Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin

Published 2016 View Full Article

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Title
Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin
Authors
Keywords
cancer metabolism, metformin, biguanide, NAD+/NADH ratio, drug sensitivity, complex I, mitochondria, aspartate
Journal
Cell Metabolism
Volume 24, Issue 5, Pages 716-727
Publisher
Elsevier BV
Online
2016-10-16
DOI
10.1016/j.cmet.2016.09.006

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