Applications of focused ultrasound in the brain: from thermoablation to drug delivery

Safety and feasibility of multiple blood-brain barrier disruptions for the treatment of glioblastoma in patients undergoing standard adjuvant chemotherapy

(2020) So Hee Park et al.   JOURNAL OF NEUROSURGERY

Blood-brain barrier disruption with low-intensity pulsed ultrasound for the treatment of pediatric brain tumors: a review and perspectives

(2020) Kévin Beccaria et al.   Neurosurgical Focus

Focused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in a mouse model of Alzheimer’s disease

(2020) K. Xhima et al.   Science Advances

Magnetic resonance-guided focused ultrasound capsulotomy for refractory obsessive compulsive disorder and major depressive disorder: clinical and imaging results from two phase I trials

(2020) Benjamin Davidson et al.   MOLECULAR PSYCHIATRY

Spinal Cord Stimulation for Very Advanced Parkinson's Disease: A 1‐Year Prospective Trial

(2020) Sreeram Prasad et al.   MOVEMENT DISORDERS

Noninvasive hippocampal blood−brain barrier opening in Alzheimer’s disease with focused ultrasound

(2020) Ali R. Rezai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cost-effectiveness analysis of MR-guided focused ultrasound thalamotomy for tremor-dominant Parkinson’s disease

(2020) Ying Meng et al.   JOURNAL OF NEUROSURGERY

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

(2019) Daniel A. Nation et al.   NATURE MEDICINE

A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease

(2019) Francesco Panza et al.   Nature Reviews Neurology

Modulation of brain function by targeted delivery of GABA through the disrupted blood-brain barrier

(2019) Nick Todd et al.   NEUROIMAGE

Blood-Brain Barrier Opening in Primary Brain Tumors with Non-invasive MR-Guided Focused Ultrasound: A Clinical Safety and Feasibility Study

(2019) Todd Mainprize et al.   Scientific Reports

Noninvasive sub-organ ultrasound stimulation for targeted neuromodulation

(2019) Victoria Cotero et al.   Nature Communications

Ultrasound Hyperthermia Technology for Radiosensitization

(2019) Lifei Zhu et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Histotripsy Clot Liquefaction in a Porcine Intracerebral Hemorrhage Model

(2019) Tyler Gerhardson et al.   NEUROSURGERY

Manipulation of Subcortical and Deep Cortical Activity in the Primate Brain Using Transcranial Focused Ultrasound Stimulation

(2019) Davide Folloni et al.   NEURON

Deep brain stimulation: current challenges and future directions

(2019) Andres M. Lozano et al.   Nature Reviews Neurology

Challenges to curing primary brain tumours

(2019) Kenneth Aldape et al.   Nature Reviews Clinical Oncology

Four-year follow-up results of magnetic resonance-guided focused ultrasound thalamotomy for essential tremor

(2019) Yong-Sook Park et al.   MOVEMENT DISORDERS

Blood-brain barrier disruption in humans using an implantable ultrasound device: quantification with MR images and correlation with local acoustic pressure

(2019) Nicolas Asquier et al.   JOURNAL OF NEUROSURGERY

Repeat magnetic resonance imaging–guided focused ultrasound thalamotomy for recurrent essential tremor: case report and review of MRI findings

(2019) Elizabeth K. Weidman et al.   JOURNAL OF NEUROSURGERY

‘Relationship between thermal dose and cell death for “rapid” ablative and “slow” hyperthermic heating’

(2019) Petros X. E. Mouratidis et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Safety and Feasibility of Repeated and Transient Blood-Brain Barrier Disruption by Pulsed Ultrasound in Patients with Recurrent Glioblastoma

(2019) Ahmed Idbaih et al.   CLINICAL CANCER RESEARCH

Randomized trial of intermittent intraputamenal glial cell line-derived neurotrophic factor in Parkinson’s disease

(2019) Alan Whone et al.   BRAIN

Abstract #45: Ultrasound Neuromodulation for the Treatment of Peripheral Nerve Compression Syndromes

(2019) Andrew Clary et al.   Brain Stimulation

Impact of skull density ratio on efficacy and safety of magnetic resonance–guided focused ultrasound treatment of essential tremor

(2019) Marissa D’Souza et al.   JOURNAL OF NEUROSURGERY

Contemporary concepts of pain surgery

(2019) Kim J. Burchiel et al.   JOURNAL OF NEUROSURGERY

Safety and efficacy of sonothrombolysis for acute ischaemic stroke: a multicentre, double-blind, phase 3, randomised controlled trial

(2019) Andrei V Alexandrov et al.   LANCET NEUROLOGY

Offline impact of transcranial focused ultrasound on cortical activation in primates

(2019) Lennart Verhagen et al.   eLife

Reversible neuroinhibition by focused ultrasound is mediated by a thermal mechanism

(2019) David P. Darrow et al.   Brain Stimulation

Tip of the Iceberg: Assessing the Global Socioeconomic Costs of Alzheimer’s Disease and Related Dementias and Strategic Implications for Stakeholders

(2019) Youssef H. El-Hayek et al.   JOURNAL OF ALZHEIMERS DISEASE

Change in some quality of life domains mimics change in tremor severity after ultrasound thalamotomy

(2019) Nadia Scantlebury et al.   MOVEMENT DISORDERS

Obsessive–compulsive disorder

(2019) Dan J. Stein et al.   Nature Reviews Disease Primers

Glymphatics visualization after focused ultrasound induced blood‐brain barrier opening in humans

(2019) Ying Meng et al.   ANNALS OF NEUROLOGY

Transcranial focused ultrasound pulsation suppresses pentylenetetrazol induced epilepsy in vivo

(2019) Sin-Guang Chen et al.   Brain Stimulation

Safety and efficacy of focused ultrasound induced blood-brain barrier opening, an integrative review of animal and human studies

(2019) Ying Meng et al.   JOURNAL OF CONTROLLED RELEASE

Transcranial Magnetic Resonance-Guided Focused Ultrasound Thalamotomy in Essential Tremor: A Comprehensive Lesion Characterization

(2019) José Angel Pineda-Pardo et al.   NEUROSURGERY

Ultrasonic Neuromodulation via Astrocytic TRPA1

(2019) Soo-Jin Oh et al.   CURRENT BIOLOGY

Resting state functional connectivity changes after MR-guided focused ultrasound mediated blood-brain barrier opening in patients with Alzheimer's disease

(2019) Ying Meng et al.   NEUROIMAGE

The neurovascular response is attenuated by focused ultrasound-mediated disruption of the blood-brain barrier

(2019) Nick Todd et al.   NEUROIMAGE

Effects of sonication parameters on transcranial focused ultrasound brain stimulation in an ovine model

(2019) Kyungho Yoon et al.   PLoS One

First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound

(2019) Agessandro Abrahao et al.   Nature Communications

Non-invasive ultrasonic modulation of visual evoked response by GABA delivery through the blood brain barrier

(2019) Charlotte Constans et al.   JOURNAL OF CONTROLLED RELEASE

Transcranial ultrasound stimulation directly influences the cortical excitability of the motor cortex in Parkinsonian mice

(2019) Zhijie Wang et al.   MOVEMENT DISORDERS

Cerebral amyloid angiopathy and Alzheimer disease — one peptide, two pathways

(2019) Steven M. Greenberg et al.   Nature Reviews Neurology

A Basal Forebrain-Cingulate Circuit in Macaques Decides It Is Time to Act

(2019) Nima Khalighinejad et al.   NEURON

American Society for Stereotactic and Functional Neurosurgery Position Statement on Magnetic Resonance-Guided Focused Ultrasound for the Management of Essential Tremor

(2019) Nader Pouratian et al.   NEUROSURGERY

Sono-optogenetics facilitated by a circulation-delivered rechargeable light source for minimally invasive optogenetics

(2019) Xiang Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced neuronal activity in mouse motor cortex with microbubbles’ oscillations by transcranial focused ultrasound stimulation

(2019) Zhiwei Cui et al.   ULTRASONICS SONOCHEMISTRY

A Clinical System for Non-invasive Blood–Brain Barrier Opening Using a Neuronavigation-Guided Single-Element Focused Ultrasound Transducer

(2019) Antonios N. Pouliopoulos et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Transcranial Pulse Stimulation with Ultrasound in Alzheimer's Disease—A New Navigated Focal Brain Therapy

(2019) Roland Beisteiner et al.   Advanced Science

A prospective trial of magnetic resonance-guided focused ultrasound thalamotomy for essential tremor: Results at the 2-year follow-up

(2018) Jin Woo Chang et al.   ANNALS OF NEUROLOGY

Treatment of Major Depressive Disorder via Magnetic Resonance–Guided Focused Ultrasound Surgery

(2018) Minsoo Kim et al.   BIOLOGICAL PSYCHIATRY

Treatment of a Patient With Task-Specific Writing Tremor Using Magnetic Resonance-Guided Focused Ultrasound

(2018) Ying Meng et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Brainstem blood brain barrier disruption using focused ultrasound: A demonstration of feasibility and enhanced doxorubicin delivery

(2018) Saira Alli et al.   JOURNAL OF CONTROLLED RELEASE

Skull bone marrow injury caused by MR-guided focused ultrasound for cerebral functional procedures

(2018) Michael L. Schwartz et al.   JOURNAL OF NEUROSURGERY

Noninvasive neuromodulation and thalamic mapping with low-intensity focused ultrasound

(2018) Robert F. Dallapiazza et al.   JOURNAL OF NEUROSURGERY

Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial

(2018) Daniel M Blumberger et al.   LANCET

Focused ultrasound subthalamotomy in patients with asymmetric Parkinson's disease: a pilot study

(2018) Raul Martínez-Fernández et al.   LANCET NEUROLOGY

Neurological adverse event profile of magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor

(2018) Paul S. Fishman et al.   MOVEMENT DISORDERS

Enhancing glioblastoma treatment using cisplatin-gold-nanoparticle conjugates and targeted delivery with magnetic resonance-guided focused ultrasound

(2018) Daniel Coluccia et al.   Nanomedicine-Nanotechnology Biology and Medicine

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Ultrasonic Neuromodulation Causes Widespread Cortical Activation via an Indirect Auditory Mechanism

(2018) Tomokazu Sato et al.   NEURON

Ultrasound Produces Extensive Brain Activation via a Cochlear Pathway

(2018) Hongsun Guo et al.   NEURON

Transplantation of Neural Progenitor Cells Expressing Glial Cell Line-Derived Neurotrophic Factor into the Motor Cortex as a Strategy to Treat Amyotrophic Lateral Sclerosis

(2018) Gretchen M. Thomsen et al.   STEM CELLS

Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound

(2018) Nir Lipsman et al.   Nature Communications

Preliminary Investigation of Focused Ultrasound-Facilitated Drug Delivery for the Treatment of Leptomeningeal Metastases

(2018) Meaghan A. O’Reilly et al.   Scientific Reports

Establishing sheep as an experimental species to validate ultrasound-mediated blood-brain barrier opening for potential therapeutic interventions

(2018) Matthew Pelekanos et al.   Theranostics

Gene Therapy for Parkinson’s Disease, An Update

(2018) Tobias M. Axelsen et al.   Journal of Parkinsons Disease

Safety and Efficacy of Scanning Ultrasound Treatment of Aged APP23 Mice

(2018) Gerhard Leinenga et al.   Frontiers in Neuroscience

Acoustically targeted chemogenetics for the non-invasive control of neural circuits

(2018) Jerzy O. Szablowski et al.   Nature Biomedical Engineering

The efficacy and limits of magnetic resonance–guided focused ultrasound pallidotomy for Parkinson’s disease: a Phase I clinical trial

(2018) Na Young Jung et al.   JOURNAL OF NEUROSURGERY

A single case of MRI-guided focused ultrasound ventro-oral thalamotomy for musician’s dystonia

(2018) Shiro Horisawa et al.   JOURNAL OF NEUROSURGERY

Novel ways to manage chronic pain are needed

(2018) The Lancet Neurology   LANCET NEUROLOGY

Noninvasive delivery of an α-synuclein gene silencing vector with magnetic resonance-guided focused ultrasound

(2018) Kristiana Xhima et al.   MOVEMENT DISORDERS

The amyloid hypothesis on trial

(2018) Simon Makin   NATURE

Time course of focused ultrasound effects on β-amyloid plaque pathology in the TgCRND8 mouse model of Alzheimer’s disease

(2018) Charissa T. Poon et al.   Scientific Reports

Outcomes from stereotactic surgery for essential tremor

(2018) Robert Francis Dallapiazza et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

In vivo histotripsy brain treatment

(2018) Jonathan R. Sukovich et al.   JOURNAL OF NEUROSURGERY

Magnetic resonance-guided focused ultrasound thalamotomy for treatment of essential tremor: A 2-year outcome study

(2018) Ying Meng et al.   MOVEMENT DISORDERS

Cost-Effectiveness of Magnetic Resonance-Guided Focused Ultrasound for Essential Tremor

(2018) Chunmei Li et al.   MOVEMENT DISORDERS

Noninvasive Ultrasonic Drug Uncaging Maps Whole-Brain Functional Networks

(2018) Jeffrey B. Wang et al.   NEURON

Sonodynamic Therapy for Malignant Glioma Using 220-kHz Transcranial Magnetic Resonance Imaging-Guided Focused Ultrasound and 5-Aminolevulinic acid

(2018) Michiharu Yoshida et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Ultrasound targeted CNS gene delivery for Parkinson's disease treatment

(2017) Ching-Hsiang Fan et al.   JOURNAL OF CONTROLLED RELEASE

Safe long-term repeated disruption of the blood-brain barrier using an implantable ultrasound device: a multiparametric study in a primate model

(2017) Catherine Horodyckid et al.   JOURNAL OF NEUROSURGERY

Amyloid β Plaque Reduction With Antibodies Crossing the Blood-Brain Barrier, Which Was Opened in 3 Sessions of Focused Ultrasound in a Rabbit Model

(2017) Tereza Alecou et al.   JOURNAL OF ULTRASOUND IN MEDICINE

Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial

(2017) Koji Abe et al.   LANCET NEUROLOGY

Cost-effectiveness of focused ultrasound, radiosurgery, and DBS for essential tremor

(2017) Vinod K. Ravikumar et al.   MOVEMENT DISORDERS

ER stress and the unfolded protein response in neurodegeneration

(2017) Claudio Hetz et al.   Nature Reviews Neurology

MRI-guided focused ultrasound thalamotomy in non-ET tremor syndromes

(2017) Alfonso Fasano et al.   NEUROLOGY

Acute Inflammatory Response Following Increased Blood-Brain Barrier Permeability Induced by Focused Ultrasound is Dependent on Microbubble Dose

(2017) Dallan McMahon et al.   Theranostics

Safety and Efficacy of Focused Ultrasound Thalamotomy for Patients With Medication-Refractory, Tremor-Dominant Parkinson Disease

(2017) Aaron E. Bond et al.   JAMA Neurology

Amyotrophic lateral sclerosis

(2017) Orla Hardiman et al.   Nature Reviews Disease Primers

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Non-invasive, Focused Ultrasound-Facilitated Gene Delivery for Optogenetics

(2017) Shutao Wang et al.   Scientific Reports

Acute effects of focused ultrasound-induced increases in blood-brain barrier permeability on rat microvascular transcriptome

(2017) Dallan McMahon et al.   Scientific Reports

Characterization of Different Microbubbles in Assisting Focused Ultrasound-Induced Blood-Brain Barrier Opening

(2017) Sheng-Kai Wu et al.   Scientific Reports

The essential tremor syndromes

(2016) Rodger J. Elble   CURRENT OPINION IN NEUROLOGY

Potential new complication in drug therapy development for amyotrophic lateral sclerosis

(2016) Svitlana Garbuzova-Davis et al.   Expert Review of Neurotherapeutics

A Phase II Study of Fornix Deep Brain Stimulation in Mild Alzheimer’s Disease

(2016) Andres M. Lozano et al.   JOURNAL OF ALZHEIMERS DISEASE

Growth inhibition in a brain metastasis model by antibody delivery using focused ultrasound-mediated blood-brain barrier disruption

(2016) Thiele Kobus et al.   JOURNAL OF CONTROLLED RELEASE

Cavitation-enhanced nonthermal ablation in deep brain targets: feasibility in a large animal model

(2016) Costas D. Arvanitis et al.   JOURNAL OF NEUROSURGERY

Dorsal anterior cingulotomy and anterior capsulotomy for severe, refractory obsessive-compulsive disorder: a systematic review of observational studies

(2016) Lauren T. Brown et al.   JOURNAL OF NEUROSURGERY

Factors associated with successful magnetic resonance-guided focused ultrasound treatment: efficiency of acoustic energy delivery through the skull

(2016) Won Seok Chang et al.   JOURNAL OF NEUROSURGERY

Pathophysiological and diagnostic implications of cortical dysfunction in ALS

(2016) Nimeshan Geevasinga et al.   Nature Reviews Neurology

Supportive and symptomatic management of amyotrophic lateral sclerosis

(2016) Esther V. Hobson et al.   Nature Reviews Neurology

Ultrasound treatment of neurological diseases — current and emerging applications

(2016) Gerhard Leinenga et al.   Nature Reviews Neurology

Early treatment of HER2-amplified brain tumors with targeted NK-92 cells and focused ultrasound improves survival

(2016) Ryan Alkins et al.   NEURO-ONCOLOGY

A Randomized Trial of Focused Ultrasound Thalamotomy for Essential Tremor

(2016) W. Jeffrey Elias et al.   NEW ENGLAND JOURNAL OF MEDICINE

Image-guided ultrasound phased arrays are a disruptive technology for non-invasive therapy

(2016) Kullervo Hynynen et al.   PHYSICS IN MEDICINE AND BIOLOGY

Disrupting the blood–brain barrier by focused ultrasound induces sterile inflammation

(2016) Zsofia I. Kovacs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Focused Ultrasound Enhances Central Nervous System Delivery of Bevacizumab for Malignant Glioma Treatment

(2016) Hao-Li Liu et al.   RADIOLOGY

Clinical trial of blood-brain barrier disruption by pulsed ultrasound

(2016) Alexandre Carpentier et al.   Science Translational Medicine

Longitudinal Motor and Behavioral Assessment of Blood–Brain Barrier Opening with Transcranial Focused Ultrasound

(2016) Oluyemi O. Olumolade et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Localized Down-regulation of P-glycoprotein by Focused Ultrasound and Microbubbles induced Blood-Brain Barrier Disruption in Rat Brain

(2016) HongSeok Cho et al.   Scientific Reports

Noninvasive, Targeted and Non-Viral Ultrasound-Mediated GDNF-Plasmid Delivery for Treatment of Parkinson’s Disease

(2016) Ching-Hsiang Fan et al.   Scientific Reports

Potential new complication in drug therapy development for amyotrophic lateral sclerosis

(2016) Svitlana Garbuzova-Davis et al.   Expert Review of Neurotherapeutics

Major depressive disorder

(2016) Christian Otte et al.   Nature Reviews Disease Primers

Focused Ultrasound-Induced Neurogenesis Requires an Increase in Blood-Brain Barrier Permeability

(2016) Skyler J. Mooney et al.   PLoS One

Transcranial focused ultrasound stimulation of human primary visual cortex

(2016) Wonhye Lee et al.   Scientific Reports

Hyperthermia Sensitizes Glioma Stem-like Cells to Radiation by Inhibiting AKT Signaling

(2015) J. Man et al.   CANCER RESEARCH

Overcoming the blood–brain tumor barrier for effective glioblastoma treatment

(2015) O. van Tellingen et al.   DRUG RESISTANCE UPDATES

Focused ultrasound-induced blood–brain barrier opening to enhance interleukin-12 delivery for brain tumor immunotherapy: a preclinical feasibility study

(2015) Pin-Yuan Chen et al.   Journal of Translational Medicine

Optogenetics: 10 years of microbial opsins in neuroscience

(2015) Karl Deisseroth   NATURE NEUROSCIENCE

Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model

(2015) Gerhard Leinenga et al.   Science Translational Medicine

Alzheimer's disease

(2015) Colin L. Masters et al.   Nature Reviews Disease Primers

Deep Brain Stimulation for Obsessive-Compulsive Disorder: A Meta-Analysis of Treatment Outcome and Predictors of Response

(2015) Pino Alonso et al.   PLoS One

Mechanisms of deep brain stimulation for essential tremor

(2014) Rodger J. Elble   BRAIN

Stimulation of Hippocampal Neurogenesis by Transcranial Focused Ultrasound and Microbubbles in Adult Mice

(2014) Tiffany Scarcelli et al.   Brain Stimulation

The Size of Blood–Brain Barrier Opening Induced by Focused Ultrasound is Dictated by the Acoustic Pressure

(2014) Hong Chen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Who Qualifies for Deep Brain Stimulation for OCD? Data From a Naturalistic Clinical Sample

(2014) Sarah L. Garnaat et al.   JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES

Delayed Disease Onset and Extended Survival in the SOD1G93A Rat Model of Amyotrophic Lateral Sclerosis after Suppression of Mutant SOD1 in the Motor Cortex

(2014) G. M. Thomsen et al.   JOURNAL OF NEUROSCIENCE

Bilateral thermal capsulotomy with MR-guided focused ultrasound for patients with treatment-refractory obsessive-compulsive disorder: a proof-of-concept study

(2014) H H Jung et al.   MOLECULAR PSYCHIATRY

Transcranial focused ultrasound modulates the activity of primary somatosensory cortex in humans

(2014) Wynn Legon et al.   NATURE NEUROSCIENCE

Obsessive–compulsive disorder: an integrative genetic and neurobiological perspective

(2014) David L. Pauls et al.   NATURE REVIEWS NEUROSCIENCE

Deep Brain Stimulation for Obsessive-Compulsive Disorder

(2014) Clement Hamani et al.   NEUROSURGERY

Thalamic Connectivity in Patients with Essential Tremor Treated with MR Imaging–guided Focused Ultrasound: In Vivo Fiber Tracking by Using Diffusion-Tensor MR Imaging

(2014) Max Wintermark et al.   RADIOLOGY

Alzheimer Disease in a Mouse Model: MR Imaging–guided Focused Ultrasound Targeted to the Hippocampus Opens the Blood-Brain Barrier and Improves Pathologic Abnormalities and Behavior

(2014) Alison Burgess et al.   RADIOLOGY

Effect of Minimally Invasive Surgery on the Risk for Surgical Site Infections

(2014) Giorgio Gandaglia et al.   JAMA Surgery

Neuroimaging essentials in essential tremor: A systematic review

(2014) Sarvi Sharifi et al.   NeuroImage-Clinical

Inhibiting drug efflux transporters improves efficacy of ALS therapeutics

(2014) Michael R. Jablonski et al.   Annals of Clinical and Translational Neurology

Focused Ultrasound Delivers Targeted Immune Cells to Metastatic Brain Tumors

(2013) R. Alkins et al.   CANCER RESEARCH

Low-Intensity Focused Ultrasound Modulates Monkey Visuomotor Behavior

(2013) Thomas Deffieux et al.   CURRENT BIOLOGY

Deep brain stimulation for Parkinsonʼs disease and other movement disorders

(2013) Suneil K. Kalia et al.   CURRENT OPINION IN NEUROLOGY

Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound

(2013) Jessica F. Jordão et al.   EXPERIMENTAL NEUROLOGY

MR-guided focused ultrasound thalamotomy for essential tremor: a proof-of-concept study

(2013) Nir Lipsman et al.   LANCET NEUROLOGY

Influence of the pressure field distribution in transcranial ultrasonic neurostimulation

(2013) Youliana Younan et al.   MEDICAL PHYSICS

A Pilot Study of Focused Ultrasound Thalamotomy for Essential Tremor

(2013) W. Jeffrey Elias et al.   NEW ENGLAND JOURNAL OF MEDICINE

Focal Delivery of AAV2/1-transgenes Into the Rat Brain by Localized Ultrasound-induced BBB Opening

(2013) Angelika Alonso et al.   Molecular Therapy-Nucleic Acids

Targeted Delivery of Self-Complementary Adeno-Associated Virus Serotype 9 to the Brain, Using Magnetic Resonance Imaging-Guided Focused Ultrasound

(2012) Emmanuel Thévenot et al.   HUMAN GENE THERAPY

Old and new facts about hyperthermia-induced modulations of the immune system

(2012) Benjamin Frey et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Ultrasound-mediated blood‐brain/blood-tumor barrier disruption improves outcomes with trastuzumab in a breast cancer brain metastasis model

(2012) Eun-Joo Park et al.   JOURNAL OF CONTROLLED RELEASE

High-Intensity Focused Ultrasound (HIFU) for Dissolution of Clots in a Rabbit Model of Embolic Stroke

(2012) Alison Burgess et al.   PLoS One

Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: Recommendations from the Alzheimer’s Association Research Roundtable Workgroup

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

Is selective primary visual cortex stimulation achievable with TMS?

(2011) Niina Salminen-Vaparanta et al.   HUMAN BRAIN MAPPING

Transcranial magnetic resonance imaging–guided focused ultrasound: noninvasive central lateral thalamotomy for chronic neuropathic pain

(2011) Daniel Jeanmonod et al.   Neurosurgical Focus

Targeted Delivery of Neural Stem Cells to the Brain Using MRI-Guided Focused Ultrasound to Disrupt the Blood-Brain Barrier

(2011) Alison Burgess et al.   PLoS One

Focused Ultrasound Surgery in Oncology: Overview and Principles

(2011) Clare M. C. Tempany et al.   RADIOLOGY

Deep Brain Stimulation of the Nucleus Accumbens for Treatment-Refractory Obsessive-Compulsive Disorder

(2010) Damiaan Denys et al.   ARCHIVES OF GENERAL PSYCHIATRY

Coupling between Beta and High-Frequency Activity in the Human Subthalamic Nucleus May Be a Pathophysiological Mechanism in Parkinson's Disease

(2010) J. Lopez-Azcarate et al.   JOURNAL OF NEUROSCIENCE

Transcranial Magnetic Resonance Imaging– Guided Focused Ultrasound Surgery of Brain Tumors

(2010) Nathan McDannold et al.   NEUROSURGERY

Antibodies Targeted to the Brain with Image-Guided Focused Ultrasound Reduces Amyloid-β Plaque Load in the TgCRND8 Mouse Model of Alzheimer's Disease

(2010) Jessica F. Jordão et al.   PLoS One

High-intensity focused ultrasound for noninvasive functional neurosurgery

(2009) Ernst Martin et al.   ANNALS OF NEUROLOGY

HIGH-INTENSITY FOCUSED ULTRASOUND SURGERY OF THE BRAIN

(2009) Jay Jagannathan et al.   NEUROSURGERY

Capsulotomy for Obsessive-Compulsive Disorder

(2008) Christian Rück et al.   ARCHIVES OF GENERAL PSYCHIATRY

Subthalamic Nucleus Stimulation in Severe Obsessive–Compulsive Disorder

(2008) Luc Mallet et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of Acoustic Parameters and Ultrasound Contrast Agent Dose on Focused-Ultrasound Induced Blood-Brain Barrier Disruption

(2008) Nathan McDannold et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Towards Aberration Correction of Transcranial Ultrasound Using Acoustic Droplet Vaporization

(2007) Kevin J. Haworth et al.   ULTRASOUND IN MEDICINE AND BIOLOGY