Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus

Metformin and cognition from the perspectives of sex, age, and disease

(2020) Kiran Chaudhari et al.   GeroScience

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

(2020) Leena P. Bharath et al.   Cell Metabolism

Long-term treatment with spermidine increases health span of middle-aged Sprague-Dawley male rats

(2020) Madalina Filfan et al.   GeroScience

Autophagy Is Required for Memory Formation and Reverses Age-Related Memory Decline

(2019) Mélissa Glatigny et al.   CURRENT BIOLOGY

Metformin administration prevents memory impairment induced by hypobaric hypoxia in rats

(2019) Ming Zhao et al.   BEHAVIOURAL BRAIN RESEARCH

Age- and sex-dependent effects of metformin on neural precursor cells and cognitive recovery in a model of neonatal stroke

(2019) Rebecca M. Ruddy et al.   Science Advances

Gut microbiota–brain axis in depression: The role of neuroinflammation

(2019) Anelise S. Carlessi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Altered function of neuronal L-type calcium channels in ageing and neuroinflammation: Implications in age-related synaptic dysfunction and cognitive decline

(2018) Sheeja Navakkode et al.   AGEING RESEARCH REVIEWS

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Therapeutic Potential of Metformin in Neurodegenerative Diseases

(2018) Carola Rotermund et al.   Frontiers in Endocrinology

Incidence of Dementia is Increased in Type 2 Diabetes and Reduced by the Use of Sulfonylureas and Metformin

(2018) Chih-Cheng Hsu et al.   JOURNAL OF ALZHEIMERS DISEASE

Long-Term Metformin Usage and Cognitive Function among Older Adults with Diabetes

(2018) Tze Pin Ng et al.   JOURNAL OF ALZHEIMERS DISEASE

Selective autophagy as a potential therapeutic target for neurodegenerative disorders

(2018) Aurora Scrivo et al.   LANCET NEUROLOGY

Differential effects of metformin on age related comorbidities in older men with type 2 diabetes

(2017) Chen-Pin Wang et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Human umbilical cord plasma proteins revitalize hippocampal function in aged mice

(2017) Joseph M. Castellano et al.   NATURE

Metformin vs sulfonylurea use and risk of dementia in US veterans aged ≥65 years with diabetes

(2017) Ariela R. Orkaby et al.   NEUROLOGY

Bassoon Controls Presynaptic Autophagy through Atg5

(2017) Nathan D. Okerlund et al.   NEURON

Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus

(2017) Qianfa Long et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metformin Impairs Spatial Memory and Visual Acuity in Old Male Mice

(2017) Nopporn Thangthaeng et al.   Aging and Disease

Pattern Separation: A Potential Marker of Impaired Hippocampal Adult Neurogenesis in Major Depressive Disorder

(2017) Kellen Gandy et al.   Frontiers in Neuroscience

Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice

(2016) Joanne S. Allard et al.   BEHAVIOURAL BRAIN RESEARCH

Anti-Inflammatory Effects of Metformin Irrespective of Diabetes StatusNovelty and Significance

(2016) Amy R. Cameron et al.   CIRCULATION RESEARCH

The neuron-astrocyte-microglia triad involvement in neuroinflammaging mechanisms in the CA3 hippocampus of memory-impaired aged rats

(2016) Daniele Lana et al.   EXPERIMENTAL GERONTOLOGY

Metformin Prevents Dopaminergic Neuron Death in MPTP/P-Induced Mouse Model of Parkinson’s Disease via Autophagy and Mitochondrial ROS Clearance

(2016) Ming Lu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Antidiabetic drugs restore abnormal transport of amyloid-β across the blood–brain barrier and memory impairment in db / db mice

(2016) Fang Chen et al.   NEUROPHARMACOLOGY

Differential metformin dose-dependent effects on cognition in rats: role of Akt

(2016) Dalia K. Mostafa et al.   PSYCHOPHARMACOLOGY

Metformin, besides exhibiting strong in vivo anti-inflammatory properties, increases mptp-induced damage to the nigrostriatal dopaminergic system

(2016) Afrah A.K. Ismaiel et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Gender-Related Differences in the Expression of Organic Cation Transporter 2 and its Role in Urinary Excretion of Metformin in Rats

(2015) Yan-rong Ma et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Sex and strategy use matters for pattern separation, adult neurogenesis, and immediate early gene expression in the hippocampus

(2015) Shunya Yagi et al.   HIPPOCAMPUS

Inhibiting tumor necrosis factor-α signaling attenuates postoperative cognitive dysfunction in aged rats

(2015) YUANZHONG MA et al.   Molecular Medicine Reports

The role of type 2 diabetes in neurodegeneration

(2015) Giuseppe Verdile et al.   NEUROBIOLOGY OF DISEASE

mTOR in Brain Physiology and Pathologies

(2015) Joël Bockaert et al.   PHYSIOLOGICAL REVIEWS

The Chemokine MIP-1α/CCL3 impairs mouse hippocampal synaptic transmission, plasticity and memory

(2015) Elodie Marciniak et al.   Scientific Reports

Improvement of functional recovery by chronic metformin treatment is associated with enhanced alternative activation of microglia/macrophages and increased angiogenesis and neurogenesis following experimental stroke

(2014) Qin Jin et al.   BRAIN BEHAVIOR AND IMMUNITY

Type 2 Diabetes and Antidiabetic Medications in Relation to Dementia Diagnosis

(2014) Chin Cheng et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

AMPK agonist AICAR improves cognition and motor coordination in young and aged mice

(2014) T. Kobilo et al.   LEARNING & MEMORY

Comparison of the independent and combined effects of sub-chronic therapy with metformin and a stable GLP-1 receptor agonist on cognitive function, hippocampal synaptic plasticity and metabolic control in high-fat fed mice

(2014) Rachael Lennox et al.   NEUROPHARMACOLOGY

Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors

(2013) V. Nair et al.   CARCINOGENESIS

Increased Risk of Cognitive Impairment in Patients With Diabetes Is Associated With Metformin

(2013) E. M. Moore et al.   DIABETES CARE

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

(2013) Russell A. Miller et al.   NATURE

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

The PI3K/AKT/mTOR Pathway as a Therapeutic Target in Endometrial Cancer

(2012) B. M. Slomovitz et al.   CLINICAL CANCER RESEARCH

A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin

(2012) A. D. McNeilly et al.   DIABETOLOGIA

Metformin, Other Antidiabetic Drugs, and Risk of Alzheimer's Disease: A Population-Based Case-Control Study

(2012) Patrick Imfeld et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Effects of metformin on learning and memory behaviors and brain mitochondrial functions in high fat diet induced insulin resistant rats

(2012) Hiranya Pintana et al.   LIFE SCIENCES

Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice

(2012) Jiejie Li et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Dynamics of the Degradation of Ubiquitinated Proteins by Proteasomes and Autophagy

(2011) Natura Myeku et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

(2010) Adem Kalender et al.   Cell Metabolism

Associative recognition and the hippocampus: Differential effects of hippocampal lesions on object-place, object-context and object-place-context memory

(2009) Rosamund F. Langston et al.   HIPPOCAMPUS