROLLED RELEASE

Gene therapy for neurological disorders: progress and prospects

(2018) Benjamin E. Deverman et al.   NATURE REVIEWS DRUG DISCOVERY

Oxcarbazepine free or loaded PLGA nanoparticles as effective intranasal approach to control epileptic seizures in rodents

(2018) Teresa Musumeci et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The impact of protein corona on the behavior and targeting capability of nanoparticle-based delivery system

(2018) Wei Xiao et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The intellectual disability gene PQBP1 rescues Alzheimer’s disease pathology

(2018) Hikari Tanaka et al.   MOLECULAR PSYCHIATRY

Gene Therapy for Neurodegenerative Diseases

(2018) Vivek Sudhakar et al.   Neurotherapeutics

Blood-Brain Barrier: From Physiology to Disease and Back

(2018) Melanie D. Sweeney et al.   PHYSIOLOGICAL REVIEWS

CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage

(2018) Jichao Sun et al.   Nature Communications

Intranasal delivery of hGDNF plasmid DNA nanoparticles results in long-term and widespread transfection of perivascular cells in rat brain

(2018) Amirah E-E. Aly et al.   Nanomedicine-Nanotechnology Biology and Medicine

Nusinersen for the treatment of spinal muscular atrophy

(2017) Claudia A. Chiriboga   Expert Review of Neurotherapeutics

Use of LDL receptor–targeting peptide vectors for in vitro and in vivo cargo transport across the blood-brain barrier

(2017) Yves Molino et al.   FASEB JOURNAL

Intranasal Adeno-Associated Virus Mediated Gene Delivery and Expression of Human Iduronidase in the Central Nervous System: A Noninvasive and Effective Approach for Prevention of Neurologic Disease in Mucopolysaccharidosis Type I

(2017) Lalitha R. Belur et al.   HUMAN GENE THERAPY

Clinical Gene Therapy for Neurodegenerative Diseases: Past, Present, and Future

(2017) Françoise Piguet et al.   HUMAN GENE THERAPY

Breast Cancer Brain Metastases: Clonal Evolution in Clinical Context

(2017) Jodi Saunus et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Blood-Brain Barrier Dysfunction and the Pathogenesis of Alzheimer’s Disease

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ultrasound targeted CNS gene delivery for Parkinson's disease treatment

(2017) Ching-Hsiang Fan et al.   JOURNAL OF CONTROLLED RELEASE

Targeting the Central Nervous System (CNS): A Review of Rabies Virus-Targeting Strategies

(2017) Mira Oswald et al.   MOLECULAR PHARMACEUTICS

AAV-PHP.B-Mediated Global-Scale Expression in the Mouse Nervous System Enables GBA1 Gene Therapy for Wide Protection from Synucleinopathy

(2017) Giuseppe Morabito et al.   MOLECULAR THERAPY

Novel Focused Ultrasound Gene Therapy Approach Noninvasively Restores Dopaminergic Neuron Function in a Rat Parkinson’s Disease Model

(2017) Brian P. Mead et al.   NANO LETTERS

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice

(2017) Lindsay A. Becker et al.   NATURE

First approval in sight for Novartis' CAR-T therapy after panel vote

(2017) Cormac Sheridan   NATURE BIOTECHNOLOGY

Oligonucleotide therapies for disorders of the nervous system

(2017) Olga Khorkova et al.   NATURE BIOTECHNOLOGY

Targeting blood-brain-barrier transcytosis – perspectives for drug delivery

(2017) Imre Mäger et al.   NEUROPHARMACOLOGY

Single-Dose Gene-Replacement Therapy for Spinal Muscular Atrophy

(2017) Jerry R. Mendell et al.   NEW ENGLAND JOURNAL OF MEDICINE

Biological Identity of Nanoparticles In Vivo : Clinical Implications of the Protein Corona

(2017) Giulio Caracciolo et al.   TRENDS IN BIOTECHNOLOGY

Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain

(2017) Y. Anraku et al.   Nature Communications

Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics

(2017) Nicolas Bertrand et al.   Nature Communications

FDA Approves Second CAR T-cell Therapy

(2017)   Cancer Discovery

Nusinersen for the treatment of spinal muscular atrophy

(2017) Claudia A. Chiriboga   Expert Review of Neurotherapeutics

Development and Function of the Blood-Brain Barrier in the Context of Metabolic Control

(2017) Roberta Haddad-Tóvolli et al.   Frontiers in Neuroscience

The Gateway Reflex, a Novel Neuro-Immune Interaction for the Regulation of Regional Vessels

(2017) Yuki Tanaka et al.   Frontiers in Immunology

Brain-Targeted Polymers for Gene Delivery in the Treatment of Brain Diseases

(2017) Yifei Lu et al.   Topics in Current Chemistry

In vivo genome editing improves motor function and extends survival in a mouse model of ALS

(2017) Thomas Gaj et al.   Science Advances

Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation

(2017) Myosotys Rodriguez et al.   Scientific Reports

Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma

(2017) Kasper Bendix Johnsen et al.   Scientific Reports

Clusterin in the protein corona plays a key role in the stealth effect of nanoparticles against phagocytes

(2016) Michihiko Aoyama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Impact of protein pre-coating on the protein corona composition and nanoparticle cellular uptake

(2016) Vahid Mirshafiee et al.   BIOMATERIALS

A brain microvasculature endothelial cell‐specific viral vector with the potential to treat neurovascular and neurological diseases

(2016) Jakob Körbelin et al.   EMBO Molecular Medicine

Proteomics and the blood–brain barrier: how recent findings help drug development

(2016) Yannis Karamanos et al.   Expert Review of Proteomics

Adeno-Associated Virus-Based Gene Therapy for CNS Diseases

(2016) Michaël Hocquemiller et al.   HUMAN GENE THERAPY

The blood–brain barrier after stroke: Structural studies and the role of transcytotic vesicles

(2016) Michael J Haley et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting

(2016) Christopher S. von Bartheld et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Gene therapy for the CNS using AAVs: The impact of systemic delivery by AAV9

(2016) Joana Saraiva et al.   JOURNAL OF CONTROLLED RELEASE

A non-viral suicide gene delivery system traversing the blood brain barrier for non-invasive glioma targeting treatment

(2016) Shiqian Gao et al.   JOURNAL OF CONTROLLED RELEASE

Non-invasive, neuron-specific gene therapy by focused ultrasound-induced blood-brain barrier opening in Parkinson's disease mouse model

(2016) Chung-Yin Lin et al.   JOURNAL OF CONTROLLED RELEASE

Vectored Intracerebral Immunization with the Anti-Tau Monoclonal Antibody PHF1 Markedly Reduces Tau Pathology in Mutant Tau Transgenic Mice

(2016) Wencheng Liu et al.   JOURNAL OF NEUROSCIENCE

Systemic application of AAV vectors targeting GFAP-expressing astrocytes in Z -Q175-KI Huntington's disease mice

(2016) Tatyana Vagner et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Development of Therapeutics for C9ORF72 ALS/FTD-Related Disorders

(2016) Maria Sara Cipolat Mis et al.   MOLECULAR NEUROBIOLOGY

Glucose Transporters at the Blood-Brain Barrier: Function, Regulation and Gateways for Drug Delivery

(2016) Simon G. Patching   MOLECULAR NEUROBIOLOGY

Widespread Central Nervous System Gene Transfer and Silencing After Systemic Delivery of Novel AAV-AS Vector

(2016) Sourav R Choudhury et al.   MOLECULAR THERAPY

In Vivo Selection Yields AAV-B1 Capsid for Central Nervous System and Muscle Gene Therapy

(2016) Sourav R Choudhury et al.   MOLECULAR THERAPY

Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain

(2016) Benjamin E Deverman et al.   NATURE BIOTECHNOLOGY

Protein adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)-coated nanocarriers

(2016) Susanne Schöttler et al.   Nature Nanotechnology

Noninvasive, Targeted and Non-Viral Ultrasound-Mediated GDNF-Plasmid Delivery for Treatment of Parkinson’s Disease

(2016) Ching-Hsiang Fan et al.   Scientific Reports

Investor Outlook: Rising from the Ashes; GSK's European Approval of Strimvelis for ADA-SCID

(2016) Joshua Schimmer et al.   Human Gene Therapy Clinical Development

Production and clinical development of nanoparticles for gene delivery

(2016) Jie Chen et al.   Molecular Therapy-Methods & Clinical Development

Microglia–blood vessel interactions: a double-edged sword in brain pathologies

(2015) Nevenka Dudvarski Stankovic et al.   ACTA NEUROPATHOLOGICA

Hyperosmotic polydixylitol for crossing the blood brain barrier and efficient nucleic acid delivery

(2015) P. Garg et al.   CHEMICAL COMMUNICATIONS

Overcoming the blood–brain tumor barrier for effective glioblastoma treatment

(2015) O. van Tellingen et al.   DRUG RESISTANCE UPDATES

Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier

(2015) Michael Abadier et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Gene therapy for neurological disorders

(2015) Chi-Jing Choong et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Intranasal gene delivery for treating Parkinson’s disease: overcoming the blood–brain barrier

(2015) Amirah E-E Aly et al.   Expert Opinion on Drug Delivery

Focused ultrasound-mediated drug delivery through the blood–brain barrier

(2015) Alison Burgess et al.   Expert Review of Neurotherapeutics

shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson’s disease model

(2015) Alevtina D. Zharikov et al.   JOURNAL OF CLINICAL INVESTIGATION

Stealth Effect of Biomolecular Corona on Nanoparticle Uptake by Immune Cells

(2015) Giulio Caracciolo et al.   LANGMUIR

E Pluribus Unum: 50 Years of Research, Millions of Viruses, and One Goal—Tailored Acceleration of AAV Evolution

(2015) Dirk Grimm et al.   MOLECULAR THERAPY

Mapping protein binding sites on the biomolecular corona of nanoparticles

(2015) Philip M. Kelly et al.   Nature Nanotechnology

Increased brain uptake of targeted nanoparticles by adding an acid-cleavable linkage between transferrin and the nanoparticle core

(2015) Andrew J. Clark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

(2015) A. Zeisel et al.   SCIENCE

Anatomy and physiology of the blood–brain barrier

(2015) Yonatan Serlin et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Glial regulation of the blood-brain barrier in health and disease

(2015) Bieke Broux et al.   Seminars in Immunopathology

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Astrocytes Control Synapse Formation, Function, and Elimination

(2015) Won-Suk Chung et al.   Cold Spring Harbor Perspectives in Biology

Lipid composition: a “key factor” for the rational manipulation of the liposome–protein corona by liposome design

(2015) G. Caracciolo et al.   RSC Advances

Focused ultrasound-mediated drug delivery through the blood–brain barrier

(2015) Alison Burgess et al.   Expert Review of Neurotherapeutics

Divalent metal transporter 1 (DMT1) in the brain: implications for a role in iron transport at the blood-brain barrier, and neuronal and glial pathology

(2015) Tina Skjørringe et al.   Frontiers in Molecular Neuroscience

First oncolytic virus approved for melanoma immunotherapy

(2015) Jonathan Pol et al.   OncoImmunology

Facilitation of Drug Transport across the Blood–Brain Barrier with Ultrasound and Microbubbles

(2015) Stephen Meairs   Pharmaceutics

Overcoming the Blood–Brain Barrier for Delivering Drugs into the Brain by Using Adenosine Receptor Nanoagonist

(2014) Xihui Gao et al.   ACS Nano

Blood–Brain Barrier Proteomics: Towards the Understanding of Neurodegenerative Diseases

(2014) Yannis Karamanos et al.   ARCHIVES OF MEDICAL RESEARCH

Drug delivery across the blood–brain barrier using focused ultrasound

(2014) Alison Burgess et al.   Expert Opinion on Drug Delivery

Quantitative targeted proteomics for understanding the blood–brain barrier: towards pharmacoproteomics

(2014) Sumio Ohtsuki et al.   Expert Review of Proteomics

The Gateway Reflex, which is mediated by the inflammation amplifier, directs pathogenic immune cells into the CNS

(2014) L. Sabharwal et al.   JOURNAL OF BIOCHEMISTRY

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Non-viral vectors for gene-based therapy

(2014) Hao Yin et al.   NATURE REVIEWS GENETICS

Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke

(2014) Daniel Knowland et al.   NEURON

Specific Binding, Uptake, and Transport of ICAM-1-Targeted Nanocarriers Across Endothelial and Subendothelial Cell Components of the Blood–Brain Barrier

(2014) Janet Hsu et al.   PHARMACEUTICAL RESEARCH

Biology of adeno-associated viral vectors in the central nervous system

(2014) Giridhar Murlidharan et al.   Frontiers in Molecular Neuroscience

Noninvasive and Targeted Drug Delivery to the Brain Using Focused Ultrasound

(2013) Alison Burgess et al.   ACS Chemical Neuroscience

Phase I Study of GRN1005 in Recurrent Malignant Glioma

(2013) J. Drappatz et al.   CLINICAL CANCER RESEARCH

 2 Integrin-Mediated Crawling on Endothelial ICAM-1 and ICAM-2 Is a Prerequisite for Transcellular Neutrophil Diapedesis across the Inflamed Blood-Brain Barrier

(2013) R. Gorina et al.   JOURNAL OF IMMUNOLOGY

Transferrin-conjugated, fluorescein-loaded magnetic nanoparticles for targeted delivery across the blood–brain barrier

(2013) Feng Yan et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

The prevalence of neutralizing antibodies against adeno-associated virus capsids is reduced in young Japanese individuals

(2013) Jun Mimuro et al.   JOURNAL OF MEDICAL VIROLOGY

Regulation of Immune Cell Infiltration into the CNS by Regional Neural Inputs Explained by the Gate Theory

(2013) Yasunobu Arima et al.   MEDIATORS OF INFLAMMATION

Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface

(2013) Anna Salvati et al.   Nature Nanotechnology

The Use of Borneol as an Enhancer for Targeting Aprotinin-Conjugated PEG-PLGA Nanoparticles to the Brain

(2013) Lin Zhang et al.   PHARMACEUTICAL RESEARCH

Angiopep-Conjugated Nanoparticles for Targeted Long-Term Gene Therapy of Parkinson’s Disease

(2013) Rongqin Huang et al.   PHARMACEUTICAL RESEARCH

Up-regulating Blood Brain Barrier Permeability of Nanoparticles via Multivalent Effect

(2013) Xihui Gao et al.   PHARMACEUTICAL RESEARCH

A Novel Peptide Delivers Plasmids across Blood-Brain Barrier into Neuronal Cells as a Single-Component Transfer Vector

(2013) Ailing Fu et al.   PLoS One

Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor

(2013) D. T. Wiley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease

(2013) D. M. Holtzman et al.   Cold Spring Harbor Perspectives in Medicine

Pre-existing Anti–Adeno-Associated Virus Antibodies as a Challenge in AAV Gene Therapy

(2013) Vedell Louis Jeune et al.   Human Gene Therapy Methods

Systemic Delivery of Tyrosine-Mutant AAV Vectors Results in Robust Transduction of Neurons in Adult Mice

(2013) Asako Iida et al.   Biomed Research International

The gateway theory: bridging neural and immune interactions in the CNS

(2013) Daisuke Kamimura et al.   Frontiers in Neuroscience

Lessons Learned from the Clinical Development and Market Authorization of Glybera

(2013) Laura M. Bryant et al.   Human Gene Therapy Clinical Development

The gateway theory: How regional neural activation creates a gateway for immune cells via an inflammation amplifier

(2013) Masaaki Murakami et al.   Biomedical Journal

Anti-glioblastoma efficacy and safety of paclitaxel-loading Angiopep-conjugated dual targeting PEG-PCL nanoparticles

(2012) Hongliang Xin et al.   BIOMATERIALS

Regional Neural Activation Defines a Gateway for Autoreactive T Cells to Cross the Blood-Brain Barrier

(2012) Yasunobu Arima et al.   CELL

Prevalence and pharmacological modulation of humoral immunity to AAV vectors in gene transfer to synovial tissue

(2012) F Mingozzi et al.   GENE THERAPY

Nonviral delivery systems for small interfering RNAs

(2012) K. V. Glebova et al.   MOLECULAR BIOLOGY

Intranasal Delivery of HMGB1 siRNA Confers Target Gene Knockdown and Robust Neuroprotection in the Postischemic Brain

(2012) Il-Doo Kim et al.   MOLECULAR THERAPY

Minimizing the Inhibitory Effect of Neutralizing Antibody for Efficient Gene Expression in the Liver With Adeno-associated Virus 8 Vectors

(2012) Jun Mimuro et al.   MOLECULAR THERAPY

Neuroinflammation and Blood-Brain Barrier Changes in Capillary Amyloid Angiopathy

(2012) Anna Carrano et al.   Neurodegenerative Diseases

Targeted Delivery of Proteins into the Central Nervous System Mediated by Rabies Virus Glycoprotein-Derived Peptide

(2012) Ailing Fu et al.   PHARMACEUTICAL RESEARCH

Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities

(2012) Z. Cheng et al.   SCIENCE

Intranasal delivery of biologics to the central nervous system

(2011) Jeffrey J. Lochhead et al.   ADVANCED DRUG DELIVERY REVIEWS

Dual targeting effect of Angiopep-2-modified, DNA-loaded nanoparticles for glioma

(2011) Shixian Huang et al.   BIOMATERIALS

A brain-targeted rabies virus glycoprotein-disulfide linked PEI nanocarrier for delivery of neurogenic microRNA

(2011) Do Won Hwang et al.   BIOMATERIALS

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

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(2011) Xiao-ning Lin et al.   International Journal of Nanomedicine

Efficacy of intravenous amphotericin B-polybutylcyanoacrylate nanoparticles against cryptococcal meningitis in mice

(2011) Xu et al.   International Journal of Nanomedicine

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AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial

(2011) Peter A LeWitt et al.   LANCET NEUROLOGY

Safety, Pharmacokinetics, and Activity of GRN1005, a Novel Conjugate of Angiopep-2, a Peptide Facilitating Brain Penetration, and Paclitaxel, in Patients with Advanced Solid Tumors

(2011) R. Kurzrock et al.   MOLECULAR CANCER THERAPEUTICS

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(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

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(2010) Thomas Misje Mathiisen et al.   GLIA

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Differential Roles for Endothelial ICAM-1, ICAM-2, and VCAM-1 in Shear-Resistant T Cell Arrest, Polarization, and Directed Crawling on Blood-Brain Barrier Endothelium

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(2010) Annika Armulik et al.   NATURE

The Mouse Blood-Brain Barrier Transcriptome: A New Resource for Understanding the Development and Function of Brain Endothelial Cells

(2010) Richard Daneman et al.   PLoS One

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice

(2010) Xing-Long Gu et al.   Molecular Brain

The role of transferrin receptor 1 and 2 in transferrin-bound iron uptake in human hepatoma cells

(2009) Carly E. Herbison et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mechanisms of brain iron transport: insight into neurodegeneration and CNS disorders

(2009) Eric Mills et al.   Future Medicinal Chemistry

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(2009) Anna L. Kiss et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

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(2009) Frederico A.C. Azevedo et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The role of apolipoprotein E in uptake of atovaquone into the brain in murine acute and reactivated toxoplasmosis

(2009) Hend M. Shubar et al.   JOURNAL OF DRUG TARGETING

Intravenous Administration of Self-complementary AAV9 Enables Transgene Delivery to Adult Motor Neurons

(2009) Sandra Duque et al.   MOLECULAR THERAPY

The cell biology of rabies virus: using stealth to reach the brain

(2009) Matthias J. Schnell et al.   NATURE REVIEWS MICROBIOLOGY

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Acute Effectors of GLUT1 Glucose Transporter Subcellular Targeting in CIT3 Mouse Mammary Epithelial Cells

(2009) Arieh Riskin et al.   PEDIATRIC RESEARCH

Discovery of New Cargo Proteins that Enter Cells through Clathrin-Independent Endocytosis

(2009) Craig A. Eyster et al.   TRAFFIC

Intravenous Inoculation of a Bat-Associated Rabies Virus Causes Lethal Encephalopathy in Mice through Invasion of the Brain via Neurosecretory Hypothalamic Fibers

(2009) Mirjam A. R. Preuss et al.   PLoS Pathogens

Poly(n-butylcyanoacrylate) nanoparticles coated with polysorbate 80 for the targeted delivery of rivastigmine into the brain to treat Alzheimer's disease

(2008) Barnabas Wilson et al.   BRAIN RESEARCH

Brain Endothelial Cell-Cell Junctions: How to “Open” the Blood Brain Barrier

(2008) Svetlana Stamatovic et al.   Current Neuropharmacology

Caffeine protects against MPTP-induced blood-brain barrier dysfunction in mouse striatum

(2008) Xuesong Chen et al.   JOURNAL OF NEUROCHEMISTRY

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(2008) Michel Demeule et al.   JOURNAL OF NEUROCHEMISTRY

Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes

(2008) Kevin D Foust et al.   NATURE BIOTECHNOLOGY

Results from a phase I safety trial of hAADC gene therapy for Parkinson disease

(2008) J. L. Eberling et al.   NEUROLOGY

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(2008) Berislav V. Zlokovic   NEURON