Mitochondrial Dysfunction Plays a Key Role in the Development of Neurodegenerative Diseases in Diabetes

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease

(2018) Xu Hou et al.   Autophagy

Insulin receptor in the brain: Mechanisms of activation and the role in the CNS pathology and treatment

(2018) Igor Pomytkin et al.   CNS Neuroscience & Therapeutics

α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton

(2018) Dalila G. Ordonez et al.   NEURON

Near-atomic model of microtubule-tau interactions

(2018) Elizabeth H. Kellogg et al.   SCIENCE

Calcium Dynamics as a Machine for Decoding Signals

(2018) Carlotta Giorgi et al.   TRENDS IN CELL BIOLOGY

Mitochondria as central regulators of neural stem cell fate and cognitive function

(2018) Mireille Khacho et al.   NATURE REVIEWS NEUROSCIENCE

Evolving and Expanding the Roles of Mitophagy as a Homeostatic and Pathogenic Process

(2018) Åsa B. Gustafsson et al.   PHYSIOLOGICAL REVIEWS

On the Pathogenesis of Alzheimer's Disease: The MAM Hypothesis

(2017) Estela Area-Gomez et al.   FASEB JOURNAL

Mitostasis in Neurons: Maintaining Mitochondria in an Extended Cellular Architecture

(2017) Thomas Misgeld et al.   NEURON

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

(2017) Jesse S. Kerr et al.   TRENDS IN NEUROSCIENCES

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival

(2017) Yunjong Lee et al.   Cell Reports

Metformin Impairs Spatial Memory and Visual Acuity in Old Male Mice

(2017) Nopporn Thangthaeng et al.   Aging and Disease

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy

(2016) Matteo Bordi et al.   Autophagy

Metformin activation of AMPK-dependent pathways is neuroprotective in human neural stem cells against Amyloid-beta-induced mitochondrial dysfunction

(2016) Ming-Chang Chiang et al.   EXPERIMENTAL CELL RESEARCH

IGF-1 Receptor Differentially Regulates Spontaneous and Evoked Transmission via Mitochondria at Hippocampal Synapses

(2016) Neta Gazit et al.   NEURON

Promotion of behavior and neuronal function by reactive oxygen species in C. elegans

(2016) Guang Li et al.   Nature Communications

High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents

(2015) Dmitry Petrov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Erratum: Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy

(2015) D J Roberts et al.   CELL DEATH AND DIFFERENTIATION

ROS-dependent signal transduction

(2015) Colleen R Reczek et al.   CURRENT OPINION IN CELL BIOLOGY

New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond

(2015) Josep A. Villena   FEBS Journal

Dysregulation of parkin in the substantia nigra of db/db and high-fat diet mice

(2015) R. Khang et al.   NEUROSCIENCE

Akt and cAMP response element binding protein mediate 17β-estradiol regulation of glucose transporter 3 expression in human SH-SY5Y neuroblastoma cell line

(2015) Yaohui Ni et al.   NEUROSCIENCE LETTERS

Metabolic learning and memory formation by the brain influence systemic metabolic homeostasis

(2015) Yumin Zhang et al.   Nature Communications

ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy

(2014) W. Wu et al.   EMBO REPORTS

PPARγ activation rescues mitochondrial function from inhibition of complex I and loss of PINK1

(2014) Juan Carlos Corona et al.   EXPERIMENTAL NEUROLOGY

Mitochondrial quality control systems sustain brain mitochondrial bioenergetics in early stages of type 2 diabetes

(2014) R. X. Santos et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

PGC-1α regulation of mitochondrial degeneration in experimental diabetic neuropathy

(2014) Joungil Choi et al.   NEUROBIOLOGY OF DISEASE

High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice

(2014) Steven E. Arnold et al.   NEUROBIOLOGY OF DISEASE

Modulation of ceramide-induced cell death and superoxide production by mitochondrial DNA-encoded respiratory chain defects in Rattus xenocybrid mouse cells

(2013) Ian A. Trounce et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives

(2013) Russell H. Swerdlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial energetic metabolism-some general principles

(2013) Jean-Pierre Mazat et al.   IUBMB LIFE

Transcriptional Regulation of Insulin-degrading Enzyme Modulates Mitochondrial Amyloid β (Aβ) Peptide Catabolism and Functionality

(2013) María C. Leal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer’s disease and insulin resistance: translating basic science into clinical applications

(2013) Fernanda G. De Felice   JOURNAL OF CLINICAL INVESTIGATION

Diabetes mellitus and risk of dementia: A meta-analysis of prospective observational studies

(2013) Kapil Gudala et al.   Journal of Diabetes Investigation

Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes

(2012) Subir K. Roy Chowdhury et al.   BRAIN

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease

(2012) S. Mandrekar-Colucci et al.   JOURNAL OF NEUROSCIENCE

Mitochondria as sensors and regulators of calcium signalling

(2012) Rosario Rizzuto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Synaptic Energy Use and Supply

(2012) Julia J. Harris et al.   NEURON

Slow calcium waves and redox changes precede mitochondrial permeability transition pore opening in the intact heart during hypoxia and reoxygenation

(2011) Sean M. Davidson et al.   CARDIOVASCULAR RESEARCH

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

MiD49 and MiD51, new components of the mitochondrial fission machinery

(2011) Catherine S Palmer et al.   EMBO REPORTS

Obesity, diabetes, and risk of Parkinson's disease

(2011) Natalia Palacios et al.   MOVEMENT DISORDERS

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

(2011) Wenjun Song et al.   NATURE MEDICINE

Rosiglitazone decreases peroxisome proliferator receptor-gamma levels in microglia and inhibits TNF-alpha production: new evidences on neuroprotection in a progressive Parkinson's disease model

(2011) A.R. Carta et al.   NEUROSCIENCE

si-RNA inhibition of brain insulin or insulin-like growth factor receptors causes developmental cerebellar abnormalities: relevance to fetal alcohol spectrum disorder

(2011) Suzanne M de la Monte et al.   Molecular Brain

Calcium-dependent mitochondrial function and dysfunction in neurons

(2010) Natalia B. Pivovarova et al.   FEBS Journal

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

(2010) I. Irrcher et al.   HUMAN MOLECULAR GENETICS

Presenilins Are Enriched in Endoplasmic Reticulum Membranes Associated with Mitochondria

(2009) Estela Area-Gomez et al.   AMERICAN JOURNAL OF PATHOLOGY

Nix is a selective autophagy receptor for mitochondrial clearance

(2009) Ivana Novak et al.   EMBO REPORTS

Constitutive androstane receptor mediates the induction of drug metabolism in mouse models of type 1 diabetes

(2009) Bingning Dong et al.   HEPATOLOGY

 -Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

(2009) Q.-L. Ma et al.   JOURNAL OF NEUROSCIENCE

Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease

(2009) Velandai Srikanth et al.   NEUROBIOLOGY OF AGING

Glucose Homeostasis in Huntington Disease

(2008) Nebojša M. Lalić et al.   ARCHIVES OF NEUROLOGY

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Shaping mitochondria: The complex posttranslational regulation of the mitochondrial fission protein DRP1

(2008) Ansgar Santel et al.   IUBMB LIFE

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Dipeptidyl-Peptidase-IV Inhibition Augments Postprandial Lipid Mobilization and Oxidation in Type 2 Diabetic Patients

(2008) Michael Boschmann et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL