Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer’s disease alleviates amyloid-related pathologies in mice
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer’s disease alleviates amyloid-related pathologies in mice
Authors
Keywords
-
Journal
Nature Biomedical Engineering
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-07-27
DOI
10.1038/s41551-021-00759-0
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The mutational constraint spectrum quantified from variation in 141,456 humans
- (2020) Konrad J. Karczewski et al. NATURE
- Multiplexed Cre-dependent selection yields systemic AAVs for targeting distinct brain cell types
- (2020) Sripriya Ravindra Kumar et al. NATURE METHODS
- Systemic AAV vectors for widespread and targeted gene delivery in rodents
- (2019) Rosemary C. Challis et al. Nature Protocols
- Therapeutic AAV Gene Transfer to the Nervous System: A Clinical Reality
- (2019) Eloise Hudry et al. NEURON
- In vivo neuronal gene editing via CRISPR–Cas9 amphiphilic nanocomplexes alleviates deficits in mouse models of Alzheimer’s disease
- (2019) Hanseul Park et al. NATURE NEUROSCIENCE
- Sequential formation of different layers of dystrophic neurites in Alzheimer’s brains
- (2019) Md Golam Sharoar et al. MOLECULAR PSYCHIATRY
- PKR knockout in the 5xFAD model of Alzheimer's disease reveals beneficial effects on spatial memory and brain lesions
- (2019) Marion Tible et al. AGING CELL
- TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice
- (2019) Jianxiong Zeng et al. Cell Reports
- Gene Therapy Tools for Brain Diseases
- (2019) Selene Ingusci et al. Frontiers in Pharmacology
- Viral Strategies for Targeting the Central and Peripheral Nervous Systems
- (2018) Claire N. Bedbrook et al. Annual Review of Neuroscience
- Generation of App knock-in mice reveals deletion mutations protective against Alzheimer’s disease-like pathology
- (2018) Kenichi Nagata et al. Nature Communications
- CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer’s Disease
- (2018) Bence György et al. Molecular Therapy-Nucleic Acids
- Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice
- (2018) Ming-Hsuan Ou-Yang et al. Science Translational Medicine
- BACE1 Inhibitor MK-8931 Alters Formation but Not Stability of Dendritic Spines
- (2018) Tanja Blume et al. Frontiers in Aging Neuroscience
- CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage
- (2018) Jichao Sun et al. Nature Communications
- Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents
- (2017) Xue Gao et al. NATURE
- Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems
- (2017) Ken Y Chan et al. NATURE NEUROSCIENCE
- Inclusion of the Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element Enhances AAV2-Driven Transduction of Mouse and Human Retina
- (2017) Maria I. Patrício et al. Molecular Therapy-Nucleic Acids
- CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer’s PSEN2 N141I neurons
- (2017) Maitane Ortiz-Virumbrales et al. Acta Neuropathologica Communications
- Molecular genetics of early-onset Alzheimer's disease revisited
- (2016) Rita Cacace et al. Alzheimers & Dementia
- The amyloid hypothesis of Alzheimer's disease at 25 years
- (2016) Dennis J Selkoe et al. EMBO Molecular Medicine
- Adeno-Associated Virus-Based Gene Therapy for CNS Diseases
- (2016) Michaël Hocquemiller et al. HUMAN GENE THERAPY
- Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain
- (2016) Benjamin E Deverman et al. NATURE BIOTECHNOLOGY
- IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline
- (2016) Amy K. Y. Fu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines
- (2016) Zhuoyi Liang et al. Nature Communications
- Replenishment of microRNA-188-5p restores the synaptic and cognitive deficits in 5XFAD Mouse Model of Alzheimer’s Disease
- (2016) Kihwan Lee et al. Scientific Reports
- Pharmacological Inhibition of BACE1 Impairs Synaptic Plasticity and Cognitive Functions
- (2015) Severin Filser et al. BIOLOGICAL PSYCHIATRY
- In vivo genome editing using Staphylococcus aureus Cas9
- (2015) F. Ann Ran et al. NATURE
- Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition
- (2015) Benjamin P Kleinstiver et al. NATURE BIOTECHNOLOGY
- Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer’s disease amyloid plaques
- (2015) Swetha Gowrishankar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Activity-Dependent p25 Generation Regulates Synaptic Plasticity and Aβ-Induced Cognitive Impairment
- (2014) Jinsoo Seo et al. CELL
- An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex
- (2014) Y. Zhang et al. JOURNAL OF NEUROSCIENCE
- The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease
- (2014) Tara L. Spires-Jones et al. NEURON
- Optimization of AAV expression cassettes to improve packaging capacity and transgene expression in neurons
- (2014) Jun-Hyeok Choi et al. Molecular Brain
- Genome engineering using the CRISPR-Cas9 system
- (2013) F Ann Ran et al. Nature Protocols
- Global Epidemiology of Amyotrophic Lateral Sclerosis: A Systematic Review of the Published Literature
- (2013) A. Chiò et al. NEUROEPIDEMIOLOGY
- Generation of mutant mice by pronuclear injection of circular plasmid expressing Cas9 and single guided RNA
- (2013) Daisuke Mashiko et al. Scientific Reports
- Neuropathological Alterations in Alzheimer Disease
- (2013) A. Serrano-Pozo et al. Cold Spring Harbor Perspectives in Medicine
- Locus-specific mutation databases for neurodegenerative brain diseases
- (2012) Marc Cruts et al. HUMAN MUTATION
- Postsynaptic degeneration as revealed by PSD-95 reduction occurs after advanced Aβ and tau pathology in transgenic mouse models of Alzheimer’s disease
- (2011) Charles Y. Shao et al. ACTA NEUROPATHOLOGICA
- Mouse genomic variation and its effect on phenotypes and gene regulation
- (2011) Thomas M. Keane et al. NATURE
- Mitochondrial dysfunction and accumulation of the β-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice
- (2011) Latha Devi et al. NEUROBIOLOGY OF DISEASE
- RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions
- (2011) B. Wiedenheft et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease
- (2010) Sadim Jawhar et al. NEUROBIOLOGY OF AGING
- -Secretase Gene Mutations in Familial Acne Inversa
- (2010) B. Wang et al. SCIENCE
- Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model
- (2008) Ryoichi Kimura et al. NEUROBIOLOGY OF DISEASE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now