Article
Neurosciences
Hengxing Zheng, Zhenhua Xie, Xuran Zhang, Jian Mao, Mengyuan Wang, Sijia Wei, Yiwen Fu, Hong Zheng, Ying He, Hui Chen, Yan Xu
Summary: This study examined the aggregation status, localization, and degradation characteristics of a-syn and p-a-syn in plasma exosomes from PD patients and healthy controls. Results indicated poor solubility of a-syn and p-a-syn after protease K treatment, with aggregates found inside and on the membrane surface of plasma exosomes. The ratios of oligomeric a-syn/total a-syn and oligomeric p-a-syn/total p-a-syn in plasma exosomes showed moderate utility in assisting PD diagnosis.
Article
Neurosciences
Xiao-Li Si, Yuan-Jian Fang, Ling-Fei Li, Lu-Yan Gu, Xin-Zhen Yin, Jun-Tian, Ya-Ping Yan, Jia-Li Pu, Bao-Rong Zhang
Summary: The study discusses the involvement of NLRP3 inflammasome in microvesicle generation and alpha-synuclein transmission in microglial cells, which could potentially lead to novel drug targets and further research in Parkinson's disease.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Clinical Neurology
Julie A. E. Christensen, Matteo Cesari, Fabio Pizza, Elena Antelmi, Rune Asger Vestergaard Frandsen, Giuseppe Plazzi, Poul Jennum
Summary: Studies have shown that patients with iRBD and Parkinson's disease exhibit abnormal eye movements during wakefulness and N2 sleep, with significant differences in eye movement coverage compared to controls and PLMD patients, indicating different stages of central nervous system involvement in neurodegenerative diseases.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Tian-Zhong Hou, Hui-Min Yang, Yun-Zhong Cheng, Li Gu, Jian-Nan Zhang, Hong Zhang
Summary: This study investigates the potential link between Parkinson's disease and liver cancer, focusing on the role of exosome-delivered alpha-synuclein in inhibiting hepatocellular carcinoma (HCC) growth, migration, and invasion. Results show that exosomes containing alpha-synuclein from a Parkinson's disease cellular model suppress HCC development, and the abundance of Integrin alpha V beta 5 in these exosomes enhances their uptake by HCC cells.
MOLECULAR CARCINOGENESIS
(2023)
Article
Neurosciences
Li Wu, Qian Xu, Mengxi Zhou, Yajing Chen, Chunyan Jiang, Yuhan Jiang, Yin Lin, Qing He, Lei Zhao, Yourong Dong, Jianren Liu, Wei Chen
Summary: Plasma levels of miR-153 and miR-223 were found to be significantly decreased in Parkinson's disease patients. MiR-153 levels were closely associated with disease duration and clinical phenotype, while miR-223 levels were linked to the presence of rapid eye movement sleep behavior disorder. These miRNAs could potentially serve as biomarkers for Parkinson's disease.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Abbie T. Rodger, Maryam A. L. Nasser, Wayne G. Carter
Summary: Currently, there are no pharmacological treatments that can completely stop or reverse the progression of Parkinson's Disease (PD). Therefore, there is a need for neuroprotective therapies. This systematic review examines the effectiveness of anti-a-synuclein (a-syn) therapies in preventing PD progression in preclinical models and human clinical trials. The review found that novel preclinical anti-a-syn therapeutics reduced a-syn aggregations and protected against dopaminergic neuronal loss. Completed clinical trials showed significant tolerability and efficacy in reducing a-syn and minimal adverse effects. Overall, this review highlights the potential of anti-a-syn therapies in both preclinical and clinical settings to reduce a-syn accumulation and potentially slow down PD progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Wei-Li Kuan, Katherine Stott, Xiaoling He, Tobias C. Wood, Sujeong Yang, Jessica C. F. Kwok, Katie Hall, Yanyan Zhao, Ole Tietz, Franklin I. Aigbirhio, Anthony C. Vernon, Roger A. Barker
Summary: A novel approach was developed to deliver complex quaternary structure proteins transvascularly to rats, leading to neuropathological changes resembling the premotor stage of Parkinson's disease. This new delivery method could potentially be used for pathogenic and therapeutic protein cargos to the brain.
MOLECULAR PSYCHIATRY
(2021)
Article
Geriatrics & Gerontology
Kyu Hwan Shim, Han Gyeol Go, Heewon Bae, Da-Eun Jeong, Danyeong Kim, Young Chul Youn, SangYun Kim, Seong Soo A. An, Min Ju Kang
Summary: Exosomal AChE activity is significantly decreased in PD patients compared to healthy controls, and shows a strong negative correlation with disease severity. This implies its potential as a reliable biomarker for early diagnosis and prognosis of PD.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Magdalena Banwinkler, Verena Dzialas, Merle C. Hoenig, Thilo van Eimeren
Summary: This study examined the differences in brain atrophy patterns between different subtypes of Parkinson's disease (PD). The results showed that there were no significant differences in gray matter volume reduction or asymmetry between patients with brain-first PD and body-first PD.
MOVEMENT DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Seon-Young Park, Hyejin Yang, Soyoung Kim, Juwon Yang, Hyemin Go, Hyunsu Bae
Summary: This study proposes a strategy for alpha-syn specific Treg expansion and demonstrates its neuroprotective effects on Parkinson's disease in a mouse model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Anna Emdina, Peter Hermann, Daniela Varges, Sabine Nuhn, Stefan Goebel, Timothy Bunck, Fabian Maass, Matthias Schmitz, Franc Llorens, Niels Kruse, Paul Lingor, Brit Mollenhauer, Inga Zerr
Summary: The study suggests that CSF oc-synuclein may serve as a potential prognostic marker for disease progression, affective symptoms, and executive cognitive function in Parkinson's disease.
Article
Chemistry, Multidisciplinary
Guiqin Chen, Eun Hee Ahn, Seong Su Kang, Yiyuan Xia, Xia Liu, Zhaohui Zhang, Keqiang Ye
Summary: This study demonstrates that AEP cleavage of UNC5C receptor contributes to dopaminergic neuronal loss in Parkinson's disease (PD), and the fragmentation of UNC5C is inversely correlated with reduced netrin-1 levels.
Article
Clinical Neurology
Lung Chan, Chen-Chih Chung, Yi-Chen Hsieh, Ruey-Meei Wu, Chien-Tai Hong
Summary: This study investigated the dynamic changes in plasma extracellular vesicle (EV) contents, including α-synuclein, tau, and β-amyloid, in Parkinson's disease (PD) patients and their correlation with clinical progression. The results suggest that these proteins may serve as biomarkers for evaluating disease deterioration risk.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2023)
Article
Clinical Neurology
Yi-Qun Yan, Jia-Li Pu, Ran Zheng, Yi Fang, Lu-Yan Gu, Tao Guo, Xiao-Li Si, Cheng Zhou, Ying Chen, Yi Liu, Xiao-Jun Guan, Xiao-Jun Xu, Ya-Ping Yan, Xin-Zhen Yin, Min-Ming Zhang, Zhi-Hua Tao, Bao-Rong Zhang
Summary: The study suggests that both plasma total exosomal alpha-Syn and neural-derived exosomal alpha-Syn were elevated in Parkinson's disease (PD) patients, while only neural-derived exosomal alpha-Syn was elevated in probable idiopathic rapid eye movement sleep behavior disorder (pRBD) patients. Additionally, the adaptor protein of inflammasome ASC is correlated with alpha-Syn and may play a role in synucleinopathy.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Zhi-ting Chen, Chu-zhui Pan, Xing-lin Ruan, Li-ping Lei, Sheng-mei Lin, Yin-zhou Wang, Zhen-Hua Zhao
Summary: This study found that the levels of ferritin and TfR in plasma neural-derived exosomes of patients with PD were significantly higher, suggesting that they may serve as potential biomarkers for PD.
FRONTIERS IN AGING NEUROSCIENCE
(2023)