Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia

Critical Role of Truncated α-Synuclein and Aggregates in Parkinson's Disease and Incidental Lewy Body Disease

(2012) Kavita Prasad et al.   BRAIN PATHOLOGY

Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts

(2011) Lisa Fellner et al.   ACTA NEUROPATHOLOGICA

Toll-Like Receptor 4 Promotes α-Synuclein Clearance and Survival of Nigral Dopaminergic Neurons

(2011) Nadia Stefanova et al.   AMERICAN JOURNAL OF PATHOLOGY

Toll-like Receptor Expression and Activation in Astroglia: Differential Regulation by HIV-1 Tat, gp120, and Morphine

(2011) Nazira El-Hage et al.   IMMUNOLOGICAL INVESTIGATIONS

Expression of mutant alpha-synuclein modulates microglial phenotype in vitro

(2011) Lalida Rojanathammanee et al.   Journal of Neuroinflammation

Glia: Initiators and progressors of pathology in Parkinson's disease

(2011) Glenda M. Halliday et al.   MOVEMENT DISORDERS

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

(2011) Marco Prinz et al.   NATURE NEUROSCIENCE

Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line

(2011) Lydia Alvarez-Erviti et al.   NEUROSCIENCE RESEARCH

Contributions of astrocytes to synapse formation and maturation — Potential functions of the perisynaptic extracellular matrix

(2010) Andreas Faissner et al.   BRAIN RESEARCH REVIEWS

Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways

(2010) Roser Gorina et al.   GLIA

Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

(2010) He-Jin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Synuclein Activates Microglia by Inducing the Expressions of Matrix Metalloproteinases and the Subsequent Activation of Protease-Activated Receptor-1

(2010) E.-J. Lee et al.   JOURNAL OF IMMUNOLOGY

Pivotal Role of TLR4 Receptors in Alcohol-Induced Neuroinflammation and Brain Damage

(2010) S. Alfonso-Loeches et al.   JOURNAL OF NEUROSCIENCE

Astrocytes and therapeutics for Parkinson’s disease

(2010) Phillip M. Rappold et al.   Neurotherapeutics

Alpha-Synuclein Stimulation of Astrocytes: Potential Role for Neuroinflammation and Neuroprotection

(2010) He-Jin Lee et al.   Oxidative Medicine and Cellular Longevity

Glial Innate Immunity Generated by Non-Aggregated Alpha-Synuclein in Mouse: Differences between Wild-type and Parkinson's Disease-Linked Mutants

(2010) Cintia Roodveldt et al.   PLoS One

SNCAvariants are associated with increased risk for multiple system atrophy

(2009) Sonja W. Scholz et al.   ANNALS OF NEUROLOGY

A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death

(2009) Kaoru Saijo et al.   CELL

Molecular pathogenesis of Parkinson disease: insights from genetic studies

(2009) Thomas Gasser   EXPERT REVIEWS IN MOLECULAR MEDICINE

CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar A -Stimulated Microglial Activation

(2009) E. G. Reed-Geaghan et al.   JOURNAL OF NEUROSCIENCE

Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy

(2009) Maria Xilouri et al.   PLoS One

Genetic Variants of the α-Synuclein Gene SNCA Are Associated with Multiple System Atrophy

(2009) Ammar Al-Chalabi et al.   PLoS One

Astrocytes and the regulation of cerebral blood flow

(2009) Raymond C. Koehler et al.   TRENDS IN NEUROSCIENCES

Clearance and deposition of extracellular α-synuclein aggregates in microglia

(2008) He-Jin Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Toll-like receptors in neurodegeneration

(2008) Eitan Okun et al.   BRAIN RESEARCH REVIEWS

Microglial phagocytosis is enhanced by monomeric α-synuclein, not aggregated α-synuclein: Implications for Parkinson's disease

(2008) Ji-Young Park et al.   GLIA

Nitrated Alpha-Synuclein and Microglial Neuroregulatory Activities

(2008) Ashley D. Reynolds et al.   Journal of Neuroimmune Pharmacology

Synuclein activates microglia in a model of Parkinson's disease

(2007) Xiaomin Su et al.   NEUROBIOLOGY OF AGING

Screening of innate immune receptors in neurodegenerative diseases: A similar pattern

(2007) Maryse Letiembre et al.   NEUROBIOLOGY OF AGING

α-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia

(2006) Andis Klegeris et al.   NEUROBIOLOGY OF AGING