A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease

Brain Pharmacokinetics of Two Prolyl Oligopeptidase Inhibitors, JTP-4819 and KYP-2047, in the Rat

(2011) Aaro J. Jalkanen et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Guide to Receptors and Channels (GRAC), 5th edition

(2011) SPH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Interaction of Prolyl Oligopeptidase with α-Synuclein

(2011) Anne-Marie Lambeir   CNS & Neurological Disorders-Drug Targets

Comparative Analysis of Different Peptidyl-Prolyl Isomerases Reveals FK506-binding Protein 12 as the Most Potent Enhancer of α-Synuclein Aggregation

(2011) Angélique Deleersnijder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Different effects of intranigral and intrastriatal administration of the proteasome inhibitor lactacystin on typical neurochemical and histological markers of Parkinson's disease in rats

(2011) Elżbieta Lorenc-Koci et al.   NEUROCHEMISTRY INTERNATIONAL

Prolyl Endopeptidase Is Involved in Cellular Signalling in Human Neuroblastoma SH-SY5Y Cells

(2011) M. José Moreno-Baylach et al.   NEUROSIGNALS

C1 Domain-Targeted Isophthalate Derivatives Induce Cell Elongation and Cell Cycle Arrest in HeLa Cells

(2011) Virpi Talman et al.   PLoS One

Prolyl oligopeptidase induces angiogenesis bothin vitroandin vivoin a novel regulatory manner

(2010) TT Myöhänen et al.   BRITISH JOURNAL OF PHARMACOLOGY

α-Synuclein mediates alterations in membrane conductance: a potential role for α-synuclein oligomers in cell vulnerability

(2010) Li Rebekah Feng et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Inhibition of FK506 Binding Proteins Reduces  -Synuclein Aggregation and Parkinson's Disease-Like Pathology

(2010) M. Gerard et al.   JOURNAL OF NEUROSCIENCE

Prolyl oligopeptidase binds to GAP-43 and functions without its peptidase activity

(2009) Elena Di Daniel et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions

(2009) Yaping Chu et al.   NEUROBIOLOGY OF DISEASE

Structural insights on physiological functions and pathological effects of α-synuclein

(2008) Marco Bisaglia et al.   FASEB JOURNAL

Distribution of prolyl oligopeptidase in the mouse whole-body sections and peripheral tissues

(2008) Timo T. Myöhänen et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Cellular and subcellular distribution of rat brain prolyl oligopeptidase and its association with specific neuronal neurotransmitters

(2008) Timo T. Myöhänen et al.   JOURNAL OF COMPARATIVE NEUROLOGY

FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha-synuclein and its clinical mutants A30P or A53T

(2008) Melanie Gerard et al.   JOURNAL OF NEUROCHEMISTRY

Accumulation and clearance of -synuclein aggregates demonstrated by time-lapse imaging

(2008) Felipe Opazo et al.   JOURNAL OF NEUROCHEMISTRY

Expression and traffic of cellular prolyl oligopeptidase are regulated during cerebellar granule cell differentiation, maturation, and aging

(2008) M.J. Moreno-Baylach et al.   NEUROSCIENCE

Prolyl oligopeptidase stimulates the aggregation of α-synuclein

(2008) Inger Brandt et al.   PEPTIDES

Impairment of microtubule system increases α-synuclein aggregation and toxicity

(2007) Myunghye Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS