Noninvasive delivery of an α-synuclein gene silencing vector with magnetic resonance-guided focused ultrasound

Differential α-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity

(2018) Esteban Luna et al.   ACTA NEUROPATHOLOGICA

Do subjects with minimal motor features have prodromal Parkinson disease?

(2018) Yaping Chu et al.   ANNALS OF NEUROLOGY

Alpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson’s disease

(2018) Silke Frahm et al.   BEHAVIOURAL BRAIN RESEARCH

Selective α-Synuclein Knockdown in Monoamine Neurons by Intranasal Oligonucleotide Delivery: Potential Therapy for Parkinson’s Disease

(2018) Diana Alarcón-Arís et al.   MOLECULAR THERAPY

Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound

(2018) Nir Lipsman et al.   Nature Communications

Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent Toxicity

(2018) Matthew J. Benskey et al.   Frontiers in Molecular Neuroscience

Therapeutic approaches to target alpha-synuclein pathology

(2017) Patrik Brundin et al.   EXPERIMENTAL NEUROLOGY

Clinical Gene Therapy for Neurodegenerative Diseases: Past, Present, and Future

(2017) Françoise Piguet et al.   HUMAN GENE THERAPY

Viral-mediated oligodendroglial alpha-synuclein expression models multiple system atrophy

(2017) Fares Bassil et al.   MOVEMENT DISORDERS

Novel Focused Ultrasound Gene Therapy Approach Noninvasively Restores Dopaminergic Neuron Function in a Rat Parkinson’s Disease Model

(2017) Brian P. Mead et al.   NANO LETTERS

Clinical tests of neurotrophic factors for human neurodegenerative diseases, part 1: Where have we been and what have we learned?

(2017) Raymond T. Bartus et al.   NEUROBIOLOGY OF DISEASE

Acute Inflammatory Response Following Increased Blood-Brain Barrier Permeability Induced by Focused Ultrasound is Dependent on Microbubble Dose

(2017) Dallan McMahon et al.   Theranostics

RNA Interference of Human α-Synuclein in Mouse

(2017) Young-Cho Kim et al.   Frontiers in Neurology

Persistent Expression of Dopamine-Synthesizing Enzymes 15 Years After Gene Transfer in a Primate Model of Parkinson's Disease

(2017) Yoshihide Sehara et al.   Human Gene Therapy Clinical Development

Acute effects of focused ultrasound-induced increases in blood-brain barrier permeability on rat microvascular transcriptome

(2017) Dallan McMahon et al.   Scientific Reports

CSF, blood-brain barrier, and brain drug delivery

(2016) William M. Pardridge   Expert Opinion on Drug Delivery

Hippocampal α-synuclein and interneurons in Parkinson's disease: Data from human and mouse models

(2016) Alicia Flores-Cuadrado et al.   MOVEMENT DISORDERS

Advances in markers of prodromal Parkinson disease

(2016) Ronald B. Postuma et al.   Nature Reviews Neurology

Disrupting the blood–brain barrier by focused ultrasound induces sterile inflammation

(2016) Zsofia I. Kovacs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Noninvasive, Targeted and Non-Viral Ultrasound-Mediated GDNF-Plasmid Delivery for Treatment of Parkinson’s Disease

(2016) Ching-Hsiang Fan et al.   Scientific Reports

Is Alpha-Synuclein Loss-of-Function a Contributor to Parkinsonian Pathology? Evidence from Non-human Primates

(2016) Timothy J. Collier et al.   Frontiers in Neuroscience

Gene delivery to the spinal cord using MRI-guided focused ultrasound

(2015) D Weber-Adrian et al.   GENE THERAPY

Enhanced Delivery and Bioactivity of the Neurturin Neurotrophic Factor through Focused Ultrasound—Mediated Blood—Brain Barrier Opening in vivo

(2015) Gesthimani Samiotaki et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson’s disease model

(2015) Alevtina D. Zharikov et al.   JOURNAL OF CLINICAL INVESTIGATION

Drug and gene delivery across the blood–brain barrier with focused ultrasound

(2015) Kelsie F. Timbie et al.   JOURNAL OF CONTROLLED RELEASE

Prediagnostic presentations of Parkinson's disease in primary care: a case-control study

(2015) Anette Schrag et al.   LANCET NEUROLOGY

MDS research criteria for prodromal Parkinson's disease

(2015) Daniela Berg et al.   MOVEMENT DISORDERS

Comparative analyses of adeno-associated viral vector serotypes 1, 2, 5, 8 and 9 in marmoset, mouse and macaque cerebral cortex

(2015) Akiya Watakabe et al.   NEUROSCIENCE RESEARCH

Propagation of prions causing synucleinopathies in cultured cells

(2015) Amanda L. Woerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model

(2015) Gerhard Leinenga et al.   Science Translational Medicine

Gene therapy for neurodegenerative diseases

(2015) Deirdre M. O’Connor et al.   TRENDS IN MOLECULAR MEDICINE

Nerve Growth Factor Gene Therapy

(2015) Mark H. Tuszynski et al.   JAMA Neurology

Targeted delivery of protein and gene medicines through the blood-brain barrier

(2015) WM Pardridge   CLINICAL PHARMACOLOGY & THERAPEUTICS

Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson’s disease

(2014) Hélène Hall et al.   BRAIN

Targeting alpha-synuclein with a microRNA-embedded silencing vector in the rat substantia nigra: Positive and negative effects

(2014) Christina E. Khodr et al.   BRAIN RESEARCH

Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice

(2014) J. Mark Cooper et al.   MOVEMENT DISORDERS

Alzheimer Disease in a Mouse Model: MR Imaging–guided Focused Ultrasound Targeted to the Hippocampus Opens the Blood-Brain Barrier and Improves Pathologic Abnormalities and Behavior

(2014) Alison Burgess et al.   RADIOLOGY

Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys

(2013) Ariadna Recasens et al.   ANNALS OF NEUROLOGY

Time course and progression of wild type α-Synuclein accumulation in a transgenic mouse model

(2013) David Amschl et al.   BMC NEUROSCIENCE

Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound

(2013) Jessica F. Jordão et al.   EXPERIMENTAL NEUROLOGY

Parkinson's Disease and Alpha Synuclein: Is Parkinson's Disease a Prion-Like Disorder?

(2013) C. Warren Olanow et al.   MOVEMENT DISORDERS

Analysis of Transduction Efficiency, Tropism and Axonal Transport of AAV Serotypes 1, 2, 5, 6, 8 and 9 in the Mouse Brain

(2013) Dominik F. Aschauer et al.   PLoS One

Transmission of multiple system atrophy prions to transgenic mice

(2013) J. C. Watts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkinson's Disease: Gene Therapies

(2013) P. G. Coune et al.   Cold Spring Harbor Perspectives in Medicine

Targeted Delivery of Self-Complementary Adeno-Associated Virus Serotype 9 to the Brain, Using Magnetic Resonance Imaging-Guided Focused Ultrasound

(2012) Emmanuel Thévenot et al.   HUMAN GENE THERAPY

Blood-Brain Barrier: Real-time Feedback-controlled Focused Ultrasound Disruption by Using an Acoustic Emissions–based Controller

(2012) Meaghan A. O’Reilly et al.   RADIOLOGY

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Adenosine A2A receptor gene disruption protects in an α-synuclein model of Parkinson's disease

(2011) Anil Kachroo et al.   ANNALS OF NEUROLOGY

A microRNA embedded AAV alpha-synuclein gene silencing vector for dopaminergic neurons

(2011) Ye Han et al.   BRAIN RESEARCH

An alpha-synuclein AAV gene silencing vector ameliorates a behavioral deficit in a rat model of Parkinson's disease, but displays toxicity in dopamine neurons

(2011) Christina E. Khodr et al.   BRAIN RESEARCH

Neuronal replacement in the injured olfactory bulb☆

(2011) Huan Liu et al.   EXPERIMENTAL NEUROLOGY

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

(2011) Christian Hansen et al.   JOURNAL OF CLINICAL INVESTIGATION

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Pre-motor features of Parkinson's disease: the Honolulu-Asia Aging Study experience

(2011) G. Webster Ross et al.   PARKINSONISM & RELATED DISORDERS

Targeted Delivery of Neural Stem Cells to the Brain Using MRI-Guided Focused Ultrasound to Disrupt the Blood-Brain Barrier

(2011) Alison Burgess et al.   PLoS One

Seeded Aggregation and Toxicity of α-Synuclein and Tau

(2010) Takashi Nonaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association between contrast-enhanced MR images and blood-brain barrier disruption following transcranial focused ultrasound

(2010) Feng-Yi Yang et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Are synucleinopathies prion-like disorders?

(2010) Elodie Angot et al.   LANCET NEUROLOGY

In Vivo RNAi-Mediated α-Synuclein Silencing Induces Nigrostriatal Degeneration

(2010) Oleg S Gorbatyuk et al.   MOLECULAR THERAPY

Antibodies Targeted to the Brain with Image-Guided Focused Ultrasound Reduces Amyloid-β Plaque Load in the TgCRND8 Mouse Model of Alzheimer's Disease

(2010) Jessica F. Jordão et al.   PLoS One

α-Synuclein Suppression by Targeted Small Interfering RNA in the Primate Substantia Nigra

(2010) Alison L. McCormack et al.   PLoS One

Intravenous Administration of Self-complementary AAV9 Enables Transgene Delivery to Adult Motor Neurons

(2009) Sandra Duque et al.   MOLECULAR THERAPY

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Is Parkinson's disease a prion disorder?

(2009) C. W. Olanow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exogenous  -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

(2009) K. C. Luk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors

(2008) Sabine Wislet-Gendebien et al.   BMC NEUROSCIENCE

In vivo silencing of alpha-synuclein using naked siRNA

(2008) Jada Lewis et al.   Molecular Neurodegeneration

Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes

(2008) Kevin D Foust et al.   NATURE BIOTECHNOLOGY

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

(2008) Jeffrey H Kordower et al.   NATURE MEDICINE

Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain

(2008) Itaru Imayoshi et al.   NATURE NEUROSCIENCE

Invited Article: Nervous system pathology in sporadic Parkinson disease

(2008) H. Braak et al.   NEUROLOGY