Metformin ameliorates arsenic trioxide hepatotoxicity via inhibiting mitochondrial complex I

Metformin potentiates the effect of arsenic trioxide suppressing intrahepatic cholangiocarcinoma: roles of p38 MAPK, ERK3, and mTORC1

(2017) Sunbin Ling et al.   Journal of Hematology & Oncology

Oxidation of NADH and ROS production by respiratory complex I

(2016) Andrei D. Vinogradov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Attenuative role of mangiferin in oxidative stress-mediated liver dysfunction in arsenic-intoxicated murines

(2016) Sukanya Saha et al.   BIOFACTORS

The Warburg effect and drug resistance

(2016) Bhaskar Bhattacharya et al.   BRITISH JOURNAL OF PHARMACOLOGY

Arsenic trioxide induces Noxa-dependent apoptosis in rhabdomyosarcoma cells and synergizes with antimicrotubule drugs

(2016) Michael Torsten Meister et al.   CANCER LETTERS

An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer

(2016) Lianfeng Wu et al.   CELL

Combination of metformin and sorafenib suppresses proliferation and induces autophagy of hepatocellular carcinoma via targeting the mTOR pathway

(2016) Sunbin Ling et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Metformin sensitizes sorafenib to inhibit postoperative recurrence and metastasis of hepatocellular carcinoma in orthotopic mouse models

(2016) Abin You et al.   Journal of Hematology & Oncology

Metformin for chemoprevention of metachronous colorectal adenoma or polyps in post-polypectomy patients without diabetes: a multicentre double-blind, placebo-controlled, randomised phase 3 trial

(2016) Takuma Higurashi et al.   LANCET ONCOLOGY

Arsenic – Poison or medicine?

(2016) Karolina Kulik-Kupka et al.   MEDYCYNA PRACY

Metformin protects against infection-induced myocardial dysfunction

(2016) Theodora Tzanavari et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

SurvivinT34A increases the therapeutic efficacy of arsenic trioxide in mouse hepatocellular carcinoma models

(2016) Anliang Huang et al.   ONCOLOGY REPORTS

Nrf2 activation ameliorates cytotoxic effects of arsenic trioxide in acute promyelocytic leukemia cells through increased glutathione levels and arsenic efflux from cells

(2016) Shoichi Nishimoto et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Withaferin-A Reduces Acetaminophen-Induced Liver Injury in Mice

(2015) Ravirajsinh N. Jadeja et al.   BIOCHEMICAL PHARMACOLOGY

Metformin enhances radiation response of ECa109 cells through activation of ATM and AMPK

(2015) Tingting Feng et al.   BIOMEDICINE & PHARMACOTHERAPY

Mitochondrial metabolism in cancer stem cells: a therapeutic target for colon cancer

(2015) In-Sung Song et al.   BMB Reports

Synergistic effects of metformin in combination with EGFR-TKI in the treatment of patients with advanced non-small cell lung cancer and type 2 diabetes

(2015) Hengyi Chen et al.   CANCER LETTERS

MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells

(2015) Patricia Sancho et al.   Cell Metabolism

Arsenic cardiotoxicity: An overview

(2015) Nafiseh Sadat Alamolhodaei et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Metformin attenuates hyperalgesia and allodynia in rats with painful diabetic neuropathy induced by streptozotocin

(2015) Junxiong Ma et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages

(2015) Beth Kelly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Azacytidine sensitizes acute myeloid leukemia cells to arsenic trioxide by up-regulating the arsenic transporter aquaglyceroporin 9

(2015) David Chau et al.   Journal of Hematology & Oncology

Metformin ameliorates acetaminophen hepatotoxicity via Gadd45β-dependent regulation of JNK signaling in mice

(2015) Yong-Hoon Kim et al.   JOURNAL OF HEPATOLOGY

Arsenic trioxide and all-trans retinoic acid treatment for acute promyelocytic leukaemia in all risk groups (AML17): results of a randomised, controlled, phase 3 trial

(2015) Alan K Burnett et al.   LANCET ONCOLOGY

Metabolic pathways promoting cancer cell survival and growth

(2015) Lindsey K. Boroughs et al.   NATURE CELL BIOLOGY

Arsenic Induces Insulin Resistance in Mouse Adipocytes and Myotubes Via Oxidative Stress-Regulated Mitochondrial Sirt3-FOXO3a Signaling Pathway

(2015) Sasidharan Padmaja Divya et al.   TOXICOLOGICAL SCIENCES

Preventing Allograft Rejection by Targeting Immune Metabolism

(2015) Chen-Fang Lee et al.   Cell Reports

Metformin and respiratory chain complex I: the last piece of the puzzle?

(2014) Eric Fontaine   BIOCHEMICAL JOURNAL

Control of Gluconeogenesis by Metformin: Does Redox Trump Energy Charge?

(2014) Joseph A. Baur et al.   Cell Metabolism

Continuation of metformin use after a diagnosis of cirrhosis significantly improves survival of patients with diabetes

(2014) Xiaodan Zhang et al.   HEPATOLOGY

Metformin inhibits proliferation and enhances chemosensitivity of intrahepatic cholangiocarcinoma cell lines

(2014) SUNBIN LING et al.   ONCOLOGY REPORTS

Apoptotic Efficacy of Etomoxir in Human Acute Myeloid Leukemia Cells. Cooperation with Arsenic Trioxide and Glycolytic Inhibitors, and Regulation by Oxidative Stress and Protein Kinase Activities

(2014) María Cristina Estañ et al.   PLoS One

Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2

(2014) W. De Haes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metformin sensitizes hepatocellular carcinoma to arsenic trioxide-induced apoptosis by downregulating Bcl2 expression

(2014) Xuejun Yang et al.   TUMOR BIOLOGY

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

(2014) William W Wheaton et al.   eLife

Metformin and liraglutide ameliorate high glucose-induced oxidative stress via inhibition of PKC-NAD(P)H oxidase pathway in human aortic endothelial cells

(2013) Battsetseg Batchuluun et al.   ATHEROSCLEROSIS

Blockade of reactive oxygen species and Akt activation is critical for anti-inflammation and growth inhibition of metformin in phosphatase and tensin homolog-deficient RAW264.7 cells

(2013) Chiou-Feng Lin et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia

(2013) Francesco Lo-Coco et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metformin Targets the Metabolic Achilles Heel of Human Pancreatic Cancer Stem Cells

(2013) Enza Lonardo et al.   PLoS One

Connections between SNAREs and autophagy

(2013) Kevin Moreau et al.   TRENDS IN BIOCHEMICAL SCIENCES

Superoxide generation by complex III: From mechanistic rationales to functional consequences

(2012) Lea Bleier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

(2012) Hartmut Jaeschke et al.   DRUG METABOLISM REVIEWS

Impact of arsenic trioxide in the treatment of acute promyelocytic leukemia

(2011) E Lengfelder et al.   LEUKEMIA

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

(2011) D. Anastasiou et al.   SCIENCE

Effect of metformin on cardiovascular events and mortality: a meta-analysis of randomized clinical trials

(2010) C. Lamanna et al.   DIABETES OBESITY & METABOLISM

Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth

(2010) Indira Jutooru et al.   EXPERIMENTAL CELL RESEARCH

Hepatic Ischemia Induced Immediate Oxidative Stress after Reperfusion and Determined the Severity of the Reperfusion-Induced Damage

(2009) Sanae Haga et al.   ANTIOXIDANTS & REDOX SIGNALING

Long-term Effects of Metformin on Metabolism and Microvascular and Macrovascular Disease in Patients With Type 2 Diabetes Mellitus

(2009) Adriaan Kooy et al.   ARCHIVES OF INTERNAL MEDICINE

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

High Dietary Fat Exacerbates Arsenic-Induced Liver Fibrosis in Mice

(2008) Jun Wu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Nanoencapsulation of quercetin enhances its dietary efficacy in combating arsenic-induced oxidative damage in liver and brain of rats

(2008) Aparajita Ghosh et al.   LIFE SCIENCES