Mitochondria as an important target of metformin: The mechanism of action, toxic and side effects, and new therapeutic applications
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Title
Mitochondria as an important target of metformin: The mechanism of action, toxic and side effects, and new therapeutic applications
Authors
Keywords
Metformin, Antidiabetic drug, Mitochondrial complex I, Oxidative stress, Multiple therapeutic uses, Toxic and side effects
Journal
PHARMACOLOGICAL RESEARCH
Volume 177, Issue -, Pages 106114
Publisher
Elsevier BV
Online
2022-02-03
DOI
10.1016/j.phrs.2022.106114
References
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Note: Only part of the references are listed.- Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus
- (2021) Maheedhar Kodali et al. AGING CELL
- Metformin Reverses the Enhanced Myocardial SR/ER–Mitochondria Interaction and Impaired Complex I-Driven Respiration in Dystrophin-Deficient Mice
- (2021) Claire Angebault et al. Frontiers in Cell and Developmental Biology
- Metformin environmental exposure: A systematic review
- (2021) Eliane Papa Ambrosio-Albuquerque et al. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
- Pharmacologic mechanisms underlying antidiabetic drug metformin’s chemopreventive effect against colorectal cancer
- (2021) Michelle Jaromy et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Mitochondria-targeting therapeutic strategies in the treatment of depression
- (2021) Katarzyna Głombik et al. MITOCHONDRION
- Metformin impairs bile acid homeostasis in ethinylestradiol-induced cholestasis in mice
- (2021) Fatemeh Alaei Faradonbeh et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Toxicity of Metformin and Hypoglycemic Therapies
- (2020) Muhammad S. Akhter et al. ADVANCES IN CHRONIC KIDNEY DISEASE
- Metformin: current clinical applications in nondiabetic patients with cancer
- (2020) Kailin Chen et al. Aging-US
- Metformin: An old drug against old age and associated morbidities
- (2020) Teresa Salvatore et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- A review of phenformin, metformin, and imeglimin
- (2020) Raghunandan Yendapally et al. DRUG DEVELOPMENT RESEARCH
- Metformin upregulates mitophagy in patients with T2DM: A randomized placebo‐controlled study
- (2020) Shipra Bhansali et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Energy Metabolism in Cancer: The Roles of STAT3 and STAT5 in the Regulation of Metabolism-Related Genes
- (2020) Arturo Valle-Mendiola et al. Cancers
- GPD1 enhances the anti-cancer effects of metformin by synergistically increasing total cellular glycerol-3-phosphate
- (2020) Jianjiang Xie et al. CANCER RESEARCH
- Maintaining Myocardial Glucose Utilization in Diabetic Cardiomyopathy Accelerates Mitochondrial Dysfunction
- (2020) Adam R. Wende et al. DIABETES
- The protective effect of metformin on mitochondrial dysfunction and endoplasmic reticulum stress in diabetic mice brain
- (2020) Taskeen Fathima Docrat et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Mitochondrial aconitase controls adipogenesis through mediation of cellular ATP production
- (2020) Yan Chen et al. FASEB JOURNAL
- Roles of Autophagy in Oxidative Stress
- (2020) Hyeong Rok Yun et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Mitochondrial dysfunction: An emerging link in the pathophysiology of polycystic ovary syndrome
- (2020) Pallavi Shukla et al. MITOCHONDRION
- The Anti-Diabetic Drug Metformin Rescues Aberrant Mitochondrial Activity and Restrains Oxidative Stress in a Female Mouse Model of Rett Syndrome
- (2020) Ilaria Zuliani et al. Journal of Clinical Medicine
- Warburg and Beyond: The Power of Mitochondrial Metabolism to Collaborate or Replace Fermentative Glycolysis in Cancer
- (2020) Shamir Cassim et al. Cancers
- Anti-Aging Effect of Metformin: A Molecular and Therapeutical Perspective
- (2020) Wheeler Torres et al. CURRENT PHARMACEUTICAL DESIGN
- Anticancer mechanisms of metformin: A review of the current evidence
- (2020) Bin Zhao et al. LIFE SCIENCES
- Metformin improves cognition of aged mice by promoting cerebral angiogenesis and neurogenesis
- (2020) Xiaoqi Zhu et al. Aging-US
- Acute metformin treatment provides cardioprotection via improved mitochondrial function in cardiac ischemia / reperfusion injury
- (2020) Siripong Palee et al. BIOMEDICINE & PHARMACOTHERAPY
- Melatonin and Autophagy in Aging-Related Neurodegenerative Diseases
- (2020) Fang Luo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Metformin protects high glucose‑cultured cardiomyocytes from oxidative stress by promoting NDUFA13 expression and mitochondrial biogenesis via the AMPK signaling pathway
- (2020) Xiang‑Dong Liu et al. Molecular Medicine Reports
- Metformin rescues Parkinson’s disease phenotypes caused by hyperactive mitochondria
- (2020) Danielle E. Mor et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rationale for the use of metformin and exercise to counteract statin‐associated side effects
- (2020) Jonida Haxhi et al. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
- Effects of metformin on body weight in polycystic ovary syndrome patients: model-based meta-analysis
- (2020) Xiao Chen et al. Expert Review of Clinical Pharmacology
- Metformin and ovarian cancer: the evidence
- (2020) Elina Urpilainen et al. Annals of Translational Medicine
- Mitochondrial Dysfunction in Type 2 Diabetes Mellitus: An Organ-Based Analysis
- (2019) Mark V Pinti et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Mitochondrial Complex I Inhibition by Metformin Limits Reperfusion Injury
- (2019) Ahmed A Mohsin et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Low glucose and metformin-induced apoptosis of human ovarian cancer cells is connected to ASK1 via mitochondrial and endoplasmic reticulum stress-associated pathways
- (2019) Liwei Ma et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression
- (2019) Peter Vaupel et al. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
- Metformin and gut microbiota: their interactions and their impact on diabetes
- (2019) Natalia G. Vallianou et al. Hormones-International Journal of Endocrinology and Metabolism
- Metformin use and cardiovascular events in patients with type 2 diabetes and chronic kidney disease
- (2019) David M. Charytan et al. DIABETES OBESITY & METABOLISM
- Metformin inhibits cervical cancer cell proliferation via decreased AMPK O-GlcNAcylation
- (2019) Min Young Kim et al. Animal Cells and Systems
- Mechanisms of action of metformin with special reference to cardiovascular protection
- (2019) Alexey V. Zilov et al. DIABETES-METABOLISM RESEARCH AND REVIEWS
- Metformin in 2019
- (2019) James Flory et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Oxidative Stress: A Key Modulator in Neurodegenerative Diseases
- (2019) Anju Singh et al. MOLECULES
- Role of Mitochondria in the Mechanism(s) of Action of Metformin
- (2019) Guillaume Vial et al. Frontiers in Endocrinology
- Mitochondrial targets of metformin—Are they physiologically relevant?
- (2019) Alena Pecinová et al. BIOFACTORS
- Studies on the interaction between HSA and new halogenated metformin derivatives: influence of lipophilic groups in the binding ability
- (2019) Otávio Augusto Chaves et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- Metformin: time to review its role and safety in chronic kidney disease
- (2019) Cara Tanner et al. MEDICAL JOURNAL OF AUSTRALIA
- Corrigendum to “Mitochondria in health and disease” [Mitochondrion 43(2018) 25–29]
- (2019) Sanjiban Chakrabarty et al. MITOCHONDRION
- Mitochondria as playmakers of apoptosis, autophagy and senescence
- (2019) Marianna Abate et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Role of GTPases in the regulation of mitochondrial dynamics in Parkinson's disease
- (2019) Xiaoling Zhang et al. EXPERIMENTAL CELL RESEARCH
- Combination simvastatin and metformin synergistically inhibits endometrial cancer cell growth
- (2019) Josephine S. Kim et al. GYNECOLOGIC ONCOLOGY
- Mitochondrial Dysfunction Plays a Key Role in the Development of Neurodegenerative Diseases in Diabetes
- (2019) Han Cheng et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Mitochondrial Oxidative Stress Impairs Energy Metabolism and Reduces Stress Resistance and Longevity of C. elegans
- (2019) Benjamin Dilberger et al. Oxidative Medicine and Cellular Longevity
- Metformin Suppresses Self-Renewal Ability and Tumorigenicity of Osteosarcoma Stem Cells via Reactive Oxygen Species-Mediated Apoptosis and Autophagy
- (2019) Bin Zhao et al. Oxidative Medicine and Cellular Longevity
- Metformin as Anti-Aging Therapy: Is It for Everyone?
- (2019) Alexander A. Soukas et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK
- (2019) Yu Wang et al. Cell Reports
- Pharmacology of metformin – An update
- (2019) Hartmut H. Glossmann et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Mitochondrial dysfunction and oxidative stress in heart disease
- (2019) Jessica N. Peoples et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Metformin in colorectal cancer: molecular mechanism, preclinical and clinical aspects
- (2019) Muhamad Noor Alfarizal Kamarudin et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Effect of Metformin on Microvascular Endothelial Function in Polycystic Ovary Syndrome
- (2019) Behnam Heidari et al. MAYO CLINIC PROCEEDINGS
- Emerging neuroprotective effect of metformin in Parkinson’s disease: A molecular crosstalk
- (2019) Yam Nath Paudel et al. PHARMACOLOGICAL RESEARCH
- Occurrence, toxic effects and removal of metformin in the aquatic environments in the world: Recent trends and perspectives
- (2019) Gustavo Axel Elizalde-Velázquez et al. SCIENCE OF THE TOTAL ENVIRONMENT
- Editorial: Metformin: Beyond Diabetes
- (2019) Frédéric Bost et al. Frontiers in Endocrinology
- Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7
- (2018) Jingqi Fang et al. AGING CELL
- Cardioprotection by Metformin: Beneficial Effects Beyond Glucose Reduction
- (2018) Leon Varjabedian et al. American Journal of Cardiovascular Drugs
- Mitochondrial uncoupling, ROS generation and cardioprotection
- (2018) Susana Cadenas BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Metformin regulates mitochondrial biogenesis and senescence through AMPK mediated H3K79 methylation: Relevance in age-associated vascular dysfunction
- (2018) Santosh Karnewar et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Effect of metformin use on the risk and prognosis of endometrial cancer: a systematic review and meta-analysis
- (2018) Danxia Chu et al. BMC CANCER
- Repurposing Metformin for Cardiovascular Disease
- (2018) Graham Rena et al. CIRCULATION
- Metformin Targets Mitochondrial Glycerophosphate Dehydrogenase to Control Rate of Oxidative Phosphorylation and Growth of Thyroid CancerIn VitroandIn Vivo
- (2018) Shilpa Thakur et al. CLINICAL CANCER RESEARCH
- Pharmacokinetics of metformin in patients with gastrointestinal intolerance
- (2018) Laura J. McCreight et al. DIABETES OBESITY & METABOLISM
- Epigenetic effects of metformin: From molecular mechanisms to clinical implications
- (2018) Stephanie Claire Bridgeman et al. DIABETES OBESITY & METABOLISM
- SIRT3 aggravates metformin-induced energy stress and apoptosis in ovarian cancer cells
- (2018) Yao Wu et al. EXPERIMENTAL CELL RESEARCH
- ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection
- (2018) Susana Cadenas FREE RADICAL BIOLOGY AND MEDICINE
- Cardioprotective Effects of Metformin
- (2018) Christine Driver et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- The Efficacy of 24-Month Metformin for Improving Menses, Hormones, and Metabolic Profiles in Polycystic Ovary Syndrome
- (2018) Po-Kai Yang et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction
- (2018) Edoardo Gaude et al. MOLECULAR CELL
- The Cardioprotective Effect of Metformin in Doxorubicin-Induced Cardiotoxicity: The Role of Autophagy
- (2018) Rita Zilinyi et al. MOLECULES
- Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo
- (2018) Anila K. Madiraju et al. NATURE MEDICINE
- A reappraisal on metformin
- (2018) Tuğba Adak et al. REGULATORY TOXICOLOGY AND PHARMACOLOGY
- Caffeic Acid Targets AMPK Signaling and Regulates Tricarboxylic Acid Cycle Anaplerosis while Metformin Downregulates HIF-1α-Induced Glycolytic Enzymes in Human Cervical Squamous Cell Carcinoma Lines
- (2018) Malgorzata Tyszka-Czochara et al. Nutrients
- Metformin selectively targets redox control of complex I energy transduction
- (2018) Amy R. Cameron et al. Redox Biology
- The Therapeutic Potential of Metformin in Neurodegenerative Diseases
- (2018) Carola Rotermund et al. Frontiers in Endocrinology
- Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes: current strategies and future perspectives
- (2018) Gantumur Battogtokh et al. Acta Pharmaceutica Sinica B
- Structure and mechanism of mitochondrial electron transport chain
- (2018) Runyu Guo et al. Biomedical Journal
- Nucleus, Mitochondrion, or Reticulum? STAT3 à La Carte
- (2018) Lidia Avalle et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Mitochondria-targeted drugs stimulate mitophagy and abrogate colon cancer cell proliferation
- (2018) Kathleen A. Boyle et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The influence of metformin and the presence of type 2 diabetes mellitus on mortality and hospitalisation in patients with heart failure
- (2018) Arkadiusz Retwiński et al. Kardiologia Polska
- Endothelial function and dysfunction: Impact of metformin
- (2018) Asma Nafisa et al. PHARMACOLOGY & THERAPEUTICS
- Metformin as an Anticancer Agent
- (2018) Ales Vancura et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Review of Biguanide (Metformin) Toxicity
- (2018) George Sam Wang et al. JOURNAL OF INTENSIVE CARE MEDICINE
- Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults
- (2018) Adam R. Konopka et al. AGING CELL
- The journey of metformin from glycaemic control to mTOR inhibition and the suppression of tumour growth
- (2018) Sam Amin et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Metformin inhibited colitis and colitis-associated cancer (CAC) through protecting mitochondrial structures of colorectal epithelial cells in mice
- (2018) Shu-Qing Wang et al. CANCER BIOLOGY & THERAPY
- Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity
- (2018) Zydrune Polianskyte-Prause et al. FASEB JOURNAL
- Low metformin causes a more oxidized mitochondrial NADH/NAD redox state in hepatocytes and inhibits gluconeogenesis by a redox-independent mechanism
- (2018) Ahmed Alshawi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Metformin Is a Direct SIRT1-Activating Compound: Computational Modeling and Experimental Validation
- (2018) Elisabet Cuyàs et al. Frontiers in Endocrinology
- Metabolomics profiling of metformin-mediated metabolic reprogramming bypassing AMPKα
- (2018) Min Yan et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- A dosing algorithm for metformin based on the relationships between exposure and renal clearance of metformin in patients with varying degrees of kidney function
- (2017) Janna K. Duong et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Metformin ameliorates hypoxia/reoxygenation-induced cardiomyocyte apoptosis based on the SIRT3 signaling pathway
- (2017) Yanyan Du et al. GENE
- Production of superoxide and hydrogen peroxide from specific mitochondrial sites under different bioenergetic conditions
- (2017) Hoi-Shan Wong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Autophagic dysregulation in doxorubicin cardiomyopathy
- (2017) Jordan J. Bartlett et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- The antidiabetic drug metformin decreases mitochondrial respiration and tricarboxylic acid cycle activity in cultured primary rat astrocytes
- (2017) Michaela C. Hohnholt et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Metformin lowers α-synuclein phosphorylation and upregulates neurotrophic factor in the MPTP mouse model of Parkinson's disease
- (2017) Nikita Katila et al. NEUROPHARMACOLOGY
- Metformin effects on the heart and the cardiovascular system: A review of experimental and clinical data
- (2017) L. Nesti et al. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
- Metformin; a review of its history and future: from lilac to longevity
- (2017) Inas Thomas et al. PEDIATRIC DIABETES
- Metformin – a Future Therapy for Neurodegenerative Diseases
- (2017) Magdalena Markowicz-Piasecka et al. PHARMACEUTICAL RESEARCH
- Antiaging Effect of Metformin on Brain in Naturally Aged and Accelerated Senescence Model of Rat
- (2017) Geetika Garg et al. REJUVENATION RESEARCH
- Metformin attenuates ER stress–induced mitochondrial dysfunction
- (2017) Qun Chen et al. Translational Research
- Metformin ameliorates arsenic trioxide hepatotoxicity via inhibiting mitochondrial complex I
- (2017) Sunbin Ling et al. Cell Death & Disease
- Activation of the ATF2/CREB-PGC-1α pathway by metformin leads to dopaminergic neuroprotection
- (2017) Hojin Kang et al. Oncotarget
- Metformin extends C. elegans lifespan through lysosomal pathway
- (2017) Jie Chen et al. eLife
- Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in mice
- (2016) Vinodkumar B. Pillai et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells
- (2016) Gang Cheng et al. CANCER RESEARCH
- Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin
- (2016) Dan Y. Gui et al. Cell Metabolism
- Metformin as a Tool to Target Aging
- (2016) Nir Barzilai et al. Cell Metabolism
- [11C]-Labeled Metformin Distribution in the Liver and Small Intestine Using Dynamic Positron Emission Tomography in Mice Demonstrates Tissue-Specific Transporter Dependency
- (2016) Jonas B. Jensen et al. DIABETES
- Metformin Suppresses Diabetes-Accelerated Atherosclerosis via the Inhibition of Drp1-Mediated Mitochondrial Fission
- (2016) Qilong Wang et al. DIABETES
- Should Restrictions Be Relaxed for Metformin Use in Chronic Kidney Disease? Yes, They Should Be Relaxed! What’s the Fuss?: Table 1
- (2016) George L. Bakris et al. DIABETES CARE
- Metformin and the gastrointestinal tract
- (2016) Laura J. McCreight et al. DIABETOLOGIA
- Comparison of two insulin sensitizers, metformin and myo-inositol, in women with polycystic ovary syndrome (PCOS)
- (2016) Franca Fruzzetti et al. GYNECOLOGICAL ENDOCRINOLOGY
- Metformin Prevents Dopaminergic Neuron Death in MPTP/P-Induced Mouse Model of Parkinson’s Disease via Autophagy and Mitochondrial ROS Clearance
- (2016) Ming Lu et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study
- (2016) Vanita R. Aroda et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Metformin associated lactic acidosis (MALA): clinical profiling and management
- (2016) Alessandra Moioli et al. JOURNAL OF NEPHROLOGY
- Mitochondrial dysfunction in Parkinson's disease
- (2016) Anindita Bose et al. JOURNAL OF NEUROCHEMISTRY
- In Vivo Imaging of Human 11C-Metformin in Peripheral Organs: Dosimetry, Biodistribution, and Kinetic Analyses
- (2016) L. C. Gormsen et al. JOURNAL OF NUCLEAR MEDICINE
- Effects of metformin on pregnancy outcomes in women with polycystic ovary syndrome
- (2016) Xian-Ling Zeng et al. MEDICINE
- Metformin-associated lactic acidosis: Current perspectives on causes and risk
- (2016) Ralph DeFronzo et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Metformin and resveratrol inhibit Drp1-mediated mitochondrial fission and prevent ER stress-associated NLRP3 inflammasome activation in the adipose tissue of diabetic mice
- (2016) Aiyun Li et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Mitochondrial Targeting of Metformin Enhances Its Activity against Pancreatic Cancer
- (2016) Stepana Boukalova et al. MOLECULAR CANCER THERAPEUTICS
- Sirt1 and the Mitochondria
- (2016) MOLECULES AND CELLS
- Anti-tumor activity of metformin: from metabolic and epigenetic perspectives
- (2016) Xilan Yu et al. Oncotarget
- Metformin: A Hopeful Promise in Aging Research
- (2016) Marta G. Novelle et al. Cold Spring Harbor Perspectives in Medicine
- The Skp1 Homologs SKR-1/2 Are Required for the Caenorhabditis elegans SKN-1 Antioxidant/Detoxification Response Independently of p38 MAPK
- (2016) Cheng-Wei Wu et al. PLoS Genetics
- Concise Review: Bridging the Gap: Novel Neuroregenerative and Neuroprotective Strategies in Spinal Cord Injury
- (2016) Christopher S. Ahuja et al. Stem Cells Translational Medicine
- Metformin Protects H9C2 Cardiomyocytes from High-Glucose and Hypoxia/Reoxygenation Injury via Inhibition of Reactive Oxygen Species Generation and Inflammatory Responses: Role of AMPK and JNK
- (2016) Mingyan Hu et al. Journal of Diabetes Research
- Metformin Prevents Nigrostriatal Dopamine Degeneration Independent of AMPK Activation in Dopamine Neurons
- (2016) Jacqueline A. Bayliss et al. PLoS One
- MATE2 Expression Is Associated with Cancer Cell Response to Metformin
- (2016) Sanjana Chowdhury et al. PLoS One
- Mechanisms of the anorexia of aging—a review
- (2015) Adam Wysokiński et al. AGE
- Regulation of Mitochondrial Biogenesis and Its Intersection with Inflammatory Responses
- (2015) Anne D. Cherry et al. ANTIOXIDANTS & REDOX SIGNALING
- Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight
- (2015) Aashiq Hussain Bhat et al. BIOMEDICINE & PHARMACOTHERAPY
- Mitochondrial dysfunctions in cancer: Genetic defects and oncogenic signaling impinging on TCA cycle activity
- (2015) Enrico Desideri et al. CANCER LETTERS
- MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells
- (2015) Patricia Sancho et al. Cell Metabolism
- Metformin Action: Concentrations Matter
- (2015) Ling He et al. Cell Metabolism
- Therapeutic Concentrations of Metformin: A Systematic Review
- (2015) Farshad Kajbaf et al. CLINICAL PHARMACOKINETICS
- Effects of metformin on mitochondrial function of leukocytes from polycystic ovary syndrome patients with insulin resistance
- (2015) Victor M Victor et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease
- (2015) Rafael P. Vázquez-Manrique et al. HUMAN MOLECULAR GENETICS
- mTOR: a pharmacologic target for autophagy regulation
- (2015) Young Chul Kim et al. JOURNAL OF CLINICAL INVESTIGATION
- Metformin reduces hyper-reactivity of platelets from patients with polycystic ovary syndrome by improving mitochondrial integrity
- (2015) Amro Elgheznawy et al. THROMBOSIS AND HAEMOSTASIS
- PGC-1 coactivators in β-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids
- (2015) Daniel Oropeza et al. Molecular Metabolism
- Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition
- (2014) S. Piel et al. Acta Physiologica
- Metformin and respiratory chain complex I: the last piece of the puzzle?
- (2014) Eric Fontaine BIOCHEMICAL JOURNAL
- Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria
- (2014) Hannah R. Bridges et al. BIOCHEMICAL JOURNAL
- Activation of AMP-activated protein kinase by metformin protects human coronary artery endothelial cells against diabetic lipoapoptosis
- (2014) Linnéa Eriksson et al. Cardiovascular Diabetology
- Control of Gluconeogenesis by Metformin: Does Redox Trump Energy Charge?
- (2014) Joseph A. Baur et al. Cell Metabolism
- AMPK at the Nexus of Energetics and Aging
- (2014) Kristopher Burkewitz et al. Cell Metabolism
- Editorial (Thematic Issue: Mitochondrial Biogenesis: Pharmacological Approaches)
- (2014) Teresa Valero CURRENT PHARMACEUTICAL DESIGN
- The effects of metformin on endothelial dysfunction, lipid metabolism and oxidative stress in women with polycystic ovary syndrome
- (2014) Derya Kocer et al. GYNECOLOGICAL ENDOCRINOLOGY
- Crosstalk between AMPK activation and angiotensin II-induced hypertrophy in cardiomyocytes: the role of mitochondria
- (2014) Jessica Soto Hernández et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Direct effects of metformin in the endometrium: a hypothetical mechanism for the treatment of women with PCOS and endometrial carcinoma
- (2014) Ruijin Shao et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
- (2014) Anila K. Madiraju et al. NATURE
- Metformin—mode of action and clinical implications for diabetes and cancer
- (2014) Ida Pernicova et al. Nature Reviews Endocrinology
- Intracerebroventricular Metformin Decreases Body Weight But Has Pro-oxidant Effects and Decreases Survival
- (2014) Luis Valmor Portela et al. NEUROCHEMICAL RESEARCH
- Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2
- (2014) W. De Haes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- SIRT1 and other sirtuins in metabolism
- (2014) Hung-Chun Chang et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis
- (2014) William W Wheaton et al. eLife
- Influences of Organic Cation Transporter Polymorphisms on the Population Pharmacokinetics of Metformin in Healthy Subjects
- (2013) Hwa Yoon et al. AAPS Journal
- SIRT3 Deacetylates ATP Synthase F1 Complex Proteins in Response to Nutrient- and Exercise-Induced Stress
- (2013) Athanassios Vassilopoulos et al. ANTIOXIDANTS & REDOX SIGNALING
- Metformin induces up-regulation of blood–brain barrier functions by activating AMP-activated protein kinase in rat brain microvascular endothelial cells
- (2013) Fuyuko Takata et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism
- (2013) Filipe Cabreiro et al. CELL
- C-Peptide Activates AMPK and Prevents ROS-Mediated Mitochondrial Fission and Endothelial Apoptosis in Diabetes
- (2013) M. P. Bhatt et al. DIABETES
- Different mtDNA mutations modify tumor progression in dependence of the degree of respiratory complex I impairment
- (2013) Luisa Iommarini et al. HUMAN MOLECULAR GENETICS
- HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
- (2013) Gregg L. Semenza JOURNAL OF CLINICAL INVESTIGATION
- Metformin improves healthspan and lifespan in mice
- (2013) Alejandro Martin-Montalvo et al. Nature Communications
- SIRT3 regulation of mitochondrial oxidative stress
- (2012) Alexandra S. Bause et al. EXPERIMENTAL GERONTOLOGY
- The Role of PPARα in Metformin-Induced Attenuation of Mitochondrial Dysfunction in Acute Cardiac Ischemia/Reperfusion in Rats
- (2012) Giselle Barreto-Torres et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Metformin in cancer: translational challenges
- (2012) Ryan J O Dowling et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- Physiological Roles of Mitochondrial Reactive Oxygen Species
- (2012) Laura A. Sena et al. MOLECULAR CELL
- Metformin pathways
- (2012) Li Gong et al. Pharmacogenetics and Genomics
- Fine Tuning Our Cellular Factories: Sirtuins in Mitochondrial Biology
- (2011) Lei Zhong et al. Cell Metabolism
- Clinical Pharmacokinetics of Metformin
- (2011) Garry G. Graham et al. CLINICAL PHARMACOKINETICS
- Metformin and digestive disorders
- (2011) M. Bouchoucha et al. DIABETES & METABOLISM
- Sirtuins: Molecular Traffic Lights in the Crossroad of Oxidative Stress, Chromatin Remodeling, and Transcription
- (2011) Ramkumar Rajendran et al. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
- Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation
- (2010) Xiaolei Qiu et al. Cell Metabolism
- Metformin selectively attenuates mitochondrial H2O2 emission without affecting respiratory capacity in skeletal muscle of obese rats
- (2010) Daniel A. Kane et al. FREE RADICAL BIOLOGY AND MEDICINE
- Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
- (2010) Marc Foretz et al. JOURNAL OF CLINICAL INVESTIGATION
- Clarifying metformin's role and risks in liver dysfunction
- (2010) Carolyn C. Brackett JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION
- Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis
- (2010) Xingxing Kong et al. PLoS One
- Metformin and Insulin Suppress Hepatic Gluconeogenesis through Phosphorylation of CREB Binding Protein
- (2009) Ling He et al. CELL
- Determination of metformin and its prodrugs in human and rat blood by hydrophilic interaction liquid chromatography
- (2009) Kristiina M. Huttunen et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Toxicity and toxicokinetics of metformin in rats
- (2009) Michael P. Quaile et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Occult Metformin Toxicity in Three Patients with Profound Lactic Acidosis
- (2008) Jeanmarie Perrone et al. JOURNAL OF EMERGENCY MEDICINE
- Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
- (2008) William G. Kaelin et al. MOLECULAR CELL
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