Neutrophil phenotypes and functions in cancer: A consensus statement

Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation

(2021) Yansen Xiao et al.   CANCER CELL

Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung

(2021) Abhishek Tyagi et al.   Nature Communications

Analysis of classical neutrophils and polymorphonuclear myeloid-derived suppressor cells in cancer patients and tumor-bearing mice

(2021) Filippo Veglia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

(2021) McLane J. Watson et al.   NATURE

Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients

(2021) Diwakar Davar et al.   SCIENCE

GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy

(2021) Pierre-Benoit Ancey et al.   CANCER RESEARCH

Genetically engineered myeloid cells rebalance the core immune suppression program in metastasis

(2021) Sabina Kaczanowska et al.   CELL

Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis

(2021) Chang Cui et al.   CELL

The cholesterol metabolite 27-hydroxycholesterol increases the secretion of extracellular vesicles which promote breast cancer progression

(2021) Amy E Baek et al.   ENDOCRINOLOGY

MDSC: Markers, development, states, and unaddressed complexity

(2021) Samarth Hegde et al.   IMMUNITY

Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity

(2021) Andrew D. Hildreth et al.   NATURE IMMUNOLOGY

The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments

(2021) Ricardo Grieshaber-Bouyer et al.   Nature Communications

RNA externalized by neutrophil extracellular traps promotes inflammatory pathways in endothelial cells

(2021) Luz P. Blanco et al.   Arthritis & Rheumatology

Tumor-associated neutrophils drive B-cell recruitment and their differentiation to plasma cells

(2021) Merav E Shaul et al.   Cancer Immunology Research

Association of Obesity With Survival Outcomes in Patients With Cancer

(2021) Fausto Petrelli et al.   JAMA Network Open

Patients with COVID-19: in the dark-NETs of neutrophils

(2021) Maximilian Ackermann et al.   CELL DEATH AND DIFFERENTIATION

Myeloid-derived growth factor regulates neutrophil motility in interstitial tissue damage

(2021) Ruth A. Houseright et al.   JOURNAL OF CELL BIOLOGY

Centriole and Golgi microtubule nucleation are dispensable for the migration of human neutrophil-like cells

(2021) Lucas C. Klemm et al.   MOLECULAR BIOLOGY OF THE CELL

Distinct transcription factor networks control neutrophil-driven inflammation

(2021) Tariq E. Khoyratty et al.   NATURE IMMUNOLOGY

FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity

(2021) Vijayashree Mysore et al.   Nature Communications

NLRP3 Inflammasome Assembly in Neutrophils Is Supported by PAD4 and Promotes NETosis Under Sterile Conditions

(2021) Patrick Münzer et al.   Frontiers in Immunology

CD47-SIRPα Checkpoint Inhibition Enhances Neutrophil-Mediated Killing of Dinutuximab-Opsonized Neuroblastoma Cells

(2021) Paula Martínez-Sanz et al.   Cancers

The PD-L1/PD-1 Axis Blocks Neutrophil Cytotoxicity in Cancer

(2021) Olga Yajuk et al.   Cells

Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy

(2021) Marie Siwicki et al.   Science Immunology

Effect of immunotherapy time-of-day infusion on overall survival among patients with advanced melanoma in the USA (MEMOIR): a propensity score-matched analysis of a single-centre, longitudinal study

(2021) David C Qian et al.   LANCET ONCOLOGY

Versatile neutrophil functions in cancer

(2021) Marie Siwicki et al.   SEMINARS IN IMMUNOLOGY

Impact of cancer cell-intrinsic features on neutrophil behavior

(2021) Danique E.M. Duits et al.   SEMINARS IN IMMUNOLOGY

NETosis in cancer: a critical analysis of the impact of cancer on neutrophil extracellular trap (NET) release in lung cancer patients vs. mice

(2020) Ludovica Arpinati et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Circulating neutrophil subsets in advanced lung cancer patients exhibit unique immune signature and relate to prognosis

(2020) Merav E. Shaul et al.   FASEB JOURNAL

Transcriptional regulation of neutrophil differentiation and function during inflammation

(2020) Zhichao Ai et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors

(2020) Haiping Wang et al.   NATURE IMMUNOLOGY

Programmed ‘disarming’ of the neutrophil proteome reduces the magnitude of inflammation

(2020) Jose M. Adrover et al.   NATURE IMMUNOLOGY

Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses

(2020) Julianna Blagih et al.   Cell Reports

Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics

(2020) Hamad Alshetaiwi et al.   Science Immunology

CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity

(2020) Álvaro Teijeira et al.   IMMUNITY

Targeting potential drivers of COVID-19: Neutrophil extracellular traps

(2020) Betsy J. Barnes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophils Recirculate through Lymph Nodes to Survey Tissues for Pathogens

(2020) Ania Bogoslowski et al.   JOURNAL OF IMMUNOLOGY

Mouse models of neutropenia reveal progenitor-stage-specific defects

(2020) David E. Muench et al.   NATURE

Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors

(2020) Kurt A. Schalper et al.   NATURE MEDICINE

High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade

(2020) Kobe C. Yuen et al.   NATURE MEDICINE

NETosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin decondensation and nuclear envelope rupture

(2020) Hawa Racine Thiam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Durable and controlled depletion of neutrophils in mice

(2020) Gael Boivin et al.   Nature Communications

Histones, DNA, and Citrullination Promote Neutrophil Extracellular Trap Inflammation by Regulating the Localization and Activation of TLR4

(2020) Theodora-Dorita Tsourouktsoglou et al.   Cell Reports

Neutrophil Extracellular Traps (NETs) Contribute to Immunothrombosis in COVID-19 Acute Respiratory Distress Syndrome

(2020) Elizabeth A Middleton et al.   BLOOD

Extracellular CIRP and TREM‐1 axis promotes ICAM‐1‐Rho‐mediated NETosis in sepsis

(2020) Atsushi Murao et al.   FASEB JOURNAL

Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor

(2020) Immanuel Kwok et al.   IMMUNITY

DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25

(2020) Linbin Yang et al.   NATURE

Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection

(2020) Xuemei Xie et al.   NATURE IMMUNOLOGY

A single-cell atlas of the peripheral immune response in patients with severe COVID-19

(2020) Aaron J. Wilk et al.   NATURE MEDICINE

Sex differences in neutrophil biology modulate response to type I interferons and immunometabolism

(2020) Sarthak Gupta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil extracellular traps in COVID-19

(2020) Yu Zuo et al.   JCI Insight

Early Neutrophil Responses to Chemical Carcinogenesis Shape Long-Term Lung Cancer Susceptibility

(2020) Stefanie K. Wculek et al.   iScience

Co-option of Neutrophil Fates by Tissue Environments

(2020) Iván Ballesteros et al.   CELL

Immune Cell Paracrine Signaling Drives the Neutrophil Response to A. fumigatus in an Infection-on-a-Chip Model

(2020) Laurel E. Hind et al.   Cellular and Molecular Bioengineering

Coexpression of CD71 and CD117 Identifies an Early Unipotent Neutrophil Progenitor Population in Human Bone Marrow

(2020) Huy Q. Dinh et al.   IMMUNITY

Frontline Science: Extracellular CIRP generates a proinflammatory Ly6G + CD11b hi subset of low‐density neutrophils in sepsis

(2020) Satoshi Takizawa et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis

(2020) Peishan Li et al.   NATURE IMMUNOLOGY

Tumor-Promoting Ly-6G+ SiglecFhigh Cells Are Mature and Long-Lived Neutrophils

(2020) Christina Pfirschke et al.   Cell Reports

CyTOF mass cytometry reveals phenotypically distinct human blood neutrophil populations differentially correlated with melanoma stage

(2020) Yanfang Peipei Zhu et al.   Journal for ImmunoTherapy of Cancer

ROS-producing immature neutrophils in giant cell arteritis are linked to vascular pathologies

(2020) Lihui Wang et al.   JCI Insight

Distinct tissue damage and microbial cues drive neutrophil and macrophage recruitment to thermal injury

(2020) Francisco Barros-Becker et al.   iScience

Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

(2020) Alison E. Ringel et al.   CELL

Inhibition of Efferocytosis by Extracellular CIRP–Induced Neutrophil Extracellular Traps

(2020) Kehong Chen et al.   JOURNAL OF IMMUNOLOGY

Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients

(2020) Erez N. Baruch et al.   SCIENCE

Kindlin3-dependent CD11b/CD18-integrin activation is required for potentiation of neutrophil cytotoxicity by CD47-SIRPα checkpoint disruption

(2020) Panagiota Bouti et al.   Cancer Immunology Research

Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage

(2019) Dvir Aran et al.   NATURE IMMUNOLOGY

Control of Leukocyte Trafficking by Stress-Associated Hormones

(2019) Louise M. Ince et al.   Frontiers in Immunology

The microbiome, cancer, and cancer therapy

(2019) Beth A. Helmink et al.   NATURE MEDICINE

Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response

(2019) Camilla Salvagno et al.   NATURE CELL BIOLOGY

Neutrophils escort circulating tumour cells to enable cell cycle progression

(2019) Barbara Maria Szczerba et al.   NATURE

Neutrophil plasticity in the tumor microenvironment

(2019) Morgan Giese et al.   BLOOD

Crosstalk between neutrophils and the microbiota

(2019) Dachuan Zhang et al.   BLOOD

Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species

(2019) Rapolas Zilionis et al.   IMMUNITY

Fatty acid transport protein 2 reprograms neutrophils in cancer

(2019) Filippo Veglia et al.   NATURE

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

(2019) Diego Adhemar Jaitin et al.   CELL

Macrophages and Metabolism in the Tumor Microenvironment

(2019) Ilio Vitale et al.   Cell Metabolism

More friend than foe: the emerging role of neutrophils in tissue repair

(2019) Moritz Peiseler et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of monocyte-like precursors of granulocytes in cancer as a mechanism for accumulation of PMN-MDSCs

(2019) Jérôme Mastio et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis

(2019) Max D. Wellenstein et al.   NATURE

Hematopoietic progenitor cells as integrative hubs for adaptation to and fine-tuning of inflammation

(2019) Triantafyllos Chavakis et al.   NATURE IMMUNOLOGY

Tumour-associated neutrophils in patients with cancer

(2019) Merav E. Shaul et al.   Nature Reviews Clinical Oncology

Immature Low-Density Neutrophils Exhibit Metabolic Flexibility that Facilitates Breast Cancer Liver Metastasis

(2019) Brian E. Hsu et al.   Cell Reports

Neutrophils as a Therapeutic Target in Cancer

(2019) Zvi Granot   Frontiers in Immunology

Neutrophil Cathepsin G and Tumor Cell RAGE Facilitate Neutrophil Anti-Tumor Cytotoxicity

(2019) Ronit Vogt Sionov et al.   OncoImmunology

Limitations of neutrophil depletion by anti-Ly6G antibodies in two heterogenic immunological models

(2019) Emilie Pollenus et al.   IMMUNOLOGY LETTERS

Metastatic-niche labelling reveals parenchymal cells with stem features

(2019) Luigi Ombrato et al.   NATURE

Neutrophils promote tumor resistance to radiation therapy

(2019) Amy J. Wisdom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Neutrophil Timer Coordinates Immune Defense and Vascular Protection

(2019) José M. Adrover et al.   IMMUNITY

Transcriptomic, epigenetic, and functional analyses implicate neutrophil diversity in the pathogenesis of systemic lupus erythematosus

(2019) Pragnesh Mistry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil extracellular traps drive inflammatory pathogenesis in malaria

(2019) Sebastian Lorenz Knackstedt et al.   Science Immunology

Microenvironmental Cues Determine Tumor Cell Susceptibility to Neutrophil Cytotoxicity

(2018) Maya Gershkovitz et al.   CANCER RESEARCH

TRPM2 Mediates Neutrophil Killing of Disseminated Tumor Cells

(2018) Maya Gershkovitz et al.   CANCER RESEARCH

LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer

(2018) Masoud F. Tavazoie et al.   CELL

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

(2018) Anette Christ et al.   CELL

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

(2018) Ioannis Mitroulis et al.   CELL

BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis

(2018) Eva Kaufmann et al.   CELL

Leukotriene B4-Mediated Neutrophil Recruitment Causes Pulmonary Capillaritis during Lethal Fungal Sepsis

(2018) Esther K.S. Lee et al.   Cell Host & Microbe

Transforming Growth Factor-β and Axl Induce CXCL5 and Neutrophil Recruitment in Hepatocellular Carcinoma

(2018) Christine Haider et al.   HEPATOLOGY

Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions

(2018) Maximilien Evrard et al.   IMMUNITY

Aged neutrophils accumulate in lymphoid tissues from healthy elderly mice and infiltrate T- and B-cell zones

(2018) Federica Tomay et al.   IMMUNOLOGY AND CELL BIOLOGY

Role of Peptidylarginine Deiminase 4 in Neutrophil Extracellular Trap Formation and Host Defense duringKlebsiella pneumoniae–Induced Pneumonia-Derived Sepsis

(2018) Theodora A. M. Claushuis et al.   JOURNAL OF IMMUNOLOGY

Frontline Science: High fat diet and leptin promote tumor progression by inducing myeloid-derived suppressor cells

(2018) Virginia K. Clements et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CIRP increases ICAM-1+ phenotype of neutrophils exhibiting elevated iNOS and NETs in sepsis

(2018) Yasumasa Ode et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms

(2018) Marco Bezzi et al.   NATURE MEDICINE

The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients

(2018) Vyara Matson et al.   SCIENCE

Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis

(2018) Hanke L. Matlung et al.   Cell Reports

Candida albicans-Induced NETosis Is Independent of Peptidylarginine Deiminase 4

(2018) Eva Guiducci et al.   Frontiers in Immunology

Neutrophil elastase and myeloperoxidase mRNA expression in overweight and obese subjects

(2018) Mohammad Ali et al.   MOLECULAR BIOLOGY REPORTS

Cirp Induces Neutrophil Reverse Transendothelial Migration in Sepsis

(2018) Hui Jin et al.   SHOCK

Dynamics of Transcription Regulation in Human Bone Marrow Myeloid Differentiation to Mature Blood Neutrophils

(2018) Luigi Grassi et al.   Cell Reports

Identification of an Early Unipotent Neutrophil Progenitor with Pro-tumoral Activity in Mouse and Human Bone Marrow

(2018) Yanfang Peipei Zhu et al.   Cell Reports

Neutrophil extracellular traps induced by IL-8 promote diffuse large B cell lymphoma progression via the TLR9 signaling

(2018) Man Nie et al.   CLINICAL CANCER RESEARCH

Neutrophils instruct homeostatic and pathological states in naive tissues

(2018) Maria Casanova-Acebes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metformin modulates innate immune-mediated inflammation and early progression of NAFLD-associated hepatocellular carcinoma in zebrafish

(2018) Sofia de Oliveira et al.   JOURNAL OF HEPATOLOGY

Unique pattern of neutrophil migration and function during tumor progression

(2018) Sima Patel et al.   NATURE IMMUNOLOGY

Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression

(2018) Christopher M. Rice et al.   Nature Communications

Neutrophils in Homeostasis, Immunity, and Cancer

(2017) José Ángel Nicolás-Ávila et al.   IMMUNITY

Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation

(2017) Thomas Riffelmacher et al.   IMMUNITY

Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes

(2017) Alberto Yáñez et al.   IMMUNITY

The CD47-SIRPα signaling axis as an innate immune checkpoint in cancer

(2017) Hanke L. Matlung et al.   IMMUNOLOGICAL REVIEWS

Neutrophil extracellular traps sequester circulating tumor cells via β1-integrin mediated interactions

(2017) Sara Najmeh et al.   INTERNATIONAL JOURNAL OF CANCER

Splenic Ly6G high mature and Ly6G int immature neutrophils contribute to eradication of S. pneumoniae

(2017) Justin F. Deniset et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Multicenter Systems Analysis of Human Blood Reveals Immature Neutrophils in Males and During Pregnancy

(2017) Jana Blazkova et al.   JOURNAL OF IMMUNOLOGY

Human haematopoietic stem cell lineage commitment is a continuous process

(2017) Lars Velten et al.   NATURE CELL BIOLOGY

Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF

(2017) Daniela F. Quail et al.   NATURE CELL BIOLOGY

An emerging role for neutrophil extracellular traps in noninfectious disease

(2017) Selina K Jorch et al.   NATURE MEDICINE

Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation

(2017) Marie Toussaint et al.   NATURE MEDICINE

Visualizing the function and fate of neutrophils in sterile injury and repair

(2017) Jing Wang et al.   SCIENCE

Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhighneutrophils

(2017) Camilla Engblom et al.   SCIENCE

Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

(2017) V. Gopalakrishnan et al.   SCIENCE

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

(2017) Bertrand Routy et al.   SCIENCE

The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells

(2017) Amy E. Baek et al.   Nature Communications

A late-lineage murine neutrophil precursor population exhibits dynamic changes during demand-adapted granulopoiesis

(2017) Min-Hyeok Kim et al.   Scientific Reports

Diverse stimuli engage different neutrophil extracellular trap pathways

(2017) Elaine F Kenny et al.   eLife

Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells

(2017) Amir A. Al-Khami et al.   OncoImmunology

Transcriptional firing helps to drive NETosis

(2017) Meraj A. Khan et al.   Scientific Reports

Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils

(2016) Yanfang Liu et al.   CANCER CELL

Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer

(2016) Sunil Singhal et al.   CANCER CELL

CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma

(2016) Colin W. Steele et al.   CANCER CELL

Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress

(2016) Samer Tohme et al.   CANCER RESEARCH

Tumor-Produced Interleukin-8 Attracts Human Myeloid-Derived Suppressor Cells and Elicits Extrusion of Neutrophil Extracellular Traps (NETs)

(2016) C. Alfaro et al.   CLINICAL CANCER RESEARCH

Myeloid-Derived Suppressor Cell Subset Accumulation in Renal Cell Carcinoma Parenchyma Is Associated with Intratumoral Expression of IL1β, IL8, CXCL5, and Mip-1α

(2016) Yana G. Najjar et al.   CLINICAL CANCER RESEARCH

Peptidylarginine deiminase 4 promotes age-related organ fibrosis

(2016) Kimberly Martinod et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus

(2016) Simone Caielli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nicotine induces neutrophil extracellular traps

(2016) Ava Hosseinzadeh et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Survival of residual neutrophils and accelerated myelopoiesis limit the efficacy of antibody-mediated depletion of Ly-6G+ cells in tumor-bearing mice

(2016) K. Moses et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Single-cell analysis of mixed-lineage states leading to a binary cell fate choice

(2016) Andre Olsson et al.   NATURE

Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation

(2016) Thomas Welte et al.   NATURE CELL BIOLOGY

New insights into the multidimensional concept of macrophage ontogeny, activation and function

(2016) Florent Ginhoux et al.   NATURE IMMUNOLOGY

Distinct myeloid progenitor–differentiation pathways identified through single-cell RNA sequencing

(2016) Roy Drissen et al.   NATURE IMMUNOLOGY

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

Body Fatness and Cancer — Viewpoint of the IARC Working Group

(2016) Béatrice Lauby-Secretan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Development of a prosaposin-derived therapeutic cyclic peptide that targets ovarian cancer via the tumor microenvironment

(2016) Suming Wang et al.   Science Translational Medicine

Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps

(2016) J. Park et al.   Science Translational Medicine

OC-16 - Neutrophil extracellular traps and tissue factor-bearing microvesicles: a liaison dangereuse causing overt DIC in cancer patients?

(2016) L. Hell et al.   THROMBOSIS RESEARCH

NETosis promotes cancer-associated arterial microthrombosis presenting as ischemic stroke with troponin elevation

(2016) Charlotte Thålin et al.   THROMBOSIS RESEARCH

Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis

(2016) Silvia Guglietta et al.   Nature Communications

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

Neutrophils Suppress Intraluminal NK Cell-Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells

(2016) A. Spiegel et al.   Cancer Discovery

Tumor Cell–Independent Estrogen Signaling Drives Disease Progression through Mobilization of Myeloid-Derived Suppressor Cells

(2016) Nikolaos Svoronos et al.   Cancer Discovery

Association of Leisure-Time Physical Activity With Risk of 26 Types of Cancer in 1.44 Million Adults

(2016) Steven C. Moore et al.   JAMA Internal Medicine

CXCR2-Dependent Accumulation of Tumor-Associated Neutrophils Regulates T-cell Immunity in Pancreatic Ductal Adenocarcinoma

(2016) T. Chao et al.   Cancer Immunology Research

Priming of neutrophils toward NETosis promotes tumor growth

(2016) Mélanie Demers et al.   OncoImmunology

Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells

(2015) Adam Blaisdell et al.   CANCER CELL

RORC1 Regulates Tumor-Promoting “Emergency” Granulo-Monocytopoiesis

(2015) Laura Strauss et al.   CANCER CELL

ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis

(2015) Juan R. Cubillos-Ruiz et al.   CELL

Immune Regulation of Metabolic Homeostasis in Health and Disease

(2015) Jonathan R. Brestoff et al.   CELL

The wound inflammatory response exacerbates growth of pre-neoplastic cells and progression to cancer

(2015) N. Antonio et al.   EMBO JOURNAL

Neutrophils in host defense: new insights from zebrafish

(2015) E. A. Harvie et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Tissue factor expressed by circulating cancer cell-derived microparticles drastically increases the incidence of deep vein thrombosis in mice

(2015) G. M. Thomas et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Neutrophil ageing is regulated by the microbiome

(2015) Dachuan Zhang et al.   NATURE

Neutrophils support lung colonization of metastasis-initiating breast cancer cells

(2015) Stefanie K. Wculek et al.   NATURE

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

(2015) Seth B. Coffelt et al.   NATURE

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

(2015) Huw D Lewis et al.   Nature Chemical Biology

Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes

(2015) Anja Hasenberg et al.   NATURE METHODS

Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils

(2015) Amy-Jo Casbon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1

(2015) Tina El Rayes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRF5 controls both acute and chronic inflammation

(2015) Miriam Weiss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx

(2015) David Nobuhiro Douda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phenotypic Diversity and Plasticity in Circulating Neutrophil Subpopulations in Cancer

(2015) Jitka Y. Sagiv et al.   Cell Reports

Virus-Induced NETs – Critical Component of Host Defense or Pathogenic Mediator?

(2015) Craig N. Jenne et al.   PLoS Pathogens

Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial

(2015) Estefanía Toledo et al.   JAMA Internal Medicine

Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer Therapies

(2015) F. Hossain et al.   Cancer Immunology Research

Presence of Insulin-Like Growth Factor Binding Proteins Correlates With Tumor-Promoting Effects of Matrix Metalloproteinase 9 in Breast Cancer

(2015) Jae-Hyun Park et al.   NEOPLASIA

Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals

(2014) Jon Hazeldine et al.   AGING CELL

Gut Microbiota Promote Hematopoiesis to Control Bacterial Infection

(2014) Arya Khosravi et al.   Cell Host & Microbe

Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity

(2014) Prabhakara R. Nagareddy et al.   Cell Metabolism

Serum Interleukin-8 Reflects Tumor Burden and Treatment Response across Malignancies of Multiple Tissue Origins

(2014) M. F. Sanmamed et al.   CLINICAL CANCER RESEARCH

γδT17 Cells Promote the Accumulation and Expansion of Myeloid-Derived Suppressor Cells in Human Colorectal Cancer

(2014) Pin Wu et al.   IMMUNITY

Obesity is associated with more activated neutrophils in African American male youth

(2014) X Xu et al.   INTERNATIONAL JOURNAL OF OBESITY

Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer

(2014) Evgeniy B. Eruslanov et al.   JOURNAL OF CLINICAL INVESTIGATION

Microbiota-Derived Compounds Drive Steady-State Granulopoiesis via MyD88/TICAM Signaling

(2014) Maria L. Balmer et al.   JOURNAL OF IMMUNOLOGY

Citrullination regulates pluripotency and histone H1 binding to chromatin

(2014) Maria A. Christophorou et al.   NATURE

Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion

(2014) Fei Chen et al.   NATURE IMMUNOLOGY

The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice

(2014) Hitesh S Deshmukh et al.   NATURE MEDICINE

Pregnancy and Infection

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Disruption of CXCR2-Mediated MDSC Tumor Trafficking Enhances Anti-PD1 Efficacy

(2014) S. L. Highfill et al.   Science Translational Medicine

Association Between Postoperative Complications and Clinical Cancer Outcomes

(2013) Courtney L. Scaife et al.   ANNALS OF SURGICAL ONCOLOGY

CXCR2-Expressing Myeloid-Derived Suppressor Cells Are Essential to Promote Colitis-Associated Tumorigenesis

(2013) Hiroshi Katoh et al.   CANCER CELL

GM-CSF Promotes the Immunosuppressive Activity of Glioma-Infiltrating Myeloid Cells through Interleukin-4 Receptor- 

(2013) G. Kohanbash et al.   CANCER RESEARCH

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance

(2013) María Casanova-Acebes et al.   CELL

Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis

(2013) Jonathan Cools-Lartigue et al.   JOURNAL OF CLINICAL INVESTIGATION

Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis

(2013) Xiaoling Qiang et al.   NATURE MEDICINE

Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice

(2013) K. Martinod et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis

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Bone Marrow–Derived Gr1 + Cells Can Generate a Metastasis-Resistant Microenvironment Via Induced Secretion of Thrombospondin-1

(2013) Raúl Catena et al.   Cancer Discovery

Neutrophil Function: From Mechanisms to Disease

(2012) Borko Amulic et al.   Annual Review of Immunology

Activation of neutrophil respiratory burst by fungal particles requires phosphatidylinositol 3-phosphate binding to p40phox in humans but not in mice

(2012) J. Bagaitkar et al.   BLOOD

Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer

(2012) Lauren J. Bayne et al.   CANCER CELL

Induction of tumoricidal function in CD4+T cells is associated with concomitant memory and terminally differentiated phenotype

(2012) Daniel Hirschhorn-Cymerman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Requirements for NADPH oxidase and myeloperoxidase in neutrophil extracellular trap formation differ depending on the stimulus

(2012) Heather Parker et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

(2012) Bryan G Yipp et al.   NATURE MEDICINE

Origins of tumor-associated macrophages and neutrophils

(2012) V. Cortez-Retamozo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis

(2012) M. Demers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Colony stimulating factors and myeloid cell biology in health and disease

(2012) John A. Hamilton et al.   TRENDS IN IMMUNOLOGY

Doubts concerning the recently reported human neutrophil lifespan of 5.4 days

(2011) P. S. Tofts et al.   BLOOD

Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung

(2011) Zvi Granot et al.   CANCER CELL

Gr-1+CD11b+Myeloid-derived Suppressor Cells Suppress Inflammation and Promote Insulin Sensitivity in Obesity

(2011) Sheng Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

(2011) Irene Puga et al.   NATURE IMMUNOLOGY

The neutrophil in vascular inflammation

(2011) Mia Phillipson et al.   NATURE MEDICINE

PAD4-Mediated Neutrophil Extracellular Trap Formation Is Not Required for Immunity against Influenza Infection

(2011) Saskia Hemmers et al.   PLoS One

Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age

(2011) W. W. Pang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days

(2010) J. Pillay et al.   BLOOD

CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow

(2010) Kyle J. Eash et al.   JOURNAL OF CLINICAL INVESTIGATION

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Novel Mechanism of Rapid Nuclear Neutrophil Extracellular Trap Formation in Response to Staphylococcus aureus

(2010) F. H. Pilsczek et al.   JOURNAL OF IMMUNOLOGY

Myeloid-derived suppressor cells in the peripheral blood of cancer patients contain a subset of immature neutrophils with impaired migratory properties

(2010) Sven Brandau et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity

(2010) Thomas B Clarke et al.   NATURE MEDICINE

Neutrophil elastase–mediated degradation of IRS-1 accelerates lung tumor growth

(2010) A McGarry Houghton et al.   NATURE MEDICINE

Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes

(2010) M. Kowanetz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps

(2009) S Yousefi et al.   CELL DEATH AND DIFFERENTIATION

Neutrophils Ameliorate Lung Injury and the Development of Severe Disease during Influenza Infection

(2009) M. D. Tate et al.   JOURNAL OF IMMUNOLOGY

Abrogation of TGFβ Signaling in Mammary Carcinomas Recruits Gr-1+CD11b+ Myeloid Cells that Promote Metastasis

(2008) Li Yang et al.   CANCER CELL

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY