Sirtuins: Molecular Traffic Lights in the Crossroad of Oxidative Stress, Chromatin Remodeling, and Transcription

mTOR's role in ageing: protein synthesis or autophagy?

(2016) Sarah L. Hands et al.   Aging-US

Distinct HIC1-SIRT1-p53 Loop Deregulation in Lung Squamous Carcinoma and Adenocarcinoma Patients

(2015) Ruo-Chia Tseng et al.   NEOPLASIA

The effects of p53 on whole organism longevity are mediated by autophagy

(2014) Nektarios Tavernarakis et al.   Autophagy

A dual role of p53 in the control of autophagy

(2014) Ezgi Tasdemir et al.   Autophagy

Protected from the inside: Endogenous histone deacetylase inhibitors and the road to cancer

(2011) Lucia Di Marcotullio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

JNK2-dependent regulation of SIRT1 protein stability

(2011) Jack Ford et al.   CELL CYCLE

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome

(2011) Eugenia Morselli et al.   JOURNAL OF CELL BIOLOGY

Autophagy in health and disease. 1. Regulation and significance of autophagy: an overview

(2010) Maryam Mehrpour et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Regulation of SIRT1 in cellular functions: Role of polyphenols

(2010) Sangwoon Chung et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

NAD: A master regulator of transcription

(2010) Sanchari Ghosh et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Inhibitors to understand molecular mechanisms of NAD+-dependent deacetylases (sirtuins)

(2010) Michael Lawson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

SIRT1 and p53, effect on cancer, senescence and beyond

(2010) Jingjie Yi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Mitochondrial sirtuins

(2010) Jing-Yi Huang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Sirtuin chemical mechanisms

(2010) Anthony A. Sauve   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Foxo3a expression and acetylation regulate cancer cell growth and sensitivity to cisplatin

(2010) Masaki Shiota et al.   CANCER SCIENCE

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

Interactions between DBC1 and SIRT1 are deregulated in breast cancer cells

(2010) Ja-Eun Kim et al.   CELL CYCLE

The emerging role of lysine acetylation of non-nuclear proteins

(2010) Pierre Close et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes

(2010) Nirmala Hariharan et al.   CIRCULATION RESEARCH

Autophagy regulation by p53

(2010) Maria Chiara Maiuri et al.   CURRENT OPINION IN CELL BIOLOGY

Role of SIRT1 in homologous recombination

(2010) Miriam Uhl et al.   DNA REPAIR

The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways

(2010) Riekelt H. Houtkooper et al.   ENDOCRINE REVIEWS

SIRT1 Regulates Autoacetylation and Histone Acetyltransferase Activity of TIP60

(2010) Jiadong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DYRK1A and DYRK3 Promote Cell Survival through Phosphorylation and Activation of SIRT1

(2010) Xiumei Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2

(2010) Barrie Peck et al.   MOLECULAR CANCER THERAPEUTICS

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

(2010) Ying Zhao et al.   NATURE CELL BIOLOGY

SIRTing out the link between autophagy and ageing

(2010) M. S. Goligorsky   NEPHROLOGY DIALYSIS TRANSPLANTATION

Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis

(2010) Xingxing Kong et al.   PLoS One

Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C

(2010) M. Ming et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human SIRT6 Promotes DNA End Resection Through CtIP Deacetylation

(2010) Abderrahmane Kaidi et al.   SCIENCE

Linking calorie restriction to longevity through sirtuins and autophagy: any role for TOR

(2010) M V Blagosklonny   Cell Death & Disease

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2

(2009) Barbara Zschoernig et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Function of SIRT1 in physiology

(2009) Xing-Xing Kong et al.   BIOCHEMISTRY-MOSCOW

Sirtuin regulation in calorie restriction

(2009) Xiaolei Qiu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Sirtuins inhibitors: The approach to affinity and selectivity

(2009) Yana Cen   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle

(2009) Takashi Nakagawa et al.   CELL

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

(2009) Tiara L.A. Kawahara et al.   CELL

E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis

(2009) M Lizé et al.   CELL DEATH AND DIFFERENTIATION

SIRT1: Regulation of longevity via autophagy

(2009) Antero Salminen et al.   CELLULAR SIGNALLING

Downregulation of MiR-199a Derepresses Hypoxia-Inducible Factor-1α and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes

(2009) Shweta Rane et al.   CIRCULATION RESEARCH

Epigenetic Histone Code and Autoimmunity

(2009) Jürgen Dieker et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

NAD+, Sirtuins, and Cardiovascular Disease

(2009) Nica Borradaile et al.   CURRENT PHARMACEUTICAL DESIGN

Epigenetics: A Molecular Link Between Environmental Factors and Type 2 Diabetes

(2009) Charlotte Ling et al.   DIABETES

Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease

(2009) D. Pons et al.   EUROPEAN HEART JOURNAL

SIRT1 Suppresses Activator Protein-1 Transcriptional Activity and Cyclooxygenase-2 Expression in Macrophages

(2009) Ran Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A c-Myc–SIRT1 feedback loop regulates cell growth and transformation

(2009) Jian Yuan et al.   JOURNAL OF CELL BIOLOGY

Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis

(2009) A. Grob et al.   JOURNAL OF CELL SCIENCE

Kaempferol induces apoptosis in two different cell lines via Akt inactivation, Bax and SIRT3 activation, and mitochondrial dysfunction

(2009) Gabriella Marfe et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice

(2009) Nagalingam R. Sundaresan et al.   JOURNAL OF CLINICAL INVESTIGATION

hSirT1-Dependent Regulation of the PCAF-E2F1-p73 Apoptotic Pathway in Response to DNA Damage

(2009) N. Pediconi et al.   MOLECULAR AND CELLULAR BIOLOGY

NF- B Activation, Dependent on Acetylation/Deacetylation, Contributes to HIF-1 Activity and Migration of Bone Metastatic Breast Carcinoma Cells

(2009) P. Bendinelli et al.   MOLECULAR CANCER RESEARCH

CBP/p300-mediated acetylation of histone H3 on lysine 56

(2009) Chandrima Das et al.   NATURE

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

SIRT1 and insulin resistance

(2009) Fengxia Liang et al.   Nature Reviews Endocrinology

Nucleosome positioning and gene regulation: advances through genomics

(2009) Cizhong Jiang et al.   NATURE REVIEWS GENETICS

Dynamics and diversity in autophagy mechanisms: lessons from yeast

(2009) Hitoshi Nakatogawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Promotion of cellular NAD+ anabolism: Therapeutic potential for oxidative stress in ageing and alzheimer’s disease

(2009) Nady Braidy et al.   NEUROTOXICITY RESEARCH

Histone deacetylases and the immunological network: implications in cancer and inflammation

(2009) A Villagra et al.   ONCOGENE

Protein deacetylation by SIRT1: An emerging key post-translational modification in metabolic regulation

(2009) Jiujiu Yu et al.   PHARMACOLOGICAL RESEARCH

Regulation of Hypoxia-Inducible Factor 2  Signaling by the Stress-Responsive Deacetylase Sirtuin 1

(2009) E. M. Dioum et al.   SCIENCE

Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1

(2009) S. D. Westerheide et al.   SCIENCE

Acetylation Goes Global: The Emergence of Acetylation Biology

(2009) K. L. Norris et al.   Science Signaling

Biochemical pathways that regulate acetyltransferase and deacetylase activity in mammalian cells

(2009) Hestia S. Mellert et al.   TRENDS IN BIOCHEMICAL SCIENCES

Energetic cell sensors: a key to metabolic homeostasis

(2009) Mourad Naïmi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Multiple roles of HDAC inhibition in neurodegenerative conditions

(2009) De-Maw Chuang et al.   TRENDS IN NEUROSCIENCES

HDAC2: a critical factor in health and disease

(2009) Oliver H. Krämer   TRENDS IN PHARMACOLOGICAL SCIENCES

The NF- B Family of Transcription Factors and Its Regulation

(2009) A. Oeckinghaus et al.   Cold Spring Harbor Perspectives in Biology

Histone deacetylase-2 and airway disease

(2009) Peter J. Barnes   Therapeutic Advances in Respiratory Disease

SIRT1, an Antiinflammatory and Antiaging Protein, Is Decreased in Lungs of Patients with Chronic Obstructive Pulmonary Disease

(2008) Saravanan Rajendrasozhan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Acetylation of Sirt2 by p300 attenuates its deacetylase activity

(2008) Younho Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRTUIN 1: Regulating the regulator

(2008) Barbara Zschoernig et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells

(2008) Keitaro Kojima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression

(2008) Kazuhiro Hasegawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT1 longevity factor suppresses NF-κB -driven immune responses: regulation of aging via NF-κB acetylation?

(2008) Antero Salminen et al.   BIOESSAYS

The R6 lines of transgenic mice: A model for screening new therapies for Huntington's disease

(2008) Joana M. Gil et al.   BRAIN RESEARCH REVIEWS

Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

(2008) Rui-Hong Wang et al.   CANCER CELL

Aging: A Sirtuin Shake-Up?

(2008) Jan Vijg et al.   CELL

SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

(2008) Philipp Oberdoerffer et al.   CELL

SIRT1 Regulates Apoptosis and Nanog Expression in Mouse Embryonic Stem Cells by Controlling p53 Subcellular Localization

(2008) Myung-Kwan Han et al.   Cell Stem Cell

Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice

(2008) Olesya Vakhrusheva et al.   CIRCULATION RESEARCH

Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

(2008) Marcella Fulco et al.   DEVELOPMENTAL CELL

Overexpression of SIRT1 Protects Pancreatic  -Cells Against Cytokine Toxicity by Suppressing the Nuclear Factor- B Signaling Pathway

(2008) J.-H. Lee et al.   DIABETES

sirt1-null mice develop an autoimmune-like condition

(2008) Jedon Sequeira et al.   EXPERIMENTAL CELL RESEARCH

Tissue-specific regulation of SIRT1 by calorie restriction

(2008) D. Chen et al.   GENES & DEVELOPMENT

Regulation of WRN Protein Cellular Localization and Enzymatic Activities by SIRT1-mediated Deacetylation

(2008) Kai Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility

(2008) Ruwin Pandithage et al.   JOURNAL OF CELL BIOLOGY

Substrates and Regulation Mechanisms for the Human Mitochondrial Sirtuins Sirt3 and Sirt5

(2008) Christine Schlicker et al.   JOURNAL OF MOLECULAR BIOLOGY

SIRT2 Suppresses Adipocyte Differentiation by Deacetylating FOXO1 and Enhancing FOXO1's Repressive Interaction with PPARγ

(2008) Fei Wang et al.   MOLECULAR BIOLOGY OF THE CELL

The SIRT2 Deacetylase Regulates Autoacetylation of p300

(2008) Joshua C. Black et al.   MOLECULAR CELL

Interplay among BRCA1, SIRT1, and Survivin during BRCA1-Associated Tumorigenesis

(2008) Rui-Hong Wang et al.   MOLECULAR CELL

Negative regulation of the deacetylase SIRT1 by DBC1

(2008) Wenhui Zhao et al.   NATURE

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

(2008) Eriko Michishita et al.   NATURE

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

Paths of Convergence: Sirtuins in Aging and Neurodegeneration

(2008) Li Gan et al.   NEURON

E2F1 regulates autophagy and the transcription of autophagy genes

(2008) S Polager et al.   ONCOGENE

PCAF is an HIF-1α cofactor that regulates p53 transcriptional activity in hypoxia

(2008) G Xenaki et al.   ONCOGENE

The FoxO code

(2008) D R Calnan et al.   ONCOGENE

How to Live Long and Prosper: Autophagy, Mitochondria, and Aging

(2008) Wei-Lien Yen et al.   PHYSIOLOGY

SIRT1 Overexpression Antagonizes Cellular Senescence with Activated ERK/S6k1 Signaling in Human Diploid Fibroblasts

(2008) Jing Huang et al.   PLoS One

The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth

(2008) Ron Firestein et al.   PLoS One

Phosphorylation Regulates SIRT1 Function

(2008) Tsutomu Sasaki et al.   PLoS One

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-34a repression of SIRT1 regulates apoptosis

(2008) M. Yamakuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ups and downs of SIRT1

(2008) Hye-Sook Kwon et al.   TRENDS IN BIOCHEMICAL SCIENCES

AsSIRTing the DNA damage response

(2008) Myriam Gorospe et al.   TRENDS IN CELL BIOLOGY

Double Strand Breaks Can Initiate Gene Silencing and SIRT1-Dependent Onset of DNA Methylation in an Exogenous Promoter CpG Island

(2008) Heather M. O'Hagan et al.   PLoS Genetics

Localization of mouse mitochondrial SIRT proteins: Shift of SIRT3 to nucleus by co-expression with SIRT5

(2007) Yasuhiko Nakamura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS