Article
Cell Biology
Mohammad Golam Sabbir, Carla G. Taylor, Peter Zahradka
Summary: This study revealed that CAMKK2 deletion inhibits cellular respiration in both HEK293 and HepG2 cells, leading to a shift towards aerobic glycolysis. Additionally, isolated mitochondria showed cell-type-specific enhancement or dampening of respiratory kinetics under CAMKK2 deletion conditions.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Xiaoqin Guo, Xiaopeng Li, Wanbao Yang, Wang Liao, James Zheng Shen, Weiqi Ai, Quan Pan, Yuxiang Sun, Kebin Zhang, Rui Zhang, Yuyang Qiu, Qian Dai, Hongting Zheng, Shaodong Guo
Summary: Metformin primarily lowers hepatic glucose production by inhibiting Foxo1, and it further suppresses glucagon-induced glucose production through inhibiting the PKA -> Foxo1 signaling pathway.
Article
Endocrinology & Metabolism
Hao Qin, Yi Qu, Rong Li, Jie Qiao
Summary: The mean age of women seeking infertility treatment has increased, which coincides with the emergence of in vitro maturation (IVM). However, IVM is associated with poor embryonic development potential and low live birth rates. In this study, we identified differentially expressed genes (DEGs) between IVM oocytes and in vivo matured oocytes from mice of advanced reproductive age. The most enriched pathway was found to be oxidative phosphorylation (OXPHOS). Antioxidant supplementation increased ATP production and reduced the gene expression profile of the OXPHOS pathway in the IVM group. Additionally, alternative splicing events were observed during oocyte maturation, with skipped exons being the most frequent type.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Editorial Material
Hematology
Aaron D. Schimmer
Summary: In this study, it is shown that ZDHHC21-mediated palmitoylation is crucial for regulating oxidative phosphorylation in a subset of acute myeloid leukemia cells.
Article
Biochemistry & Molecular Biology
Hun Ho Park, Junseong Park, Hye Joung Cho, Jin-Kyoung Shim, Ju Hyung Moon, Eui Hyun Kim, Jong Hee Chang, Soo Youl Kim, Seok-Gu Kang
Summary: This study demonstrates that combination therapy with the chemotherapeutic drug, gossypol, and phenformin can significantly reduce the stemness and invasiveness of GBM tumorspheres, enhancing therapeutic effects through multiple mechanisms of action.
Review
Developmental Biology
Stavroula Petridi, Dnyanesh Dubal, Richa Rikhy, Jelle van den Ameele
Summary: Mitochondria play a central role in the behavior and fate decisions of neural stem cells, influencing cellular metabolism and the activity of chromatin-modifying enzymes.
Article
Biochemistry & Molecular Biology
Pavla Stankova, Otto Kucera, Eva Peterova, Moustafa Elkalaf, David Rychtrmoc, Jan Melek, Miroslav Podhola, Veronika Zubanova, Zuzana Cervinkova
Summary: The study found that after consuming a Western-style diet for 30 weeks, mice showed reduced succinate-activated respiration, decreased SDH activity, reduced expression of the SDH activator sirtuin 3 and SDH subunits, and increased succinate levels. The gene and protein expression of SUCNR1 also decreased in the livers of mice fed the diet, but no signs of oxidative damage were observed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Odeya Marciano, Linoy Mehazri, Sally Shpungin, Alexander Varvak, Eldad Zacksenhaus, Uri Nir
Summary: Aerobic glycolysis is an important metabolic adaptation of cancer cells, but there is increasing evidence that reprogrammed mitochondria also play a crucial role in metastatic dissemination. Fer and FerT are shown to regulate mitochondrial susceptibility to therapeutic and hypoxic stress in metastatic colon and non-small cell lung cancer cells, making them sensitive to metformin treatment and hypoxia under glucose-restrictive conditions. Targeting Fer and FerT could potentially provide a novel anticancer treatment by disrupting mitochondrial function in malignant cells.
Review
Oncology
Kaylee B. Punter, Charles Chu, Edmond Y. W. Chan
Summary: It is proposed that targeting pathways within mitochondria can compromise the ability of cancer cells to cause disease. Modulating mitochondrial dynamics can target key metabolic or apoptotic pathways, impair oxidative phosphorylation, and alter sensitivity to chemotherapeutic compounds in cancer cells. Further investigation is needed to map the underlying molecular mechanisms and develop rational therapeutic strategies based on these pathways.
ENDOCRINE-RELATED CANCER
(2023)
Article
Oncology
Jukka Westermarck
Summary: Targeted therapies are commonly used in cancer treatment, but their effectiveness is limited by acquired drug resistance. Recent studies have highlighted the role of mitochondrial mechanisms in cancer cell sensitivity to targeted therapies, leading to the development of triplet therapies that target vulnerabilities in cancer cells, including the mitochondria. These triplet therapies show promising preclinical effects in overcoming drug resistance, but challenges in clinical translation need to be addressed.
MOLECULAR ONCOLOGY
(2023)
Article
Immunology
Hongxu Xian, Yuan Liu, Alexandra Rundberg Nilsson, Raphaella Gatchalian, Timothy R. Crother, Warren G. Tourtellotte, Yi Zhang, German R. Aleman-Muench, Gavin Lewis, Weixuan Chen, Sarah Kang, Melissa Luevanos, Dorit Trudler, Stuart A. Lipton, Pejman Soroosh, John Teijaro, Juan Carlos de la Torre, Moshe Arditi, Michael Karin, Elsa Sanchez-Lopez
Summary: The study found that metformin can attenuate COVID-19-induced ARDS by inhibiting NLRP3 inflammasome activation, IL-1 beta and IL-6 secretion, and by blocking ATP and mtDNA synthesis.
Article
Multidisciplinary Sciences
Teng Ma, Xiao Tian, Baoding Zhang, Mengqi Li, Yu Wang, Chunyan Yang, Jianfeng Wu, Xiaoyan Wei, Qi Qu, Yaxin Yu, Shating Long, Jin-Wei Feng, Chun Li, Cixiong Zhang, Changchuan Xie, Yaying Wu, Zheni Xu, Junjie Chen, Yong Yu, Xi Huang, Ying He, Luming Yao, Lei Zhang, Mingxia Zhu, Wen Wang, Zhi-Chao Wang, Mingliang Zhang, Yuqian Bao, Weiping Jia, Shu-Yong Lin, Zhiyun Ye, Hai-Long Piao, Xianming Deng, Chen-Song Zhang, Sheng-Cai Lin
Summary: The molecular target of the antidiabetic medicine metformin is identified as PEN2, and the PEN2-ATP6AP1 axis activates the AMPK pathway, providing therapeutic effects without substantial adverse effects.
Article
Physiology
Kenny W. Huynh, Matthew E. Pamenter
Summary: In hypoxic conditions, NMR cardiac mitochondria cannot directly oxidize lactate, but lactate inhibits mitochondrial respiration and decreases complex IV maximum respiratory capacity. Additionally, exposure to in vivo hypoxia reduces the extent of lactate-mediated inhibition of mitochondrial respiration.
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2022)
Article
Cell Biology
Huihui Li, Caroline Guglielmetti, Yoshitaka J. Sei, Misha Zilberter, Lydia M. Le Page, Lauren Shields, Joyce Yang, Kevin Nguyen, Brice Tiret, Xiao Gao, Neal Bennett, Iris Lo, Talya L. Dayton, Martin Kampmann, Yadong Huang, Jeffrey C. Rathmell, Matthew Vander Heiden, Myriam M. Chaumeil, Ken Nakamura
Summary: Metabolomics analysis revealed that human neurons can metabolize glucose through glycolysis and rely on it to supply TCA cycle metabolites. Mice with postnatal deletion of neuronal glucose transporter or pyruvate kinase isoform showed age-dependent learning and memory deficits. Hyperpolarized MRS imaging showed altered pyruvate-to-lactate conversion and decreased brain volume in these mice, indicating the importance of glycolysis in neuronal function.
Article
Biochemistry & Molecular Biology
Xiao-Qian Ma, Yu-Yin Liu, Zhi-Qi Zhong, Si-Man Chen, Wen-Ting Hu, Yan-Ran Sheng, Yu-Kai Liu, Chun-Yan Wei, Ming-Qing Li, Xiao-Yong Zhu
Summary: Endometriosis is an estrogen-dependent, progesterone-resistant gynecological disease. In this study, the dysregulated expression of heme-trafficking proteins and heme-degrading enzymes was investigated, revealing that heme mediates progesterone resistance and induces endometriosis via the mitochondrial oxidative phosphorylation pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Endocrinology & Metabolism
Sriram Gubbi, Mohammad Al-Jundi, Jaydira Del Rivero, Abhishek Jha, Marianne Knue, Joy Zou, Baris Turkbey, Jorge Amilcar Carrasquillo, Emily Lin, Karel Pacak, Joanna Klubo-Gwiezdzinska, Frank I-Kai Lin
Summary: The study reported a case of a patient who developed symptomatic primary hypothyroidism after receiving Lu-177-DOTATATE therapy, with notable changes in TFTs and thyroid auto-antibody titers before and after treatment. Functional imaging revealed diffuse uptake of Lu-177-DOTATATE in the thyroid gland.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Letter
Medicine, General & Internal
Sriram Gubbi, Katherine Andrea Araque, Shirisha Avadhanula, Asma Azam, Roxanne Merkel, Craig Cochran, Peter Denis Burbelo, Meryl Waldman, Susanne Neumann, Marvin Carl Gershengorn, Monica Skarulis, Joanna Klubo-Gwiezdzinska
ANNALS OF INTERNAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Dorina Ylli, Steven J. Soldin, Brian Stolze, Bin Wei, Girum Nigussie, Hung Nguyen, Damodara Rao Mendu, Mihriye Mete, Di Wu, Cristiane J. Gomes-Lima, Joanna Klubo-Gwiezdzinska, Kenneth D. Burman, Leonard Wartofsky
Summary: This study found that biotin intake can lead to variations in thyroid-related laboratory test results, especially in data measured on the Roche Cobas 6000 and Siemens IMMULITE 2000 platforms. Taking 10 mg of biotin per day can interfere with the measurement results of specific indices such as TSH, fT4, TT3, and Tg.
Editorial Material
Endocrinology & Metabolism
Joanna Klubo-Gwiezdzinska
LANCET DIABETES & ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Christine C. Krieger, George J. Kahaly, Asma Azam, Joanna Klubo-Gwiezdzinska, Susanne Neumann, Marvin C. Gershengorn
Summary: The study found a positive correlation between TSAb stimulation of cAMP production in engineered cells and secretion of TG by thyrocytes and HA by orbital fibroblasts. TSAbs from GH patients stimulated thyrocytes more effectively than those from GO patients, while TSAbs from GO patients were more effective in activating orbital fibroblasts than TSAbs from GH patients.
Article
Oncology
Meghali Goswami, Gege Gui, Laura W. Dillon, Katherine E. Lindblad, Julie Thompson, Janet Valdez, Dong-Yun Kim, Jack Y. Ghannam, Karolyn A. Oetjen, Christin B. Destefano, Dana M. Smith, Hanna Tekleab, Yeusheng Li, Pradeep Dagur, Thomas Hughes, Jennifer L. Marte, Jaydira del Rivero, Joanna Klubo-Gwiezdzinksa, James L. Gulley, Katherine R. Calvo, Catherine Lai, Christopher S. Hourigan
Summary: This study aimed to investigate the feasibility and efficacy of the combination of PD-1 blockade and hypomethylating therapy in patients with R-AML. The results showed that this combination therapy achieved disease stability or better response in some patients. Moreover, clonal T cell expansions and immunological changes were observed during treatment, which may be associated with treatment-related adverse events.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Endocrinology & Metabolism
Sowmya Swamy, Christian A. Koch, Fady Hannah-Shmouni, Ernesto L. Schiffrin, Joanna Klubo-Gwiezdzinska, Sriram Gubbi
Summary: Older age and certain components of metabolic syndrome (including hypertension) have been associated with an increased risk of severe illness and death in COVID-19 patients. The role of antihypertensive agents in the pathogenesis of COVID-19 has been extensively studied.
JOURNAL OF CLINICAL AND TRANSLATIONAL ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Sriram Gubbi, Namrata Vijayvergia, Jian Q. Yu, Joanna Klubo-Gwiezdzinska, Christian A. Koch
Summary: Neuroendocrine tumors (NETs) have complex clinical and biochemical characteristics, and their molecular basis is not fully understood. The treatment of NETs involves surgery, locoregional therapy, and systemic therapy. Although various forms of systemic therapy have been extensively studied, the use of immune checkpoint inhibitors (ICI) in the management of NETs has only recently received attention. It is currently unclear whether ICI therapy provides any distinct advantages in terms of efficacy or safety compared to other available systemic therapies. Identifying the characteristics of NETs that would make them more responsive to ICI therapy has been challenging.
HORMONE AND METABOLIC RESEARCH
(2022)
Letter
Endocrinology & Metabolism
Cristiane J. Gomes-Lima, Sanjita Chittimoju, Leen Wehbeh, Sunita Dia, Prathyusha Pagadala, Mohammad Al-Jundi, Sakshi Jhawar, Eshetu Tefera, Mihriye Mete, Joanna Klubo-Gwiezdzinska, Douglas Van Nostrand, Jacqueline Jonklaas, Leonard Wartofsky, Kenneth D. Burman
JOURNAL OF THE ENDOCRINE SOCIETY
(2023)
Article
Endocrinology & Metabolism
Johannes F. Fahrmann, Amanda R. Wasylishen, Carolina R. C. Pieterman, Ehsan Irajizad, Jody Vykoukal, Ranran Wu, Jennifer B. Dennison, Christine B. Peterson, Hua Zhao, Kim-Anh Do, Daniel M. Halperin, Sunita K. Agarwal, Jenny E. Blau, Smita Jha, Jaydira Del Rivero, Naris Nilubol, Mary F. Walter, James M. Welch, Lee S. Weinstein, Menno R. Vriens, Rachel S. van Leeuwaarde, Mark J. C. van Treijen, Gerlof D. Valk, Nancy D. Perrier, Samir M. Hanash, Hiroyuki Katayama
Summary: This study identified novel circulating protein markers associated with disease progression in MEN1-related dpNET through mass spectrometry-based proteomic profiling.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Rana Tora, James Welch, Jian Sun, Sunita K. Agarwal, Debra A. Bell, Maria Merino, Lee S. Weinstein, William F. Simonds, Smita Jha
Summary: This study retrospectively characterized HPT-JT syndrome and found an increased risk of parathyroid cancer associated with the disease. The study also identified a correlation between HPT-JT and uterine tumors and kidney tumors, and investigated the mutations of the CDC73 gene.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Elias Chuki, Akua Graf, Anisha Ninan, Rana Tora, Tomilowo Abijo, Lynn Bliss, Naris Nilubol, Lee S. Weinstein, Sunita K. Agarwal, William F. Simonds, Smita Jha
Summary: Long-term outcomes of parathyroid autografts in patients with heritable forms of primary hyperparathyroidism (PHPT) were investigated. The study found that post-graft recurrence of PHPT occurs frequently within the first decade after graft and is challenging to localize, with graft-related recurrences having a shorter time to recurrence and higher parathyroid hormone (PTH) gradient.
JOURNAL OF THE ENDOCRINE SOCIETY
(2023)
Article
Endocrinology & Metabolism
Vaishali Parekh, Lauren R. Brinster, Bin Guan, William F. Simonds, Lee S. Weinstein, Sunita K. Agarwal
Summary: This study used CRISPR/Cas9 gene editing technology to generate a mouse model carrying the GCM2 p.Y392S variant. The results showed that this variant is tolerated in mice and does not increase parathyroid gland cell proliferation or circulating calcium or PTH levels. Further investigation of this variant in early events of parathyroid gland development will be interesting.
JOURNAL OF THE ENDOCRINE SOCIETY
(2023)
Article
Endocrinology & Metabolism
Vaishali Parekh, Hui Sun, Min Chen, Lee S. Weinstein, Sunita K. Agarwal
Summary: The loss of Meg3 gene leads to hyperplasia in the pituitary but not in pancreatic islets, serving as a valuable model to study pathways associated with pituitary cell proliferation and function.
JOURNAL OF THE ENDOCRINE SOCIETY
(2022)
Article
Endocrinology & Metabolism
Akua Graf, James Welch, Rashika Bansal, Adel Mandl, Vaishali Parekh, Craig Cochran, Elliot Levy, Naris Nilubol, Dhaval Patel, Samira Sadowski, Smita Jha, Sunita K. Agarwal, Corina Millo, Jenny E. Blau, William F. Simonds, Lee S. Weinstein, Jaydira Del Rivero
Summary: This article reports a case of a patient with MEN1 who has a rare and aggressive G3 GEP-NET. Due to limited treatment recommendations for G3 tumors in MEN1, the patient was counseled based on standard NET treatment guidelines and recommended Lu-177-DOTATATE treatment.
JOURNAL OF THE ENDOCRINE SOCIETY
(2022)
